Search Our Scientific Publications & Authors

Mar Environ Res 2021 Mar 27;168:105319. Epub 2021 Mar 27.

Centre for Marine Science and Innovation, School of Biological, Earth and Environmental Science, University of New South Wales, Sydney, NSW, Australia; Sydney Institute of Marine Science, 19 Chowder Bay Road, Mosman, NSW, 2088, Australia.

As habitat-forming species continue to decline globally, it is important to understand how associated communities respond to habitat loss and fragmentation. Changes in the density and spatial configuration of habitat have important consequences for associated communities. However, tests of these factors are often confounded by morphological variation of habitat-formers, which can be resolved by using standardised habitat-mimics. Read More

J Org Chem 2021 Apr 12. Epub 2021 Apr 12.

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California, San Diego, La Jolla, California 92093, United States.

The chemical examination of two undescribed marine actinobacteria has yielded three rare merosesterterpenoids, marinoterpins A-C (-, respectively). These compounds were isolated from the culture broth extracts of two marine-derived actinomycetes associated with the family Streptomycetaceae, (our strains were CNQ-253 and AJS-327). The structures of the new compounds were determined by extensive interpretation of 1D and 2D NMR, MS, and combined spectroscopic data. Read More

Antonie Van Leeuwenhoek 2021 Apr 12. Epub 2021 Apr 12.

College of Food and Pharmaceutical Sciences, Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo, 315800, People's Republic of China.

A new bacterium was successfully isolated from a mangrove sediment sample in Haikou City, Hainan Province, China. The organism is a Gram-negative, rod-shaped, non-motile and strictly aerobic bacterium, named NBU-8HK146. Strain NBU-8HK146 was able to grow at temperatures of 10-40 °C, at salinities of 0-11% (w/v) and at pH 5. Read More

ACS Omega 2021 Apr 26;6(13):8942-8949. Epub 2021 Mar 26.

CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China.

In devotion to investigating structurally novel and biologically active marine natural products, a dimer of a zinc complex, dizinchydroxyneoaspergillin (), aspernones A-E (-), five cyclopentenone derivatives together with known polyketides (-), and neoaspergillic acid analogues (-) were isolated from the sponge-associated fungus SCSIO 41018. Their structures were elucidated on the basis of spectroscopic analysis, electronic circular dichroism (ECD) analysis, and X-ray diffraction. Dizinchydroxyneoaspergillin () displayed significant bactericide effects toward methicillin-resistant , , , , and with MIC values of 0. Read More

Iran J Pharm Res 2020 ;19(4):290-305

Molecular Biotechnology Laboratory, Department of Biology, Faculty of Science, Shiraz University, Iran.

Screening of bioactive compounds with potential binding affinity to DNA as one of the target molecules in fighting against cancer cells has gained the attention of many scientists. Finding such compounds in the cellular content of microorganisms, especially marine bacteria as valuable and rich natural resources, is of great importance. sp. Read More

Front Microbiol 2021 24;12:631144. Epub 2021 Mar 24.

CAS Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.

The cosmopolitan phytoplankton species is a common harmful algal bloom (HAB) species that have been found to cause HABs in essentially all coastal regions except the Polar regions. However, molecular information for this HAB species is limited with only a few molecular markers. In this project, we constructed the mitochondrial genome (mtDNA) of , which was also the first mtDNA constructed for any species in the order Hemiaulales that includes 145 reported species (including two additional HAB species and ). Read More

Crit Rev Food Sci Nutr 2021 Apr 10:1-79. Epub 2021 Apr 10.

Jiangxi Key Laboratory for Postharvest Technology and Nondestructive Testing of Fruits & Vegetables, College of Agronomy, Jiangxi Agricultural University, Nanchang, People's Republic of China.

Marine organisms are considered a cache of biologically active metabolites with pharmaceutical, functional, and nutraceutical properties. Among these, marine bioactive peptides (MBAs) present in diverse marine species (fish, sponges, cyanobacteria, fungi, ascidians, seaweeds, & mollusks) have acquired attention owing to their broad-spectrum health-promoting benefits. Nowadays, scientists are keener exploring marine bioactive peptides precisely due to their unique structural and biological properties. Read More

Int J Food Microbiol 2021 Mar 31;347:109188. Epub 2021 Mar 31.

