47 results match your criteria iups data

External validation of risk prediction model M4 in an Australian population: Rationalising the management of pregnancies of unknown location.

Aust N Z J Obstet Gynaecol 2020 12 15;60(6):928-934. Epub 2020 Jun 15.

Acute Gynaecology, Early Pregnancy and Advanced Endoscopic Surgery Unit, Nepean Hospital, Nepean Clinical School University of Sydney, Sydney, New South Wales, Australia.

Background: The prediction model M4 can successfully classify pregnancy of unknown location (PUL) into a low- or high-risk group in developing ectopic pregnancy. M4 was validated in UK centres but in very few other countries outside UK.

Aim: To validate the M4 model's ability to correctly classify PULs in a cohort of Australian women. Read More

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December 2020

Laparoscopic Management of 42 Cases of Tubal Stump Pregnancy and Postoperative Reproductive Outcomes.

J Minim Invasive Gynecol 2020 Mar - Apr;27(3):618-624. Epub 2019 Nov 12.

Department of Gynecology & Obstetrics, International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, and the Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China (all authors). Electronic address:

Study Objective: Tubal stump pregnancy is a rare variant of ectopic pregnancy. The aim of this study was to evaluate laparoscopic surgery for tubal stump pregnancy and to investigate postoperative pregnancy outcomes.

Design: Retrospective study. Read More

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October 2020

Distinct mutational landscape of inverted urothelial papilloma.

J Pathol 2019 09 2;249(1):3-5. Epub 2019 Jul 2.

Department of Pathology, Indiana University School of Medicine, Indianapolis, IN, USA.

A recent study has identified gene mutations involving the MAPK/ERK pathway, particularly the HRAS gene, in all inverted urothelial papillomas (IUPs), in the absence of pathway mutations in TERT promoter, FGFR3, and TP53/RB1genes. Neither recurrence nor progression was observed in IUPs. These data support several longstanding hypotheses: (1) IUPs are benign and do not recur or progress; (2) they harbor mutations that are different from those of urothelial carcinoma; and (3) they arise through different molecular mechanisms than low- or high-grade urothelial carcinoma. Read More

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September 2019

Illicit Use of Prescription Stimulants: Gender Differences in Perceptions of Risk.

Subst Use Misuse 2019 7;54(10):1654-1662. Epub 2019 May 7.

a Mississippi State University , Mississippi State , Mississippi , USA.

: Little research exists on gender differences regarding the relationship between illicit use of prescription stimulants (IUPS) and perceptions of risk of illicit use. Risk perception is a common target for both prevention and intervention programs. : To measure gender differences in prevalence rates of illicit use and perceptions of legal, health, and social risks of illicit use. Read More

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Methotrexate Administration to Patients With Presumed Ectopic Pregnancy Leads to Methotrexate Exposure of Intrauterine Pregnancies.

J Ultrasound Med 2019 Mar 23;38(3):675-684. Epub 2018 Sep 23.

Department of Obstetrics, Gynecology, and Women's Health, Montefiore Medical Center, Bronx, New York, USA.

Objective: To report clinical experience with methotrexate (MTX) treatment for suspected but not definite ectopic pregnancy (EP).

Methods: This was a retrospective cohort study. All patients treated with MTX for presumed EP between 2000 and 2016 were included. Read More

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Tubulin Binding and Polymerization Promoting Properties of Tubulin Polymerization Promoting Proteins Are Evolutionarily Conserved.

Biochemistry 2017 02 6;56(7):1017-1024. Epub 2017 Feb 6.

Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences , Magyar tudósok körútja 2, Budapest H-1117, Hungary.

Tubulin polymerization promoting proteins (TPPPs) constitute a eukaryotic protein family. There are three TPPP paralogs in the human genome, denoted as TPPP1-TPPP3. TPPP1 and TPPP3 are intrinsically unstructured proteins (IUPs) that bind and polymerize tubulin and stabilize microtubules, but TPPP2 does not. Read More

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February 2017

The Virtual Physiological Human: The Physiome Project Aims to Develop Reproducible, Multiscale Models for Clinical Practice.

