22,062 results match your criteria iugr


Pregnancy and Viral infections: Mechanisms of fetal damage, diagnosis and prevention of neonatal adverse outcomes from cytomegalovirus to SARS-CoV-2 and Zika virus.

Biochim Biophys Acta Mol Basis Dis 2021 Jun 9:166198. Epub 2021 Jun 9.

Fetal and Perinatal Medicine and Surgery Unit, Medical and Surgical Department of Fetus, Newborn and Infant - "Bambino Gesù" Children's Hospital IRCCS, Rome, Italy.

Some maternal infections, contracted before or during pregnancy, can be transmitted to the fetus, during gestation (congenital infection), during labor and childbirth (perinatal infection) and through breastfeeding (postnatal infection). The agents responsible for these infections can be viruses, bacteria, protozoa, fungi. Among the viruses most frequently responsible for congenital infections are Cytomegalovirus (CMV), Herpes simplex 1-2, Herpes virus 6, Varicella zoster. Read More

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Relevance of maternal sodium level for preeclampsia-associated adverse pregnancy outcomes.

Pregnancy Hypertens 2021 May 29;25:110-115. Epub 2021 May 29.

Department of Obstetrics, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Germany. Electronic address:

Objective: To evaluate maternal sodium levels in women with preeclampsia (PE) or at high risk for preeclampsia and their relevance for severe PE-associated adverse pregnancy outcome and remaining pregnancy duration.

Study Design: In a retrospective cohort of 198 patients presenting with signs and symptoms of preeclampsia (PE), we investigated maternal sodium level and the sFlt-1/PlGF-ratio within 14 days prior to delivery.

Main Outcome Measures: In total, 88 patients (44. Read More

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Magnetic resonance imaging of skull and brain parameters in fetuses with intrauterine growth restriction.

Radiol Bras 2021 May-Jun;54(3):141-147

Department of Obstetrics and Gynecology, Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (FMRP-USP), Ribeirão Preto, SP, Brazil.

Objective: To compare fetuses with intrauterine growth restriction (IUGR) and those with normal growth, in terms of skull and brain measurements obtained by magnetic resonance imaging (MRI).

Materials And Methods: This was a prospective cohort study including 26 single fetuses (13 with IUGR and 13 with normal growth), evaluated from 26 to 38 weeks of gestation. Using MRI, we measured skull and brain biparietal diameters (BPDs); skull and brain occipitofrontal diameters (OFDs); corpus callosum length and area; transverse cerebellar diameter; extracerebral cerebrospinal fluid (eCSF); and right and left interopercular distances (IODs). Read More

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Resveratrol and its derivative pterostilbene ameliorate intestine injury in intrauterine growth-retarded weanling piglets by modulating redox status and gut microbiota.

J Anim Sci Biotechnol 2021 Jun 10;12(1):70. Epub 2021 Jun 10.

College of Animal Science and Technology, Nanjing Agricultural University, No.1 Weigang Street, Nanjing, Jiangsu, 210095, People's Republic of China.

Background: Intestinal disorder is an important factor contributing to growth lag and high rates of morbidity and mortality of piglets with intrauterine growth retardation (IUGR). Resveratrol (RSV) and its derivative pterostilbene (PT) are natural stilbenes possessing various bioactivities, such as antioxidative and anti-inflammatory effects. This study compared the protective potential of RSV and PT on the intestinal redox status and gut microbiota in weanling piglets with IUGR. Read More

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Pregnancy-related acute kidney injury at high altitude: a retrospective observational study in a single center.

BMC Nephrol 2021 Jun 9;22(1):215. Epub 2021 Jun 9.

Department of Nephrology, Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

Background: Pregnancy-related acute kidney injury (Pr-AKI) is associated with maternal and fetal morbidity and mortality. There are few studies focusing on Pr-AKI at high altitude in the literature.

Objectives: to investigate the incidence, etiology, clinical features and maternal-fetal outcomes of Pr-AKI in women living at high altitude. Read More

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Dietary dimethylglycine sodium salt supplementation improves growth performance, redox status, and skeletal muscle function of intrauterine growth restriction weaned piglets.

J Anim Sci 2021 Jun 9. Epub 2021 Jun 9.

College of Animal Sciences and Technology, Nanjing Agricultural University, Nanjing, Jiangsu, P. R. China.