TEDA Institute of Biological Sciences and Biotechnology, Nankai University, 23 Hongda Street, TEDA, Tianjin 300457, PR China; The Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, 23 Hongda Street, TEDA, Tianjin 300457, PR China. Electronic address:

Vibrio parahaemolyticus, which is commonly found in marine and estuarine environments worldwide and isolated from aquatic products, is one of the most important food-borne pathogens. Among the various typing methods, serotyping is widely accepted and utilized by infectious disease specialists and infection control agencies for the detection and epidemiological investigation of this pathogen. Thus far, 13 O serotypes and 71 K serotypes have been defined; however, untypeable strains are frequently isolated during routine detection, and some new O and/or K antigens have been identified and characterized. Read More

Carbohydr Polym 2021 Jun 20;262:117969. Epub 2021 Mar 20.

Weihai Marine Organism & Medical Technology Research Institute, Harbin Institute of Technology, Weihai, 264209, PR China; Weihai Huiankang Biotechnology Co., Ltd, Weihai 264200, PR China. Electronic address:

A fucosylated chondroitin sulfate was isolated from the body wall of sea cucumber Stichopus japonicus (FCSsj), whose structure was characterized by NMR spectroscopy and HILIC-FTMS. At the ratio of 1.00:0. Read More

Carbohydr Polym 2021 Jun 15;262:117941. Epub 2021 Mar 15.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 159/2, Prospect 100 let Vladivostoku, Vladivostok, 690022, Russia; Far Eastern Federal University, 8, Sukhanova Str., Vladivostok, 690950, Russia.

Psychrobacter submarinus KMM 225 is a Gram-negative bacterium isolated from a sea-water sample collected at a depth of 300 m in the Northwest Pacific Ocean. Here we report the structure of the capsular polysaccharide from P. submarinus KMM 225 and its effect on the viability and colony formation of cancer cells. Read More

Geobiology 2021 Apr 10. Epub 2021 Apr 10.

Department of Earth Science, University of Oxford, Oxford, UK.

Microbes are known to accumulate intracellular SiO (aq) up to 100s of mmol/l from modern seawater (SiO (aq) <100 µmol/l), despite having no known nutrient requirement for Si. Before the evolution of siliceous skeletons, marine silica concentrations were likely an order of magnitude higher than the modern ocean, raising the possibility that intracellular SiO (aq) accumulation interfered with normal cellular function in non-silicifying algae. Yet, because few culturing studies have isolated the effects of SiO (aq) at high concentration, the potential impact of elevated marine silica on early microbial evolution is unknown. Read More

Cell Tissue Res 2021 Apr 10. Epub 2021 Apr 10.

Department of Animal and Marine Bioresource Sciences, Faculty of Agriculture, Kyushu University, 744 Moto-oka, Nishi-ku, Fukuoka, 819-0395, Japan.

Glandular epithelial cells (GE) in the endometrium are thought to support the elongation and survival of ruminant embryos by secreting histotrophs. In the present study, the gene expression of bovine endometrial epithelial cells cultured in matrigel was analyzed and examined whether it could be an in vitro model of GE. Bovine endometrial epithelial cells (BEE) and stromal cells (BES) were isolated from the slaughterhouse uteri and cultured in DMEM/F12 + 10% FBS. Read More

Steroids 2021 Apr 6:108831. Epub 2021 Apr 6.

Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, CAS, Guangzhou 510301, China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 510301, China. Electronic address:

Four new steroids derivatives, namely arthriniumsteroids A - D (1-4), together with two known compounds, were isolated from the soft coral-derived fungus Simplicillium lanosoniveum SCSIO41212. Their structures were elucidated by spectroscopic analysis and by comparison with those reported in the literature. The absolute configuration of 2 was confirmed by single-crystal X-ray diffraction. Read More

J Agric Food Chem 2021 Apr 9. Epub 2021 Apr 9.

Institute of Marine Drugs, School of Pharmaceutical Sciences, Guangxi Key Laboratory of Efficacy Study on Chinese Materia Medica, Guangxi University of Chinese Medicine, NO. 13 Wuhe Rood, Nanning 530200, China.

