548 results match your criteria isolated garcinia


Structure Elucidation and Confirmation of Phloroglucinols from the Roots of by Comparison of Experimental and Calculated ECD Spectra and Specific Rotations.

J Nat Prod 2021 Apr 6. Epub 2021 Apr 6.

Department of Chemistry, Virginia Tech, Blacksburg, Virginia 24061, United States.

Eight phloroglucinols from were recently reported to have good to moderate antiplasmodial and anticancer activities, consistent with other phloroglucinol derivatives isolated from natural sources. Chiroptical properties were previously calculated and compared to experimental data for compound as a means to deduce its absolute configuration. Tentative assignments for the remaining compounds were also reported based on these data. Read More

View Article and Full-Text PDF

Garcinoxanthones SV, new xanthone derivatives from the pericarps of Garcinia mangostana together with their cytotoxic and antioxidant activities.

Fitoterapia 2021 Mar 10;151:104880. Epub 2021 Mar 10.

School of Chemical Engineering, Hanoi University of Science and Technology (HUST), Hanoi 100000, Viet Nam; College of Pharmacy, Drug Research and Development Center, Daegu Catholic University, Gyeongbuk 38430, Republic of Korea. Electronic address:

Xanthones (9H-xanthene-9-ones) are considered to be very promising compounds due to a variety of interesting biological and pharmacological activities. In this study, column chromatography of the methanol extract of the Garcinia mangostana L. pericarps resulted in the isolation of four new xanthones (garcinoxanthones SV, 1-4) and five known analogs including garcinone E (5), 11-hydroxy-1-isomangostin (6) mangostenone E (7), 1,3,6,7-tetrahydroxyxanthone (8), and α-mangostin (9). Read More

View Article and Full-Text PDF

Bioactivity of natural biflavonoids in metabolism-related disease and cancer therapies.

Pharmacol Res 2021 Mar 3;167:105525. Epub 2021 Mar 3.

Department of Pharmacy, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, South Korea. Electronic address:

Natural biflavonoids, such as amentoflavone, bilobetin, ginkgetin, isoginkgetin, taiwaniaflavone, morelloflavone, delicaflavone, hinokiflavone, and other derivatives (~ 40 biflavonoids), are isolated from Selaginella sp., Ginkgo biloba, Garcinia sp., and several other species of plants. Read More

View Article and Full-Text PDF

Structural Elucidation of Garcipaucinones A and B From Using Quantum Chemical Calculations.

J Nat Prod 2021 Mar 5. Epub 2021 Mar 5.

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, People's Republic of China.

Two tocotrienol derivatives, garcipaucinones A () and B (), and a biosynthetically related known analogue () were isolated from the fruit of . Their structures including absolute configurations were unequivocally determined by spectroscopic methods complemented with electronic circular dichroism (ECD) calculations and gauge-independent atomic orbital (GIAO) NMR calculations. Compounds and are the first naturally occurring tocotrienol derivatives with a 3,10-dioxatricyclo-[7. Read More

View Article and Full-Text PDF

Garcimultiflorone K from Garcinia multiflora attenuates hepatocellular carcinoma metastasis by suppressing transforming growth factor-β signaling.

Phytomedicine 2021 Apr 12;84:153502. Epub 2021 Feb 12.

Department of Biological Sciences, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan ROC; Department of Biotechnology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ROC; Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ROC. Electronic address:

Background: Transforming growth factor‑β (TGF-β) signaling is a crucial inducer of tissue fibrosis and extracellular matrix accumulation and a vital suppressor of epithelial cell proliferation and cancer metastasis. The nature of this multifunctional cytokine has prompted the development of TGF-β signaling inhibitors as therapeutic agents. Our research group has recently isolated the polyprenylated polycyclic acylphloroglucinol garcimultiflorone K (GMK) from the stems of Garcinia multiflora; GMK exhibits antiangiogenic activity in endothelial cells. Read More

View Article and Full-Text PDF

Phytotoxic property of metabolites isolated from Garcinia gardneriana.

Comput Biol Chem 2021 Feb 16;92:107460. Epub 2021 Feb 16.

Departamento De Química, Universidade Federal De Viçosa, Avenida Peter Henry Rolfs, s/n, Campus Universitário, 36570-900 Viçosa, MG, Brazil. Electronic address:

Garcinia gardneriana is a medicinal tree species used in Brazil in the treatment of hepatitis and gastritis. This use is attributed to phenolic compounds, mainly 7-epiclusianone, guttiferone-A and fukugetin, which present several proven biological activities. However, to the best of our knowledge, no study on the phytotoxic activity of G. Read More

View Article and Full-Text PDF
February 2021

Targeted Chinese Medicine Delivery by A New Family of Biodegradable Pseudo-Protein Nanoparticles for Treating Triple-Negative Breast Cancer: and Study.

