19,541 results match your criteria ivig


Angiotensin II Type 1 Receptor Antibody Mediated Rejection Following Orthotopic Heart Transplant: A Single Center Experience.

Transplantation 2021 Feb 22. Epub 2021 Feb 22.

1Division of Cardiology, Department of Medicine 2Department of Pathology & Immunology 3Department of Developmental Biology Washington University in St. Louis, St. Louis, MO, 63130.

Background: Antibody mediated rejection (AMR) following orthotopic heart transplant (OHT) causes significant morbidity and mortality. There is limited data on antibodies to the angiotensin II type 1 receptor (AT1R-Ab) causing rejection following OHT.

Methods: This is a retrospective, single center study that presents our 2-year experience with a series of 11 patients with evidence of nonspecific graft dysfunction and pathologic levels of AT1R-Ab. Read More

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February 2021

Multisystemic Inflammatory Syndrome in Children Associated With SARS-CoV-2 Infection: A Case Series Report in a Pediatric Center in Mexico.

J Med Cases 2020 Dec 21;11(12):375-378. Epub 2020 Oct 21.

Evidence-Based Medicine Department, Hospital Pediatrico de Sinaloa, Culiacan, Mexico.

We report four cases of patients with multisystem inflammatory syndrome in children (MIS-C) associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, of which three patients presented characteristics of Kawasaki disease (KD). All presented fever of more than 3 days, and gastrointestinal involvement, significant increase in C-reactive protein (CRP), polymorphonuclear cells, procalcitonin, D-dimer, fibrinogen and troponin, lymphopenia and hypoalbuminemia. Myocardial involvement was observed in two patients. Read More

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December 2020

Delayed Severe Hemolytic Transfusion Reaction During Pregnancy in a Woman with β-Thalassemia Intermediate: Successful Outcome After Eculizumab Administration.

Am J Case Rep 2021 May 13;22:e931107. Epub 2021 May 13.

Department of Internal Medicine, Lyon Civil Hospices, Edouard Herriot Hospital, Lyon, France.

BACKGROUND Delayed hemolytic transfusion reactions (DHTR) are life-threatening complications mostly triggered by red blood cell (RBC) transfusions in patients with hemoglobinopathy. CASE REPORT We present a case of DHTR and hyperhemolysis syndrome in a 39-year-old pregnant woman with a history of ß-thalassemia intermediate in whom the hemoglobin (Hb) level fell to 27 g/L after transfusion of 2 units of crossmatch-compatible packed RBCs. No allo- or auto-antibody formation was detected. Read More

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GAD65 autoimmunity after treatment with nivolumab: a multifocal presentation.

Neurol Sci 2021 May 11. Epub 2021 May 11.

Neurology Unit, Department of Neurosciences, Biomedicine, and Movement Sciences, University of Verona, Policlinico GB Rossi, P.le LA Scuro 10, 37134, Verona, Italy.

Introduction: Neurological disorders are considered rare complications of immune-checkpoint inhibitor.

Case Description: We report a 63-year-old man with recurrence of melanoma who presented epilepsy, limbic encephalitis, cerebellar ataxia, and stiff person syndrome soon after treatment with nivolumab, an immune-checkpoint inhibitor. On autoimmune screening, serum and CSF GAD65 were detected. Read More

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Intravenous immunoglobulin in COVID-19 associated Guillain-Barré syndrome in pregnancy.

BMJ Case Rep 2021 May 11;14(5). Epub 2021 May 11.

Department of Neurosciences, Philippine General Hospital, Manila, Philippines.

The COVID-19 pandemic has led to a rise in cases of Guillain-Barré syndrome (GBS). This autoimmune sequela is a manifestation of the neurotropism potential of the virus. At present, knowledge regarding the pathophysiology, clinical features, management and outcomes of the condition is still evolving. Read More

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Immune-Based Therapy for COVID-19.

