457 results match your criteria ivcm


Deterioration of Avellino corneal dystrophy in a Chinese family after LASIK.

Int J Ophthalmol 2021 18;14(6):795-799. Epub 2021 Jun 18.

Eye Hospital, the First Affiliated Hospital of Harbin Medical University, Harbin 150001, Heilongjiang Province, China.

Aim: To reveal the importance of gene screening for candidates with a family history of corneal disease or granular opacities in corneal stroma before refractive surgery.

Methods: A 37-year-old male (proband) underwent bilateral laser-assisted keratomileusis (LASIK) in 2002, with right vision decreased significantly in 2006. The proband and other 32 members of the family underwent a detailed ophthalmic examination, including vision acuity, intraocular pressure, slit-lamp photograph, fundus examination, optical coherence tomography (OCT) of cornea, and confocal microscope (IVCM) and peripheral blood was used for genomic DNA extraction. Read More

View Article and Full-Text PDF

In vivo confocal microscopy assessment of meibomian glands microstructure in patients with Graves' orbitopathy.

BMC Ophthalmol 2021 Jun 19;21(1):261. Epub 2021 Jun 19.

Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Background: To evaluate microstructural changes in the meibomian glands (MGs) in patients with active and inactive Graves' orbitopathy (GO), using in vivo confocal microscopy (IVCM), and to investigate the correlations between clinical and confocal findings.

Methods: Forty patients (80 eyes) with GO (34 eyes with active GO, 46 eyes with inactive GO), and 31 age- and sex-matched control participants (62 eyes) were enrolled consecutively. A researcher recorded the clinical activity score (CAS) for each patient. Read More

View Article and Full-Text PDF

The relationship between corneal subbasal nerve density and corneal sensitivity in patients with Fuchs endothelial corneal dystrophy.

Indian J Ophthalmol 2021 Jul;69(7):1730-1734

Private Physician, Ophthalmology , Ankara, Turkey.

Purpose: The aim of this study was to investigate the association between alterations in corneal subbasal nerve plexus and tactile corneal sensitivity in patients with Fuchs' endothelial corneal dystrophy (FECD).

Methods: This retrospective, cross-sectional study included 24 (10 M/14 F) patients with FECD and 25 age- and sex-matched (10 M/15 F) healthy subjects as controls. Subjects with FECD were classified as having early (grades 1 and 2) and late (grades 3 and 4) disease. Read More

View Article and Full-Text PDF

The effects of systemic aromatase inhibitors on meibomian glands and corneal structure.

Eye (Lond) 2021 Jun 11. Epub 2021 Jun 11.

Private Practice, Ankara, Turkey.

Objectives: To evaluate the ocular surface, meibomian glands and corneal structural changes using in vivo confocal microscopy (IVCM) in patients receiving aromatase inhibitor (AI) therapy due to the breast cancer.

Methods: This prospective observational study included 13 patients undergoing AI therapy. The patients were evaluated before the treatment, at 3- and 6-month timepoints of AI therapy. Read More

View Article and Full-Text PDF

Corneal Changes in Acanthamoeba Keratitis at Various Levels of Severity: An In Vivo Confocal Microscopic Study.

Transl Vis Sci Technol 2021 Jun;10(7):10

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing, China.

Purpose: To investigate the relationship between Acanthamoeba cysts and inflammatory cells in Acanthamoeba keratitis (AK) by in vivo confocal microscopy (IVCM).

Methods: A case-control study included 30 patients with AK and 20 normal controls. The severity of the AK was divided into mild, moderate, and severe. Read More

View Article and Full-Text PDF

Relationships between activated dendritic cells and dry eye symptoms and signs.

Ocul Surf 2021 Jun 6;21:186-192. Epub 2021 Jun 6.

Miami Veterans Administration Medical Center, Miami, FL, USA; Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA. Electronic address:

Purpose: To examine whether "activated" dendritic cells (aDCs) could serve as a biomarker of systemic immune disorders in individuals with dry eye (DE) symptoms. Secondarily, to examine the impact of a topical anti-inflammatory agent on aDC number.

Methods: Retrospective analysis was conducted to identify individuals with DE symptoms who had in-vivo confocal microscopy (IVCM) imaging between October 2018 and July 2020 at the Miami Veterans Hospital. Read More

View Article and Full-Text PDF

Functional and Structural Changes Following Corneal Neurotisation in the Management of Neurotrophic Keratopathy: UK Single Centre Series.

Clin Ophthalmol 2021 24;15:2149-2160. Epub 2021 May 24.

