1,820 results match your criteria ivt


Patient preferences in retinal drug delivery.

Sci Rep 2021 Sep 23;11(1):18996. Epub 2021 Sep 23.

Eugene and Marilyn Glick Eye Institute and Department of Ophthalmology, Indiana University School of Medicine, 1160 West Michigan Street, Indianapolis, IN, 46202, USA.

Retinal vascular diseases (RVDs) are often treated with intravitreally (IVT) injected drugs, with relatively low patient compliance and potential risks. Ongoing research explores alternative RVD treatments, including eye drops and oral tablets. This study surveyed RVD patients treated with IVT injections to establish factors influencing low compliance rates while gauging treatment delivery method preferences. Read More

View Article and Full-Text PDF
September 2021

Right ventricular time intervals - Comparison between pulsed wave Doppler and tissue Doppler imaging.

Echocardiography 2021 Sep 23. Epub 2021 Sep 23.

Anesthesia and Intensive Care, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.

Background: Cardiac time intervals are used as indices of systolic and diastolic function. Echocardiographic assessment of these intervals is based on either pulsed wave Doppler (PWD) or tissue Doppler imaging (TDI). We investigated the agreement between the two techniques in the evaluation of right ventricular (RV) time intervals in healthy adults. Read More

View Article and Full-Text PDF
September 2021

Effect of renal impairment on the efficacy and safety of intra-arterial treatment: A post-hoc analysis of DIRECT-MT study.

Int J Stroke 2021 Sep 22:17474930211045805. Epub 2021 Sep 22.

Department of Stroke Center, Changhai Hospital, Naval Military Medical University, Shanghai, China.

Objective: To determine the influence of renal impairment on clinical outcomes in patients presenting emergent anterior circulation occlusion treated with mechanical thrombectomy.

Methods: Consecutive patients with anterior circulation stroke treated with mechanical thrombectomy at 41 academic tertiary care centers were included. renal impairment was defined as glomerular filtration rate <60 mL/min/1. Read More

View Article and Full-Text PDF
September 2021

Update of Intravenous Thrombolytic Therapy in Acute Ischemic Stroke.

Acta Neurol Taiwan 2021 Jun;30(2):44-53

Department of Neurology and Stroke Center, National Taiwan University Hospital, Taipei, Taiwan.

Upon acute ischemic stroke, rapid recanalization of the occluded cerebral vessel via intravenous thrombolytic therapy (IVT) is crucial to achieve good functional outcome. The time window of IVT with recombinant tissue plasminogen activator (rt-PA) has been extended from post-stroke 3 to 4.5 hours. Read More

View Article and Full-Text PDF

The Maryland Acute Stroke Emergency Medical Services Routing Pilot: Expediting Access to Thrombectomy for Stroke.

Front Neurol 2021 31;12:663472. Epub 2021 Aug 31.

Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Mechanical thrombectomy (MT) is the standard of care for acute ischemic stroke caused by large vessel occlusion, but is not available at all stroke centers. Transfers between hospitals lead to treatment delays. Transport directly to a facility capable of MT based on a prehospital stroke severity scale score has been recommended, if transportation time is less than 30 min. Read More

View Article and Full-Text PDF

A new protocol reduces median door-to-needle time to the benchmark of 30 minutes in acute stroke treatment.

Neurologia (Engl Ed) 2021 Sep 18;36(7):487-494. Epub 2020 Mar 18.

Sección de Neurología Vascular, Unidad de Ictus, Hospital General Universitario Gregorio Marañón, Madrid, Spain.

Introduction: Recent analyses emphasise that The Benchmark Stroke Door-to-Needle Time (DNT) should be 30min. This study aimed to determine if a new in-hospital IVT protocol is effective in reducing door-to-needle time and correcting previously identified factors associated with delays.

Material And Methods: In 2014, we gradually introduced a series of measures aimed to reduce door-to-needle time for patients receiving IVT, and compared it before (2009-2012) and after (2014-2017) the new protocol was introduced. Read More

View Article and Full-Text PDF
September 2021

Spontaneous Spinal Epidural Hematoma Mimicking Stroke and Its Outcome post Intravenous Thrombolysis.

Cerebrovasc Dis 2021 Sep 15:1-5. Epub 2021 Sep 15.

Department of Medicine and Geriatrics, United Christian Hospital, Kwun Tong, Hong Kong, China.