Adv Exp Med Biol 2021 ;1318:449-468

School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel zoonotic virus identified as the cause of coronavirus disease 2019 (COVID-19) that has crossed species and infected humans. In order to develop new insights on the immune-based treatments against this disease, it is vital to understand the immunopathology of the COVID-19, implications of the immune response to SARS-CoV-2, and immune dysfunction in response to SARS-CoV-2. There is no approved drug for the treatment of COVID-19. Read More

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Sodium-containing versus sodium-trace preparations of IVIG for children with Kawasaki disease in the acute phase.

Eur J Pediatr 2021 May 10. Epub 2021 May 10.

Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Tokyo, Japan.

Kawasaki disease (KD) is an acute systemic vasculitis that most commonly causes acquired cardiac disease in children in developed countries. The most highly recommended treatment for KD is 2 g/kg intravenous immunoglobulin (IVIG). There are two types of IVIG, sodium-containing (high-Na) and sodium-trace (low-Na) preparations. Read More

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Primary Refractory Catastrophic Antiphospholipid Syndrome Masquerading as Buerger's Disease.

Cureus 2021 Apr 7;13(4):e14350. Epub 2021 Apr 7.

Division of Hematology and Oncology, University of California - Irvine, Irvine, USA.

Catastrophic antiphospholipid syndrome (CAPS) is a lethal disease with up to 30% mortality rate. It can occur as a primary disease or secondary to an underlying autoimmune disease. Current treatment focuses on disease control with anticoagulation and steroids. Read More

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Boolean analysis of the transcriptomic data to identify novel biomarkers of IVIG response.

Autoimmun Rev 2021 May 7;20(7):102850. Epub 2021 May 7.

Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, Sorbonne Université, Université de Paris, F-75006 Paris, France; Indian Institute of Technology Palakkad, Palakkad 678623, India. Electronic address:

Intravenous immunoglobulin (IVIG) is used to treat several autoimmune and inflammatory diseases, but some patients are refractory to IVIG and require alternative treatments. Identifying a biomarker that could segregate IVIG responders from non-responders has been a subject of intense research. Unfortunately, previous transcriptomic studies aimed at addressing IVIG resistance have failed to predict a biomarker that could identify IVIG-non-responders. Read More

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Treatment of donor-specific antibody-mediated rejection after heart transplantation by IgM-enriched human immunoglobulin.

ESC Heart Fail 2021 May 10. Epub 2021 May 10.

Department of Cardiac Surgery, Medical Faculty, Heinrich-Heine-University Medical School, Moorenstraße 5, Duesseldorf, 40225, Germany.

Antibody-mediated graft rejection caused by donor-specific antibodies (DSA-MR) remains a serious problem after heart transplantation (HTx). IgM-enriched human intravenous immunoglobulin (IGM-IVIG) consists of 76% IgG, 12% IgM, and 12% IgA and provides a new multifactorial approach for DSA-MR. Between 2017 and 2020, four (P1-4) of 102 patients developed DSA-MR after HTx in our department and were repetitively treated with IGM-IVIG in combination with anti-thymocyte globulin. Read More

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Nivolumab induced systemic capillary leak syndrome as an ultra rare life-threatening phenomenon of late toxicity and intravenous immunoglobulin efficacy.

Immunotherapy 2021 May 9. Epub 2021 May 9.

The Legacy Heritage Oncology Center & Dr Larry Norton Institute, Soroka Medical Center & Ben-Gurion University, Beer-Sheva, Israel.

Systemic capillary leak syndrome (SCLS) is a life-threatening disease. It is characterized by severe capillary hyperpermeability to proteins resulting in hemoconcentration, hypoalbuminemia and hypovolemic shock. Its treatment remains supportive, and the prognosis is generally poor. Read More

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The Epidemiology of Guillain-Barré syndrome in Thailand over 13 years (2005 - 2017): A nationwide population-based retrospective cohort study.

J Peripher Nerv Syst 2021 May 10. Epub 2021 May 10.

Division of Critical Care Medicine, Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Background: There have been no published studies examining the epidemiology of Guillain-Barré syndrome (GBS) in large populations in Thailand.

Aims: This study aimed to explore the incidence, patient characteristics, seasonality, treatments, and outcomes of GBS in Thailand.