Corneo Plastic Unit, Queen Victoria Hospital, East Grinstead, UK.

Objective: To report the functional and anatomical outcomes including structural changes in corneal nerve density and morphology using in vivo confocal microscopy (IVCM) after corneal neurotisation in patients with neurotrophic keratopathy (NK), using a sural nerve graft.

Patients And Methods: Prospective study of patients undergoing corneal neurotisation for NK. Functional outcomes were measured through visual acuity, slit-lamp examination of corneal and conjunctival staining, tear production (Schirmer's 1 test), tear film break-up time, tear film meniscus height, quality and osmolarity, central corneal thickness and corneal sensation using Cochet-Bonnet esthesiometry. Read More

View Article and Full-Text PDF

Diagnosing Paraproteinemic Keratopathy: A Case Report.

Case Rep Ophthalmol 2021 May-Aug;12(2):337-343. Epub 2021 May 7.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, New Territories, Hong Kong, Hong Kong, China.

A 65-year-old man presented with bilateral, painless, progressive blurring of vision over 9 years. Slit-lamp examination revealed bilateral subepithelial corneal opacities in clusters located at the mid-periphery. Anterior segment optical coherence tomography, in vivo confocal microscopy (IVCM), serum protein electrophoresis, and molecular genetic testing were performed to evaluate the cause of corneal opacities. Read More

View Article and Full-Text PDF

An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis.

Sci Rep 2021 May 27;11(1):11111. Epub 2021 May 27.

Department of Ophthalmology, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, 4032, Debrecen, Hungary.

To investigate corneal microstructure of systemic sclerosis (SSc) patients using in vivo confocal microscopy (IVCM). 33 patients with SSc and 30 age-matched healthy subjects were recruited. All participants underwent comprehensive ophthalmic examination including IVCM (Heidelberg Retina Tomograph III, Heidelberg Engineering GmbH, Heidelberg, Germany) and ocular surface evaluation. Read More

View Article and Full-Text PDF

Generative Adversarial Network Based Automatic Segmentation of Corneal Subbasal Nerves on In Vivo Confocal Microscopy Images.

Transl Vis Sci Technol 2021 May;10(6):33

Department of Electrical and Electronics Engineering, Yeditepe University, Istanbul, Turkey.

Purpose: In vivo confocal microscopy (IVCM) is a noninvasive, reproducible, and inexpensive diagnostic tool for corneal diseases. However, widespread and effortless image acquisition in IVCM creates serious image analysis workloads on ophthalmologists, and neural networks could solve this problem quickly. We have produced a novel deep learning algorithm based on generative adversarial networks (GANs), and we compare its accuracy for automatic segmentation of subbasal nerves in IVCM images with a fully convolutional neural network (U-Net) based method. Read More

View Article and Full-Text PDF

Update on fungal keratitis in France: a case-control study.

Acta Ophthalmol 2021 May 24. Epub 2021 May 24.

GRC32 Sorbonne Université, Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, Paris, France.

Purpose: To report an epidemiological update of documented fungal keratitis (FK) in a French tertiary ophthalmological centre from 2014 to 2018 in comparison with a previous period from 1993 to 2008.

Methods: Sixty-two consecutive FK documented by microbiological corneal scrapings were compared with the 64 FK of the previous study. Amphotericin B and voriconazole eye drops were administered hourly. Read More

View Article and Full-Text PDF

In vivo confocal microscopic images of atypical amiodarone-induced keratopathy in patient with epithelial basement membrane dystrophy.

Am J Ophthalmol Case Rep 2021 Jun 2;22:101105. Epub 2021 May 2.

Department of Ophthalmology, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, 791-0295, Japan.

A 73-year-old man presented with bilateral corneal opacities. Slit-lamp biomicroscopy showed vortex and oval-shaped opacities. confocal microscopy (IVCM) showed findings characteristic of amiodarone-induced keratopathy along with epithelial basement membrane dystrophy (EBMD). Read More

View Article and Full-Text PDF

Correlation of the retinopathy degree with the change of ocular surface and corneal nerve in patients with type 2 diabetes mellitus.

Int J Ophthalmol 2021 18;14(5):750-758. Epub 2021 May 18.

Department of Ophthalmology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, Jiangsu Province, China.

Aim: To investigate the change of ocular surface and corneal nerve and their correlation in patients suffering from type 2 diabetes mellitus under different degrees of retinopathy.

