100 results match your criteria javanica oil


Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells.

Chin J Nat Med 2021 Aug;19(8):608-620

Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China. Electronic address:

Brucea javanica oil emulsion (BJOE) has been used to treat tumor in China for more than 40 years. However, its components and effectiveness in the treatment of acute lymphocytic leukemia (ALL) and its mechanism of anti-cancer activity remain unknown. In the current study, high-performance liquid chromatography-evaporative light scattering detector (HPLC-ELSD) was used to analyze the components of BJOE. Read More

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Brusatol-Enriched Brucea javanica Oil Ameliorated Dextran Sulfate Sodium-Induced Colitis in Mice: Involvement of NF-B and RhoA/ROCK Signaling Pathways.

Biomed Res Int 2021 9;2021:5561221. Epub 2021 Aug 9.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510000, China.

Brucea javanica oil (BJO) is beneficial for the treatment of ulcerative colitis (UC), and that quassinoids in particular brusatol are bioactive components. However, it is still uncertain whether or not other components in BJO, such as oleic acid and fatty acids, have an anti-UC effect. The present study is aimed at comparing the anti-UC effects between brusatol-enriched BJO (BE-BJO) and brusatol-free BJO (BF-BJO) and at exploring the effects and mechanisms of BE-BJO on colon inflammation and intestinal epithelial barrier function. Read More

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Clinical Application of Chinese Herbal Injection for Cancer Care: Evidence-Mapping of the Systematic Reviews, Meta-analyses, and Randomized Controlled Trials.

Front Pharmacol 2021 7;12:666368. Epub 2021 May 7.

Centre for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.

Cancer is a life-threatening disease worldwide and current standard therapy cannot fulfill all clinical needs. Chinese herbal injections have been widely used for cancer in Chinese and Western hospitals in China. This study aimed to apply evidence mapping in order to provide an overview of the clinical application of Chinese herbal injections in cancer care based on randomized controlled trials, systematic reviews, and meta-analyses. Read More

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Traditional Chinese Medicine Brucea Javanica Oil Enhances the Efficacy of Anlotinib in a Mouse Model of Liver-Metastasis of Small-cell Lung Cancer.

In Vivo 2021 May-Jun;35(3):1437-1441

AntiCancer Inc., San Diego, CA, U.S.A.

Background/aim: Small-cell lung cancer (SCLC) is a recalcitrant disease with liver and other metastasis. The present study evaluated the efficacy of the traditional Chinese medicine Brucea javanica oil (BJO) combined with anlotinib, a multi-tyrosine kinase inhibitor with anti-angiogenic activity, on a nude-mouse model of SCLC liver metastasis.

Materials And Methods: The mouse model was established by injecting NCI-H446 cells (1×10) in Matrigel (20 μl) into the upper liver lobe. Read More

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Isolation, fermentation, and formulation of entomopathogenic fungi virulent against adults of Diaphorina citri.

Pest Manag Sci 2021 Sep 1;77(9):4040-4053. Epub 2021 Jun 1.

State Key Laboratory of Agricultural Microbiology, Key Laboratory of Horticultural Plant Biology (MOE), College of Plant Science and Technology, Institute of Urban and Horticultural Entomology, Huazhong Agricultural University, Wuhan, China.

Background: Mycopesticides are important for integrated management of the Asian citrus psyllid, Diaphorina citri. However, there are few reports on the fermentation and formulation for mycopesticides with high virulence against D. citri. Read More

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September 2021

The Promotional Effect of Hollow MnO with Brucea Javanica Oil Emulsion (BJOE) on Endometrial Cancer Apoptosis.

Biomed Res Int 2021 18;2021:6631533. Epub 2021 Mar 18.

Department of Gynecology, Fudan University Shanghai Cancer Center, Shanghai, China.

Endometrial cancer (EC) is a common gynecological malignancy worldwide whose therapy mainly depends on chemotherapy. In past years, an increasing number of studies indicate that hollow MnO could serve as a nanoplatform in the drug delivery system. The Brucea javanica oil emulsion (BJOE) has been illustrated to play a vital role in cancers. Read More

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Investigation on the Efficiency of Chinese Herbal Injections for Treating Non-small Cell Lung Cancer With Vinorelbine and Cisplatin Based on Multidimensional Bayesian Network Meta-Analysis.

Front Pharmacol 2020 29;11:631170. Epub 2021 Jan 29.

Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

As non-small cell lung cancer (NSCLC) seriously threatens human health, several clinical studies have reported that Chinese herbal injections (CHIs) combined with vinorelbine and cisplatin (NP) are beneficial. This multidimensional network meta-analysis was performed to explore the preferable options among different CHIs for treating NSCLC. A literature search was performed in several databases to identify randomized controlled trials (RCTs) of CHIs in the treatment of NSCLC from inception to January 31, 2019. Read More

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January 2021

The Use of Essential Oil and Hydrosol Extracted from Seeds for the Control of and .

Plants (Basel) 2020 Dec 28;10(1). Epub 2020 Dec 28.

Laboratory of Agricultural Zoology and Entomology, Department of Science of Crop Production, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.

The essential oil (EO) and hydrosol (HL) isolated from (cumin) seeds were evaluated against the root-knot nematodes and . The efficacy of extracts on the motility, hatching, and survival in soil of second-stage juveniles (J2s), and the activity on egg differentiation were tested. All J2s were paralyzed after immersion in the EO at 62. Read More

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December 2020

The anti-hepatocellular carcinoma effect of Brucea javanica oil in ascitic tumor-bearing mice: The detection of brusatol and its role.

Biomed Pharmacother 2021 Feb 16;134:111122. Epub 2020 Dec 16.

School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, PR China. Electronic address:

Brucea javanica oil (BJO), one of the main products of Brucea javanica, has been widely used in treating different kinds of malignant tumors. Quassinoids are the major category of anticancer phytochemicals of B. javanica. Read More

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February 2021

Medicinal Activities and Nanomedicine Delivery Strategies for Oil and Its Molecular Components.

Molecules 2020 Nov 19;25(22). Epub 2020 Nov 19.

School of Chemical Engineering and Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon 16419, Korea.

oil (BJO) is widely used in traditional Chinese medicine to treat various types of cancer and inflammatory diseases. There is significant interest in understanding the medicinal activities of BJO and its molecular components, especially quassinoids, and in exploring how they can be incorporated into nanomedicine delivery strategies for improved application prospects. Herein, we cover the latest progress in developing different classes of drug delivery vehicles, including nanoemulsions, liposomes, nanostructured lipid carriers, and spongosomes, to encapsulate BJO and purified quassinoids. Read More

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November 2020

Efficacy and safety of Brucea javanica oil emulsion for liver cancer: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2020 Nov;99(47):e23197

Department of Oncology.

Background: Brucea javanica oil emulsion (BJOE), extracted from the Chinese herb Bruceae Fructus (Yadanzi), is a broad-spectrum anti-tumor drug and has been widely used for the treatment of liver cancer in China. The aim of this study is to systematically investigate the efficacy and safety of BJOE for the treatment of liver cancer.

Methods: Seven electronic databases including the Cochrane Library, PubMed, Excerpt Medica Database, Chinese Biomedical Literature Database, China National Knowledge Infrastructure, China Scientific Journal Database, and Wanfang Database will be systematically retrieved for data extraction from their inceptions to September 2020. Read More

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November 2020

The Use of Essential Oil and Hydrosol Extracted from for the Control of and .

Plants (Basel) 2020 Jul 7;9(7). Epub 2020 Jul 7.

Laboratory of Agricultural Zoology and Entomology, Department of Science of Crop Production, Agricultural University of Athens, Iera Odos 75, 11855 Athens, Greece.

Essential oil (EO) and hydrosol (HL) isolated from an indigenous plant species were evaluated against and . Particularly, the activity of extracts on a second stage juvenile's (J2s) motility, the hatching of J2s from eggs, egg differentiation and the effect on J2s in soil were tested. A paralysis of 100% of the J2s of both species was recorded after 96 h of immersion in the essential oil, at a dose of 2000 μL/L. Read More

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Brucea javanica oil emulsion injection (BJOEI) as an adjunctive therapy for patients with advanced colorectal carcinoma: A protocol for a systematic review and meta-analysis.

Medicine (Baltimore) 2020 Jul;99(27):e21155

Department of Gastroenterology.

Background: Brucea javanica oil emulsion injection (BJOEI) has been widely applied as a promising adjunctive drug for colorectal carcinoma (CRC). However, the exact effects and safety of BJOEI remains controversial. In this study, we aimed to summarize the efficacy and safety of BJOEI for the treatment of advanced CRC through the meta-analysis, in order to provide scientific reference for the design of future clinical trials. Read More

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A bioinformatics investigation into the pharmacological mechanisms of javanica oil emulsion injection in non-small cell lung cancer based on network pharmacology methodologies.