Methods: The National Health Security Office (NHSO) provided data on in-patient admission between fiscal year 2005 and 2017. Read More

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Intravenous Immunoglobulins: an eye opener on the successful treatment of severe adult-onset paraprotein-associated xanthogranulomatosis.

Clin Exp Dermatol 2021 May 10. Epub 2021 May 10.

Department of Dermatology, AP-HP, Henri Mondor hospital, Créteil, France.

Xanthogranulomatosis (XG) is a granulomatous dermatitis defined as multiple xanthogranulomas. XG is a common non-Langerhans histiocytosis mainly observed in children (juvenile XG) and usually regresses over time. It was first described in adults in 1963 and consists of persistent lesions. Read More

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Successful Plasmapheresis and Immunoglobulin treatment for severe lipid storage myopathy: doing the right thing for the wrong reason.

Neuropathol Appl Neurobiol 2021 May 10. Epub 2021 May 10.

Department of Neuropathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, 10117, Berlin, Germany.

Lipid myopathies are rare and heterogeneous multi-systemic diseases that may be hereditary or acquired and affect the skeletal muscle [1]. Four types usually demonstrate accumulation of lipids in muscle biopsy specimens that can be visualised using Oil-Red-O (ORO) stain. These comprise (i) Multiple Acyl-CoA Dehydrogenase deficiency (MADD), (ii) Primary Carnitine Deficiency (PCD), (iii) Neutral Lipid Storage Disease with Ichthyosis (NLSDI), and (iv) Neutral Lipid Storage Disease with myopathy (NLSDM) [2]. Read More

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Clinical Characteristics and Prognostic Factors of Children With Anti-N-Methyl-D-Aspartate Receptor Encephalitis.

Front Pediatr 2021 22;9:605042. Epub 2021 Apr 22.

Department of Neurology, Hunan Children's Hospital, Changsha, China.

Anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis is the most common autoimmune encephalitis in pediatric patients. The study aimed to investigate the clinical characteristics and prognostic factors of anti-NMDA receptor encephalitis in children in South China. This was a retrospective study of children diagnosed with anti-NMDA receptor encephalitis between 01/2014 and 12/2017 at Hunan Children's Hospital. Read More

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Clinical features and outcome of MIS-C patients: an experience from Central Anatolia.

Clin Rheumatol 2021 May 6. Epub 2021 May 6.

Department of Pediatric Critical Care, Selcuk University Faculty of Medicine, Konya, Turkey.

Background: Multisystem inflammatory syndrome in children (MIS-C) is a new clinical condition characterized by signs of inflammation and multiorgan dysfunction due to cytokine storm associated with SARS-CoV-2. The clinical spectrum of MIS-C ranges from mild to severe, and even to mortal multisystem involvement. To guide clinicians, we evaluated detailed demographic characteristics, clinical features, laboratory findings, and outcomes of MIS-C cases. Read More

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Treatment of children with primary immunodeficiencies with a subcutaneous immunoglobulin 16.5% (cutaquig [octanorm]).

Immunotherapy 2021 May 6. Epub 2021 May 6.

Division of Basic and Clinical Immunology, University of California, Irvine, CA 92697, USA.

Subcutaneous human immunoglobulin (16.5%; octanorm/cutaquig) was efficacious and well tolerated in patients with primary immunodeficiencies in a Phase III study. A subanalysis of pediatric data is presented here. Read More

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Peripheral Gangerene, an Unusual Presentation of Infantile Kawasaki: A Case Report and Literature Review.

Case Rep Rheumatol 2021 13;2021:6629405. Epub 2021 Apr 13.

Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Diagnosing infantile Kawasaki disease with atypical symptoms is difficult, and it also has higher risk of coronary abnormalities which is one of the most common complications of KD. Other complications such as pericardial effusion, mitral insufficiency, congestive heart failure, myocardial systolic dysfunction, and systemic vasculitis were also reported. Peripheral gangrene and necrosis are among the rare complications of this systemic vasculitis. Read More

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Rituximab Treatment in Acute Disseminated Encephalomyelitis Associated with Infection.

Case Rep Pediatr 2021 17;2021:5570566. Epub 2021 Apr 17.

