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Subgroups of failure after surgery for pelvic organ prolapse and associations with quality of life outcomes: a longitudinal cluster analysis.

Am J Obstet Gynecol 2021 Jun 19. Epub 2021 Jun 19.


Background: Treatment outcomes after pelvic organ prolapse (POP) surgery are often presented as dichotomous 'success or failure' based upon anatomic and symptom criteria. However, clinical experience suggests some women with outcome 'failures' are asymptomatic and perceive their surgery to be successful, while others have anatomic resolution, but continue to report symptoms. Characterizing failure types could be a useful step to refine definitions of success, understand mechanisms of failure, and identify individuals who may benefit from specific therapies. Read More

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Help-seeking behaviour and attitudes towards internet-administered psychological support among adolescent and young adults previously treated for cancer during childhood: protocol for a survey and embedded qualitative interview study in Sweden.

BMJ Open 2021 04 8;11(4):e041350. Epub 2021 Apr 8.

Clinical Psychology in Healthcare, Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

Introduction: A subgroup of adolescent and young adult childhood cancer survivors (AYACCS) are at increased risk of psychological distress. Despite this, AYACCS experience difficulties accessing psychological support. E-mental health (e-MH) may offer a solution to reduce this treatment gap. Read More

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EMS Program Graduates Who Did Not Retest After Initial Attempt on The National Certification Exam.

Prehosp Emerg Care 2021 Jun 15:1-12. Epub 2021 Jun 15.

National Registry of Emergency Medical Technicians, Columbus, Ohio.

Becoming an EMS professional in most of the United States requires successful completion of the National Certification process. While multiple attempts are allowed, some candidates who are unsuccessful on their first cognitive examination attempt do not return despite personal investment. We describe the demographic and testing characteristics of EMT and paramedic candidates that do not return for a second examination attempt after an initial unsuccessful attempt on the National EMS Certification Cognitive Examination. Read More

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App-based data collection, mental imagery, and naming performance in adults with aphasia.

Complement Ther Clin Pract 2021 May 29;44:101422. Epub 2021 May 29.

Department of Communication Sciences and Disorders, Georgia State University, United States; Department of Learning Sciences, Georgia State University, United States. Electronic address:

Background And Purpose: Naming impairments are often found in aphasia. Combining mHealth technology with mental imagery may offer new insights into novel approaches to naming interventions in persons with aphasia. The aims of this study are to (1) explore whether mental imagery can improve performance during a naming task in adults with aphasia; and, (2) demonstrate the use of app-based data collection for research in aphasia rehabilitation through utilization of an app designed specifically for this study. Read More

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P components and distractor inhibition in visual search: New evidence for the signal suppression hypothesis.

Psychophysiology 2021 Jun 10:e13878. Epub 2021 Jun 10.

Department of Psychological Sciences, Birkbeck, University of London, London, UK.

The hypothesis that salient distractors in visual search are actively suppressed is supported by the fact that these objects elicit P components believed to be associated with inhibition. This account was challenged by researchers who found that a P to lateral color singleton distractors was followed by a contralateral negativity, which they interpreted as an N2pc indicative of attentional capture. As this would be at odds with successful distractor suppression, they proposed an alternative lateral-first serial scanning hypothesis, which assumes that the P might actually be an N2pc elicited when a lateral context item is selected. Read More

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Helicobacter pylori reinfection and its risk factors after initial eradication: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(19):e25949

Jiangxi University of Traditional Chinese Medicine.

Background: Helicobacter pylori (H pylori) infection is a common health problem, which is closely related to peptic ulcers, gastric cancer, and extragastric diseases. Drugs can successfully eradicate it. However, the recurrence of H pylori often occurs after initial eradication. Read More

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Design and Implementation of an Informatics Infrastructure for Standardized Data Acquisition, Transfer, Storage, and Export in Psychiatric Clinical Routine: Feasibility Study.