Background And Purpose: Spontaneous spinal epidural hematoma (SSEH) is a rare neurological emergency. Its presentation, depending on location of hematoma, could mimic stroke. While intravenous thrombolysis (IVT) is recommended to commence as early as possible in case of acute ischemic stroke, it is likely that it could be given to SSEH patients. Read More

View Article and Full-Text PDF
September 2021

The level of urbanization influences acute ischemic stroke care: A nationwide ecological study from Germany.

J Neurol Sci 2021 Sep 13;430:119983. Epub 2021 Sep 13.

Department of Neurology, St. Josef-Hospital Bochum, Ruhr University Bochum, Germany; Medical Faculty, Ruhr University Bochum, Germany. Electronic address:

Background And Purpose: Regional differences in acute ischemic stroke (AIS) care are still reported for Germany but not fully understood. We aimed to analyze the impact of the level of urbanization on the application of proved treatment procedures and the incidence of hospitalized AIS cases in Germany.

Methods: The level of urbanization of the 401 districts and district-free cities in Germany was defined according to the Federal Institute for Building, Urban Affairs and Spatial Research classification. Read More

View Article and Full-Text PDF
September 2021

Incidence of Newly Registered Blindness From Age-Related Macular Degeneration in Australia Over a 21-Year Period: 1996-2016.

Asia Pac J Ophthalmol (Phila) 2021 Sep 16. Epub 2021 Sep 16.

Centre for Ophthalmology and Visual Science (Incorporating Lions Eye Institute), The University of Western Australia, Nedlands, Western Australia, Australia Department of Ophthalmology, Royal Perth Hospital, Perth, Western Australia, Australia School of Population and Global Health, The University of Western Australia, Crawley, Western Australia, Australia Department of Ophthalmology, Perth Children's Hospital, Nedlands, Western Australia, Australia.

Purpose: Report the age-standardized annual incidence of blindness registration due to age-related macular degeneration (AMD) in Australia in patients aged 50 years and older. Frequencies of photodynamic therapy (PDT) and intravitreal therapy (IVT) were examined.

Design: Retrospective observational study. Read More

View Article and Full-Text PDF
September 2021

Gene therapy for inherited retinal diseases.

Ann Transl Med 2021 Aug;9(15):1278

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.

Inherited retinal diseases (IRDs) are a genetically variable collection of devastating disorders that lead to significant visual impairment. Advances in genetic characterization over the past two decades have allowed identification of over 260 causative mutations associated with inherited retinal disorders. Thought to be incurable, gene supplementation therapy offers great promise in treating various forms of these blinding conditions. Read More

View Article and Full-Text PDF

Effect of Intravenous Thrombolysis on Clot Survival during Mechanical Thrombectomy in Acute Large Vessel Occlusion Strokes.

Neurosurgery 2021 Sep 15. Epub 2021 Sep 15.

Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.

Background: The benefit of intravenous thrombolysis (IVT) before mechanical thrombectomy (MT) in patients with large vessel occlusion (LVO) stroke is uncertain. Conventional metrics of final modified thrombolysis in cerebral ischemia (mTICI) score and 90-d modified Rankin Scale may be insensitive to IVT effects on procedural complexity and duration.

Objective: To study the effect of IVT prior to MT on clot survival. Read More

View Article and Full-Text PDF
September 2021

Unique clinical features and long term follow up of survivors of sudden cardiac death in an Asian multicenter study.

Sci Rep 2021 Sep 14;11(1):18250. Epub 2021 Sep 14.

Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital , Taipei City, 100, Taiwan, ROC.

There has been no long-term clinical follow-up data of survivors or victims of sudden cardiac death (SCD). The Taiwan multi-center sudden arrhythmia death syndrome follow-up and clinical study (TFS-SADS) is a collaborative multi-center study with median follow-up time 43 months. In this cohort, the clinical characteristics of these SADS patients were compared with those with ischemic heart disease (IHD). Read More

View Article and Full-Text PDF
September 2021

Thrombectomy with or without thrombolysis in patients with acute ischemic stroke: a systematic review and meta-analysis.

J Neurol 2021 Sep 14. Epub 2021 Sep 14.

Department of Neurosurgery and Brain and Nerve Research Laboratory, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou, 215006, Jiangsu Province, China.

Background: Recently, several randomized controlled trials (RCTs) about direct mechanical thrombectomy (d-MT) vs. intravenous thrombolysis before MT (IVT + MT) for acute ischemic stroke (AIS) patients have been reported. This study aims to investigate the differences in efficacy and safety of MT with or without IVT for the treatment of patients with AIS. Read More

View Article and Full-Text PDF
September 2021

Contemporary Trends in the Treatment of Mild Ischemic Stroke with Intravenous Thrombolysis: Paul Coverdell National Acute Stroke Program.

