1,957 results match your criteria isolated polyphenols


Insoluble dietary fibre scavenges reactive carbonyl species under simulated physiological conditions: The key role of fibre-bound polyphenols.

Food Chem 2021 Jul 16;349:129018. Epub 2021 Jan 16.

Food Quality & Design Group, Wageningen University & Research, NL-6708 WG, The Netherlands.

Polyphenols bound to insoluble fibre may scavenge reactive carbonyl species by surface chemical reactions. In the present study, this hypothesis was tested by investigating the ability of bound-polyphenol rich insoluble dietary fibre (BP-IDF) isolated from blackberry pomace, red cabbage, and wheat bran in scavenging carbonyl compounds. Three BP-IDF showed high scavenging efficacy for glyoxal, methylglyoxal, acrolein and malondialdehyde. Read More

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Structural characterization of anticoagulant and antithrombotic polysaccharides isolated from Caesalpinia ferrea stem barks.

Int J Biol Macromol 2021 Apr 30;175:147-155. Epub 2021 Jan 30.

Instituto Superior de Ciências Biomédicas, Universidade Estadual do Ceará, Av. Dr. Silas Munguba 1700, 60740-000 Fortaleza, CE, Brazil; Faculdade de Educação, Ciências e Letras do Sertão Central, Universidade Estadual do Ceará, Rua José de Queiroz 2554, 63900-000 Quixadá, CE, Brazil. Electronic address:

This study aimed to isolate, characterize chemical-structurally and evaluate the effects of polysaccharides from Caesalpinia (Libidibia) ferrea stem barks in the haemostatic system. The deproteinated-polysaccharide extract (PE-Cf) after being fractionated by ion exchange chromatography-DEAE-cellulose resulted in three fractions (FI, FII, FIII) containing total carbohydrates (14.3-38%), including uronic acid (5-16%), and polyphenols (0. Read More

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The isolation of secondary metabolites from Rheum ribes L. and the synthesis of new semi-synthetic anthraquinones: Isolation, synthesis and biological activity.

Food Chem 2021 Apr 15;342:128378. Epub 2020 Oct 15.

Department of Chemistry, Faculty of Science and Arts, Çankiri Karatekin University, Cankiri, Turkey.

Rheum ribes L. (Rhubarb) is one of the most important edible medicinal plants in the Eastern Anatolia region and is called "Işkın" by local people. Resveratrol and 6-O-methylalaternin were isolated from the Rhubarb for the first time in addition to well-known secondary metabolites including emodin, aloe-emodin, β-sitosterol and rutin. Read More

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Analytical Profile and Antioxidant and Anti-Inflammatory Activities of the Enriched Polyphenol Fractions Isolated from Bergamot Fruit and Leave.

Antioxidants (Basel) 2021 Jan 20;10(2). Epub 2021 Jan 20.

Department of Pharmaceutical Sciences, University of Milan, 20133 Milan, Italy.

The aim of the study is to compare the qualitative and semi-quantitative profile of the polyphenol fraction purified from the leaf (BLPF) and fruit (BFPF) of bergamot (), and to evaluate their antioxidant and anti-inflammatory activity. The analytical qualitative profile was carried out by LC-ESI/MS using three different approaches: targeted (searching analytes already reported in bergamot extract), semi-targeted (a selective search of 3-hydroxy-3-methylglutarate [HMG] derivatives involved in the cholesterol reducing activity of BPF) and untargeted. A total number of 108 compounds were identified by using the three approaches, 100 of which are present in both the extracts thus demonstrating a good qualitative overlapping of polyphenols between the two extracts. Read More

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January 2021

A review of plant characteristics, phytochemistry and bioactivities of the genus Glechoma.

J Ethnopharmacol 2021 May 17;271:113830. Epub 2021 Jan 17.

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education; Yunnan Provincial Center for Research & Development of Natural Products; School of Chemical Science and Technology, Yunnan University, Kunming, 650091, PR China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences Kunming, 650201, PR China. Electronic address:

Ethnopharmacological Relevance: Plants of the genus Glechoma have been abundantly used for thousands of years in China as folk treatments for cholelithiasis, urolithiasis, inflammation, and other conditions.

Aim Of The Study: This review discusses the potential application of Glechoma as an herbal medicine. The plant characteristics, ethnobotanical uses, phytochemistry, and pharmacological activities of Glechoma are summarized as a guide for phytochemical and pharmacological investigations. Read More

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Synthesis, Stability, and Antidiabetic Activity Evaluation of (-)-Epigallocatechin Gallate (EGCG) Palmitate Derived from Natural Tea Polyphenols.

