23,766 results match your criteria janus


Social context factors and refugee children's emotional health.

Soc Psychiatry Psychiatr Epidemiol 2021 Sep 25. Epub 2021 Sep 25.

Human Early Learning Partnership, School of Population and Public Health, University of British Columbia, Vancouver, Canada.

Background: Refugee children face numerous challenges associated with pre-migration trauma and post-migration adaptation. Much research pertaining to refugee children's well-being focuses on psychiatric symptoms. Relatively few studies have examined how social context factors-such as perceptions of peer belonging, and support from adults at home and at school-contribute to the emotional health of refugee children. Read More

View Article and Full-Text PDF
September 2021

Apoptotic Tumor DNA Activated Nanomotor Chemotaxis.

Nano Lett 2021 Sep 24. Epub 2021 Sep 24.

School of Materials Science and Engineering, Sun Yat-Sen University, Guangzhou 510275, China.

Inspired by the tactic organisms in Nature that can self-direct their movement following environmental stimulus gradient, we proposed a DNase functionalized Janus nanoparticle (JNP) nanomotor system for the first time, which can be powered by ultralow nM to μM levels of DNA. The system exhibited interesting chemotactic behavior toward a DNA richer area, which is physiologically related with many diseases including tumors. In the presence of the subtle DNA gradient generated by apoptotic tumor cells, the cargo loaded nanomotors were able to sense the DNA signal released by the cells and demonstrate directional motion toward tumor cells. Read More

View Article and Full-Text PDF
September 2021

Synergistic Theranostics of Magnetic Resonance Imaging and Photothermal Therapy of Breast Cancer Based on the Janus Nanostructures FeO-Au-PEG.

Int J Nanomedicine 2021 16;16:6383-6394. Epub 2021 Sep 16.

Department of Radiology, Xinqiao Hospital, Army Medical University, Chongqing, People's Republic of China.

Background: Satisfactory prognosis of breast cancer (BC) is limited by difficulty in early diagnosis and insufficient treatment. The combination of molecular imaging and photothermal therapy (PTT) may provide a solution.

Methods: FeO-Au nanoparticles (NPs) were prepared by thermal decomposition, seeded growth and galvanic replacement and were comprehensively characterized. Read More

View Article and Full-Text PDF
September 2021

Effect of combination therapy with neural stem cell transplantation and teramethylpyrazine in rats following acute spinal cord injury.

Neuroreport 2021 Sep 21. Epub 2021 Sep 21.

Department of Orthopaedics, The General Hospital of Northern Theater Command, Shenyang The Second Clinical College of Graduate School, Dalian Medical University, Dalian, Liaoning, China.

Objectives: This study was to explore the effects of teramethylpyrazine (TMP) administered in conjunction with neural stem cell transplantation on motor function, pathological lesions and the Janus kinase (JAK)2/signal transducer and activator of transcription 3 signal transduction pathway in rats following acute spinal cord injury (SCI).

Methods: Female Sprague-Dawley rats were randomly divided into sham, model, neural stem cells (NSCs) and NSCs+TMP groups. Motor function was evaluated using the Basso, Beattie, Bresnahan scale. Read More

View Article and Full-Text PDF
September 2021

Risk of venous thromboembolism associated with Janus kinase inhibitors for rheumatoid arthritis: case presentation and literature review.

Clin Rheumatol 2021 Sep 23. Epub 2021 Sep 23.

Divsion of Cardiology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan.

Janus kinase (JAK) inhibitors have been developed as disease-modifying antirheumatic drugs. Despite the positive therapeutic impacts of JAK inhibitors, concerns have been raised regarding the risk of venous thromboembolism (VTE), such as deep vein thrombosis (DVT) and pulmonary embolism (PE). A recent post hoc safety analysis of placebo-controlled trials of JAK inhibitors in rheumatoid arthritis (RA) reported an imbalance in the incidence of VTE for a 4-mg daily dose of baricitinib versus placebo. Read More

View Article and Full-Text PDF
September 2021

Janus PtXO (X = S, Se) monolayers: the visible light driven water splitting photocatalysts with high carrier mobilities.

Phys Chem Chem Phys 2021 Sep 23. Epub 2021 Sep 23.

Physicochemical Group of College of Criminal Science and Technology & Forensic Center of Public Security of Bureau of National Forestry Bureau, Nanjing Forest Police College, Nanjing 210023, China.