JMIR Ment Health 2021 Jun 9;8(6):e26681. Epub 2021 Jun 9.

Department of Psychiatry, University of Münster, Münster, Germany.

Background: Empirically driven personalized diagnostic applications and treatment stratification is widely perceived as a major hallmark in psychiatry. However, databased personalized decision making requires standardized data acquisition and data access, which are currently absent in psychiatric clinical routine.

Objective: Here, we describe the informatics infrastructure implemented at the psychiatric Münster University Hospital, which allows standardized acquisition, transfer, storage, and export of clinical data for future real-time predictive modelling in psychiatric routine. Read More

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HiTOP Assessment of the Somatoform Spectrum and Eating Disorders.

Assessment 2021 Jun 9:10731911211020825. Epub 2021 Jun 9.

University of Mainz, Mainz, Germany.

We report on Phase 1 efforts of the Hierarchical Taxonomy of Psychopathology (HiTOP) measurement subgroup tasked with developing provisional scales for the somatoform spectrum and eating disorders. In Study 1, items were written to assess five somatoform spectrum constructs (bodily distress symptoms, conversion symptoms, health anxiety, disease conviction, and somatic preoccupation). Scale development analyses were conducted on 550 university students. Read More

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Role of Radiomics in the Prediction of Muscle-invasive Bladder Cancer: A Systematic Review and Meta-analysis.

Eur Urol Focus 2021 Jun 4. Epub 2021 Jun 4.

Urology Clinic, Centre of Postgraduate Medical Education, Department of Urology, Professor Witold Orlowski Independent Public Hospital, Warsaw, Poland.

Context: Radiomics is a field of science that aims to develop improved methods of medical image analysis by extracting a large number of quantitative features. New data have emerged on the successful application of radiomics and machine-learning techniques to the prediction of muscle-invasive bladder cancer (MIBC).

Objective: To systematically review the diagnostic performance of radiomic techniques in predicting MIBC. Read More

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COVID-19 Pandemic: Knowledge, Attitude And Perception Of Medical Students Towards The Novel Coronavirus Disease.

Disaster Med Public Health Prep 2021 Jun 7:1-23. Epub 2021 Jun 7.

Lecturer of Public Health & Community Medicine, Faculty of Medicine, University of Tanta, Egypt.

Background: Medical students are vulnerable to infection by the Coronavirus. Their awareness of the disease is crucial for their safety, and for the management of the epidemic by spreading supportive information in their communities.

Objectives: To assess COVID-19 related knowledge, attitude, and preventive practices among Egyptian medical students. Read More

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Coping with stress during the first wave of the COVID-19 pandemic by Turkish people with Multiple Sclerosis: The relationship between perceived stress and quality of life.

Mult Scler Relat Disord 2021 May 24;53:103039. Epub 2021 May 24.

Tekirdag Namık Kemal University, Health Center for Medical Research and Practice, Department of Neurology, Tekirdag, Turkey. Electronic address:

Background: Multiple sclerosis (MS) is a chronic inflammatory disease and acute exacerbations are also a part of the clinical course. The presence of the disease and relapses cause stress in people with MS (pwMS). For this reason, stress coping strategies of the patients are important in reducing perceived stress. Read More

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Direct Comparison of Preoperative Imaging Modalities for Localization of Primary Hyperparathyroidism: A Systematic Review and Network Meta-analysis.

JAMA Otolaryngol Head Neck Surg 2021 Jun 3. Epub 2021 Jun 3.

Department of Nuclear Medicine, Pusan National University Yangsan Hospital, Yangsan, South Korea.

Importance: Accurate preoperative localization of primary hyperparathyroidism (pHPT) is an important and challenging issue for a successful parathyroidectomy. Although new imaging modalities have been introduced during the past decade, direct comparative studies on advanced imaging techniques are limited.

Objective: To compare the performance of different preoperative imaging modalities for the localization of pHPT by performing a network meta-analysis (NMA). Read More

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Accumulation of endogenous and exogenous nucleic acids in "Touch DNA" components on hands.