Cerebrovasc Dis 2021 Aug 17:1-7. Epub 2021 Aug 17.

Division of Heart Disease and Stroke Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Background: Presentation with mild symptoms is a common reason for intravenous thrombolysis (IVT) nonuse among acute ischemic stroke (AIS) patients. We examined the impact of IVT on the outcomes of mild AIS over time.

Methods: Using the Paul Coverdell National Stroke Program data, we examined trends in IVT utilization from 2010 to 2019 among AIS patients presenting with National Institutes of Health Stroke Scale (NIHSS) scores ≤5. Read More

View Article and Full-Text PDF

Treat COVID-19, but Not Only COVID-19: Stroke Matters as Well.

Cerebrovasc Dis 2021 Aug 11:1-8. Epub 2021 Aug 11.

International Clinical Research Center, St. Anne's University Hospital, Brno, Czechia.

Introduction: During the COVID-19 pandemic, studies reported less number of hospitalizations for acute stroke and reduction in the use of recanalization treatments. This study analyzes nationwide data on stroke admissions and management in the Czech Republic during the first wave of the COVID-19 pandemic.

Methods: We compared the early COVID-19 pandemic (March-May 2020) with the pre-pandemic period (January-February 2020 and March-May 2019): (a) the National Register of Reimbursed Health Services provided volume of all admissions for subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), and ischemic stroke (IS), and volume of recanalization treatments (intravenous thrombolysis [IVT] and mechanical thrombectomy [MT]); (b) Registry of Stroke Care Quality provided door-to-needle time (DNT), onset-to-door time (ODT), and stroke severity at admission (National Institutes of Health Stroke Scale, NIHSS) for IS. Read More

View Article and Full-Text PDF

Evaluation of Intraventricular/Intrathecal Antimicrobial Therapy in the Treatment of Nosocomial Meningitis Caused by Multidrug-Resistant Gram-Negative Bacteria after Central Nervous System Surgery.

Can J Infect Dis Med Microbiol 2021 27;2021:9923015. Epub 2021 Aug 27.

University of Health Science, Istanbul Training and Research Hospital, Department of Neurological Surgery, Istanbul, Turkey.

Introduction: Postoperative meningitis (POM) is an infection with high mortality and morbidity following central nervous system surgery due to trauma or tumor. Intrathecal/intraventricular (IT/IVT) antibiotic administrations have been considered as the last treatment options for multidrug-resistance (MDR) Gram-negative bacteria that do not respond to intravenous (IV) regimens. IT/IVT can bypass the blood-brain barrier, obtain a more effective antibiotic concentration in CSF, and reduce systemic side effects. Read More

View Article and Full-Text PDF

A Random-Screening Approach to Identify RNAi Targets for the Control of Western Corn Rootworm (Diabrotica. virgifera virgifera Le Conte).

Authors:
Xu Hu Adane Kassa

Methods Mol Biol 2022 ;2360:91-103

Corteva AgriScience, Johnston, IA, USA.

Identification of active target genes in bioassay screening is the first important step for application of RNA interference (RNAi) for pest control. Here, we describe the methodology for performing high-throughput RNAi target screening against important agriculture pest, Western corn rootworm in 96-well microplate. Two approaches are presented to identify active targets from random-cDNA library or testing a certain group of specific targets via in silico sequence analysis. Read More

View Article and Full-Text PDF
January 2022

Synergistic Effect of Hypokalemia and Atrial Fibrillation on Prognosis in Patients with Stroke after Intravenous Thrombolysis.

Curr Neurovasc Res 2021 Sep 6. Epub 2021 Sep 6.

Department of Rehabilitation, The First Affiliated Hospital of Wenzhou Medical University. China.

Background: The association between atrial fibrillation (AF) and the prognosis of intravenous thrombolysis (IVT) in patients with acute ischemic stroke (AIS) is debated. Hypokalemia is highly prevalent in patients with AF. We aimed to investigate the effect of hypokalemia and AF on the prognosis of AIS patients following IVT. Read More

View Article and Full-Text PDF
September 2021

Simulation-based training improves process times in acute stroke care (STREAM).

Eur J Neurol 2021 Sep 3. Epub 2021 Sep 3.

University Hospital Frankfurt, Department of Neurology, Goethe University, Frankfurt am Main, Germany.