Triggered by the recent experimental synthesis of the Janus PtSSe monolayer, we use the first-principles calculations to predict two new Janus photocatalysts PtXO (X = S, Se), based on the systematic investigations of the structural stabilities, electronic structures, band alignments, catalytic activity and optical absorption. The two Janus structures are found to be mechanically, dynamically and thermodynamically stable, and have suitable band edge positions for the overall water splitting. Owing to the high electron mobility (up to 2164. Read More

View Article and Full-Text PDF
September 2021

A "Janus" face of the RASSF4 signal in cell fate.

J Cell Physiol 2021 Sep 22. Epub 2021 Sep 22.

Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Universidad Complutense de Madrid(UCM), and Research Institute Hospital 12 de October (i+12), Madrid, Spain.

RASSF4 (Ras-association domain family 4) is a protein-coding gene, regarded as a tumor suppressor regulated by DNA methylation. However, RASSF4 acts as a "Janus" in cell fate: death and survival. This review article focuses on the regulatory mechanisms of RASSF4 on cell death and cell survival and puts forward a comprehensive analysis of the relevant signaling pathways. Read More

View Article and Full-Text PDF
September 2021

Single-cell transcriptomics reveal in mature B cell as a dynamic network biomarker before lymph node metastasis in CRC.

Mol Ther Oncolytics 2021 Sep 12;22:495-506. Epub 2021 Jun 12.

School of Biology and Biological Engineering, South China University of Technology, 381 Wushan Road, Guangzhou, Guangdong 510641, China.

Increasing evidence indicates that mature B cells in the adjacent tumor tissue, both as an intermediate state, are vital in advanced colorectal cancer (CRC), which is associated with a low survival rate. Developing predictive biomarkers that detect the tipping point of mature B cells before lymph node metastasis in CRC is critical to prevent irreversible deterioration. We analyzed B cells in the adjacent tissues of CRC samples from different stages using the dynamic network biomarker (DNB) method. Read More

View Article and Full-Text PDF
September 2021

Shear-induced orientational ordering in an active glass former.

Proc Natl Acad Sci U S A 2021 09;118(39)

Institute for Theoretical Physics, Georg-August-Universität Göttingen, 37 077 Göttingen, Germany.

Dense assemblies of self-propelled particles that can form solid-like states also known as active or living glasses are abundant around us, covering a broad range of length scales and timescales: from the cytoplasm to tissues, from bacterial biofilms to vehicular traffic jams, and from Janus colloids to animal herds. Being structurally disordered as well as strongly out of equilibrium, these systems show fascinating dynamical and mechanical properties. Using extensive molecular dynamics simulation and a number of distinct dynamical and mechanical order parameters, we differentiate three dynamical steady states in a sheared model active glassy system: 1) a disordered state, 2) a propulsion-induced ordered state, and 3) a shear-induced ordered state. Read More

View Article and Full-Text PDF
September 2021

Retrospective analysis of pacritinib in patients with myelofibrosis and severe thrombocytopenia.

Haematologica 2021 Sep 23. Epub 2021 Sep 23.

Icahn School of Medicine at Mount Sinai, New York.

Thrombocytopenia is common in patients with myelofibrosis and is a well-established adverse prognostic factor. Both of the approved Janus kinase (JAK) inhibitors, ruxolitinib and fedratinib, can worsen thrombocytopenia and have not been evaluated in patients with severe thrombocytopenia (. Read More

View Article and Full-Text PDF
September 2021

Comparative Efficacy and Tolerability of Janus Kinase Inhibitor Therapies for Moderate to Severe Crohn's Disease: Α Network Meta-analysis.

J Gastrointestin Liver Dis 2021 Sep 21;30(3):388-397. Epub 2021 Sep 21.

Ariel University, Ministry of Health, Israel.

Background And Aims: A number of Janus kinase (JAK) inhibitors (tofacitinib, filgotinib, upadacitinib) have been tested for moderate and severe Crohn's disease (CD) in randomized control trials (RCTs). However, data on their comparative efficacy and tolerability is lacking. We aimed to study their performance comparatively, by means of network meta-analysis (NWM). Read More

View Article and Full-Text PDF
September 2021

Two-faced Janus: The dual role of macrophages in atherosclerotic calcification.

