75 results match your criteria issue bio-medical

Redefining bio medical waste management during COVID- 19 in india: A way forward.

Mater Today Proc 2021 Oct 12. Epub 2021 Oct 12.

Karvy Insights, Delhi 110016, India.

India is ranked 120 among 165 nations with respect to sustainable development and critically suffers from insufficient waste treatment provisions and amenities. And the abrupt occurrence of the COVID-19 virus has aggravated the issue of managing of medical waste in India, manifolds. As a result, the safe disposal of a huge volume of hazardous medical waste has become a top priority. Read More

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October 2021

LitCovid-AGAC: cellular and molecular level annotation data set based on COVID-19.

Genomics Inform 2021 Sep 30;19(3):e23. Epub 2021 Sep 30.

Hubei Key Lab of Agricultural Bioinformatics, College of Informatics, Huazhong Agricultural University, 430070 Wuhan, China.

Currently, coronavirus disease 2019 (COVID-19) literature has been increasing dramatically, and the increased text amount make it possible to perform large scale text mining and knowledge discovery. Therefore, curation of these texts becomes a crucial issue for Bio-medical Natural Language Processing (BioNLP) community, so as to retrieve the important information about the mechanism of COVID-19. PubAnnotation is an aligned annotation system which provides an efficient platform for biological curators to upload their annotations or merge other external annotations. Read More

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September 2021

Dysregulation of murine immune functions on inhalational exposure to ammonia, dimethyl disulfide, 3-methylindole, or propionic acid.

Toxicol Ind Health 2021 Apr 5;37(4):219-228. Epub 2021 Mar 5.

Department of Preventive Medicine, 37128College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Animal husbandry workers are exposed to various malodorous compounds in the workplace. Although these compounds cause severe nuisance, no systemic investigation of their effects on the immune system has been conducted. To address this issue, we evaluated the effects of inhalational exposure to ammonia, dimethyl disulfide, 3-methylindole (3-MI), and propionic acid (PA), representing four major groups of malodorous compounds, on humoral and cellular immunity in mice. Read More

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Negative Regulation of ULK1 by microRNA-106a in Autophagy Induced by a Triple Drug Combination in Colorectal Cancer Cells .

Genes (Basel) 2021 02 9;12(2). Epub 2021 Feb 9.

Biochemistry Unit, Institute of Medical Sciences and Nutrition, Salvador Zubirán, Tlalpan, Mexico City C.P. 14080, Mexico.

Colorectal cancer (CRC) is among the top three most deadly cancers worldwide. The survival rate for this disease has not been reduced despite the treatments, the reason why the search for therapeutic alternatives continues to be a priority issue in oncology. In this research work, we tested our successful pharmacological combination of three drugs, metformin, doxorubicin, and sodium oxamate (triple therapy, or TT), as an autophagy inducer. Read More

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February 2021

Automatic Screening of COVID-19 Using an Optimized Generative Adversarial Network.

Cognit Comput 2021 Jan 25:1-16. Epub 2021 Jan 25.

Department of Radiology, Silchar Medical College and Hospital, Silchar, Assam 788014 India.

The quick spread of coronavirus disease (COVID-19) has resulted in a global pandemic and more than fifteen million confirmed cases. To battle this spread, clinical imaging techniques, for example, computed tomography (CT), can be utilized for diagnosis. Automatic identification software tools are essential for helping to screen COVID-19 using CT images. Read More

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January 2021

Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes.

Part Fibre Toxicol 2021 01 6;18(1). Epub 2021 Jan 6.

Department of Chemistry, Life Sciences and Environmental Sustainability, University of Parma, Parco Area delle Scienze 11/a, 43124, Parma, Italy.

Background: Nanotoxicology is an increasingly relevant field and sound paradigms on how inhaled nanoparticles (NPs) interact with organs at the cellular level, causing harmful conditions, have yet to be established. This is particularly true in the case of the cardiovascular system, where experimental and clinical evidence shows morphological and functional damage associated with NP exposure. Giving the increasing interest on cobalt oxide (CoO) NPs applications in industrial and bio-medical fields, a detailed knowledge of the involved toxicological effects is required, in view of assessing health risk for subjects/workers daily exposed to nanomaterials. Read More

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January 2021

White matter alteration in adults with prelingual deafness: A TBSS and SBM analysis of fractional anisotropy data.