Background: The objective of the STREAM trial was to evaluate the effect of simulation training on process times in acute stroke care.

Methods: The multicenter prospective interventional STREAM trial was conducted between 10/2017 and 04/2019 at seven tertiary care neurocenters in Germany with a pre- and post-interventional observation phase. We recorded patient characteristics, acute stroke care process times, stroke team composition and simulation experience for consecutive direct-to-center patients receiving i. Read More

View Article and Full-Text PDF
September 2021

Real-World Outcomes of Intravitreal Aflibercept for Neovascular Age-Related Macular Degeneration: A Large-Scale Postmarketing Surveillance in Korea.

Clin Ophthalmol 2021 26;15:3601-3611. Epub 2021 Aug 26.

Department of Ophthalmology, Yeungnam University College of Medicine, Daegu, Republic of Korea.

Purpose: To investigate the efficacy and safety of intravitreal aflibercept (IVT-AFL) in Asian patients with neovascular age-related macular degeneration (nAMD) in a real-world clinical setting.

Patients And Methods: In this analysis of a prospective, regulatory, postmarketing surveillance study for IVT-AFL, 3115 patients with nAMD were included and followed for 8 months. The mean changes in best-corrected visual acuity (BCVA) and central retinal thickness (CRT) were analyzed using last observation carried forward method. Read More

View Article and Full-Text PDF

Impact of COVID-19 Pandemic on Stroke Severity and Mortality in the South-East of Santiago, Chile.

J Stroke Cerebrovasc Dis 2021 Jun 18;30(11):105953. Epub 2021 Jun 18.

Neurology department, Padre Hurtado hospital, Faculty of Medicine, Clínica Alemana, Universidad del Desarrollo, Esperanza 2150, San Ramón, Santiago, Chile. Electronic address:

Background and purpose; Chile has been one of the most affected countries by the COVID-19 pandemic, with one of the highest case rates per population. This has affected the epidemiological behaviour of various pathologies. We analyze the impact of the pandemic on the number of admissions due to stroke, its severity and mortality in Santiago, Chile. Read More

View Article and Full-Text PDF

The infinite possibilities of RNA therapeutics.

J Ind Microbiol Biotechnol 2021 Aug 31. Epub 2021 Aug 31.

School of Biological Sciences and Engineering, Yachay Tech University, 100119, San Miguel de Urcuquí, Ecuador.

Although the study of RNA therapeutics started decades ago, for many years, this field of research was overshadowed by the growing interest in DNA-based therapies. Nowadays, the role of several types of RNA in cell regulation processes and the development of various diseases have been elucidated, and research in RNA therapeutics is back with force. This short literature review aims to present general aspects of many of the molecules currently used in RNA therapeutics, including in vitro transcribed mRNA, antisense oligonucleotides, aptamers, small interfering RNAs, and microRNAs. Read More

View Article and Full-Text PDF

Treatment of ChAdOx1 nCoV-19 Vaccine-Induced Immune Thrombotic Thrombocytopenia Related Acute Ischemic Stroke.

J Stroke Cerebrovasc Dis 2021 Aug 27;30(11):106072. Epub 2021 Aug 27.

Department of Vascular Neurology, Neurology Clinic, UMC Ljubljana, Zaloška 2a, 1000 Ljubljana, Slovenia.

Recently cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) and thrombosis following the adenoviral vector vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were reported. A mechanism similar to heparin-induced thrombocytopenia was proposed with antibodies to platelet factor 4 (PF4). Vaccine related arterial thrombosis in the brain is rare but life-threatening and optimal treatment is not established. Read More

View Article and Full-Text PDF

[Importance of the forewarning system and assistance center selection in acute stroke].

Medicina (B Aires) 2021 ;81(4):581-587

Unidad de ACV, Centro Universitario de Neurología, Universidad de Buenos Aires, Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina.

Acute ischemic stroke (AIS) is a time-dependent emergency, since the greatest impact depends on the time elapsed to treatment. The objective of this work was to analyze door to needle (DTN) and start treatment (STT) times and the effect of pre-notification system (PNS) and the appropriate choice of the healthcare center on these variables. An observational study with data obtained from records of patients admitted to the Stroke Unit (SU) was conducted between August 2015 to December 2019. Read More

View Article and Full-Text PDF

In Vitro Investigations on Optimizing and Nebulization of IVT-mRNA Formulations for Potential Pulmonary-Based Alpha-1-Antitrypsin Deficiency Treatment.