Cardiovasc Res 2021 Sep 22. Epub 2021 Sep 22.

Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, Netherlands.

Calcification is an independent predictor of atherosclerosis-related cardiovascular events. Microcalcification is linked to inflamed, unstable lesions, in comparison to the fibrotic stable plaque phenotype generally associated with advanced calcification. This paradox relates to recognition that calcification presents in a wide spectrum of manifestations that differentially impact plaque's fate. Read More

View Article and Full-Text PDF
September 2021

Prediagnostic Serum 25-Hydroxyvitamin D and Mortality Among Bladder Cancer Patients in the Janus Serum Bank Cohort.

Clin Epidemiol 2021 14;13:801-811. Epub 2021 Sep 14.

Department of Research, Cancer Registry of Norway, Oslo, Norway.

Purpose: Circulating 25-hydroxyvitamin D (25(OH)D) is inversely associated with overall cancer mortality and selected cancers, while for urothelial bladder cancer (BC) this relationship is unclear. We aimed to examine the association between 25(OH)D and BC mortality.

Materials And Methods: We used prediagnostic serum from 378 BC cases within the population-based Janus Cohort. Read More

View Article and Full-Text PDF
September 2021

Lattice-Confined Ir Clusters on Pd Nanosheets with Charge Redistribution for the Hydrogen Oxidation Reaction under Alkaline Conditions.

Adv Mater 2021 Sep 21:e2105400. Epub 2021 Sep 21.

School of Materials Science and Engineering, State Key Laboratory of Clean Energy Utilization, Zhejiang University, Hangzhou, 310027, P. R. China.

Electrocatalysts with high activity and long-term stability for the hydrogen oxidation reaction (HOR) under alkaline conditions is still a major challenge for anion exchange membrane fuel cells (AEMFCs). Herein, a heterostructured [email protected] electrocatalyst with ultrasmall Ir nanoclusters (NCs) epitaxially confined on Pd nanosheets (NSs) for catalyzing the sluggish alkaline HOR is reported. Apparent charge redistribution occurs across the heterointerface, and both experimental and theoretical results suggest that the electrons transfer from Pd to Ir, which consequently greatly weakens the hydrogen binding on Pd. Read More

View Article and Full-Text PDF
September 2021

Systemic inflammatory responses after orthopedic surgery in patients with rheumatoid arthritis treated with tofacitinib.

Clin Rheumatol 2021 Sep 21. Epub 2021 Sep 21.

Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.

Objective: To investigate the acute phase response to surgical stress in patients with rheumatoid arthritis (RA) treated with tofacitinib, a Janus kinase (JAK) inhibitor.

Methods: A retrospective matched pair analysis of 34 patients treated with tofacitinib and 34 patients treated with conventional disease-modifying anti-rheumatic drugs (csDMARDs) was performed. Patients were matched for age, sex, and type of surgery; body temperature, C-reactive protein (CRP) level, and white blood cell (WBC) count, neutrophil count, and lymphocyte count were compared between the tofacitinib and csDMARDs groups within 2 weeks after orthopedic surgery. Read More

View Article and Full-Text PDF
September 2021

Extracellular matrix protein N-glycosylation mediates immune self-tolerance in .

Proc Natl Acad Sci U S A 2021 09;118(39)

Department of Entomology, University of Arizona, Tucson, AZ 85719.

In order to respond to infection, hosts must distinguish pathogens from their own tissues. This allows for the precise targeting of immune responses against pathogens and also ensures self-tolerance, the ability of the host to protect self tissues from immune damage. One way to maintain self-tolerance is to evolve a self signal and suppress any immune response directed at tissues that carry this signal. Read More

View Article and Full-Text PDF
September 2021

Circ_0128846/miR-140-3p/JAK2 Network in Osteoarthritis Development.

Immunol Invest 2021 Sep 21:1-19. Epub 2021 Sep 21.

Department of Rheumatology and Immunology, Tianjin Medical University Genenral Hospital, Tianjin, China.

Circular RNAs (circRNAs) titrate the function of microRNAs (miRNAs), regulate transcription, and interfere with splicing. This study attempted to confirm the role of a novel circRNA circ_0128846 during osteoarthritis (OA) progression. Tissues and chondrocytes were isolated from OA patients. Read More

View Article and Full-Text PDF
September 2021

Treatment patterns and sequencing in patients with rheumatic diseases: a retrospective claims data analysis.