Few studies have focused on the role of dimethylglycine sodium salt (DMG-Na) in protecting the redox status of skeletal muscle, although it is reported to be beneficial in animal husbandry. This study investigated the beneficial effects of DMG-Na on the growth performance, longissimus dorsi muscle (LM) redox status, and mitochondrial function in weaning piglets that were intrauterine growth restricted (IUGR). Ten normal birth weight (NBW) newborn piglets (1. Read More

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Hemoglobin Level and Associated Factors among Pregnant Women in Rural Southwest Ethiopia.

Biomed Res Int 2021 19;2021:9922370. Epub 2021 May 19.

Department of Nutrition and Dietetics, Jimma University, Jimma, Ethiopia.

Background: Anemia is a situation in which the number and size of red blood cells, or the concentration of hemoglobin, fall below established cut-off values. Low hemoglobin level during pregnancy favors the alteration of placental angiogenesis and resulted in restricting the availability of nutrients to the fetus and consequently causing fetal growth retardation and low weight at birth. This study is aimed at assessing the hemoglobin level and associated factors among pregnant women in rural communities of Jimma zone, Southwest Ethiopia. Read More

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Continuous activation of polymorphonuclear myeloid-derived suppressor cells during pregnancy is critical for fetal development.

Cell Mol Immunol 2021 Jun 7. Epub 2021 Jun 7.

Department of Immunology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.

The maternal immune system is vital in maintaining immunotolerance to the semiallogeneic fetus for a successful pregnancy. Although studies have shown that myeloid-derived suppressor cells (MDSCs) play an important role in maintaining feto-maternal tolerance, little is known about the role of MDSCs in pregnancies with intrauterine growth retardation (IUGR). Here, we reported that the activation of polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) during pregnancy was closely associated with fetal growth. Read More

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Intrauterine growth restriction followed by oxygen support uniquely interferes with genetic regulators of myelination.

eNeuro 2021 Jun 7. Epub 2021 Jun 7.

Children's Hospital of Chicago, Department of Pediatrics, Division of Neonatology, Chicago, Illinois, USA.

Intrauterine growth restriction (IUGR) and oxygen exposure in isolation and combination adversely affect the developing brain, putting infants at risk for neurodevelopmental disability including cerebral palsy. Rodent models of IUGR and postnatal hyperoxia have demonstrated oligodendroglial injury with subsequent white matter injury (WMI) and motor dysfunction. Here we investigate transcriptomic dysregulation in IUGR with and without hyperoxia exposure to account for the abnormal brain structure and function previously documented. Read More

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Automated quantitative evaluation of atrioventricular annular plane systolic excursion in human fetuses.

Ultrasound Obstet Gynecol 2021 Jun 7. Epub 2021 Jun 7.

Department of Clinical Science, Intervention and Technology - CLINTEC, Karolinska Institutet, Stockholm, Sweden.

Objectives: The primary aim of this study was to evaluate the feasibility of measuring fetal atrioventricular plane displacement (AVPD) using an automated analysis software. The secondary objectives were to establish reference ranges for AVPD during the second half of normal pregnancy, assess fetal AVPD in prolonged pregnancies in relation to adverse perinatal outcome and in fetuses with a suspicion of intrauterine growth restriction (IUGR).

Methods: The reference population consisted of women with uncomplicated pregnancies at 18-42 weeks of gestation (n=201). Read More

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ZIKV Disrupts Placental Ultrastructure and Drug Transporter Expression in Mice.

Front Immunol 2021 21;12:680246. Epub 2021 May 21.

Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Congenital Zika virus (ZIKV) infection can induce fetal brain abnormalities. Here, we investigated whether maternal ZIKV infection affects placental physiology and metabolic transport potential and impacts the fetal outcome, regardless of viral presence in the fetus at term. Low (10 PFU-ZIKV; low ZIKV) and high (5x10 PFU-ZIKV; high ZIKV) virus titers were injected into immunocompetent (ICompetent C57BL/6) and immunocompromised (ICompromised A129) mice at gestational day (GD) 12. Read More

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Cell death mechanisms and their roles in pregnancy related disorders.

Adv Protein Chem Struct Biol 2021 27;126:195-225. Epub 2021 Feb 27.

Department of Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be University), Pune, India. Electronic address:

Autophagy and apoptosis are catabolic pathways essential for homeostasis. They play a crucial role for normal placental and fetal development. These cell death mechanisms are exaggerated in placental disorders such as preeclampsia, intrauterine growth restriction (IUGR) and gestational diabetes mellitus (GDM). Read More

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February 2021

Pregnancy complications in G20210A mutation carriers associated with high prothrombin activity.