Pharmaceutics 2021 Aug 17;13(8). Epub 2021 Aug 17.

Department of Pediatrics, Ludwig-Maximilians University of Munich, 80337 Munich, Germany.

In vitro-transcribed (IVT) mRNA has come into focus in recent years as a potential therapeutic approach for the treatment of genetic diseases. The nebulized formulations of IVT-mRNA-encoding alpha-1-antitrypsin (A1AT-mRNA) would be a highly acceptable and tolerable remedy for the protein replacement therapy for alpha-1-antitrypsin deficiency in the future. Here we show that lipoplexes containing A1AT-mRNA prepared in optimum conditions could successfully transfect human bronchial epithelial cells without significant toxicity. Read More

View Article and Full-Text PDF

Biopharmaceutics 4.0, Advanced Pre-Clinical Development of mRNA-Encoded Monoclonal Antibodies to Immunosuppressed Murine Models.

Vaccines (Basel) 2021 Aug 11;9(8). Epub 2021 Aug 11.

Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece.

Administration of mRNA against SARS-CoV-2 has demonstrated sufficient efficacy, tolerability and clinical potential to disrupt the vaccination field. A multiple-arm, cohort randomized, mixed blind, placebo-controlled study was designed to investigate the in vivo expression of mRNA antibodies to immunosuppressed murine models to conduct efficacy, safety and bioavailability evaluation. Enabling 4. Read More

View Article and Full-Text PDF

Hyperdense middle cerebral artery sign and response to combination of mechanical Thrombectomy plus intravenous thrombolysis in acute stroke patients.

J Neurol Sci 2021 Oct 16;429:117618. Epub 2021 Aug 16.

Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, NY, United States of America.

Background And Purpose: Combining intra-arterial mechanical thrombectomy (IAMT) and intravenous thrombolysis (IVT) has shown to have an excellent recanalization rate and better clinical outcome in acute ischemic stroke (AIS) patients. Hyperdense middle cerebral artery sign (HMCAS) on pretreatment non-contrast head CT scan of AIS patients is one of the early ischemic radiological findings in middle cerebral artery territory AIS. We aimed to evaluate whether the presence of HMCAS predicts the outcome of AIS patients receiving combination therapy with IAMT and IVT. Read More

View Article and Full-Text PDF
October 2021

Does prior administration of rtPA influence acute ischemic stroke clot composition? Findings from the analysis of clots retrieved with mechanical thrombectomy from the RESTORE registry.

J Neurol 2021 Aug 20. Epub 2021 Aug 20.

Department of Physiology and Galway Neuroscience Centre, School of Medicine, National University of Ireland Galway, University Road, Galway, Ireland.

Background And Purpose: There is still much debate whether bridging-therapy [intravenous thrombolysis (IVT) prior to mechanical thrombectomy (MT)] might be beneficial compared to MT alone. We investigated the effect of IVT on size and histological composition of the clots retrieved from patients undergoing bridging-therapy or MT alone.

Methods: We collected mechanically extracted thrombi from 1000 acute ischemic stroke (AIS) patients included in RESTORE registry. Read More

View Article and Full-Text PDF

Systemic thrombolysis in ischaemic stroke patients with COVID-19.

Acta Neurol Scand 2021 Aug 20. Epub 2021 Aug 20.

Medical Simulation Center, Medical University of Gdańsk, Gdańsk, Poland.

Objective: Intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator is the core medical therapy of acute ischaemic stroke (AIS). COVID-19 infection negatively modifies acute stroke procedures and, due to its pro-coagulative effect, may potentially impact on IVT outcome. Thus, short-term efficacy and safety of IVT were compared in patients with and without evidence of SARS-CoV-2. Read More

View Article and Full-Text PDF

[The Spanish Catheter Ablation Registry. 20th Official Report of the Heart Rhythm Association of the Spanish Society of Cardiology (2020)].

Rev Esp Cardiol 2021 Aug 14. Epub 2021 Aug 14.

Unidad de Arritmias, Servicio de Cardiología, Hospital Universitario y Politécnico La Fe, Instituto de Investigación Sanitaria La Fe, Valencia, España.

Introduction And Objectives: This article reports the results of the 2020 Spanish Catheter Ablation Registry, a year marked by the SARS-CoV-2 pandemic.

Methods: Data were collected retrospectively through completion and return of a specific form by the participating centers.

Results: Data from 97 centers (67 public, 30 private) were analyzed. Read More

View Article and Full-Text PDF