Peter Hunter

IEEE Pulse 2016 Jul-Aug;7(4):36-42

The Physiome Project was initiated by the International Union of Physiological Sciences (IUPS; www.iups.org) in 1997 to bring multiscale engineering modeling approaches to the physiological interpretation of the wealth of molecular data that was becoming available at that time [1]. Read More

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February 2017

Use of double decidual sac sign to confirm intrauterine pregnancy location prior to sonographic visualization of embryonic contents.

Ultrasound Obstet Gynecol 2017 May 2;49(5):643-648. Epub 2017 Apr 2.

Nurture Fertility, The East Midlands Fertility Clinic, Nottingham, UK.

Objectives: To determine the diagnostic accuracy of the double decidual sac sign (DDSS) for predicting an intrauterine pregnancy (IUP) prior to visualization of embryonic contents, using modern high-resolution transvaginal sonography (TVS).

Methods: The study was conducted following STARD guidelines and participants were recruited prospectively from Nurture Fertility, Nottingham, UK, following in-vitro fertilization/intracytoplasmic sperm injection treatment between 1 January 2015 and 31 October 2015. Women were excluded if there was no evidence of intrauterine fluid collection during the index test, a yolk sac or fetal pole was visible during the index test, no outcome data were available or pregnancy location could not be determined by the reference standard. Read More

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The Illicit Use of Prescription Stimulants on College Campuses: A Theory-Guided Systematic Review.

Health Educ Behav 2015 Dec 1;42(6):719-29. Epub 2015 Jun 1.

Oregon State University, Corvallis, OR, USA.

The illicit use of prescription stimulants (IUPS) is a substance use behavior that remains prevalent on college campuses. As theory can guide research and practice, we provide a systematic review of the college-based IUPS epidemiological literature guided by one ecological framework, the theory of triadic influence (TTI). We aim to assess prevalence, elucidate the behavior's multietiological nature, and discuss prevention implications. Read More

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December 2015

Laparoscopic surgery for distal tubal occlusions: lessons learned from a historical series of 434 cases.

Fertil Steril 2014 Oct 20;102(4):1203-8. Epub 2014 Aug 20.

Department of Obstetrics and Gynecology, Centre Hospitalier Universitaire de Bichat, Paris, France.

Objective: To evaluate the success rate of laparoscopic neosalpingostomy and the factors affecting the results in terms of intrauterine pregnancy (IUP), delivery (DEL), and ectopic pregnancy (EP).

Design: Retrospective analysis of prospectively recorded data.

Setting: Private practice. Read More

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October 2014

Using structural equation modeling to understand prescription stimulant misuse: a test of the Theory of Triadic Influence.

Drug Alcohol Depend 2014 May 12;138:193-201. Epub 2014 Mar 12.

Prevention Research Center, United States.

Objective: To test a theory-driven model of health behavior to predict the illicit use of prescription stimulants (IUPS) among college students.

Participants: A probability sample of 554 students from one university located in California (response rate=90.52%). Read More

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Rationalizing the management of pregnancies of unknown location: temporal and external validation of a risk prediction model on 1962 pregnancies.

Hum Reprod 2013 Mar 4;28(3):609-16. Epub 2013 Jan 4.

Department of Development and Regeneration, KU Leuven, Belgium.

Study Question: Can we accurately define a group of pregnancies of unknown location (PULs) as low risk in order to safely reduce follow-up for these pregnancies and allocate resources to pregnancies at an increased risk of being ectopic?

Summary Answer: Prediction model M4 classified around 70% of PULs as low risk, of which around 97% were later characterized as failed PULs or intrauterine pregnancies (IUPs), while still classifying 88% of ectopic pregnancies as high risk.

What Is Known Already: Depending on the level of suspicion of ectopic pregnancy (EP), women with a PUL receive a lengthy follow-up in order to confirm the location and viability of the pregnancy.

Study Design, Size, Duration: A multi-centre diagnostic accuracy study of 1962 patients was carried out between 2003 and 2007 for retrospective temporal validation and between 2009 and 2011 for prospective external validation. Read More

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Structural characterization of an intrinsically unfolded mini-HBX protein from hepatitis B virus.

Mol Cells 2012 Aug 20;34(2):165-9. Epub 2012 Jul 20.