Curr Med Res Opin 2021 Sep 21. Epub 2021 Sep 21.

Pfizer Inc., Calle Las Orquídeas, San Isidro, Lima, 15046.

Objectives: Long-term real-world management of inflammatory rheumatic diseases remains unclear, especially with the advent of new treatment options. This study characterizes the number of advanced treatments used by patients with selected rheumatic diseases (rheumatoid arthritis [RA], psoriatic arthritis [PsA], ankylosing spondylitis, juvenile idiopathic arthritis) and provides a contemporary portrait of treatment patterns and therapeutic sequencing among patients with RA and PsA.

Method: Patients were selected from a large US claims database and classified into disease subsamples based on the latest rheumatic diagnosis recorded before/on the day of initiation of the first advanced treatment (index date). Read More

View Article and Full-Text PDF
September 2021

A Comparison of Two Molecular Methods for Detecting CALR Mutations in Myeloproliferative Neoplasms.

Clin Lab 2021 Sep;67(9)

Background: Myeloproliferative neoplasms (MPN) are hematopoietic disorders characterized by abnormal proliferation of the myeloid lineage. Three classic subtypes are polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). These disorders are well known for their association with the JAK2 V617F mutation, in addition to mutations in MPL exon 10, and JAK2 exon 12. Read More

View Article and Full-Text PDF
September 2021

Repigmentation of vitiligo-associated eyelash leukotrichia with topical tofacitinib.

JAAD Case Rep 2021 Oct 27;16:90-91. Epub 2021 Jul 27.

Department of Dermatology, Yale School of Medicine, New Haven, Connecticut.

View Article and Full-Text PDF
October 2021

Systematic Review on the Efficacy and Safety of Oral Janus Kinase Inhibitors for the Treatment of Atopic Dermatitis.

Front Med (Lausanne) 2021 1;8:682547. Epub 2021 Sep 1.

Division of Dermatology, McGill University Health Centre, Montreal, QC, Canada.

Atopic dermatitis is a chronic, relapsing and remitting disease that can be difficult to treat despite a recently approved biologic therapy targeting IL-4/IL-13 receptor. Oral janus kinase inhibitors (JAKi) represent a novel therapeutic class of targeted therapy to treat moderate-to-severe atopic dermatitis (AD). To review the efficacy, safety, and pharmacokinetic characteristics of oral JAKi in the treatment of AD. Read More

View Article and Full-Text PDF
September 2021

Dysbiosis, gut-blood barrier rupture and autoimmune response in rheumatoid arthritis and schizophrenia.

Reumatologia 2021 11;59(3):180-187. Epub 2021 Jul 11.

Department and Clinic of Psychiatric Rehabilitation, Department of Psychiatry and Psychotherapy, Faculty of Medical Sciences, Medical University of Silesia in Katowice, Poland.

The primary cause of chronic autoimmune diseases is elusive both in somatic medicine and psychiatry. Examples of such conditions are rheumatoid arthritis and schizophrenic disorders. Immune disturbances occur in both diseases, but it is difficult to combine them into a meaningful pathogenetic model. Read More

View Article and Full-Text PDF

Janus kinase (JAK)-inhibitors and coronavirus disease 2019 (Covid-19) outcomes: a systematic review and meta-analysis.

Expert Rev Anti Infect Ther 2021 Sep 20. Epub 2021 Sep 20.

Department of Anesthesiology and Intensive Care, Universitas Indonesia - Rumah Sakit Cipto Mangunkusumo, Jakarta, 10430, Indonesia.

Background: Janus Kinase (JAK)-inhibitors have been known as treatment agents for inflammatory diseases, such as rheumatoid arthritis and ankylosing spondylitis. Currently, JAK-inhibitors are repurposed for therapy of coronavirus disease 2019 (Covid-19) because of their ability in restraining immune response, yet the corroboration regarding their advantage are still unclear. This study sought to analyze the efficacy of JAK-inhibitors to ameliorate the outcomes of Covid-19 sufferer. Read More

View Article and Full-Text PDF
September 2021

Pain symptoms and pain management options in SARS-CoV-2 environment

Orv Hetil 2021 09 19;162(38):1511-1519. Epub 2021 Sep 19.