Molecules 2021 Jan 13;26(2). Epub 2021 Jan 13.

Department of Chemistry, Zhejiang University, Hangzhou 310027, China.

This work describes a novel approach for the synthesis of (-)-epigallocatechin gallate (EGCG) palmitate by a chemical-synthesis method, where the elevated stability of the EGCG derivative is achieved. Various parameters affecting the acylation process, such as the base, solvent, as well as the molar ratio of palmitoyl chloride, have been studied to optimize the acylation procedure. The optimized reaction condition was set as follows: EGCG/palmitoyl chloride/sodium acetate was under a molar ratio of 1:2:2, with acetone as the solvent, and the reaction temperature was 40 °C. Read More

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January 2021

Transcriptome analysis to identify key genes involved in terpenoid and rosmarinic acid biosynthesis in lemon balm (Melissa officinalis).

Gene 2021 Mar 12;773:145417. Epub 2021 Jan 12.

Department of Agronomy and Plant Breeding, Agricultural and Natural Resources College, University of Tehran, Karaj, Iran. Electronic address:

Melissa officinalis (lemon balm) is a well-known pharmaceutical plant in traditional medicine around the world because of the high-value secondary metabolites. Nowadays, advances in computational biology and bioinformatics have opened new avenues to plant-based natural product drug discovery. Despite the pharmacological importance, there is low information about the genes encoding the important biosynthetic pathways related to the secondary metabolite in M. Read More

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Euphorbia helioscopia L.: A phytochemical and pharmacological overview.

Phytochemistry 2021 Apr 10;184:112649. Epub 2021 Jan 10.

Department of Bioengineering, Zhuhai Campus of Zunyi Medical University, Zhuhai, 519041, China. Electronic address:

Euphorbia helioscopia L. which is called "Zeqi" in China, is a medicinal plant extensively distributed worldwide, especially in China, and has been widely used for decades to treat various diseases including edema, phlegm and cough, malaria, dysentery, scab, tuberculous fistula, osteomyelitis, and cancer. The present review aims to provide up-to-date information on E. Read More

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GTE53: Phosphate solubilising and bioremediation bacterium isolated from new biotope "phosphate sludge enriched-compost".

Saudi J Biol Sci 2021 Jan 15;28(1):371-379. Epub 2020 Oct 15.

Laboratoire Polyvalent en Recherche et Développement, Faculté Polydisciplinaire, Université Sultan Moulay Slimane, Beni Mellal, Morocco.

The isolation and identification of beneficial bacteria from the active phase of composting is considered to be a key bio-quality parameter for the assessment of the process. The aim of this work was the selection and identification of beneficial bacteria from a co-composting experiment of vegetable waste (VW), olive oil mill waste (OMW), and phosphate sludge (PS). Phosphate-solubilizing strains were isolated from the thermophilic phase using Pikovskaya (PVK) solid medium supplemented with tricalcium phosphate Ca3(PO4) (TCP) as the sole source of phosphorus (P). Read More

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January 2021

Phytochemicals and Biological Activity of Desert Date ( (L.) Delile).

Plants (Basel) 2020 Dec 25;10(1). Epub 2020 Dec 25.

Plant Production Department, P.O. Box 2460, College of Food and Agriculture Sciences, King Saud University, Riyadh 11451, Saudi Arabia.

Many underutilized tree species are good sources of food, fodder and possible therapeutic agents. (L.) Delile belongs to the Zygophyllaceae family and is popularly known as "desert date", reflecting its edible fruits. Read More

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December 2020

Macrotyloma uniflorum a plant food alleviates the metabolic syndrome through modulation of adipokines and PPARs.

J Food Biochem 2021 Feb 23;45(2):e13595. Epub 2020 Dec 23.

Natural Products Research Laboratory, Department of Biotechnology, School of Life Sciences, Pondicherry University, Puducherry, India.

A sedentary lifestyle combined with the intake of high-calorie diet has been the paramount cause of metabolic syndrome (MS) which is now a serious concern of public health worldwide as it involves the coexistence of hypertension, hyperlipidemia, glucose intolerance, and obesity. Hence, identifying a suitable strategy to overcome the worldwide menace of MS is imperative. Macrotyloma uniflorum a lesser known legume is highly nutritious and notable for its ethano-medicinal potential. Read More

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February 2021

Antimicrobial Blue Light versus Pathogenic Bacteria: Mechanism, Application in the Food Industry, Hurdle Technologies and Potential Resistance.

Foods 2020 Dec 18;9(12). Epub 2020 Dec 18.

AgResearch Ltd., Hopkirk Research Institute, Cnr University and Library Road, Massey University, Palmerston North 4442, New Zealand.