BMC Complement Med Ther 2020 Jun 5;20(1):174. Epub 2020 Jun 5.

Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 11 of North Three-ring East Road, Chao Yang District, Beijing, China.

Background: Javanica oil emulsion injection (JOEI) is an effective therapeutic option for patients with non-small cell lung cancer (NSCLC), but its mechanisms have not been fully elucidated.

Methods: In this study, we utilized network pharmacology to systematically investigate the bioactive components and targets of JOEI, identify common targets in NSCLC, and understand and evaluate the underlying mechanism of JOEI in the treatment of NSCLC through expression level, correlation, enrichment, Cox, survival and molecular docking analyses. The results indicated that five compounds of JOEI interact with five pivotal targets (LDLR, FABP4, ABCB1, PTGS2, and SDC4) that might be strongly correlated with the JOEI-mediated treatment of NSCLC. Read More

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Nematicidal Activity of (Bertoni) Assisted by Phytochemical Analysis.

Toxins (Basel) 2020 05 12;12(5). Epub 2020 May 12.

Laboratory of Pesticides' Toxicology, Department of Pesticides Control and Phytopharmacy, Benaki Phytopathological Institute, 8 St. Delta Street, 14561 Athens, Greece.

To date, there has been great demand for ecofriendly nematicides with beneficial properties to the nematode hosting plants. Great efforts are made towards the chemical characterization of botanical extracts exhibiting nematicidal activity against , but only a small percentage of these data are actually used by the chemical industry in order to develop new formulates. On the other hand, the ready to use farmer produced water extracts based on edible plants could be a sustainable and economic solution for low income countries. Read More

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Comparative efficacy and safety of Chinese herbal injections combined with transcatheter hepatic arterial chemoembolization in treatment of liver cancer: a bayesian network Meta-analysis.

J Tradit Chin Med 2020 04;40(2):167-187

Department of Clinical Pharmacology of Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.

Objective: To address the optimal Chinese herbal injections (CHIs) against liver cancer, the present network Meta-analysis is designed to investigate the comparative efficacy and safety of different CHIs.

Methods: Several electronic databases were searched up to June 1st, 2017. The quality assessment was conducted and network Meta-analysis was performed to compare the efficacy and safety of different CHIs plus transcatheter hepatic arterial chemoembolization (TACE). Read More

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(Schreb) Botanical Products as Ecofriendly Nematicides with Bio-Fertilizing Properties.

Plants (Basel) 2020 Feb 6;9(2). Epub 2020 Feb 6.

Department of Science and Technology, International Hellenic University, 57001 Thessaloniki, Greece.

In recent years, interest has surged in the development of plant extracts into botanical nematicides as ecofriendly plant protection products. Aromatic plants are maybe the most studied category of botanicals used in this direction and the yielding essential oils are obtained on a commodity scale by hydro distillation. Nevertheless, can the bioactivity of aromatic plants always be attributed to the terpenes content? What would it mean for soil microcosms to bear the treatment of an essential oil to cure against sp. Read More

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February 2020

The Impact of Javanica Oil Emulsion Injection on Chemotherapy Efficacy and Cellular Immune Indicators in Patients with Advanced NSCLC: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2019 22;2019:7560269. Epub 2019 Oct 22.

Department of Oncology, RenMin Hospital of Wuhan University, Wuhan 430000, China.

Background: This meta-analysis aimed to evaluate the efficacy and safety of Javanica oil emulsion injection (JOI) combined with chemotherapy versus chemotherapy in patients with advanced non-small-cell lung cancer (NSCLC).

Methods: Electronic databases including EMBASE, PUBMED, the Cochrane library, and Chinese Biological Medical disc (CBM) were searched until May 2018. The clinical trials reporting efficacy and immune function of JOI combined with chemotherapy versus chemotherapy in advanced NSCLC were included according to the inclusion and exclusion criteria. Read More

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October 2019

pH Responsiveness of Hexosomes and Cubosomes for Combined Delivery of Oil and Doxorubicin.

Langmuir 2019 11 4;35(45):14532-14542. Epub 2019 Nov 4.

Shanghai Key Laboratory of Functional Materials Chemistry, State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry, School of Chemistry and Molecular Engineering , East China University of Science and Technology , Shanghai 200237 , P. R. China.