Eskisehir Osmangazi University Faculty of Medicine, Pediatric Intensive Care Unit, Eskisehir, Turkey.

Acute disseminated encephalomyelitis (ADEM) is an inflammatory, demyelinating, and rapidly progressive disorder of the central nervous system. This condition is also known as postinfectious encephalomyelitis, and it is characterized by multifocal lesions in the brain and spinal cord with widespread neurological findings. High doses of intravenous (IV) methylprednisolone, intravenous immunoglobulin (IVIG), and plasma exchange (PLEX) treatments comprise the first-line therapy. Read More

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Tregitopes Improve Asthma by Promoting Highly Suppressive and Antigen-Specific Tregs.

Front Immunol 2021 19;12:634509. Epub 2021 Apr 19.

The Research Institute of the McGill University Health Centre, Division of Pediatric Allergy Immunology and Dermatology, Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada.

Tregitopes (T regulatory epitopes) are IgG-derived peptides with high affinity to major histocompatibility complex class II (MHCII), that are known to promote tolerance by activating T regulatory cell (Treg) activity. Here we characterized the effect of IgG Tregitopes in a well-established murine model of allergic asthma, demonstrating antigen-specific tolerance adoptive transfer of Tregitope-and-allergen-activated Tregs. Asthma is a heterogeneous chronic inflammatory condition affecting the airways and impacting over 300 million individuals worldwide. Read More

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Hematological involvement in pediatric systemic lupus erythematosus: A multi-center study.

Lupus 2021 May 6:9612033211014271. Epub 2021 May 6.

Division of Rheumatology, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.

Introduction: Systemic lupus erythematosus (SLE) may present with features of several systems, including hematological manifestations. In this study, we aimed to evaluate the characteristics of hematological involvement and assess possible associations and correlations in pediatric SLE patients.

Method: This is a retrospective multi-center study. Read More

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Lupus acute cardiomyopathy is highly responsive to intravenous immunoglobulin treatment: Case series and literature review.

Medicine (Baltimore) 2021 May;100(18):e25591

Department of Internal Medicine E, Meir Medical Center, Kfar Saba.

Introduction: Intravenous immunoglobulin (IVIg) is currently used with considerable success for the treatment of many autoimmune diseases, including systemic lupus erythematosus (SLE). Among its various indications, IVIg has also been found to be beneficial in myocarditis, whether or not it is associated with an autoimmune disease. Nevertheless, data regarding IVIg treatment for myocarditis/cardiomyopathy in patients with SLE are sparse. Read More

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Switch from intravenous to subcutaneous immunoglobulin IgPro20 in CIDP patients: a prospective observational study under real-world conditions.

Ther Adv Neurol Disord 2021 16;14:17562864211009100. Epub 2021 Apr 16.

Department of Neurology, Hannover Medical School, Carl-Neuberg-Str. 1, Hannover 30625, Germany.

Background: IgPro20 is the first approved subcutaneous immunoglobulin (SCIg) preparation for the treatment of patients with chronic inflammatory demyelinating polyneuropathy (CIDP). Two different doses of the SCIg preparation were investigated in the pivotal PATH study. Real-world data, and particularly the efficacy of an equivalent dose switch from intravenous immunoglobulin (IVIg) to SCIg, are still not available. Read More

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A case report of atypical Kawasaki disease presented with severe elevated transaminases and literature review.

BMC Infect Dis 2021 May 4;21(1):415. Epub 2021 May 4.

Department of Paediatrics, ShaoXing KeQiao Women And Children's Hospital, ShaoXing, 312030, Zhejiang Province, PR China.

Background: Kawasaki disease (KD) is the most common cause of acquired heart disease among children in developed countries, in which the resulting coronary artery (CA) abnormalities cause myocardial ischemia, infarction, and death. Prompt diagnosis was essential, and supplemental information should be used to assist the diagnosis when classical clinical criteria are incomplete. The elevated levels of serum transaminases in most KD patients are mild. Read More

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Hyperammonemia in Patients With Status Epilepticus Treated With or Without Valproic Acid.