Blue light primarily exhibits antimicrobial activity through the activation of endogenous photosensitizers, which leads to the formation of reactive oxygen species that attack components of bacterial cells. Current data show that blue light is innocuous on the skin, but may inflict photo-damage to the eyes. Laboratory measurements indicate that antimicrobial blue light has minimal effects on the sensorial and nutritional properties of foods, although future research using human panels is required to ascertain these findings. Read More

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December 2020

Polyphenols from Brown Seaweeds (Ochrophyta, Phaeophyceae): Phlorotannins in the Pursuit of Natural Alternatives to Tackle Neurodegeneration.

Mar Drugs 2020 Dec 18;18(12). Epub 2020 Dec 18.

REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, Rua de Jorge Viterbo Ferreira n.º 228, 4050-313 Porto, Portugal.

Globally, the burden of neurodegenerative disorders continues to rise, and their multifactorial etiology has been regarded as among the most challenging medical issues. Bioprospecting for seaweed-derived multimodal acting products has earned increasing attention in the fight against neurodegenerative conditions. Phlorotannins (phloroglucinol-based polyphenols exclusively produced by brown seaweeds) are amongst the most promising nature-sourced compounds in terms of functionality, and though research on their neuroprotective properties is still in its infancy, phlorotannins have been found to modulate intricate events within the neuronal network. Read More

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December 2020

Natural phenolic antioxidants electrochemistry: Towards a new food science methodology.

Compr Rev Food Sci Food Saf 2020 07 24;19(4):1680-1726. Epub 2020 Jun 24.

CEMMPRE, Department of Chemistry, University of Coimbra, Coimbra, 3004-535, Portugal.

Natural phenolic compounds are abundant in the vegetable kingdom, occurring mainly as secondary metabolites in a wide variety of chemical structures. Around 10,000 different plant phenolic derivatives have been isolated and identified. This review provides an exhaustive overview concerning the electron transfer reactions in natural polyphenols, from the point of view of their in vitro antioxidant and/or pro-oxidant mode of action, as well as their identification in highly complex matrixes, for example, fruits, vegetables, wine, food supplements, relevant for food quality control, nutrition, and health research. Read More

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Screening the dermatological potential of species components: antioxidant and inhibitory capacities over elastase, collagenase and tyrosinase.

J Enzyme Inhib Med Chem 2021 Dec;36(1):257-269

Research Center for Biosciences and Health Technologies (CBIOS), Universidade Lusófona de Humanidades e Tecnologias, Lisboa, Portugal.

A series of spp. plant extracts (aqueous, acetonic, methanolic and ethyl acetic) obtained from eight different species, and previously isolated compounds (ranging from polyphenols, diterpenes and triterpenes), were assayed for inhibition of the skin-related enzymes tyrosinase, collagenase and elastase, and for studying their antioxidant properties. The ethyl acetic extracts of and registered the highest antioxidant activity, whereas acetonic, methanolic and ethyl acetic extracts of , , and concerning the enzymatic inhibition assays revealed high anti-tyrosinase and anti-collagenase activities. Read More

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December 2021

Anacardium humile St. Hil as a novel source of antioxidant, antiglycation and α-amylase inhibitors molecules with potential for management of oxidative stress and diabetes.

J Ethnopharmacol 2021 Mar 7;268:113667. Epub 2020 Dec 7.

Graduate Program in Cell Biology, Institute of Biomedical Science (ICBIM), Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil; Institute of Biotechnology (IBTEC), Federal University of Uberlândia (UFU), Uberlândia, MG, Brazil. Electronic address:

Ethnopharmacological Relevance: The substantial increase in diabetes cases worldwide has been a major public health problem, and the use of medicinal plants can be considered an interesting alternative to control the disease and its complications. Anacardium humile St. Hill. Read More

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p53 Enhances L. Polyphenols-Induced Cell Death Through Upregulation of p53-Dependent Targets and Cleavage of PARP1 and Lamin A/C in HCT116 Colorectal Cancer Cells.

Int J Mol Sci 2020 Dec 7;21(23). Epub 2020 Dec 7.

Departments of Biochemistry, Institute of Health Sciences, Gyeongsang National University School of Medicine, Jinju 52727, Korea.

Plant-derived natural polyphenols exhibit anticancer activity without showing any noticeable toxicities to normal cells. The aim of this study was to investigate the role of p53 on the anticancer effect of polyphenols isolated from Korean L. (pKAL) in HCT116 human colorectal cancer cells. Read More

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December 2020

Antioxidant Supplementation Modulates Neutrophil Inflammatory Response to Exercise-Induced Stress.