Biomedical Translational Research Center, Division of Convergent Biomedical Research, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.

The hepatitis B virus x protein (HBX) is expressed in HBV-infected liver cells and can interact with a wide range of cellular proteins. In order to understand such promiscuous behavior of HBX we expressed a truncated mini-HBX protein (named Tr-HBX) (residues 18-142) with 5 Cys → Ser mutations and characterized its structural features using circular dichroism (CD) spectropolarimetry, NMR spectroscopy as well as bioinformatics tools for predicting disorder in intrinsically unstructured proteins (IUPs). The secondary structural content of Tr-HBX from CD data suggests that Tr-HBX is only partially folded. Read More

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Diffusive oxygen shunting between vessels in the preglomerular renal vasculature: anatomic observations and computational modeling.

Am J Physiol Renal Physiol 2012 Sep 6;303(5):F605-18. Epub 2012 Jun 6.

School of Computer Science and Software Engineering, The Univ. of Western Australia, 35 Stirling Highway, Crawley, WA 6009, Australia.

To understand how geometric factors affect arterial-to-venous (AV) oxygen shunting, a mathematical model of diffusive oxygen transport in the renal cortex was developed. Preglomerular vascular geometry was investigated using light microscopy (providing vein shape, AV separation, and capillary density near arteries) and published micro-computed tomography (CT) data (providing vessel size and AV separation; Nordsletten DA, Blackett S, Bentley MD, Ritman EL, Smith NP. IUPS Physiome Project. Read More

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September 2012

Intrinsic protein flexibility in regulation of cell proliferation: advantages for signaling and opportunities for novel therapeutics.

Adv Exp Med Biol 2012 ;725:27-49

Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.

It is now widely recognized that intrinsically disordered (or unstructured) proteins (IDPs, or IUPs) are found in organisms from all kingdoms of life. In eukaryotes, IDPs are highly abundant and perform a wide range of biological functions, including regulation and signaling. Despite increased interest in understanding the structural biology of IDPs, questions remain regarding the mechanisms through which disordered proteins perform their biological function(s). Read More

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BQP35 is a novel member of the intrinsically unstructured protein (IUP) family which is a potential antigen for the sero-diagnosis of Babesia sp. BQ1 (Lintan) infection.

Vet Parasitol 2012 Jul 21;187(3-4):421-30. Epub 2012 Jan 21.

State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Science, Xujiaping 1, Lanzhou, Gansu 730046, PR China.

A new gene of Babesia sp. BQ1 (Lintan) (BQP35) was cloned by screening a merozoite cDNA expression library with infected sheep serum and using rapid amplification of cDNA ends (RACE). The nucleotide sequence of the cDNA was 1140bp with an open reading frame (ORF) of 936bp encoding a 35-kDa predicted polypeptide with 311 amino acid residues. Read More

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Performance of human chorionic gonadotropin curves in women at risk for ectopic pregnancy: exceptions to the rules.

Fertil Steril 2012 Jan;97(1):101-6.e2

Department of Obstetrics and Gynecology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Objective: To investigate the accuracy of serial hCG to predict outcome of a pregnancy of unknown location in an ethnically and geographically diverse setting.

Design: Multisite cohort study.

Setting: University hospital. Read More

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January 2012

Expression of claudins and their prognostic significance in noninvasive urothelial neoplasms of the human urinary bladder.

J Histochem Cytochem 2011 Oct 10;59(10):932-41. Epub 2011 Aug 10.

2nd Department of Pathology, Semmelweis University, Budapest, Hungary.

The members of the claudin family are major integral transmembrane protein constituents of tight junctions. Normal and neoplastic tissues can be characterized by unique qualitative and quantitative distribution of claudin subtypes, which may be related to clinicopathological features. Differential diagnosis and prognosis of nonmuscle invasive tumor entities of urinary bladder epithelium are often challenging. Read More

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October 2011

Intrinsically unstructured proteins and neurodegenerative diseases: conformational promiscuity at its best.

IUBMB Life 2011 Jul;63(7):478-88

Structural Genomics Division, Saha Institute of Nuclear Physics, 1/AF Bidhan Nagar, Kolkata, WB, India.