Neurologist 2021 May 5;26(3):80-82. Epub 2021 May 5.

Department of Neurology, Mayo Clinic, Rochester, MN.

Background: Hyperammonemia is a common side effect of valproic acid (VPA) and can occur after generalized seizures, but the clinical significance is unclear. The aim of this study was to better understand the clinical practice and utility of ammonia testing in status epilepticus (SE) treated with or without VPA.

Methods: Charts of adult patients with SE from St. Read More

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Pathogen dependent effects of high amounts of oxytocin on the bloodmilk barrier integrity during mastitis in dairy cows.

Schweiz Arch Tierheilkd 2021 May;163(5):327-337

Veterinary Physiology, Vetsuisse Faculty, University of Bern, Switzerland.

Introduction: The reduction of antibiotic use in food producing animals becomes increasingly important. Therefore, suitable alternatives for mastitis treatment in dairy cows have to be considered. Oxytocin (OT) induces milk ejection and hence supports milk removal from infected mammary quarters. Read More

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Morvan syndrome associated with LGI1 antibody: a case report.

BMC Neurol 2021 May 3;21(1):185. Epub 2021 May 3.

Department of Neurology and Research Center of Neurology in Second Affiliated Hospital, Key Laboratory of Medical Neurobiology of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou, China.

Background: Morvan syndrome (MoS) is a rare autoimmune syndrome associated with antibodies against two kinds of potassium channel proteins, contactin associated protein-like 2 (CASPR2) and leucine-rich glioma inactivated protein 1 (LGI1). MoS patients with only LGI1-antibody seropositivity have rarely been reported. Here, we describe a 64-year-old male MoS patient with only LGI1-antibody seropositivity. Read More

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Case Report: Wound Closure Acceleration in a Patient With Toxic Epidermal Necrolysis Using a Lyophilised Amniotic Membrane.

Front Bioeng Biotechnol 2021 16;9:649317. Epub 2021 Apr 16.

Department of Burns and Plastic Surgery, Faculty of Medicine, University Hospital Brno, Masaryk University, Brno, Czechia.

Toxic epidermal necrolysis (TEN) is a rare life-threatening disease that mainly affects the skin and mucous membranes, resulting from a toxic delayed-type hypersensitivity (DTH) reaction (type IV reaction) to the presence of foreign antigens such as drugs. The clinical symptoms are caused by pathophysiological processes leading to massive apoptosis of keratinocytes in the dermo-epidermal junction. This results in the formation of a bulla and subsequent separation of the entire epidermis with the exposure of the dermis. Read More

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Kawasaki Disease Complicated by Coinfection.

Case Rep Pediatr 2021 2;2021:5584514. Epub 2021 Apr 2.

University of Florida Shands Children's Hospital, Department of Pediatric Hospital Medicine, Gainesville, FL, USA.

Kawasaki disease is a medium vessel vasculitis with a multisystem presentation affecting 9-20 per 100,000 children under 5 years of age in the United States. coinfection has not been previously described. We present a 12-month-old vaccinated male with Kawasaki disease in the setting of bacteremia. Read More

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Case Report: Splenic Irradiation for the Treatment of Chronic Active Antibody-Mediated Rejection in Kidney Allograft Recipients With Donor-Specific Antibodies.

Front Immunol 2021 15;12:661614. Epub 2021 Apr 15.

Tongji Hospital, Tongji Medical College, Institute of Organ Transplantation, Huazhong University of Science and Technology, Wuhan, China.

Chronic active antibody-mediated rejection (AMR) in renal transplantation is usually refractory to current conventional treatment with rituximab, plasmapheresis (PP), and intravenous immunoglobulins (IVIG). Splenic irradiation has been reported to be effective in the rescue of early severe acute AMR after kidney transplantation; however, its effect in chronic active AMR has not been reported to date. In order to reduce donor-specific antibody (DSA) and prevent the progression of chronic AMR, we used repetitive low-dose splenic irradiation, together with rituximab and PP/IVIG, in two living-related kidney transplant recipients with pathologically diagnosed chronic active AMR and the presence of long-term class II- DSA. Read More

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