Electrophoresis 2021 Jun 3. Epub 2021 Jun 3.

King's Forensics, Department of Analytical, Environmental & Forensic Sciences, School of Population Health & Environmental Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.

Successful forensic DNA profiling from handled items is increasingly routine in casework. This "touch DNA" is thought to contain both cellular and acellular nucleic acid sources. However, there is little clarity on the origins or characteristics of this material. Read More

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Impaired Behavioral Pattern Separation in Refractory Temporal Lobe Epilepsy and Mild Cognitive Impairment.

J Int Neuropsychol Soc 2021 Jun 3:1-13. Epub 2021 Jun 3.

San Diego State University, University of California San Diego Joint Doctoral Program in Clinical Psychology, San Diego, CA, USA.

Objective: Episodic memory impairment and hippocampal pathology are hallmark features of both temporal lobe epilepsy (TLE) and amnestic mild cognitive impairment (aMCI). Pattern separation (PS), which enables the distinction between similar but unique experiences, is thought to contribute to successful encoding and retrieval of episodic memories. Impaired PS has been proposed as a potential mechanism underling episodic memory impairment in aMCI, but this association is less established in TLE. Read More

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Evaluation Framework for Successful Artificial Intelligence-Enabled Clinical Decision Support Systems: Mixed Methods Study.

J Med Internet Res 2021 Jun 2;23(6):e25929. Epub 2021 Jun 2.

School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Background: Clinical decision support systems are designed to utilize medical data, knowledge, and analysis engines and to generate patient-specific assessments or recommendations to health professionals in order to assist decision making. Artificial intelligence-enabled clinical decision support systems aid the decision-making process through an intelligent component. Well-defined evaluation methods are essential to ensure the seamless integration and contribution of these systems to clinical practice. Read More

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Dealing with Anxious Patients: A Systematic Review of the Literature on Nonpharmaceutical Interventions to Reduce Anxiety in Patients Undergoing Medical or Dental Procedures.

J Altern Complement Med 2021 Jun 1. Epub 2021 Jun 1.

Orthopedic Physical Therapy Program, Walk the Line Recovery Therapy, Southfield, MI, USA.

State (situational) anxiety can create suboptimal outcomes for patients across a variety of health care specializations. While anxiolytic medications reduce anxiety, problematic side effects can compromise outcomes. These challenges have spurred searches for nonpharmaceutical approaches to alleviate patient anxiety. Read More

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Dealing with Anxious Patients: An Integrative Review of the Literature on Nonpharmaceutical Interventions to Reduce Anxiety in Patients Undergoing Medical or Dental Procedures.

J Altern Complement Med 2021 Jun 1. Epub 2021 Jun 1.

Department of Psychology and University of Detroit Mercy, Detroit, MI, USA.

A previous systematic literature review (SLR) evaluated 501 experiments on reducing patient anxiety across medical and dental environments. This integrative review examines those interventions and explores possible mechanisms leading to relative success or failure within those environments, in the interest of interprofessional education and communication. Reviewers evaluated 501 experiments testing interventions for reducing patient anxiety in a variety of medical and dental health care settings. Read More

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EEG Correlates of Old/New Discrimination Performance Involving Abstract Figures and Non-Words.

Brain Sci 2021 May 28;11(6). Epub 2021 May 28.

Department of Neuropsychology and Psychopharmacology, Maastricht University, 6229 ER Maastricht, The Netherlands.

The processing of pre-experimentally unfamiliar stimuli such as abstract figures and non-words is poorly understood. Here, we considered the role of memory strength in the discrimination process of such stimuli using a three-phase old/new recognition memory paradigm. Memory strength was manipulated as a function of the levels of processing (deep vs. Read More

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Perioperative Management of Complex Hepatectomy for Colorectal Liver Metastases: The Alliance between the Surgeon and the Anesthetist.