Brain Cogn 2021 03 31;148:105676. Epub 2020 Dec 31.

Department of Special Education (Hearing Impairments), Dr. Shakuntala Misra National Rehabilitation University, Lucknow, India.

A loss of hearing in early life leads to diversifications of important white matter networks. Previous studies related to WM alterations in adult deaf individuals mainly involved univariate analysis of fractional anisotropy (FA) data and volumetric analysis, which yielded inconsistent results. To address this issue, we investigated the FA value alterations in 38 prelingual adult deaf individuals and compared the results with those obtained from the same number of adults with normal hearing by using univariate (tract-based spatial statistics) and multivariate (source-based morphometry) methods. Read More

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Stigmatize the use, not the user? Attitudes on opioid use, drug injection, treatment, and overdose prevention in rural communities.

Soc Sci Med 2021 01 22;268:113470. Epub 2020 Oct 22.

Department of Medicine, Section of Infectious Diseases and Global Health, University of Chicago Medicine, Chicago, IL, USA.

Stigma is a known barrier to treating substance use disorders and dramatically diminishes the quality of life of people who use drugs (PWUD) nonmedically. Stigma against PWUD may be especially pronounced in rural areas due to their decreased anonymity and residents' limited access, or resistance, to "neutralizing" information on factors associated with drug use. Stigma often manifests in the attitudes of professionals whom stigmatized individuals regularly interact with and often materially impact. Read More

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January 2021

Subcircuits of Deep and Superficial CA1 Place Cells Support Efficient Spatial Coding across Heterogeneous Environments.

Neuron 2021 01 19;109(2):363-376.e6. Epub 2020 Nov 19.

Neuroscience Institute, New York University, Langone Medical Center, New York, NY 10016, USA. Electronic address:

The hippocampus is thought to guide navigation by forming a cognitive map of space. Different environments differ in geometry and the availability of cues that can be used for navigation. Although several spatial coding mechanisms are known to coexist in the hippocampus, how they are influenced by various environmental features is not well understood. Read More

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January 2021

Editorial for the Special Issue on Micro/Nanofabrication for Retinal Implants.

Maesoon Im

Micromachines (Basel) 2020 Nov 14;11(11). Epub 2020 Nov 14.

Brain Science Institute, KIST (Korea Institute of Science and Technology), Seoul 02792, Korea.

The retinal prosthetic community has witnessed tremendous technological advances during the last two decades since the emergence of pioneering work [... Read More

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November 2020

Cathepsin B-Responsive Liposomes for Controlled Anticancer Drug Delivery in Hep G2 Cells.

Pharmaceutics 2020 Sep 14;12(9). Epub 2020 Sep 14.

Department of Biochemistry, Chungnam National University, Daejeon 34134, Korea.

In recent decades, several types of anticancer drugs that inhibit cancer cell growth and cause cell death have been developed for chemotherapeutic application. However, these agents are usually associated with side effects resulting from nonspecific delivery, which may induce cytotoxicity in healthy cells. To reduce the nonspecific delivery issue, nanoparticles have been successfully used for the delivery of anticancer drugs to specific target sites. Read More

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September 2020

The continued citation of retracted publications in dentistry.

J Med Libr Assoc 2020 Jul;108(3):389-397

Bio-Medical Library, University of Minnesota, Minneapolis, MN.

Objective: Publications are retracted for many reasons, but the continued use and citation of retracted publications presents a problem for future research. This study investigated retractions in the dental literature to understand the characteristics of retracted publications, the reasons for their retractions, and the nature and context of their citations after retraction.

Methods: In September 2018, the authors identified retracted dentistry publications using the Retraction Watch database. Read More

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Drosophila, Chitin and Insect Pest Management.