Antioxidants (Basel) 2020 Dec 7;9(12). Epub 2020 Dec 7.

CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.

The aim of the present report was to evaluate the inflammatory response to a 2000-m running test considering neutrophil myeloperoxidase as an inflammatory marker, and to verify if supplements rich in antioxidants could modulate Post-test antioxidant and anti-inflammatory responses. To this end, a 21-day homogenization period was carried out with three groups: a control group, a supplemented group taking an almond beverage enriched with vitamins C and E and a third group consuming the same beverage but enriched with extract. At the end of this period, participants performed a 2000-m run, and blood samples were obtained the day before and immediately after the running test. Read More

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December 2020

Traditional usage and biological activity of Plectranthus madagascariensis and its varieties: A review.

J Ethnopharmacol 2021 Apr 3;269:113663. Epub 2020 Dec 3.

Department of Plant and Soil Sciences, University of Pretoria, Pretoria, South Africa; School of Natural Resources, University of Missouri, Columbia, MO, United States; College of Pharmacy, JSS Academy of Higher Education and Research, India. Electronic address:

Ethnopharmacological Relevance: Plectranthus madagascariensis (Pers.) Benth. is an indigenous aromatic South African plant species that are traditionally used to treat various dermatological and respiratory ailments. Read More

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Production Mechanisms of Black Tea Polyphenols.

Chem Pharm Bull (Tokyo) 2020 ;68(12):1131-1142

Graduate School of Biomedical Sciences, Nagasaki University.

Black tea accounts for 70-80% of world tea production, and the polyphenols therein are produced by enzymatic oxidation of four tea catechins during tea fermentation. However, only limited groups of dimeric oxidation products, such as theaflavins, theasinensins, and theacitrins, have been isolated from black tea and chemically characterized. This is largely because of the complexity and heterogeneity of the oxidation products. Read More

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January 2020

Content of Phenolic Compounds in Meadow Vegetation and Soil Depending on the Isolation Method.

Molecules 2020 Nov 22;25(22). Epub 2020 Nov 22.

Department of Biogeochemistry and Soil Science, University of Science and Technology, 6 Bernardynska St., 85-029 Bydgoszcz, Poland.

The aim of this paper was to determine the effect of the hydrolysis method on the amounts of phenolic compounds in the plant material in soil and, as a consequence, on the parameters to determine the degree of lignins transformation in soils. The study included the plant material (hay, sward, and roots) and soil-Albic Brunic Arenosol (horizon A, AE, and Bsv) samples. Phenolic compounds were isolated at two stages by applying acid hydrolysis followed by alkaline re-hydrolysis. Read More

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November 2020

Rescued chlorhexidine activity by resveratrol against carbapenem-resistant Acinetobacter baumannii via down-regulation of AdeB efflux pump.

PLoS One 2020 2;15(12):e0243082. Epub 2020 Dec 2.

Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

The aim of this study was to determine the activity and synergistic mechanisms of resveratrol in combination with chlorhexidine against carbapenem-resistant Acinetobacter baumannii clinical isolates. The activity of resveratrol plus antimicrobial agents was determined by checkerboard and time-kill assay against carbapenem-resistant A. baumannii isolated from patients at the King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Read More

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January 2021

Endemic Vis. ssp. -Chemical Composition and Antioxidant Activity of Free Volatile Compounds.

Plants (Basel) 2020 Nov 25;9(12). Epub 2020 Nov 25.

Faculty of Science, University of Split, Ruđera Boškovića 33, HR-21000 Split, Croatia.

Chemical profile and antioxidant activity of the species Vis. ssp. (Plantaginaceae)-which is endemic to Croatia, Bosnia and Herzegovina and Montenegro -were investigated. Read More

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November 2020

Gastroprotective activity of kaempferol glycosides from Malvaviscus arboreus Cav.

J Ethnopharmacol 2021 Mar 28;268:113633. Epub 2020 Nov 28.

Centro de Desarrollo de Productos Bióticos, Instituto Politécnico Nacional, Col. San Isidro, Yautepec, Morelos, C.P. 62731, Mexico. Electronic address:

Ethnopharmacological Relevance: Malvaviscus arboreus is traditionally used in Mexico and Central America for culinary and medicinal purposes. Leaves and flowers of this species are commonly used for preparation of salads, herbal teas and herbal dyes. Panamanian, Guatemalan and Mexican healers use this medicinal plant for the management of fever, respiratory complications, dysentery, liver and gallbladder problems, stomachache and gastritis between other health troubles. Read More

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Gustavia gracillima Miers. flowers effects on enzymatic targets underlying metabolic disorders and characterization of its polyphenolic content by HPLC-DAD-ESI/MS.