Front Oncol 2020 20;10:600298. Epub 2021 Jan 20.

Biomedical Engineering Field, and Fiber Science Program, Department of Fiber Science and Apparel Design, Cornell University, Ithaca, NY, United States.

Triple negative breast cancer (TNBC) has the worst overall survival among all breast cancer subtypes; 80% of TNBC harbors TP53 mutation. Gambogic acid (GA) is an herbal compound isolated from the dry brownish gamboge resin of . A new family of biodegradable polymer, the folate (FA)-conjugated arginine-based poly(ester urea urethane)s nanoparticles (FA-Arg-PEUU NP), was developed as nano-carrier for GA. Read More

View Article and Full-Text PDF
January 2021

Protective Effect of γ-mangostin Isolated from the Peel of against Glutamate-Induced Cytotoxicity in HT22 Hippocampal Neuronal Cells.

Biomolecules 2021 Jan 27;11(2). Epub 2021 Jan 27.

College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, 1 Gwanak-lo, Gwanak-gu, Seoul 08826, Korea.

The aim of the present study was to examine the protective effect of γ-mangostin, a component of the mangosteen shell, against oxidative damage to nerve cells induced by excessive glutamate, a known excitatory neurotransmitter. To investigate the effect of γ-mangostin on apoptosis, 5 mM of glutamate was used to induce apoptotic cell death in mouse hippocampal HT22 cells. In this study, γ-mangostin was found to exert a stronger protection than N-acetyl cysteine against glutamate-induced cell damage. Read More

View Article and Full-Text PDF
January 2021

Natural biflavonoids as potential therapeutic agents against microbial diseases.

Sci Total Environ 2021 May 16;769:145168. Epub 2021 Jan 16.

Department of Organic Chemistry, Institute of Chemistry, Fluminense Federal University, Campus do Valonguinho, 24020-141 Niterói, Rio de Janeiro, Brazil.

Microbes broadly constitute several organisms like viruses, protozoa, bacteria, and fungi present in our biosphere. Fast-paced environmental changes have influenced contact of human populations with newly identified microbes resulting in diseases that can spread quickly. These microbes can cause infections like HIV, SARS-CoV2, malaria, nosocomial Escherichia coli, methicillin-resistant Staphylococcus aureus (MRSA), or Candida infection for which there are no available vaccines/drugs or are less efficient to prevent or treat these infections. Read More

View Article and Full-Text PDF

New alkaloids from the diversity-enhanced extracts of an endophytic fungus Aspergillus flavus GZWMJZ-288.

Bioorg Chem 2021 Feb 5;107:104623. Epub 2021 Jan 5.

State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266003, China. Electronic address:

Three new alkaloids (1-3) together with four previously reported compounds (4-7) were identified from the extracts and the diversity-enhanced extracts of the fermentation broth of the endophytic fungus, Aspergillus flavus GZWMJZ-288 associated with Garcinia multiflora. The structures of new compounds were respectively determined as 19-amino-19-dehydroxy 5-epi-α-cyclopiazonic acid (1), 2-hydroxymethyl-5-(3-oxobutan-2-yl)aminopyran-4(4H)-one (2) and 4-amino-2-hydroxymethylpyridin-5-ol (3) by spectroscopic analysis, ECD calculation and X-ray single crystal diffraction. Compounds 1 and 4 with 19-enamine were dynamic equilibrium of Z- and E- isomers in the solution but favored in Z- isomers in the solid state, while compound 7 with 19-enol was favored in Z- isomer in the solution but a mixture of Z- and E- isomers in solid state. Read More

View Article and Full-Text PDF
February 2021

The Natural Compound Oblongifolin C Exhibits Anticancer Activity by Inhibiting HSPA8 and Cathepsin B .

Front Pharmacol 2020 17;11:564833. Epub 2020 Dec 17.

Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

PPAPs (Polycyclic polyprenylated acylphloroglucinols) are a class of compounds with diverse bioactivities, including anticancer effects. Oblongifolin C (OC) is a PPAP isolated from the plant of Hu. We previously discovered that OC induces apoptosis, inhibits autophagic flux, and attenuates metastasis in cancer cells. Read More

View Article and Full-Text PDF
December 2020

DNA Repair Biosensor-Identified DNA Damage Activities of Endophyte Extracts from .