Thromb J 2021 Jun 5;19(1):41. Epub 2021 Jun 5.

Altai Regional Clinical Hospital, Barnaul, Russia.

Objective: To study the association between high activity of Factor II (prothrombin) in blood plasma with G20210A mutation and the development of great obstetrical syndromes.

Material And Methods: A prospective clinical cohort study was conducted on 290 pregnant women (average age 31.7 ± 4. Read More

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Fetal proximal and distal limb anomalies following exposure to mycophenolate mofetil during pregnancy: A case report and review of the literature.

Lupus 2021 Jun 4:9612033211021486. Epub 2021 Jun 4.

Mansoura Nephrology and Dialysis Unit (MNDU), Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Background: Mycophenolate mofetil (MMF) is currently used in a wide spectrum of autoimmune diseases and has been rendered very effective in the management of systemic lupus erythematosus and lupus nephritis. MMF is known to be teratogenic (FDA category D) and therefore, women in childbearing period receiving MMF should be counselled to use effective contraceptive methods to avoid an unplanned pregnancy.

Case: A 22-year-old lady accidentally discovered to be pregnant while using MMF as a treatment of lupus nephritis which was replaced later on by azathioprine. Read More

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Dimming the Powerhouse: Mitochondrial Dysfunction in the Liver and Skeletal Muscle of Intrauterine Growth Restricted Fetuses.

Front Endocrinol (Lausanne) 2021 17;12:612888. Epub 2021 May 17.

School of Animal and Comparative Biomedical Sciences, The University of Arizona, Tucson, AZ, United States.

Intrauterine growth restriction (IUGR) of the fetus, resulting from placental insufficiency (PI), is characterized by low fetal oxygen and nutrient concentrations that stunt growth rates of metabolic organs. Numerous animal models of IUGR recapitulate pathophysiological conditions found in human fetuses with IUGR. These models provide insight into metabolic dysfunction in skeletal muscle and liver. Read More

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Polyphenols and IUGR Pregnancies: Effects of the Antioxidant Hydroxytyrosol on Brain Neurochemistry and Development in a Porcine Model.

Antioxidants (Basel) 2021 May 31;10(6). Epub 2021 May 31.

Departament de Bioquímica i Biologia Molecular, Facultat de Veterinària, Universitat Autònoma de Barcelona, Cerdanyola del Vallès, 08193 Barcelona, Spain.

Supplementation of a mother's diet with antioxidants, such as hydroxytyrosol (HTX), has been proposed to ameliorate the adverse phenotypes of fetuses at risk of intrauterine growth restriction. In the present study, sows were treated daily with or without 1.5 mg of HTX per kilogram of feed from day 35 of pregnancy (at 30% of total gestational period), and individuals were sampled at three different ages: 100-day-old fetuses and 1-month- and 6-month-old piglets. Read More

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Age-Related Changes in Bone-Marrow Mesenchymal Stem Cells.

Cells 2021 May 21;10(6). Epub 2021 May 21.

A.N. Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, 119992 Moscow, Russia.

The use of stem cells is part of a strategy for the treatment of a large number of diseases. However, the source of the original stem cells for use is extremely important and determines their therapeutic potential. Mesenchymal stromal cells (MSC) have proven their therapeutic effectiveness when used in a number of pathological models. Read More

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Residential proximity to pesticide applications in Argentine Patagonia: impact on pregnancy and newborn parameters.

Environ Sci Pollut Res Int 2021 May 31. Epub 2021 May 31.

Departamento de Biodiversidad y Biología Experimental, and Laboratorio de Toxicología de Mezclas Químicas (LATOMEQ), Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, 4to piso. Intendente Güiraldes 2160, (C1428EGA), Ciudad Autónoma de Buenos Aires, Argentina.

Among residents living close to agricultural fields who are potentially exposed to pesticides, pregnant women and their fetuses are of particular concern for their vulnerability to environmental chemicals. In this collaborative multicenter study, we covered a wide distribution of participants in the most important fruit production zone of north Patagonia (Argentina) to investigate whether maternal residential proximity to fruit croplands with intense pesticide applications (rural group -RG-) is associated with pregnancy complications and alterations in their newborn parameters compared to the urban population (urban group -UG-). A total of 776 pregnant women met the inclusion criteria. Read More

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The effect of ultrasound-guided intraperitoneal injection of ulinastatin on lung development in intrauterine growth-restricted fetal rabbits.