Neurodegenerative diseases are complex, multifactorial disorders where misfolding of proteins cause aberrant protein-protein interactions. They are not usually characterized by specific mutations especially for nonfamilial disease types. Most of the causative proteins, however, are intrinsically unstructured (IUP), loss of whose fine balance could play pivotal role in these processes. Read More

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Context-dependent resistance to proteolysis of intrinsically disordered proteins.

Protein Sci 2011 Aug 8;20(8):1285-97. Epub 2011 Jun 8.

The Israel Structural Proteomics Center, Weizmann Institute of Science, Rehovot, Israel.

Intrinsically disordered proteins (IDPs), also known as intrinsically unstructured proteins (IUPs), lack a well-defined 3D structure in vitro and, in some cases, also in vivo. Here, we discuss the question of proteolytic sensitivity of IDPs, with a view to better explaining their in vivo characteristics. After an initial assessment of the status of IDPs in vivo, we briefly survey the intracellular proteolytic systems. Read More

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Cardiac cell modelling: observations from the heart of the cardiac physiome project.

Prog Biophys Mol Biol 2011 Jan 18;104(1-3):2-21. Epub 2010 Mar 18.

Department of Physiology, Anatomy and Genetics, University of Oxford, OX1 3JP, United Kingdom.

In this manuscript we review the state of cardiac cell modelling in the context of international initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim to integrate computational models across scales and physics. In particular we focus on the relationship between experimental data and model parameterisation across a range of model types and cellular physiological systems. Finally, in the context of parameter identification and model reuse within the Cardiac Physiome, we suggest some future priority areas for this field. Read More

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January 2011

Endometrial thickness predicts intrauterine pregnancy in patients with pregnancy of unknown location.

Ultrasound Obstet Gynecol 2008 Dec;32(7):929-34

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.

Objective: To determine whether endometrial thickness and other parameters are useful predictors of normal intrauterine pregnancy (IUP) in the setting of vaginal bleeding and sonographic diagnosis of pregnancy of unknown location (PUL).

Methods: We reviewed the clinical and sonographic records of all 591 patients with vaginal bleeding and a sonographic diagnosis of PUL between 1 July 2005 and 30 June 2006. Data on maternal age, gravidity, parity, estimated gestational age by last menstrual period (EGA by LMP), endometrial thickness and serum beta-human chorionic gonadotropin (beta-hCG) were collected. Read More

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December 2008

Structure and dynamics of the N-terminal half of hepatitis C virus core protein: an intrinsically unstructured protein.

Biochem Biophys Res Commun 2009 Jan 4;378(1):27-31. Epub 2008 Nov 4.

CREFSIP and Department of Biochemistry and Microbiology, Université Laval, 1030 Avenue de la Médecine, Local 3255, Québec, QC, Canada G1V 0A6.

Hepatitis C virus core protein plays an important role in the assembly and packaging of the viral genome. We have studied the structure of the N-terminal half of the core protein (C82) which was shown to be sufficient for the formation of nucleocapsid-like particle (NLP) in vitro and in yeast. Structural bioinformatics analysis of C82 suggests that it is mostly unstructured. Read More

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January 2009

Detailed structural characterization of unbound protein phosphatase 1 inhibitors.

Biochemistry 2008 Nov;47(47):12346-56

Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island 02912, USA.

Protein phosphatase 1 (PP1) is an essential and ubiquitous serine/threonine protein phosphatase that is regulated by more than 100 known inhibitor and targeting proteins. It is currently unclear how protein inhibitors distinctly and specifically regulate PP1 to enable rapid responses to cellular alterations. We demonstrate that two PP1 inhibitors, I-2 and DARPP-32, belong to the class of intrinsically unstructured proteins (IUPs). Read More

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November 2008

The hCG ratio can predict the ultimate viability of the intrauterine pregnancies of uncertain viability in the pregnancy of unknown location population.

Hum Reprod 2008 Sep 10;23(9):1964-7. Epub 2008 Jun 10.

Early Pregnancy and Gynaecological Ultrasound Unit, Department of Obstetrics and Gynaecology, St George's, University of London, Cranmer Terrace, London SW17 0RE, UK.