Biomolecules 2020 12 16;10(12). Epub 2020 Dec 16.

Section for Translational Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand.

Recent developments in chemotherapy focus on target-specific mechanisms, which occur only in cancer cells and minimize the effects on normal cells. DNA damage and repair pathways are a promising target in the treatment of cancer. In order to identify novel compounds targeting DNA repair pathways, two key proteins, 53BP1 and RAD54L, were tagged with fluorescent proteins as indicators for two major double strand break (DSB) repair pathways: non-homologous end-joining (NHEJ) and homologous recombination (HR). Read More

View Article and Full-Text PDF
December 2020

Screening of Xanthones from Identified Oliganthin H as a Novel Natural Inhibitor of Convulsions.

J Nat Prod 2020 12 9;83(12):3706-3716. Epub 2020 Dec 9.

State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macau, China.

Epilepsy is a chronic neurological disorder, characterized by recurrent, spontaneous, and transient seizures, and affects more than 70 million people worldwide. Although two dozen antiepileptic drugs (AEDs) are approved and available in the market, seizures remain poorly controlled in one-third of epileptic patients who are suffering from drug resistance or various adverse effects. Recently, the xanthone skeleton has been regarded as an attractive scaffold for the discovery and development of emerging anticonvulsants. Read More

View Article and Full-Text PDF
December 2020

Garcinol protects against cerebral ischemia-reperfusion injury in vivo and in vitro by inhibiting inflammation and oxidative stress.

Mol Cell Probes 2020 12 11;54:101672. Epub 2020 Nov 11.

Cisen Pharmaceutical Co. Ltd., High Tech District, Jining, Shandong, China. Electronic address:

Garcinol, a polyisoprenylated benzophenone derivative, is isolated from fruit rind of Garcinia indica. It is known to exert potent anti-inflammatory and anti-oxidative properties. In the present study, we tried to investigate the neuroprotective effects of garcinol on a rat model with middle cerebral artery occlusion/reperfusion (MCAO/R) and a cell model subjected to oxygen glucose deprivation and reperfusion (OGD/R). Read More

View Article and Full-Text PDF
December 2020

Polycyclic polyprenylated acylphloroglucinols from Garcinia xanthochymus fruits exhibit antitumor effects through inhibition of the STAT3 signaling pathway.

Food Funct 2020 Dec 13;11(12):10568-10579. Epub 2020 Nov 13.

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, P. R. China.

The fruits of Garcinia xanthochymus can be eaten raw or processed into jams, preserves and vinegar. They provide not only vitamin and protein nutrients, but also pharmacologically active compounds, among which polycyclic polyprenylated acylphloroglucinols (PPAPs) are a major class. According to the literature, PPAPs exhibited good anti-cancer effects. Read More

View Article and Full-Text PDF
December 2020

Kolaviron: A Biflavonoid with Numerous Health Benefits.

Curr Pharm Des 2021 ;27(4):490-504

Department of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban 4000, South Africa.

Background: The increasing interests on the healing properties of medicinal plants have led to a paradigm shift from the use of synthetic drug to the search of natural medicines for the treatment and management of several diseases. Like other phenolics flavonoids have been continuously explored for their medicinal benefits, with their potent antioxidant activity being a major interest. Kolaviron (KVN) is a biflavonoid isolated from Garcinia kola Heckel, which has been reported for its potent antioxidant and anti-inflammatory properties. Read More

View Article and Full-Text PDF
January 2021

Prenylated xanthones and benzophenones from the fruits of Garcinia bracteata and their potential antiproliferative and anti-inflammatory activities.

Bioorg Chem 2020 11 6;104:104339. Epub 2020 Oct 6.

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, PR China. Electronic address:

Ten previously undescribed compounds, including five prenylated xanthones (1-5), two caged xanthones (16-17) and three rearranged benzophenones (27-29), together with nineteen known compounds were isolated from the fruits of Garcinia bracteata. Their structures were established on the basis of spectroscopic analysis, electronic circular dichroism calculations, and X-ray crystallographic data. Compound 17 was a caged xanthone bearing a rare 8, 8a-epoxy moiety. Read More

View Article and Full-Text PDF
November 2020

Synthesis of nano-α mangostin based on chitosan and Eudragit S 100.

J Adv Pharm Technol Res 2020 Jul-Sep;11(3):95-100. Epub 2020 Jul 14.

Departement of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, Sumedang, Java, Indonesia.