Curr Pharm Des 2020 ;26(29):3546-3553

Interfaculty Institute for Cell Biology (Ifiz), University of Tübingen, Auf der Morgenstelle 15, 72076 Tübingen, Germany.

Insects are a great menace in agriculture and vectors of human diseases. Hence, controlling insect populations is an important issue worldwide. A common strategy to control insects is the application of insecticides. Read More

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January 2021

The Flint women's study: community perspectives on contraception and family planning, sexuality education and barriers to reproductive health.

Cult Health Sex 2021 07 2;23(7):961-975. Epub 2020 Jun 2.

College of Human Medicine, Michigan State University, Flint, MI, USA.

Teenage pregnancy can have adverse social and health outcomes, and rates are high in Flint, Michigan as compared to the rest of the state and the USA. It is important to understand contributing factors to adolescent pregnancy to be able to better address this issue. This study examined qualitative data from interviews with 100 community members who participated in the Flint Women's Study, a study designed to better understand the hopes, dreams and needs of women in Flint, and their suggestions for how to address identified needs. Read More

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A New Thresholding Method for IR-UWB Radar-Based Detection Applications.

Sensors (Basel) 2020 Apr 18;20(8). Epub 2020 Apr 18.

Department of Electronics and Computer Engineering, Hanyang University, 222 Wangsimini-ro, Seongdong-gu, Seoul 04763, Korea.

In this paper, we proposed a new thresholding method for impulse radio ultra-wideband (IR-UWB) radar-based detection applications by taking both the false alarm and miss-detection rates into consideration. The thresholding algorithm is the key point of the detection application, and there have been numerous studies on these developments. Most of these studies were related to the occurrence of false alarms, such as the constant false alarm rate algorithm (CFAR). Read More

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Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases.

Environ Sci Pollut Res Int 2020 Dec 23;27(36):44659-44672. Epub 2020 Mar 23.

Center for Neuroscience, Korea Institute of Science and Technology (KIST), 5 Hwarang-ro 14-gil, Seongbuk-gu, Seoul, 02792, Republic of Korea.

Neurodegenerative disorders are typically sporadic in nature in addition to usually influenced through an extensive range of environmental factors, lifestyle, and genetic elements. Latest observations have hypothesized that exposure of environmental factors may increase the prospective risk of Alzheimer's diseases (AD). However, the role of environmental factors as a possible dangerous issue has extended importance concerned in AD pathology, although actual etiology of the disorder is still not yet clear. Read More

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December 2020

Microphysiological systems for recapitulating physiology and function of blood-brain barrier.

Biomaterials 2020 02 26;232:119732. Epub 2019 Dec 26.

Center for BioMicrosystems, Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul, 02792, Republic of Korea. Electronic address:

Central nervous system (CNS) diseases are emerging as a major issue in an aging society. Although extensive research has focused on the development of CNS drugs, the limited transport of therapeutic agents across the blood-brain barrier (BBB) remains a major challenge. Conventional two-dimensional culture dishes do not recapitulate in vivo physiology and real-time observations of molecular transport are not possible in animal models. Read More

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February 2020

Mitochondrial dysfunction and Alzheimer's disease: prospects for therapeutic intervention.

BMB Rep 2020 Jan;53(1):47-55

Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792; Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology, Seoul 02792, Korea.

Alzheimer's disease (AD) is a multifactorial neurodegenerative disease and has become a major socioeconomic issue in many developed countries. Currently available therapeutic agents for AD provide only symptomatic treatments, mainly because the complete mechanism of the AD pathogenesis is still unclear. Although several different hypotheses have been proposed, mitochondrial dysfunction has gathered interest because of its profound effect on brain bioenergetics and neuronal survival in the pathophysiology of AD. Read More

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January 2020

Antimicrobial Biophotonic Treatment of Ampicillin-Resistant with Hypericin and Ampicillin Cotreatment Followed by Orange Light.

Pharmaceutics 2019 Dec 1;11(12). Epub 2019 Dec 1.

Natural Products Informatics Research Center, Gangneung Institute of Natural Products, Korea Institute of Science and Technology, Gangwon-do 25451, Korea.

