85,584 results match your criteria ischemic stroke


Hospital Revisits for Post-Ischemic Stroke Epilepsy after Acute Stroke Interventions.

J Stroke Cerebrovasc Dis 2021 Oct 20;31(1):106155. Epub 2021 Oct 20.

Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Yale University School of Medicine, 15 York St., LLCI Room 1004B, P.O. Box 208018, New Haven, CT 06520, USA. Electronic address:

Objectives: Improvements in acute stroke care have led to an increase in ischemic stroke survivors, who are at risk for development of post-ischemic stroke epilepsy (PISE). The impact of therapies such as thrombectomy and thrombolysis on risk of hospital revisits for PISE is unclear. We utilized administrative data to investigate the association between stroke treatment and PISE-related visits. Read More

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October 2021

Transcranial Doppler 6 h after Successful Reperfusion as a Predictor of Infarct Volume.

J Stroke Cerebrovasc Dis 2021 Oct 20;31(1):106149. Epub 2021 Oct 20.

Stroke Unit, Neurology Department, Hospital Clínico San Carlos, Calle Profesor Martín Lagos s/n, Madrid, 28040, Spain.

Objectives: The aim of the study is to analyze the hemodynamic changes in the middle cerebral artery (MCA) after endovascular revascularization in acute ischemic stroke (AIS) due to large vessel occlusion and its association with the infarct volume size in the control head CT.

Materials And Methods: Prospective study of patients with AIS due to internal carotid artery terminus or M1 segment of the MCA occlusion, who underwent endovascular treatment with a final TICI 2b-3 score, without concomitant stenosis ≥50% in both cervical carotid arteries. Transcranial Doppler ultrasound (TCD) of both MCAs was carried out at 6 h after the endovascular procedure. Read More

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October 2021

Stent Opening Visualization During Mechanical Thrombectomy; Relationship with the Retrieved Clot and Procedural Success.

J Stroke Cerebrovasc Dis 2021 Oct 20;31(1):106168. Epub 2021 Oct 20.

Department of Radiology, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

Purpose: The angiographic visualization of the stent during mechanical thrombectomy (MT) may provide information regarding the characteristics of the underlying occluding clot, device-clot interaction, and recanalization. The purpose of this study was to evaluate the open stent sign in relation to the retrieved clot and recanalization.

Methodology: 78 patients treated with the stent retriever for acute stroke were retrospectively reviewed. Read More

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October 2021

Impact of heat waves and cold spells on cause-specific mortality in the city of São Paulo, Brazil.

Int J Hyg Environ Health 2021 Oct 20;239:113861. Epub 2021 Oct 20.

Department of Geography, School of Philosophy, Literature and Human Sciences of the University of São Paulo, São Paulo, SP, Brazil; Institute of Advanced Studies, of the University of São Paulo, São Paulo, SP, Brazil. Electronic address:

The impact of heat waves and cold spells on mortality has become a major public health problem worldwide, especially among older adults living in low-to middle-income countries. This study aimed to investigate the effects of heat waves and cold spells under different definitions on cause-specific mortality among people aged ≥65 years in São Paulo from 2006 to 2015. A quasi-Poisson generalized linear model with a distributed lag model was used to investigate the association between cause-specific mortality and extreme air temperature events. Read More

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October 2021

Gender, racial and ethnic disparities in index hospitalization operations for symptomatic carotid stenosis in texas hospitals.

Ann Vasc Surg 2021 Oct 20. Epub 2021 Oct 20.

Division of Vascular Surgery and Endovascular Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine / Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas 77030. Electronic address:

Objective: Recent literature and societal recommendations support early revascularization of symptomatic carotid patients over the traditional six-week period. Nonetheless, the timing of these interventions can vary widely among populations. The goal of this study is to identify any factors influencing carotid revascularization during the index hospitalization for patients with symptomatic disease. Read More

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October 2021

Initial in-hospital heart rate is associated with long-term survival in patients with acute ischemic stroke.

Clin Res Cardiol 2021 Oct 23. Epub 2021 Oct 23.

Department of Neurology, Linkou Chang Gung Memorial Hospital, Taoyuan, and College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Aims: Increased heart rate has been associated with stroke risk and outcomes. The purpose of this study was to explore the long-term prognostic value of initial in-hospital heart rate in patients with acute ischemic stroke (AIS).

Methods: We analyzed data from 21,655 patients with AIS enrolled (January 2010-September 2018) in the Chang Gung Research Database. Read More

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October 2021

Remote but not Distant: a Review on Experimental Models and Clinical Trials in Remote Ischemic Conditioning as Potential Therapy in Ischemic Stroke.

Mol Neurobiol 2021 Oct 22. Epub 2021 Oct 22.

UCIBIO, Applied Molecular Biosciences Unit, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, Campus de Caparica, 2829-526, Caparica, Portugal.