Alpha-mangostin is a xanthone compound isolated from the mangosteen plant ( L.), which has various pharmacological activities. However, in its utilization alpha-mangostin is unstable and shows low solubility in the oral delivery system. Read More

View Article and Full-Text PDF

Guttiferone K Exerts the Anti-inflammatory Effect on Mycobacterium Tuberculosis- (H37Ra-) Infected Macrophages by Targeting the TLR/IRAK-1 Mediated Akt and NF-B Pathway.

Mediators Inflamm 2020 10;2020:8528901. Epub 2020 Oct 10.

Center for Traditional Chinese Medicine and Immunology Research, School of Basic Medical Sciences, Shanghai University of Traditional Chinese Medicine, 201203 Shanghai, China.

(Mtb) remains a great threat to global health, killing more people than any other single infectious agent and causing uncontrollable inflammation in the host. Poorly controlled inflammatory processes can be deleterious and result in immune exhaustion. The current tuberculosis (TB) control is facing the challenge of drugs deficiency, especially in the context of increasingly multidrug resistant (MDR) TB. Read More

View Article and Full-Text PDF
October 2020

Cytotoxic activity of phytochemicals from L. and (Planch. & Triana) Pipoly against breast cancer cells.

Nat Prod Res 2020 Oct 23:1-6. Epub 2020 Oct 23.

School of Biosciences, Taylor's University, Lakeside Campus, Subang Jaya, Selangor, Malaysia.

Four xanthones, α-mangostin (), β-mangostin (), mangostenol (), mangaxanthone B (), three benzophenones, mangaphenone (), benthamianone (), congestiflorone () and one sterol, stigmasterol () were isolated from the stem barks of L. and (Planch. & Triana) Pipoly. Read More

View Article and Full-Text PDF
October 2020

Anti-Tumor Xanthones from Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells.

Drug Des Devel Ther 2020 25;14:3965-3976. Epub 2020 Sep 25.

Department of Pharmacy, School & Hospital of Stomatology, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, Shanghai 200072, People's Republic of China.

Background: Ovarian cancer (OC) is a serious public health concern in the world. It is important to develop novel drugs to inhibit OC.

Purpose: This study investigated the isolation, elucidation, efficiency, molecular docking, and pharmaceutical mechanisms of xanthones isolated from . Read More

View Article and Full-Text PDF
September 2020

Targeting MHC Regulation Using Polycyclic Polyprenylated Acylphloroglucinols Isolated from .

Biomolecules 2020 09 2;10(9). Epub 2020 Sep 2.

Université de Nantes, CHU Nantes, Inserm, Centre de Recherche en Transplantation et Immunologie, UMR 1064, ITUN, F-44000 Nantes, France.

Modulation of major histocompatibility complex (MHC) expression using drugs has been proposed to control immunity. Phytochemical investigations on species have allowed the isolation of bioactive compounds such as polycyclic polyprenylated acylphloroglucinols (PPAPs). PPAPs such as guttiferone J (), display anti-inflammatory and immunoregulatory activities while garcinol () is a histone acetyltransferases (HAT) p300 inhibitor. Read More

View Article and Full-Text PDF
September 2020

Kolaviron suppresses dysfunctional reproductive axis associated with multi-walled carbon nanotubes exposure in male rats.

Environ Sci Pollut Res Int 2021 Jan 18;28(1):354-364. Epub 2020 Aug 18.

Drug Metabolism and Toxicology Research Laboratories, Department of Biochemistry, College of Medicine, University of Ibadan, Ibadan, Nigeria.

Reproductive toxicity associated with excessive exposure to multi-walled carbon nanotubes (MWCNTs), which are commonly used in medicine as valuable drug delivery systems, is well documented. Kolaviron, a bioflavonoid isolated from Garcinia kola seeds, elicits numerous health beneficial effects related to its anti-inflammatory, anti-genotoxic activities, anti-apoptotic, and antioxidant properties. However, information on the role of kolaviron in MWCNTs-induced reproductive toxicity is not available in the literature. Read More

View Article and Full-Text PDF
January 2021

Antiproliferative activity of a new xanthone derivative from leaves of Engl.

Nat Prod Res 2020 Aug 13:1-8. Epub 2020 Aug 13.

Department of Chemistry, Organic and Bioorganic Chemistry, Bielefeld University, Bielefeld, Germany.

A new xanthone, mboudiexanthone (), together with five known compounds, euxanthone (), isogarcinol (), garcinol (), betulinic acid () and zeorin () were isolated from the leaves of Engl. The structures were determined by 1D and 2D NMR techniques and X-ray diffraction for . The antiproliferative properties of isolated compounds were evaluated against the human breast cancer cell line MCF-7. Read More

View Article and Full-Text PDF

Bicyclic polyprenylated acylphloroglucinols and their derivatives: structural modification, structure-activity relationship, biological activity and mechanism of action.