We report pH-responsive liquid crystalline lipid nanoparticles, which are dual-loaded by oil (BJO) and doxorubicin hydrochloride (DOX) and display a pH-induced inverted hexagonal (pH = 7.4) to cubic (pH = 6.8) to emulsified microemulsion (pH = 5. Read More

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November 2019

Chemical Composition and Biological Activities of subsp. Essential Oils and Hydrolate.

Biomolecules 2019 10 2;9(10). Epub 2019 Oct 2.

Instituto de Ciencias Agrarias, Consejo Superior de Investigaciones Científicas, 28006 Madrid, Spain.

Given the importance of the genus as a source of valuable natural products, the rare plant subspecies endemic to the Iberian Peninsula, has been experimentally cultivated in the greenhouse and aeroponically, to produce biomass for essential oil (EO) extraction. The chemical composition of the EOs was analyzed, and their plant protection (insects: , and ; plants: and ; fungi: and nematode: ) and antiparasitic (, and antiplasmodial by the ferriprotoporphyrin biocrystallization inhibition test) properties were studied, in addition to the hydrolate by-product. The EOs showed a 1,8-cineole and camphor profile, with quantitative and qualitative chemical differences between the cultivation methods. Read More

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October 2019

Identification and transmission of phytoplasmas and their impact on essential oil composition in .

3 Biotech 2019 Aug 30;9(8):310. Epub 2019 Jul 30.

3Department of Agricultural and Food Sciences, Alma Mater Studiorum-University of Bologna, Bologna, Italy.

plants showing symptoms of witches' broom, little leaf, and leaf roll were observed in 50% of the plants grown in the deserts of Hormozgan province, Iran. This study was carried out to verify possible phytoplasma association with this disease, insect vector, and modification of the chemical composition of symptomatic . Aerial parts were collected at the full flowering stage from symptomatic and asymptomatic plants and samples were examined for phytoplasma presence by nested-PCR assays. Read More

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Anti-Oral Pathogens of (L.) and (L.) Flower Volatile Oils in Comparison with Chlorhexidine in Accordance with Their Folk Medicinal Uses.

Medicina (Kaunas) 2019 Jun 24;55(6). Epub 2019 Jun 24.

Pharmacognosy Department, Faculty of Pharmacy, Al-Azhar University, Cairo 11371, Egypt.

: Teeth decay and plaque are complicated problems created by oral pathogens. (L.) and (L. Read More

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oil emulsion improves the effect of radiotherapy on esophageal cancer cells by inhibiting cyclin D1-CDK4/6 axis.

World J Gastroenterol 2019 May;25(20):2463-2472

Department of Interventional Therapy, Affiliated Hospital of Jining Medical University, Jining, 272000, Shandong Province, China.

Background: Esophageal cancer is one of the most common cancers around the world, and it has high incidence and mortality rates. The conventional therapy for esophageal cancer is radiotherapy, although its effect is highly limited by the resistance of esophageal cancer cells. Thus, strong radiosensitizers can be very crucial during radiotherapy against esophageal cancer. Read More

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Potential of Fatty Oils from Traditional Chinese Medicine in Cancer Therapy: A Review for Phytochemical, Pharmacological and Clinical Studies.

Am J Chin Med 2019 16;47(4):727-750. Epub 2019 May 16.

* School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cai-lun Road, Pudong District, Shanghai 201203, P. R. China.

Cancer management is a worldwide challenge. In addition to effective cancer therapies like chemotherapy, radiotherapy and surgery, treatment based on traditional Chinese medicine (TCM) and combined TCM with western medicine has gradually gained attention in Oriental countries. One potential TCM approach using extracted fatty oils, containing fatty acids which are important active ingredients with a variety of pharmacological activities, makes significant contributions to cancer treatment. Read More

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October 2019

Therapeutic effect of Brucea javanica oil emulsion on experimental Crohn's disease in rats: Involvement of TLR4/ NF-κB signaling pathway.

Biomed Pharmacother 2019 Jun 20;114:108766. Epub 2019 Mar 20.

Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, PR China. Electronic address:

Brucea javanica is an important Chinese folk medicine traditionally used for the treatment of dysentery (also known as inflammatory bowel diseases). Brucea javanica oil emulsion (BJOE), the most common preparation of Brucea javanica, has a variety of pharmacological activities. In this follow-up investigation, we endeavored to illuminate the potential benefit of BJOE on 2, 4, 6-trinitrobenzenesulfonic acid (TNBS)-induced Crohn's disease (CD) in rats and decipher the mechanism of action. Read More

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Clinical Evaluation of Javanica Oil Emulsion Injection Combined with the Radiotherapy in the Treatment of Esophageal Cancer: A Systematic Review and Meta-Analysis.

J Altern Complement Med 2019 May 19;25(5):542-551. Epub 2019 Feb 19.

Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing, China.

This meta-analysis aimed to assess the clinical effectiveness and safety of Javanica oil emulsion injection (JOEI) combined with the radiotherapy (RT) for treating esophageal cancer (EC). A literature search was conducted for collecting the randomized controlled trials (RCTs) on EC treated by JOEI in the Cochrane Library, PubMed, Embase, the Chinese Biomedical Literature Database (SinoMed), the China National Knowledge Infrastructure Database, the China Science and Technology Journal Database (VIP), and the Wanfang Database from inception to February 4, 2017. The quality of the RCTs was evaluated by the Cochrane risk of bias assessment tool, and objective remission rate, performance status, adverse drug reactions (ADRs), 1-year survival rate, and 2-year survival rate were analyzed by Review Manager 5. Read More

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[Effect of Brucea javanica oil emulsion on proliferation, migration and autophagy of non-small cell lung cancer A549 cells and the underlying mechanisms].

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1202-1208

Department of Respiratory Medicine, Xiangya Hospital, Central South University; National Clincial Research Center for Respiratory Disease, Changsha 410008, China.

Objective: To investigate the effect of Brucea javanica oil emulsion on proliferation, migration and autophagy of non-small cell lung cancer A549 cells.
 Methods: First, A549 cells were divided into a control group and a low, medium or high dose of Brucea javanica oil emulsion groups (0, 2.5, 5. Read More

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November 2018

Self-nanoemulsifying drug delivery system of bruceine D: a new approach for anti-ulcerative colitis.

Int J Nanomedicine 2018 28;13:5887-5907. Epub 2018 Sep 28.

Department of Pharmacy, The First Affiliated Hospital of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, People's Republic of China,

Background: Bruceine D (BD) is a major bioactive component isolated from the traditional Chinese medicinal plant which has been widely utilized to treat dysentery (also known as ulcerative colitis [UC]).

Methods: To improve the water solubility and absolute bioavailability of BD, we developed a self-nanoemulsifying drug delivery system (SNEDDS) composing of MCT (oil), Solutol HS-15 (surfactant), propylene glycol (co-surfactant) and BD. The physicochemical properties and pharmacokinetics of BD-SNEDDS were characterized, and its anti-UC activity and potential mechanism were evaluated in TNBS-induced UC rat model. Read More

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November 2018

Efficacy of Oil Emulsion Injection Combined with the Chemotherapy for Treating Gastric Cancer: A Systematic Review and Meta-Analysis.

Evid Based Complement Alternat Med 2018 2;2018:6350782. Epub 2018 May 2.

Department of Clinical Chinese Pharmacy, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China.

Objective: This meta-analysis sought to assess the efficacy and safety of oil emulsion injection (BJOEI) combined with chemotherapy for treating gastric cancer (GC).

Method: Randomized controlled trials (RCTs) regarding BJOEI to treat GC were searched in PubMed, the Cochrane Library, Embase, the China National Knowledge Infrastructure Database (CNKI), the Wan-Fang Database, China Science and Technology Journal Database (VIP), and the Chinese Biomedical Literature Database (SinoMed) up to January 9, 2017. The clinical total effective rate, performance status, adverse drug reactions (ADRs), and other outcomes were analyzed with Review Manager 5. Read More

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Activity of oil emulsion against gastric ulcers in rodents.

Asian J Pharm Sci 2018 May 8;13(3):279-288. Epub 2017 Dec 8.

School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, China.

The present study aims to investigate the gastroprotective effect of oil emulsion (BJOE) in animals. Gastroprotective potential of BJOE was studied on absolute ethanol, aspirin, reserpine and restraint plus water immersion-induced gastric ulcers in mice as well as glacial acetic acid (GAA) and pyloric ligation (PL)-induced gastric ulcers in rats. Except for ulcer scores, total acidity as well as pepsin activity as for the PL-induced gastric ulcer model and ulcer incidence as for the GAA-induced gastric ulcer model were also determined. Read More

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