Sugarcane smut, caused by , is one of the most devastating fungal diseases affecting sugarcane worldwide. To develop a potent sugarcane smut fungicide, secondary metabolites of marine-derived were isolated and screened for inhibitory activities, which led to the discovery of five new 24-membered macrolactins, bamemacrolactins A-E (-), with being the most potent inhibitor. The antifungal mechanism of was studied by assessing its effects on mycelial morphology and the cell wall. Read More

Front Microbiol 2021 23;12:645411. Epub 2021 Mar 23.

School of Earth Sciences and Environmental Engineering, Gwangju Institute of Science and Technology, Gwangju, South Korea.

High level carbapenem and extensively drug resistant (XDR) strain N7, which produces a variant of New Delhi metallo-β-lactamase (NDM-5), was isolated from the influent of the Jungnang wastewater treatment plant located on Han River, Seoul, South Korea. Phenotypic and genotypic resistances to carbapenem were tested using agar and broth dilution methods, and polymerase chain reaction. Whole-genome sequencing was performed to characterize the genetic structure of strain N7. Read More

Sci Rep 2021 Apr 8;11(1):7805. Epub 2021 Apr 8.

PSL Research University: EPHE - UPVD - CNRS, USR 3278 CRIOBE, 66860, Perpignan, France.

The fan mussel, Pinna nobilis, endemic to the Mediterranean Sea, is a critically endangered species facing mass mortality events in almost all of its populations, following the introduction of the parasite Haplosporidium pinnae. Such a unique pandemic in a marine organism, which spreads rapidly and with mortality rates reaching up to 100%, could lead to the potential extinction of the species. Only few regions, involving lagoon habitats, remain healthy throughout the entire Mediterranean Sea. Read More

Arch Microbiol 2021 Apr 8. Epub 2021 Apr 8.

G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Prospect 100 Let Vladivostoku, 159, Vladivostok, 690022, Russia.

An aerobic, Gram-negative, non-pigmented non-motile bacterium designed КMM 8518 was isolated from a seawater sampled from the Sea of Japan seashore. Strain КMM 8518 grew at 7-42 °C and in the presence of 1-7% NaCl. The phylogenetic analyses based on 16S rRNA gene and whole-genome sequences placed the novel strain КMM 8518 into the genus Thalassobius as a separate lineage. Read More

J Nutr 2021 Apr 8. Epub 2021 Apr 8.

Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, HI, USA.

Background: Obesity is among the most serious public health problems worldwide, with few safe pharmaceutical interventions. Natural products have become an important source of potential anti-obesity therapeutics. Dihydromyricetin (DHM) exerts antidiabetic effects. Read More

Arch Microbiol 2021 Apr 7. Epub 2021 Apr 7.

Institute of Biology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Vibrio fluvialis is a halophilic bacterium frequently found in estuarine and coastal waters environments. The strain 362.3 was isolated from Mussismilia braziliensis coral of Abrolhos Bank. Read More

J Nat Prod 2021 Apr 6. Epub 2021 Apr 6.

Universidad Nacional de Colombia-Sede Bogotá, Facultad de Ciencias, Departamento de Química, Bogotá D.C. 111321, Colombia.

Brown algae and soft corals represent the main marine sources of dolabellane diterpenes. The antiviral activity of dolabellanes has been studied for those isolated from algae, whereas dolabellanes isolated from soft corals have been barely studied. In this work, a collection of dolabellane diterpenes consisting of five natural and 21 semisynthetic derivatives was constructed, and their antiviral activities against Zika (ZIKV) and Chikungunya (CHIKV) viruses were tested. Read More

J Nat Prod 2021 Apr 6. Epub 2021 Apr 6.

Genome Biol Evol 2021 Apr 2. Epub 2021 Apr 2.

Marine Genomics Unit, Okinawa Institute of Science and Technology Graduate University, Onna, Okinawa, 904-0495, Japan.

Chromosomal rearrangements can reduce fitness of heterozygotes and can thereby prevent gene flow. Therefore, such rearrangements can play a role in local adaptation and speciation. In particular, inversions are considered to be a major potential cause for chromosomal speciation. Read More

Comput Struct Biotechnol J 2021 10;19:1531-1540. Epub 2021 Mar 10.