Food Res Int 2020 11 16;137:109694. Epub 2020 Sep 16.

REQUIMTE/LAQV, Laboratório de Farmacognosia, Departamento de Química, Faculdade de Farmácia, Universidade do Porto, R. Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal. Electronic address:

Notwithstanding Gustavia gracillima Miers widespread distribution in neotropical regions, its chemical profile and biological properties remain uninvestigated. A methanol extract obtained from the flowers was characterized through HPLC-DAD-ESI/MS, nine ellagic acid derivatives and twelve kaempferol 3-O-glycosides being identified and quantitated for the first time at the species and genus. Preliminary cytotoxicity screening did not reveal noticeable effects upon gastrointestinal representative cell lines (AGS, Caco-2 and Hep G2), which further prompted us to evaluate the impact in a series of targets involved in metabolic disorders and associated complications. Read More

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November 2020

Polyphenols in amaranth (A. manteggazianus) flour and protein isolate: Interaction with other components and effect of the gastrointestinal digestion.

Food Res Int 2020 11 21;137:109524. Epub 2020 Jul 21.

Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA) - (CCT La Plata-CONICET, CICPBA, UNLP), 47 y 116 (1900) La Plata, Argentina. Electronic address:

In this work, there were analysed the interaction between phenolics present in amaranth flour (F) and amaranth protein isolate (I) with other components, as well as the effect of the gastrointestinal digestion on them (Fd and Id). Extractions were performed under different conditions (temperature, acid, organic solvent, alkali). Methanol/water extracts (25 °C and 80 °C) from F showed the presence of isoquercetin/rutin, quercetin, kaempferol and two unidentified peaks (II and III). Read More

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November 2020

Cardioprotective potential of polyphenols rich Thraatchathi Chooranam against isoproterenol induced myocardial necrosis in experimental rats.

BMC Complement Med Ther 2020 Nov 23;20(1):356. Epub 2020 Nov 23.

Research and Policy Department, World Innovation Summit for Health (WISH), Qatar Foundation, P.O. Box 5825, Doha, Qatar.

Background: The present study establishes the cardioprotective role of Thraatchathi Chooranam (TC), a polyherbal traditional Siddha medicine, in terms of membrane stabilizing and antioxidant properties in isoproterenol (ISO) induced myocardial necrosis model in rats.

Methods: Animals were divided into six groups (n = 6), normal (received vehicle 0.5% CMC, p. Read More

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November 2020

A previously undescribed phenylethanoid glycoside from Callicarpa kwangtungensis Chun acts as an agonist of the Na/K-ATPase signal transduction pathway.

Phytochemistry 2021 Jan 12;181:112577. Epub 2020 Nov 12.

Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, PR China; Jiangsu Food and Pharmaceutical Science College, Huai'an, 223003, PR China. Electronic address:

The new concept that Na/K-ATPase acts as a receptor prompted us to look for new ligands from Callicarpa kwangtungensis Chun. Using column chromatography, an undescribed phenethyl alcohol glycoside, callicarpanoside A, and an undescribed benzyl alcohol glycoside, callicarpanoside B, along with twelve known polyphenols were isolated from Callicarpa kwangtungensis Chun. All the isolated compounds were evaluated for their Na/K-ATPase (NKA) inhibitory activities. Read More

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January 2021

The extract of Gnaphalium affine D. Don protects against HO-induced apoptosis by targeting PI3K/AKT/GSK-3β signaling pathway in cardiomyocytes.

J Ethnopharmacol 2021 Mar 12;268:113579. Epub 2020 Nov 12.

Hubei Key Laboratory of Diabetes and Angiopathy, Hubei University of Science and Technology, Xianning, 437100, China. Electronic address:

Ethnopharmacological Relevance: Gnaphalium affine D. Don is an important Traditional Chinese herbal Medicine (TCM) used to treat hyperuricemia, asthma, rheumatic arthritis, antitussive, expectorant and cardiovascular in folk medicine because of anti-inflammatory and anti-oxidant activity. The aim of this study was to investigate the potential beneficial effect of G. Read More

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Important Flavonoids and Their Role as a Therapeutic Agent.

Molecules 2020 Nov 11;25(22). Epub 2020 Nov 11.

Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.

Flavonoids are phytochemical compounds present in many plants, fruits, vegetables, and leaves, with potential applications in medicinal chemistry. Flavonoids possess a number of medicinal benefits, including anticancer, antioxidant, anti-inflammatory, and antiviral properties. They also have neuroprotective and cardio-protective effects. Read More

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November 2020