Eur J Med Chem 2020 Nov 24;205:112646. Epub 2020 Jul 24.

Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. Electronic address:

Bicyclic polyprenylated acylphloroglucinols (BPAPs), the principal bioactive benzophenone products isolated from plants of genera Garcinia and Hypericum, have attracted noticeable attention from the synthetic and biological communities due to their fascinating chemical structures and promising biological activities. However, the potential drug interaction, undesired physiochemical properties and toxicity have limited their potential use and development. In the last decade, pharmaceutical research on the structural modifications, structure-activity relationships (SARs) and mechanisms of action of BPAPs has been greatly developed to overcome the challenges. Read More

View Article and Full-Text PDF
November 2020

Natural Polyketides Isolated from the Endophytic Fungus Phomopsis sp. CAM212 with a Semisynthetic Derivative Downregulating the ERK/IκBα Signaling Pathways.

Planta Med 2020 Sep 5;86(13-14):1032-1042. Epub 2020 Aug 5.

Center for Natural Products Research, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.

Three previously undescribed natural products, phomopsinin A - C (1:  - 3: ), together with three known compounds, namely, -hydroxymellein (4: ), phomoxanthone A (5: ) and cytochalasin L-696,474 (6: ), were isolated from the solid culture of sp. CAM212, an endophytic fungus obtained from . Their structures were determined on the basis of spectroscopic data, including IR, NMR, and MS. Read More

View Article and Full-Text PDF
September 2020

Xanthone-enriched fraction of Garcinia mangostana and α-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion rats.

J Pharm Pharmacol 2020 Nov 2;72(11):1629-1644. Epub 2020 Aug 2.

Centre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia.

Objectives: Xanthones isolated from the pericarp of Garcinia mangostana has been reported to exhibit neuroprotective effect.

Methods: In this study, the effect of xanthone-enriched fraction of Garcinia mangostana (XEFGM) and α-mangostin (α-MG) were investigated on cognitive functions of the chronic cerebral hypoperfusion (CCH) rats.

Key Findings: HPLC analysis revealed that XEFGM contained 55. Read More

View Article and Full-Text PDF
November 2020

Acylphloroglucinol and tocotrienol derivatives from the fruits of Garcinia paucinervis.

Fitoterapia 2020 Oct 21;146:104688. Epub 2020 Jul 21.

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, PR China. Electronic address:

Three undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs) and three tocotrienols derivatives, named as paucinochymol A-F (1-3 and 10-12), together with six known PPAPs, were isolated from the fruits of Garcinia paucinervis. Their structures and absolute configurations were determined by extensive NMR analysis and electronic circular dichroism (ECD) calculation methods. Paucinochymol A (1) is the first compound of this type featuring a ω-isogeranyl with tetrahydrofuran unit at C-1. Read More

View Article and Full-Text PDF
October 2020

Inhibition of CDK2/CyclinE1 by xanthones from the mangosteen (): a structure-activity relationship study.

Nat Prod Res 2020 Jul 21:1-5. Epub 2020 Jul 21.

Department of Pharmacy Practice, College of Pharmacy, University of Illinois at Chicago, Chicago, IL, USA.

Uncontrolled regulation of cyclin dependent kinases (CDKs) has negative implications in many cancers and malignancies and has recently led to the approval of select CDK inhibitors. Herein we present data reporting that xanthones, a class of compounds isolated from the purple mangosteen () fruit, can inhibit CDK2/CyclinE1. We evaluated nine different xanthones, including α-mangostin, β-mangostin, γ-mangostin, gartanin, 8-desoxygartanin, garcinone C, garcinone D, 9-hydroxycalabaxanthone, and 3-isomangostin for toxicity in 22Rν1 (prostate cancer cells) and MDA-MB-231 (breast cancer cells). Read More

View Article and Full-Text PDF

Kolaviron stimulates glucose uptake with concomitant modulation of metabolic activities implicated in neurodegeneration in isolated rat brain, without perturbation of tissue ultrastructural morphology.

Neurosci Res 2020 Jul 6. Epub 2020 Jul 6.

Department of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa. Electronic address:

Reduced glucose uptake usually occurs in type 2 diabetes due to down-regulation of brain glucose transporters. The potential of kolaviron, a biflavonoid from Garcinia kola to stimulate glucose uptake and suppress glucose-induced oxidative toxicity were investigated in rat brain. Its molecular interactions with the target proteins were investigated in silico. Read More

View Article and Full-Text PDF