School of Chemical and Biological Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea.

Macroalgae is regarded as a promising third-generation marine biomass that can be utilized as a sustainable feedstock for bio-industry due to the high sugar level and absence of lignin. Alginate, composed of 1,4-linked D-mannuronate (M) and L-guluronate (G), is one of the major carbohydrates in brown macroalgae. It is difficult to be assimilated by most industrial microorganisms. Read More

Front Microbiol 2021 18;12:652766. Epub 2021 Mar 18.

School of Environment, Harbin Institute of Technology, Harbin, China.

Bacteria of are widely distributed in various environments and play a substantial role in the nutrient cycle. In this report, 14 strains capable of aerobic denitrification and heterotrophic sulfur oxidation were isolated from different habitats. Based on the phenotypic, genotypic, and chemotaxonomic analyses, these strains were considered to represent six novel species of the genus , for which the names sp. Read More

Philos Trans R Soc Lond B Biol Sci 2021 May 5;376(1825):20200155. Epub 2021 Apr 5.

Unaffiliated, Saint Paul, MN, USA.

The byssus is a structure unique to bivalves. Byssal threads composed of many proteins extend like tendons from muscle cells, ending in adhesive pads that attach underwater. Crucial to settlement and metamorphosis, larvae of virtually all species are byssate. Read More

Curr Microbiol 2021 Apr 3. Epub 2021 Apr 3.

Marine College, Shandong University, Weihai, 264209, Shandong, People's Republic of China.

A Gram-stain-negative, yellow-pigmented, rod-shaped, strictly aerobic, non-motile bacterium, designated BDHS18, was isolated from the sediment of the Hasuhai Lake, China. Phylogenetic analysis based on 16S rRNA gene sequences revealed that this strain belongs to the genus Moheibacter in the family Flavobacteriaceae and its closest relative was Moheibacter sediminis JCM 19634 (96.0%), followed by Moheibacter stercoris DSM 29388 (95. Read More

Zoolog Sci 2021 Apr;38(2):193-202

Misaki Marine Biological Station, School of Science, The University of Tokyo, Misaki, Miura, Kanagawa 238-0225, Japan,

The heteronemertean (Takakura, 1898) was originally described as based on material from Misaki, Japan. Although this species was regarded as consisting of two color variants, purple and brown-yellow, the identity of these variants has never been examined based on topotypes. In this study, we performed a multi-locus phylogeny reconstruction, species delimitation analyses, and cross-fertilization experiments to examine the species status of Takakura's original taxon concept consisting of these color variants. Read More

Pharmacol Res 2021 Mar 31;168:105589. Epub 2021 Mar 31.

MARE - Marine and Environmental Sciences Centre, ESTM, Polytechnic of Leiria, 2520-614 Peniche, Portugal. Electronic address:

The treatment of Parkinson´s disease (PD) has benefited from significant advances resulting from the increasing research efforts focused on new therapeutics. However, the current treatments for PD are mostly symptomatic, alleviating disease symptoms without reversing or retarding disease progression. Thus, it is critical to find new molecules that can result in more effective treatments. Read More

Comp Biochem Physiol B Biochem Mol Biol 2021 Apr 1;255:110594. Epub 2021 Apr 1.

Institute of Marine and Environmental Technology, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD, United States.

Paramyosin is a key component of thick filaments in invertebrate muscles. In this study, we isolated the full length cDNA of paramyosin from Pacific oyster (Crassostrea gigas), and determined its pattern of expression during myogenesis. The full length paramyosin (CgPM) cDNA contains an open reading frame (ORF) of 2586 bp encoding a 861-amino acid protein. Read More

Toxicol Lett 2021 Mar 31. Epub 2021 Mar 31.

Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China. Electronic address:

Our previous studies found that M10, a myricetin-3-O-β-d-lactose sodium salt, possessed higher effects of ameliorating ulcerative colitis (UC) than Myricetin in mice. Here, we aim to investigate whether the inhibition of UC is the consequence of the effects of M10 that leads to the changed microbiota. Mice model of UC was induced by dextran sulfate sodium (DSS) treatment. Read More