1 Pécsi Tudományegyetem, Általános Orvostudományi Kar, Janus Pannonius Klinikai Központ, Aneszteziológiai és Intenzív Terápiás Intézet, Fájdalomterápiás Tanszék, Pécs.

Összefoglaló. Az új koronavírusként megismert SARS-CoV-2-fertőzés legsúlyosabb szövődményeként a gyulladásos folyamatok jelátvivő molekuláinak elszabadulása - az ún. citokinvihar - kritikus légzési elégtelenséggel társuló akut respirációs diszfunkciós szindrómát vagy többszervi gyulladásos szindrómát okoz. Read More

View Article and Full-Text PDF
September 2021

Janus effects of NaCl on structure of egg yolk granules.

Food Chem 2021 Sep 15;371:131077. Epub 2021 Sep 15.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China. Electronic address:

Egg yolk granules are supramolecular assembly of high-density lipoproteins and phosvitin driven by calcium bridges. However, applications of granules are severely restricted by the large particle size and poor water dispersibility. This study revealed the Janus effects of NaCl on structure of granules at varied pH values. Read More

View Article and Full-Text PDF
September 2021

Stretchable, rapid self-healing guar gum-poly(acrylic acid) hydrogels as wearable strain sensors for human motion detection based on Janus graphene oxide.

Int J Biol Macromol 2021 Sep 15. Epub 2021 Sep 15.

School of Chemistry and Materials Science, Ludong University; Key Laboratory of High Performance and Functional Polymer in the Universities of Shandong Province; Collaborative Innovation Center of Shandong Province for High Performance Fibers and Their Composites, Yantai 264025, China.

Wearable strain sensors have received widespread attention in research fields due to their applications in human motion detection. In this manuscript, the fabrication of functionalized Janus graphene oxide (GO) nanosheets were used by Pickering emulsion template. Polypyrrole (PPy) and poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) were asymmetrically grafted on the two sides of GO ([email protected]/PDMAEMA Janus NS), which successfully applied to synthesize Janus NS/guar gum-poly(acrylic acid) (GG-PAA) self-healing nanocomposite hydrogels. Read More

View Article and Full-Text PDF
September 2021

Early-onset pulmonary and cutaneous vasculitis driven by constitutively active SRC-family kinase HCK.

J Allergy Clin Immunol 2021 Sep 15. Epub 2021 Sep 15.

Department of Pediatrics, 2nd Faculty of Medicine, Charles University, and University Hospital Motol, Prague, Czech Republic.

Background: Inborn errors of immunity (IEI) are genetic disorders characterized by various degrees of immune dysregulation that can manifest as immune deficiency, autoimmunity or autoinflammation. The routine use of next-generation sequencing in the clinic has facilitated the identification of an ever-increasing number of IEI, revealing the roles of immunologically important genes in human pathologies. However, despite this progress, treatment is still extremely challenging. Read More

View Article and Full-Text PDF
September 2021

Diaphragmatic pacemaker-induced ventricular tachycardia leading to cardiac arrest: a case report.

Eur Heart J Case Rep 2021 Sep 7;5(9):ytab352. Epub 2021 Sep 7.

Harrington Heart and Vascular Institute, University Hospital Cleveland Medical Center, 11100 Euclid Ave Cleveland 44106, OH, USA.

Background: Diaphragmatic pacemakers are used to assist respiration in ventilator-dependent patients. Electromagnetic interference with intrinsic cardiac electrical activity is a theoretical risk but has never been reported in the literature. This case highlights a serious complication of cardiac arrest as a result of diaphragmatic pacing. Read More

View Article and Full-Text PDF
September 2021

Janus kinase inhibitors for the therapy of atopic dermatitis.

Allergol Select 2021 27;5:293-304. Epub 2021 Aug 27.

Department of Dermatology, Allergology and Venereology, Hannover Medical School, Hannover, Germany.

The JAK-STAT pathway is involved in the signaling of multiple cytokines driving cutaneous inflammation in atopic dermatitis (AD). Janus kinase (JAK) inhibitors target individual receptor-associated kinases, thereby preventing the mediation of inflammatory signals. Several JAK inhibitors with varying mechanism of action, potency, and safety represent potential therapeutic options for AD in both topical and systemic application. Read More

View Article and Full-Text PDF