Stroke is one of the main causes of neurological disability worldwide and the second cause of death in people over 65 years old, resulting in great economic and social burden. Ischemic stroke accounts for 85% of total cases, and the approved therapies are based on re-establishment of blood flow, and do not directly target brain parenchyma. Thus, novel therapies are urgently needed. Read More

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October 2021

Carotid artery revascularization using the Walrus balloon guide catheter: safety and feasibility from a US multicenter experience.

J Neurointerv Surg 2021 Oct 22. Epub 2021 Oct 22.

Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, USA

Introduction: The Walrus balloon guide catheter (BGC) is a new generation of BGC, designed to eliminate conventional limitations during mechanical thrombectomy.

Objective: To report a multi-institutional experience using this BGC for proximal flow control (PFC) in the setting of carotid artery angioplasty/stenting (CAS) in elective (eCAS) and tandem strokes (tCAS).

Methods: Prospectively maintained databases at 8 North American centers were queried to identify patients with cervical carotid disease undergoing eCAS/tCAS with a Walrus BGC. Read More

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October 2021

Risk Stratification and Management of Extracranial Carotid Artery Disease.

Cardiol Clin 2021 Nov;39(4):539-549

Richard A. and Susan F. Smith Center for Outcomes Research in Cardiology, Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, 375 Longwood Avenue, 4th Floor, Boston, MA 02215, USA; Harvard Medical School, Boston, MA, USA; Division of Cardiology, Department of Medicine, Beth Israel Deaconess Medical Center, 185 Pilgrim Road, Palmer Building, 4th Floor, Boston, MA 02215, USA. Electronic address:

Stroke is the fifth leading cause of death in the United States and is a leading cause of disability. Extracranial internal carotid artery stenosis is a major cause of ischemic stroke, as it is estimated to cause 8% to 15% of ischemic strokes. It is critical to improve our strategies for stroke prevention and treatment in order to reduce the burden of this disease. Read More

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November 2021

Chemical Constituents of the Leaves of (Persimmon).

Plants (Basel) 2021 Sep 28;10(10). Epub 2021 Sep 28.

Department of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul 02447, Korea.

(persimmon) leaves have long been utilized as traditional medicine for the treatment of ischemic stroke, angina, and hypertension and as a healthy beverage and cosmetic for anti-aging. This study aimed to isolate as many compounds as possible from an ethanol extract of the persimmon leaves to identify the biologically active compounds. The antioxidative effect of the ethyl acetate layer from the ethanol extract of the persimmon leaves was demonstrated by 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and online high-performance liquid chromatography-2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (HPLC-ABTS) analysis. Read More

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September 2021

Sildenafil-Mediated Neuroprotection from Adult to Neonatal Brain Injury: Evidence, Mechanisms, and Future Translation.

Cells 2021 Oct 15;10(10). Epub 2021 Oct 15.

Laboratory of Child Growth and Development, University of Geneva, 1211 Geneva, Switzerland.

Cerebral stroke, traumatic brain injury, and hypoxic ischemic encephalopathy are among the most frequently occurring brain injuries. A complex pathogenesis, characterized by a synergistic interaction between alterations of the cerebrovascular system, cell death, and inflammation, is at the basis of the brain damage that leads to behavioral and neurodevelopmental disabilities in affected subjects. Sildenafil is a selective inhibitor of the enzyme phosphodiesterase 5 (PDE5) that is able to cross the blood-brain barrier. Read More

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October 2021

Acute Inflammation in Cerebrovascular Disease: A Critical Reappraisal with Focus on Human Studies.

Life (Basel) 2021 Oct 17;11(10). Epub 2021 Oct 17.

Department of Neurology, Centro Hospitalar Universitário São João, 4200-319 Porto, Portugal.

Recent attention has been focused on the field of inflammatory biomarkers associated with vascular disorders, regarding diagnosis, prognosis, and possible therapeutical targets. In this study, we aimed to perform a comprehensive review of the literature regarding the use of inflammatory biomarkers in stroke patients. We searched studies that evaluated inflammation biomarkers associated with Cerebrovascular Disease (CVD), namely, ischemic Stroke (IS), Intracerebral Hemorrhage (ICH) and Cerebral Venous Thrombosis (CVT). Read More

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October 2021

A Novel Phenylpyrrolidine Derivative: Synthesis and Effect on Cognitive Functions in Rats with Experimental Ishemic Stroke.

Molecules 2021 Oct 11;26(20). Epub 2021 Oct 11.

Department of Medicinal Chemistry and Toxicology, Pirogov Russian National Research Medical University, 117997 Moscow, Russia.

We performed an in silico, in vitro, and in vivo assessment of a potassium 2-[2-(2-oxo-4-phenylpyrrolidin-1-yl) acetamido]ethanesulfonate (compound ) as a potential prodrug for cognitive function improvement in ischemic brain injury. Using in silico methods, we predicted the pharmacological efficacy and possible safety in rat models. In addition, in silico data showed neuroprotective features of compound , which were further supported by in vitro experiments in a glutamate excitotoxicity-induced model in newborn rat cortical neuron cultures. Read More

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October 2021

Fibromuscular Dysplasia/Carotid Web in Angio-CT Imaging: A Rare Cause of Ischemic Stroke.