J Matern Fetal Neonatal Med 2021 May 31:1-8. Epub 2021 May 31.

Department of Ultrasound, Second Affiliated Hospital of Fujian Medical University, Quanzhou, China.

Objectives: To investigate the effect and mechanism of ulinastatin (UTI) on development of lungs in fetal rabbits with intrauterine growth retardation (IUGR).

Methods: Twenty pregnant rabbits were equally divided into normal, IUGR, UTI, and LY groups. The normal group was only injected with saline and marked with tattoo ink. Read More

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Vascular tone regulation in renal interlobar arteries of male rats is dysfunctional after intrauterine growth restriction.

Am J Physiol Renal Physiol 2021 05 31. Epub 2021 May 31.

Medical Faculty and University Hospital Cologne, Department of Pediatrics and Adolescent Medicine, University of Cologne, Germany

Intrauterine growth restriction (IUGR) due to an adverse intrauterine environment predisposes to arterial hypertension and loss of kidney function. Here we investigated whether vascular dysregulation in renal interlobar arteries (RIA) may contribute to hypertensive glomerular damage after IUGR. In rats, IUGR was induced by bilateral uterine vessel ligation. Read More

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Tumor Necrosis Factor-alpha Blockade Improves Uterine Artery Resistance, Maternal Blood Pressure, and Fetal Growth in Placental Ischemic Rats.

Pregnancy Hypertens 2021 May 14;25:39-47. Epub 2021 May 14.

Departments of Pharmacology and Toxicology, University of Mississippi Medical Center, United States; Emergency Medicine, University of Mississippi Medical Center, United States. Electronic address:

We recently reported that adoptive transfer of cytolytic Natural Killer cells (cNKs) from the Reduced Uterine Perfusion Pressure (RUPP) rat induces a preeclampsia (PE)-like phenotype in pregnant rats, accompanied by increased TNF-α. The purpose of this study was to investigate a role for increased TNF-α to induce oxidative stress (ROS), decrease nitric oxide (NO) bioavailability, and induce vascular dysfunction as mechanisms of hypertension (HTN) and intrauterine growth restriction (IUGR) in RUPPs. Pregnant Sprague Dawley rats underwent the RUPP or a Sham procedure on gestation day (GD) 14. Read More

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A Review of Research Progress of Pregnancy with Twins with Preeclampsia.

Risk Manag Healthc Policy 2021 18;14:1999-2010. Epub 2021 May 18.

Department of Emergency Medicine, Shengjing Hospital of China Medical University, Shenyang, 110004, People's Republic of China.

Preeclampsia has a significant long-term effect on the health of both mothers and babies. Preeclampsia-related pregnancy complications increase the morbidity and mortality of pregnant women and their fetuses by 5-8%. The recent advancement of assisted reproductive technology, combined with a rise in the number of elderly pregnant women, has resulted in pregnancy incidence with twins. Read More

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Characteristics and outcomes among pregnant women with end-stage renal disease on hemodialysis.

J Matern Fetal Neonatal Med 2021 May 24:1-7. Epub 2021 May 24.

Department of Obstetrics and Gynecology, Jewish General Hospital, McGill University, Montreal, Canada.

Purpose: Pregnancy among women with end-stage renal disease (ESRD) has risen in frequency, which may be attributed to improvements in hemodialysis care. Our objective was to describe baseline characteristics and pregnancy outcomes among women with ESRD on hemodialysis.

Methods: Using the United States' Healthcare Cost and Utilization Project-Nationwide Inpatient Sample, we created a cohort of women with ESRD on hemodialysis who gave birth between 2005 and 2015. Read More

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Prenatal diagnosis, associated findings and postnatal outcome of fetuses with truncus arteriosus communis (TAC).

Arch Gynecol Obstet 2021 May 24. Epub 2021 May 24.

Division of Prenatal Medicine, Department of Obstetrics and Gynecology, University of Cologne, Kerpenerstr. 34, 50931, Cologne, Germany.

Purpose: To assess the spectrum of associated anomalies, the intrauterine course, postnatal outcome and management of fetuses with truncus arteriosus communis (TAC) METHODS: All cases of TAC diagnosed prenatally over a period of 8 years were retrospectively collected in two tertiary referral centers. All additional prenatal findings were assessed and correlated with the outcome. The accuracy of prenatal diagnosis was assessed. Read More

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Hokkaido birth cohort study on environment and children's health: cohort profile 2021.

Environ Health Prev Med 2021 May 22;26(1):59. Epub 2021 May 22.