Methods: Totally 129 type 2 diabetes mellitus patients (257 eyes) were included. They were divided into three groups: no diabetic retinopathy (NDR) group (33 cases, 66 eyes), non-proliferative diabetic retinopathy (NPDR) group (32 cases, 64 eyes), and proliferative diabetic retinopathy (PDR) group (34 cases, 67 eyes). Read More

View Article and Full-Text PDF

Face Mask-Related Ocular Surface Modifications During COVID-19 Pandemic: A Clinical, In Vivo Confocal Microscopy, and Immune-Cytology Study.

Transl Vis Sci Technol 2021 03;10(3):22

Institute of Ophthalmology, University of Modena and Reggio Emilia, Modena, Italy.

Purpose: The purpose of this study was to describe the face mask (FM)-related ocular surface changes using clinical tests, in vivo confocal microscopy (IVCM) and impression cytology (IC), and to investigate the Dry Eye-related Quality of life Score (DEQS).

Methods: Sixty-six patients with dry eye disease (DED) and 62 healthy subjects (group 2) using FM were enrolled. Groups were divided into: groups 1A and 2A: < 3 hours of FM wear; groups 1B and 2B: 3 to 6 hours; and groups 1C and 2C: > 6 hours. Read More

View Article and Full-Text PDF

The role of imaging technologies for ocular surface tumors.

Curr Opin Ophthalmol 2021 07;32(4):369-378

Bascom Palmer Eye Institute, Department of Ophthalmology University of Miami, Miami, Florida, USA.

Purpose Of Review: This review will discuss the utility of high-resolution anterior segment optical coherence tomography (HR-OCT), in-vivo confocal microscopy (IVCM) and ultrasound biomicroscopy (UBM) in characterizing and diagnosing various ocular surface tumors, namely ocular surface squamous neoplasia (OSSN), conjunctival lymphoma and conjunctival melanoma. The strengths and limitations of each imaging modality will be discussed along with the characteristics findings of each lesion on each imaging platform.

Recent Findings: HR-OCT can consistently be utilized in the clinic setting to distinguish between epithelial ocular surface tumors such as OSSN as compared with subepithelial tumors such as conjunctival lymphoma and conjunctival melanoma given their distinctive findings. Read More

View Article and Full-Text PDF

Corneal nerve structure in patients with primary Sjögren's syndrome in China.

BMC Ophthalmol 2021 May 12;21(1):211. Epub 2021 May 12.

Department of Ophthalmology, Peking University People's Hospital, Eye Diseases and Optometry Institute, 11 Xizhimen South Street, Beijing, 100044, Xicheng District, China.

Background: The aim of this study was to evaluate the in vivo confocal microscopic morphology of corneal subbasal nerves and its relationship with clinical parameters in patients with primary Sjögren's syndrome in China.

Methods: This was a case control study of 22 dry eye disease (DED) patients with primary Sjögren's syndrome (pSS) and 20 control subjects with non-Sjögren dry eye disease (NSDE). Each patient underwent an evaluation of ocular surface disease using the tear film break-up time (TBUT), noninvasive tear film break-up time (NIKBUT), noninvasive tear meniscus height (NIKTMH), corneal staining (National Eye Institute scale, NEI), Schirmer I test, meibography, and corneal subbasal nerve analysis with in vivo confocal microscopy (IVCM). Read More

View Article and Full-Text PDF

Bilateral Limbal Stem Cell Alterations in Patients With Unilateral Herpes Simplex Keratitis and Herpes Zoster Ophthalmicus as Shown by In Vivo Confocal Microscopy.

Invest Ophthalmol Vis Sci 2021 May;62(6):12

Eye Hospital, The First Affiliated Hospital of Harbin Medical University, No.143, Yiman Street, Harbin City, Nangang District, Heilongjiang Province, China.

Purpose: The purpose of this study was to investigate the limbal changes in the palisades of Vogt (POV) in patients with herpes simplex keratitis (HSK) and herpes zoster ophthalmicus (HZO) with the application of in vivo confocal microscopy (IVCM).

Methods: We enrolled 35 eyes of 35 consecutive patients with HSK and 4 patients with HZO in this observational study. Thirty-five participants were also recruited from a healthy population as the control group. Read More

View Article and Full-Text PDF

In vivo confocal microscopy study of corneal nerve alterations in children and youths with Type 1 diabetes.

Pediatr Diabetes 2021 May 2. Epub 2021 May 2.

Department of Neuroscience, Biomedicine and Movement Sciences, Eye Clinic, University of Verona, Verona, Italy.

Objective: To determine whether children and youths with Type 1 diabetes (T1D) have early alterations of the corneal subbasal nerve plexus detectable with in vivo confocal microscopy (IVCM) and to investigate the role of longitudinally measured major risk factors for diabetes complications associated with these alterations.