Cancers (Basel) 2021 May 3;13(9). Epub 2021 May 3.

Department of Anesthesia and Intensive Care Units, IRCCS Humanitas Research Hospital, 20089 Milan, Italy.

Hepatic resection has been widely accepted as the first choice for the treatment of colorectal metastases. Liver surgery has been recognized as a major abdominal procedure; it exposes patients to a high risk of perioperative adverse events. Decision sharing and the multimodal approach to the patients' management are the two key items for a safe outcome, even in such a high-risk surgery. Read More

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The Effects of Powered Exoskeleton Gait Training on Cardiovascular Function and Gait Performance: A Systematic Review.

Sensors (Basel) 2021 May 5;21(9). Epub 2021 May 5.

Sports Lab North West, Letterkenny Institute of Technology, Port Road, Letterkenny, F92 FC93 Donegal, Ireland.

Patients with neurological impairments often experience physical deconditioning, resulting in reduced fitness and health. Powered exoskeleton training may be a successful method to combat physical deconditioning and its comorbidities, providing patients with a valuable and novel experience. This systematic review aimed to conduct a search of relevant literature, to examine the effects of powered exoskeleton training on cardiovascular function and gait performance. Read More

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Adaptation and validation of simple tools to screen and monitor for oral PrEP adherence.

PLoS One 2021 27;16(5):e0251823. Epub 2021 May 27.

CONRAD, Eastern Virginia Medical School, Norfolk, Virginia, United States of America.

Introduction: Oral, vaginal and other pre-exposure prophylaxis (PrEP) products for HIV prevention are in various stages of development. Low adherence poses a serious challenge to successful evaluation in trials. In a previous study, we developed tools to screen for general adherence and specifically monitor intravaginal ring adherence within the context of HIV prevention clinical trials. Read More

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Prediction of successful hearing aid treatment in first-time and experienced hearing aid users: Using the International Outcome Inventory for Hearing Aids.

Int J Audiol 2021 May 25:1-11. Epub 2021 May 25.

Research Unit for ORL - Head & Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

Objective: Primarily to understand whether clinically relevant factors affect the International Outcome Inventory (IOI-HA) scores and to examine if IOI-HA scores improve when renewing the hearing aids (HA) for experienced users. Secondly, to estimate the overall HA effectiveness using the IOI-HA.

Design: A prospective observational study. Read More

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Beneath the Surface: An Investigation of General Chemistry Students' Study Skills to Predict Course Outcomes.

J Chem Educ 2021 Feb 29;98(2):281-292. Epub 2020 Dec 29.

Department of Chemistry and Chemical Biology and Cyberlearning Innovation and Research Center, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854-8087, United States.

As the conversation in higher education shifts from diversity to inclusion, the attrition rates of students in the STEM fields continues to be a point of discussion. Combined with the demand for expansion in the STEM workforce, various retention reforms have been proposed, implemented, and in some cases integrated into policy following evidence of success. Still, new findings, technological advances, and socio-cultural shifts inevitably necessitate an on-going investigation as to how students approach learning. Read More

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February 2021

[Guidelines 2.0: systematic development of a comprehensive checklist for a successful guideline enterprise].

Z Evid Fortbild Qual Gesundhwes 2021 Jun 20;163:76-84. Epub 2021 May 20.

Department of Health Research Methods, Evidence & Impact, McMaster University, Hamilton, Kanada. Electronic address:

Background: Although several tools to evaluate the credibility of health care guidelines exist, guidance on practical steps for developing guidelines is lacking. We systematically compiled a comprehensive checklist of items linked to relevant resources and tools that guideline developers could consider, without the expectation that every guideline would address each item.

Methods: We searched data sources, including manuals of international guideline developers, literature on guidelines for guidelines (with a focus on methodology reports from international and national agencies, and professional societies) and recent articles providing systematic guidance. Read More

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Direct mechanical thrombectomy without intravenous thrombolysis versus bridging therapy for acute ischemic stroke: A meta-analysis of randomized controlled trials.