Faculty of Medicine and Graduate School of Medicine, Center for Medical Education and International Relations, Hokkaido University, Sapporo, Japan.

Background: The Hokkaido Study on Environment and Children's Health is an ongoing study consisting of two birth cohorts of different population sizes: the Sapporo cohort and the Hokkaido cohort. Our primary objectives are to (1) examine the effects that low-level environmental chemical exposures have on birth outcomes, including birth defects and growth retardation; (2) follow the development of allergies, infectious diseases, and neurobehavioral developmental disorders, as well as perform a longitudinal observation of child development; (3) identify high-risk groups based on genetic susceptibility to environmental chemicals; and (4) identify the additive effects of various chemicals, including tobacco.

Methods: The purpose of this report is to provide an update on the progress of the Hokkaido Study, summarize recent results, and suggest future directions. Read More

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Hourly fetal urine production rate in isolated oligohydramnios at term.

PLoS One 2021 21;16(5):e0250659. Epub 2021 May 21.

Department of Obstetrics & Gynecology, College of Medicine, Korea University, Seoul, Korea.

Objective: The aim of this study was to evaluate the hourly fetal urine production rate (HFUPR) via three-dimensional ultrasonography in women with isolated oligohydramnios and compare with normal pregnant women at term.

Materials And Methods: This was a prospective observational cohort study of 112 women from 34 to 40 6/7 weeks' gestation. They were classified into three groups according to the amniotic fluid index (AFI) and ultrasonographic estimated fetal weight (EFW) as isolated oligohydramnios (defined as AFI below 5% and appropriate EFW corresponding to gestational age) (n = 34) and IUGR (defined as EFW below 5% corresponding to gestational age irrespective amniotic fluid) (n = 17), and normal pregnancy (n = 61). Read More

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Association of family history with incidence and gestational hypertension outcomes of preeclampsia.

Int J Cardiol Hypertens 2021 Jun 23;9:100084. Epub 2021 Apr 23.

Department of Cardiology, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City, Taiwan, ROC.

Background: Gestational hypertension and preeclampsia are hypertensive disorders related to pregnancy that can cause maternal morbidity and fetal growth retardation. The association of these disorders with family history remains unclear.

Objectives: To examine the degree of family aggregation of preeclampsia and gestational hypertension in Taiwan. Read More

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Developmental Toxicity of the Neural Tube Induced by Titanium Dioxide Nanoparticles in Mouse Embryos.

Avicenna J Med Biotechnol 2021 Apr-Jun;13(2):74-80

Department of Anatomical Sciences, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.

Background: This study investigated the potential effects of Titanium dioxide nanoparticles (Tio2NPs) followed by maternal gavage on fetal development and neural tube formation during pregnancy in mice.

Methods: Thirty pregnant mice were randomly divided into five main study groups including the untreated control and 4 experimental groups (n=6 per group). The control group was treated with normal saline and the experimental groups were orally treated with doses of 30, 150, 300, and 500 Body Weight (BW) of Tio2NPs during pregnancy. Read More

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Classification of intrauterine growth restriction at 34-38 weeks gestation with machine learning models.

Inform Med Unlocked 2021 12;23. Epub 2021 Feb 12.

Department of Obstetrics and Gynaecology, Faculty of Medicine and Health Science, Stellenbosch University, Tygerberg, South Africa.

Objective: Intrauterine growth restriction (IUGR) is one of the most common causes of stillbirths. The objective of this study is to develop a machine learning model that will be able to accurately and consistently predict whether the estimated fetal weight (EFW) will be below the 10th percentile at 34+0-37 + 6 week's gestation stage, by using data collected at 20 + 0 to 23 + 6 weeks gestation.

Methods: Recruitment for the prospective Safe Passage Study (SPS) was done over 7. Read More

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February 2021

Investigation Into the Current Situation and Analysis of the Factors Influencing Extrauterine Growth Retardation in Preterm Infants.

Front Pediatr 2021 30;9:643387. Epub 2021 Apr 30.

Department of Neonatology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.

This study aims to explore the occurrence of extrauterine growth retardation (EUGR) in preterm infants with a gestational age of <34 weeks, at discharge, and the factors influencing the occurrence of EUGR. A retrospective analysis of 691 preterm infants with a gestational age of less than 34 weeks, born in our hospital over the past 3 years. At discharge, the growth indicators head circumference, weight, and length were used to divide the infants into an EUGR group ( = 255) and the non-EUGR group ( = 436). Read More

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