Methods: One hundred and fifty children and youths with T1D and 51 age-matched controls were enrolled and underwent IVCM. Corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal fiber total branch density (CTBD), and corneal fiber fractal dimension (CNFrD) were measured. Read More

View Article and Full-Text PDF

Clinical outcomes of modified simple limbal epithelial transplantation for limbal stem cell deficiency in Chinese population: a retrospective case series.

Stem Cell Res Ther 2021 May 1;12(1):259. Epub 2021 May 1.

Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Ophthalmology & Visual Sciences Key Laboratory, Capital Medical University, Beijing, 100730, China.

Objective: To report the clinical outcomes of a novel surgical technique, namely simple limbal epithelial transplantation (SLET), for the treatment of limbal stem cell deficiency (LSCD).

Methods: Thirteen patients (13 eyes) with LSCD who underwent autologous (10 eyes) or allogeneic (3 eyes) modified SLET between 2018 and 2021 were enrolled in this study. Grades of symblepharon, corneal conjunctivalization, vascularization, opacification, and visual acuity (VA) were evaluated preoperatively and postoperatively. Read More

View Article and Full-Text PDF

Noninvasive Diagnosis of Viral Keratouveitis with Retro-corneal Endothelial Plaques: A Case Series.

Ocul Immunol Inflamm 2021 Apr 7:1-7. Epub 2021 Apr 7.

Department of Ophthalmology, Peking University Third Hospital, Beijing, China.

: The aim of this study was to evaluate the noninvasive diagnostic methods in managing the herpetic keratouveitis with retro-corneal endothelial plaques.: 12 patients suspected to have unilateral herpetic keratouveitis with retro-corneal endothelial plaques were included. Slit lamp photos, AS-OCT, IVCM and corneal scraping culture were taken in all cases to help diagnosing and managing the disease. Read More

View Article and Full-Text PDF

Keratic Precipitates: The Underutilized Diagnostic Clue.

Ocul Immunol Inflamm 2021 Apr 7:1-10. Epub 2021 Apr 7.

Singapore National Eye Centre, Singapore, Singapore.

The morphology of keratic precipitates (KPs) may yield important diagnostic clues. However, KPs have not been described in a standardized manner and the traditional classification of granulomatous or non-granulomatous KPs is not helpful in differentiating infectious from noninfectious uveitis. A granulomatous uveitis may initially appear non-granulomatous. Read More

View Article and Full-Text PDF

Acanthamoeba Keratitis in Egypt: Characteristics and Treatment Outcomes.

Clin Ophthalmol 2021 29;15:1339-1347. Epub 2021 Mar 29.

Ophthalmology Department, Tanta University, Faculty of Medicine, Tanta, Egypt.

Purpose: To study the predisposing factors, clinical manifestations, and treatment outcome of patients with Acanthamoeba keratitis (AK) at Tanta University's Ophthalmology Hospital in Tanta, Egypt.

Methods: A retrospective study of 42 patients (44 eyes) with Acanthamoeba keratitis who had medical records available for review over 4 years.

Results: Forty-four eyes of 42 patients were treated for AK over the study period. Read More

View Article and Full-Text PDF

A novel investigation method for axonal damage in neuromyelitis optica spectrum disorder: In vivo corneal confocal microscopy.

Mult Scler J Exp Transl Clin 2021 Jan-Mar;7(1):2055217321998060. Epub 2021 Mar 19.

Koc University Research Center for Translational Medicine (KUTTAM), Istanbul, Turkey.

Background: Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disorder that damages optic nerves, brainstem, and spinal cord. In vivo corneal confocal microscopy (IVCM) is a noninvasive technique that provides corneal images with dendritic cells (DCs) and corneal subbasal nerve plexus (SBP), which arises from the trigeminal nerve.

Objective: We investigated corneal SBP changes in NMOSD and proposed IVCM as a potential new disease severity biomarker for NMOSD. Read More

View Article and Full-Text PDF

In Vivo Confocal Microscopy in Blepharitis Patients with Ocular Demodex Infestation.

Ocul Immunol Inflamm 2021 Apr 1:1-6. Epub 2021 Apr 1.

Department of Ophthalmology, Koç University School of Medicine, Istanbul, Turkey.

Purpose: To compare corneal in-vivo confocal microscopy (IVCM) findings in patients with seborrheic blepharitis with healthy controls and to evaluate the correlation with the load.

Methods: Sixty-two positive seborrheic blepharitis patients and 24 controls were included. Four eyelashes from each eye were examined. Read More

View Article and Full-Text PDF

In Vivo Confocal Microscopic Evaluation of the Limbus and Cornea in Vogt Koyanagi Haradas Syndrome.