Bacterial antibiotic resistance is an alarming global issue that requires alternative antimicrobial methods to which there is no resistance. Antimicrobial photodynamic therapy (APDT) is a well-known method to combat this problem for many pathogens, especially Gram-positive bacteria and fungi. Hypericin and orange light APDT efficiently kill , methicillin-resistant (MRSA), and the yeast . Read More

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December 2019

Deterioration of neuroregenerative plasticity in association with testicular atrophy and dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis in Huntington's disease: A putative role of the huntingtin gene in steroidogenesis.

J Steroid Biochem Mol Biol 2020 03 9;197:105526. Epub 2019 Nov 9.

School of Life Sciences, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India; Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli 620024, Tamil Nadu, India; Faculty Recharge Programme, University Grants Commission (UGC-FRP), New Delhi, India. Electronic address:

Huntington's disease (HD) is an autosomal dominant progressive neurodegenerative disorder mainly affecting the structure and functions of the striatum, cerebral cortex and hippocampus leading to movement disorders, cognitive dysfunctions and emotional disturbances. The onset of HD has been linked to a pathogenic CAG repeat expansion in the huntingtin (HTT) gene that encodes for the polyglutamine (polyQ) stretches in the huntingtin (Htt) protein. Notably, the neuropathogenic events of the mutant HTT gene appear to be primed during adulthood and magnified along the ageing process. Read More

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A Review of Perovskite Photovoltaic Materials' Synthesis and Applications via Chemical Vapor Deposition Method.

Materials (Basel) 2019 Oct 11;12(20). Epub 2019 Oct 11.

Chinese Academy of Sciences Key Lab of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, Jiangsu, China.

Perovskite photovoltaic materials (PPMs) have emerged as one of superstar object for applications in photovoltaics due to their excellent properties-such as band-gap tunability, high carrier mobility, high optical gain, astrong nonlinear response-as well as simplicity of their integration with other types of optical and electronic structures. Meanwhile, PPMS and their constructed devices still present many challenges, such as stability, repeatability, and large area fabrication methods and so on. The key issue is: how can PPMs be prepared using an effective way which most of the readers care about. Read More

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October 2019

An Assessment of the Interoperability of Electronic Health Record Exchanges Among Hospitals and Clinics in Taiwan.

JMIR Med Inform 2019 Mar 28;7(1):e12630. Epub 2019 Mar 28.

Section of Biostatistics and Bioinformatics, Department of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan.

Background: The rapid aging of the Taiwanese population in recent years has led to high medical needs for the elderly and increasing medical costs. Integrating patient information through electronic health records (EHRs) to reduce unnecessary medications and tests and enhance the quality of care has currently become an important issue. Although electronic data interchanges among hospitals and clinics have been implemented for many years in Taiwan, the interoperability of EHRs has not adequately been assessed. Read More

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Development of tau-directed small molecule modulators for Alzheimer's disease: a recent patent review (2014-2018).

Pharm Pat Anal 2019 Jan 14;8(1):15-39. Epub 2019 Mar 14.

Convergence Research Center for Diagnosis, Treatment & Care System of Dementia, Korea Institute of Science & Technology, Seoul 02792, Republic of Korea.

Alzheimer's disease (AD) is a progressive neurodegenerative disease that is characterized by memory loss and cognitive impairment. As this disease is becoming a serious global health issue, development of disease modifying therapeutics is urgently required. AD is characterized by deposits of two protein, amyloid β and tau. Read More

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January 2019

Interface Engineering of Fully Metallic Stents Enabling Controllable HO Generation for Antirestenosis.

Langmuir 2019 03 27;35(10):3634-3642. Epub 2019 Feb 27.

Center for Biomaterials , Korea Institute of Science and Technology (KIST) , Seoul 02792 , Republic of Korea.