Int J Stroke 2021 Jun 2:17474930211021353. Epub 2021 Jun 2.

Stroke, Division of Mental Health and Clinical Neurosciences, School of Medicine, University of Nottingham, UK.

Background: Direct mechanical thrombectomy may result in similar outcomes compared to a bridging approach with intravenous thrombolysis (IVT + MT) in acute ischemic stroke. Recent randomized controlled trials have varied in their design and noninferiority margin.

Aim: We sought to meta-analyze accumulated trial data to assess the difference and non-inferiority in clinical and procedural outcomes between direct mechanical thrombectomy and bridging therapy. Read More

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Health literacy in people with venous leg ulcers: a protocol for scoping review.

BMJ Open 2021 05 11;11(5):e044604. Epub 2021 May 11.

School of Psychology, University of Birmingham Edgbaston Campus, Birmingham, UK.

Introduction: Chronic venous leg ulcer (VLU) healing is a complex clinical problem. It requires intervention from skilled, costly, multidisciplinary wound-care teams, working with patients to manage their care. Compression therapy has been shown to help heal venous ulcers and to reduce recurrence, with some evidence suggesting the value of exercise as well. Read More

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Diversity in neurology leadership: Nuances and nudges.

J Neurol Sci 2021 Jul 3;426:117475. Epub 2021 May 3.

Department of Neurology, University of California, San Francisco, CA, United States of America.

Underrepresented in medicine (UIM) academic physicians are poorly represented among medical school faculty when compared with their proportion in the US population, receive NIH research awards less frequently, are promoted less often, indicate lower career satisfaction, and report higher social isolation, than faculty who are not under-represented. Supporting a successful and sustainable workforce of UIM academic physicians is essential in neurology, because such neurologists are more likely to engage in research to reduce disparities in neurological outcomes that affect underserved and/or low-income communities, and help improve the paucity of diverse race-ethnic participation in clinical trials. Having more diverse academic neurologists serve in such roles could bolster their careers and model possibilities for others who share similar cultures and backgrounds. Read More

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Exploring the strategies for successfully building e-portfolios in medical schools.

Korean J Med Educ 2021 Jun 1;33(2):133-137. Epub 2021 Jun 1.

Department of Medical Education, Catholic Kwandong University College of Medicine, Incheon, Korea.

Purpose: The purpose of this study is to examine the characteristics of resistance among medical students toward e-portfolios and find the strategies for them to successfully prepare e-portfolios.

Methods: Participants were a group of 258 medical students. The questionnaire comprised 13 items developed based on the innovation resistance theory. Read More

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What the Tech? The Management of Neurological Dysfunction Through the Use of Digital Technology.

Adv Exp Med Biol 2021 ;1317:131-145

School of Life Sciences, University of Glasgow, Glasgow, UK.

Worldwide, it is estimated that millions of individuals suffer from a neurological disorder which can be the result of head injuries, ischaemic events such as a stroke, or neurodegenerative disorders such as Parkinson's disease (PD) and multiple sclerosis (MS). Problems with mobility and hemiparesis are common for these patients, making daily life, social factors and independence heavily affected. Current therapies aimed at improving such conditions are often tedious in nature, with patients often losing vital motivation and positive outlook towards their rehabilitation. Read More

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Implementation of an organ space infection prevention bundle reduces the rate of organ space infection after elective colorectal surgery.

BMJ Open Qual 2021 05;10(2)

Colorectal Surgery, Western Health, Footscray, Victoria, Australia.

Background: Surgical site infections (SSIs) are morbid and costly complications after elective colorectal surgery. SSI prevention bundles have been shown to reduce SSI in colorectal surgery, but their impact on organ space infections (OSI) is variable. Adoption of an evidence-based practice without an implementation strategy is often unsuccessful. Read More

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