Ocul Immunol Inflamm 2021 Apr 1:1-8. Epub 2021 Apr 1.

Chief Uvea Services, Aravind Eye Hospital, Madurai, India.

: To elucidate the microarchitecture of limbus and cornea in subjects with Vogt Koyanagi Haradas syndrome (VKH): From January 2019 to December 2019 a total of 17 VKH subjects, 5 acute and 12 chronic, 18 non VKH uveitis controls, and 6 healthy controls were recruited for this study . In vivo confocal microscopic (IVCM) analysis of the limbal basal epithelium, scleral side of the limbus, limbal niche, corneal keratocytes, and corneal nerves was carried out .: Absence of pigmented cells in the limbal basal epithelium, presence of inflammatory cells on the scleral side of the limbus, fibrotic niche, degenerated keratocytes, thinning, and beading of corneal nerves were noted in VKH eyes as compared to controls. Read More

View Article and Full-Text PDF

Can in vivo confocal microscopy differentiate between sub-types of dry eye disease? A review.

Clin Exp Ophthalmol 2021 Mar 26. Epub 2021 Mar 26.

Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami, Miami, Florida, USA.

Many studies utilised in vivo confocal microscopy (IVCM) to associate variations in corneal structures with dry eye disease (DED). However, DED is an umbrella term that covers various aetiologies and presentations. This review analyses populations by DED aetiology to determine the relationships between IVCM parameters and specific DED sub-types. Read More

View Article and Full-Text PDF

Impact of corneal parameters, refractive error and age on density and morphology of the subbasal nerve plexus fibers in healthy adults.

Sci Rep 2021 Mar 16;11(1):6076. Epub 2021 Mar 16.

Ophthalmology Clinic, Department of Biomedical Sciences, University Hospital of Messina, Via Consolare Valeria, 98100, Messina, Italy.

The purpose of this study was to analyze corneal sub-basal nerve plexus (SBNP) density and morphology and their relationships with corneal parameters and refractive status. In this single center study, in vivo confocal microscopy (IVCM) was performed in 76 eyes of 38 healthy subjects aged 19-87 (mean age 34.987 ± 1. Read More

View Article and Full-Text PDF

Associated Neurotrophic Keratopathy in Complex Regional Pain Syndrome.

Cornea 2021 Feb 15. Epub 2021 Feb 15.

Duke Eye Center, Duke University, Durham, NC; Foster Center for Ocular Immunology, Duke University, Durham, NC; Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA; and Department of Neurology, Division: Headache/Pain, University of North Carolina, Chapel Hill.

Purpose: To report a case of neurotrophic keratopathy (NK) in a patient with complex regional pain syndrome (CRPS) with ipsilateral facial involvement.

Methods: Case report.

Results: An 18-year old woman with a 5-year history of CRPS type I, a systemic disorder with a neuropathic component with associated limb and right facial involvement, presented with an insidious onset of blurred vision and pain in the right eye. Read More

View Article and Full-Text PDF
February 2021

Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review.

Br J Ophthalmol 2021 Feb 10. Epub 2021 Feb 10.

Department of Optometry and Vision Sciences, The University of Melbourne, Parkville, Victoria, Australia

Background/aims: This systematic review critically evaluated peer-reviewed publications describing morphological features consistent with, or using terms related to, a 'neuroma' or 'microneuroma' in the human cornea using laser-scanning in vivo confocal microscopy (IVCM).

Methods: The review was prospectively registered on PROSPERO (CRD42020160038). Comprehensive literature searches were performed in Ovid MEDLINE, Ovid Embase and the Cochrane Library in November 2019. Read More

View Article and Full-Text PDF
February 2021

Investigation of the Lid Infestation with in Vivo Confocal Microscopy versus Light Microscopy in Patients with Seborrheic Blepharitis.

Ocul Immunol Inflamm 2021 Feb 9:1-5. Epub 2021 Feb 9.

Department of Ophthalmology, Koc University Medical Faculty, Istanbul, Turkey.

: The comparison of the diagnostic efficiency of a reference method (light microscopy [LM] using 10% potassium hydroxide [KOH]) with the use of 100% alcohol to confocal microscopy (IVCM) for the detection of eyelid infestation in seborrheic blepharitis patients.: Eyelashes were epilated from the right eyes for the reference method and the left eyes for the alcohol group in 58 eyes of 29 patients. IVCM was used on the left eyes. Read More

View Article and Full-Text PDF
February 2021