Despite significant advances in the design of metallic materials for bare metal stents (BMSs), restenosis induced by the accumulation of smooth muscle cells (SMCs) has been a major constraint on improving the clinical efficacy of stent implantation. Here, a new strategy for avoiding this issue by utilizing hydrogen peroxide (HO) generated by the galvanic coupling of nitinol (NiTi) stents and biodegradable magnesium-zinc (Mg-Zn) alloys is reported. The amount of HO released is carefully optimized via the biodegradability engineering of the alloys and by controlling the immersion time to selectively inhibit the proliferation and function of SMCs without harming vascular endothelial cells. Read More

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Parallel multi-parameter study of PEI-functionalized gold nanoparticle synthesis for bio-medical applications: part 1-a critical assessment of methodology, properties, and stability.

J Nanopart Res 2019 ;21(8)

Materials Measurement Science Division, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

Cationic polyethyleneimine (PEI)-conjugated gold nanoparticles (AuNPs) that are chemically and physically stable under physiological conditions are an ideal candidate for certain bio-medical applications, in particular DNA transfection. However, the issue remains in reproducibly generating uniform stable species, which can cause the inadequate characterization of the resulting product under relevant conditions and timepoints. The principal objective of the present study was to develop an optimized and reproducible synthetic route for preparing stable PEI-conjugated AuNPs (Au-PEIs). Read More

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January 2019

l-Serine-modified polyamidoamine dendrimer as a highly potent renal targeting drug carrier.

Proc Natl Acad Sci U S A 2018 10 24;115(41):10511-10516. Epub 2018 Sep 24.

Department of Biopharmaceutics, Kyoto Pharmaceutical University, 607-8414 Kyoto, Japan.

Effective delivery of drug carriers selectively to the kidney is challenging because of their uptake by the reticuloendothelial system in the liver and spleen, which limits effective treatment of kidney diseases and results in side effects. To address this issue, we synthesized l-serine (Ser)-modified polyamidoamine dendrimer (PAMAM) as a potent renal targeting drug carrier. Approximately 82% of the dose was accumulated in the kidney at 3 h after i. Read More

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October 2018

Pattern of neural divergence in adults with prelingual deafness: Based on structural brain analysis.

Brain Res 2018 12 23;1701:58-63. Epub 2018 Jul 23.

Department of Special Education (Hearing Impairments), Dr. Shakuntala Misra National Rehabilitation University, Lucknow, India.

Sensory input for hearing plays a significant role in the development of human brain. Absence of an early auditory input leads to the alteration of important neural regions, which in turn results in a complex process known as cross-modal neuroplasticity. Previous studies related to the structural brain alteration of adult deaf individuals have shown inconsistent results. Read More

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December 2018

Phyto-mediated synthesized multifunctional Zn/CuO NPs hybrid nanoparticles for enhanced activity for kidney cancer therapy: A complete physical and biological analysis.

J Photochem Photobiol B 2018 Sep 6;186:131-136. Epub 2018 Jul 6.

Third Medical Section, Infectious disease Hospital of Yantai, Yantai City, Shandong Province 264000, PR China. Electronic address:

Cancer in human society is one of the most problematic health issue responsible for outnumbered deaths worldwide. The consumption of developed NPs in cancer diagnosis is a rapidly emerging field of bio-medical nanotechnology. Recent years, greener synthesized metal oxide hybrid nanoparticles have attracted great attention in cytotoxicity to different cancer therapy. Read More

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September 2018

Special Issue on High Performance Computing in Bio-medical Informatics.

Neuroinformatics 2018 10;16(3-4):283

University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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October 2018

Resection of esophageal diverticulum through uniportal video-assisted thoracoscopic surgery.

Ann Transl Med 2018 May;6(10):179

Thoracic Surgery Unit, Istituto Oncologico del Mediterraneo, Viagrande, Italy.

Open surgery remains the standard strategy for management of esophageal diverticulum in symptomatic patients. However, in the last years an increasing number of minimally invasive approaches have been proposed for this issue in order to reduce the surgical trauma and favor a fast return to daily activity. Herein, we describe a novel technique as uniportal video-assisted thoracoscopic surgery (VATS) for performing resection of esophageal diverticulum. Read More

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