Background: To determine whether hCG ratio at 48 h can predict ultimate viability of intrauterine pregnancies of uncertain viability (IPUVs) in the pregnancy of unknown location (PUL) population.

Methods: Prospective observational study from June 2001 to October 2004. All women classified with PUL had serum hCG levels measured at 0 and 48 h to calculate hCG ratio (hCG 48/hCG 0 h). Read More

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September 2008

A robust approach for analyzing a heterogeneous structural ensemble.

Proteins 2008 Dec;73(4):918-28

Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Life Science South, Moscow, Idaho 83844-3052, USA.

Intrinsically unstructured proteins (IUP) are widespread in eukaryotes and participate in numerous cellular processes, but a structural explanation of the mechanisms they use to recognize and bind their diverse targets has proved elusive. Transcriptional activator domains are one class of IUP that function by recruiting other factors into basal transcription complexes. Transcriptional activator domains are known to use electrostatic interactions for recognition, but it is unclear how this could be accomplished by a structurally heterogeneous ensemble. Read More

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December 2008

A glycosylated form of the human cardiac hormone pro B-type natriuretic peptide is an intrinsically unstructured monomeric protein.

Arch Biochem Biophys 2008 Jul 13;475(1):36-41. Epub 2008 Apr 13.

Department of Pathology and Immunology, Division of Laboratory and Genomic Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA.

The N-terminal fragment of pro B-type natriuretic peptide (NT-proBNP) and proBNP are used as gold standard clinical markers of myocardial dysfunction such as cardiac hypertrophy and left ventricle heart failure. The actual circulating molecular forms of these peptides have been the subject of intense investigation particularly since these analytes are measured in clinical assays. Conflicting data has been reported and no firm consensus on the exact nature of the molecular species exists. Read More

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Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.

Proteins 2008 Mar;70(4):1357-66

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot 76100, Israel.

Intrinsically unstructured proteins (IUPs), also known as natively unfolded proteins, lack well-defined secondary and tertiary structure under physiological conditions. In recent years, growing experimental and theoretical evidence has accumulated, indicating that many entire proteins and protein sequences are unstructured under physiological conditions, and that they play significant roles in diverse cellular processes. Bioinformatic algorithms have been developed to identify such sequences in proteins for which structural data are lacking, but still generate substantial numbers of false positives and negatives. Read More

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Dynamic behavior of an intrinsically unstructured linker domain is conserved in the face of negligible amino acid sequence conservation.

J Mol Evol 2007 Sep 25;65(3):277-88. Epub 2007 Aug 25.

Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID 83844-3052, USA.

Proteins or regions of proteins that do not form compact globular structures are classified as intrinsically unstructured proteins (IUPs). IUPs are common in nature and have essential molecular functions, but even a limited understanding of the evolution of their dynamic behavior is lacking. The primary objective of this work was to test the evolutionary conservation of dynamic behavior for a particular class of IUPs that form intrinsically unstructured linker domains (IULD) that tether flanking folded domains. Read More

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September 2007

Genomics, evolution, and expression of TBPL2, a member of the TBP family.

DNA Cell Biol 2007 Jun;26(6):369-85

Dipartimento di Scienze Biomediche-Unità di Biologia Genetica e BioInformatica, Università di Catania, Catania, Italy, EU.

TBPL2 is the most recently discovered and less characterized member of the TATA box binding protein (TBP) family that also comprises TBP, TATA box binding protein-like 1 (TBPL1), and Drosophila melanogaster TBP related factor (TRF). In this paper we report our in silico and in vitro data on (i) the genomics of the TBPL2 gene in Homo sapiens, Pan troglodytes, Mus musculus, Rattus norvegicus, Gallus gallus, Xenopus tropicalis, and Takifugu rubripes; (ii) its evolution and phylogenetic relationship with TBP, TBPL1, and TRF; (iii) the structure of the TBPL2 proteins that belong to the recently identified group of the intrinsically unstructured proteins (IUPs); and (iv) TBPL2 expression in different organs and cell types of Homo sapiens and Rattus norvegicus. Similar to TBP, both the TBPL2 gene and protein are bimodular. Read More

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