Medicina (Kaunas) 2021 Oct 15;57(10). Epub 2021 Oct 15.

Department of Neurology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-752 Katowice, Poland.

: Carotid web (CaW) is an intimal variant of fibromuscular dysplasia and may constitute as one of rare causes of acute ischemic stroke (AIS). The objective of this study was to determine the prevalence of CaW in patients with AIS or transient ischemic attack (TIA) based on head/neck CT angiography (CTA) in a Polish cohort study. : A retrospective study was performed by analyzing 1480 electronic clinical and imaging data regarding patients with AIS or TIA, hospitalized in the years 2018-2020 in the authors' institution. Read More

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October 2021

MiRNA: Involvement of the MAPK Pathway in Ischemic Stroke. A Promising Therapeutic Target.

Medicina (Kaunas) 2021 Oct 1;57(10). Epub 2021 Oct 1.

IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy.

Ischemic stroke (IS) is a cerebrovascular disease with a high rate of disability and mortality. It is classified as the second leading cause of death that arises from the sudden occlusion of small vessels in the brain with consequent lack of oxygen and nutrients in the brain tissue. Following an acute ischemic event, the cascade of events promotes the activation of multiple signaling pathways responsible for irreversible neuronal damage. Read More

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October 2021

Plasma Anion Gap and Risk of In-Hospital Mortality in Patients with Acute Ischemic Stroke: Analysis from the MIMIC-IV Database.

J Pers Med 2021 Oct 4;11(10). Epub 2021 Oct 4.

Division of Hematology and Oncology Medicine, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.

We aimed to investigate the association between the plasma anion gap (AG) and in-hospital mortality among patients with acute ischemic stroke (AIS). In total, 1236 AIS patients were enrolled using the Medical Information Mart for Intensive Care Database IV. Primary outcome was in-hospital mortality. Read More

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October 2021

Incidence and Transition of Acute Kidney Injury, Acute Kidney Disease to Chronic Kidney Disease after Acute Type A Aortic Dissection Surgery.

J Clin Med 2021 Oct 18;10(20). Epub 2021 Oct 18.

Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou Medical Center, Taoyuan City 33305, Taiwan.

Acute kidney disease (AKD) is the persistence of renal injury between days 8 and 90 after an initial acute kidney injury (AKI). In this study, we aimed to explore the incidence of AKD, the association between AKD, and patient outcomes after acute type A aortic dissection (type A AAD) surgery. We identified 696 participants who underwent type A AAD surgery. Read More

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October 2021

Influence of Estimated Glomerular Filtration Rate on Clinical Outcomes in Patients with Acute Ischemic Stroke Not Receiving Reperfusion Therapies.

J Clin Med 2021 Oct 14;10(20). Epub 2021 Oct 14.

Department of Neurology, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Korea.

Background: We aimed to determine whether estimated glomerular filtration rate (eGFR) is an independent predictor of clinical outcomes in patients with acute ischemic stroke not treated with reperfusion therapy.

Methods: A total of 1420 patients with acute ischemic stroke from a hospital-based stroke registry were included in this study. Patients managed with intravenous thrombolysis or endovascular reperfusion therapy were excluded. Read More

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October 2021

Lack of Sex Disparity in Oral Anticoagulation in Atrial Fibrillation Patients Presenting with Ischemic Stroke in a Rural Population.

J Clin Med 2021 Oct 12;10(20). Epub 2021 Oct 12.

Department of Neurology, Neuroscience Institute, Geisinger Health System, 100 North Academy Ave, Danville, PA 17822, USA.

Various studies on oral anticoagulants (OAC) use among atrial fibrillation (AF) patients have shown high rates of undertreatment and the presence of sex disparity. This study used the 'Geisinger Neuroscience Ischemic Stroke' (GNSIS) database to examine sex differences in OAC treatment among ischemic stroke patients with the pre-event diagnosis of AF in rural Pennsylvania between 2004 and 2019. We examined sex disparities in OAC undertreatment and associated risks based on age group and ischemic stroke year. Read More

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October 2021

High Mobility Group Box 1 Protein in Cerebral Thromboemboli.

Int J Mol Sci 2021 Oct 19;22(20). Epub 2021 Oct 19.

Department of Neurology, University Hospital Würzburg, 97080 Würzburg, Germany.

High-mobility group box 1 protein (HMGB1) is a damage-associated molecular pattern (DAMP) involved in neutrophil extracellular trap (NET) formation and thrombosis. NETs are regularly found in cerebral thromboemboli. We here analyzed associated HMGB1 expression in human thromboemboli retrieved via mechanical thrombectomy from 37 stroke patients with large vessel occlusion. Read More

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October 2021

Defective Uteroplacental Vascular Remodeling in Preeclampsia: Key Molecular Factors Leading to Long Term Cardiovascular Disease.

Int J Mol Sci 2021 Oct 18;22(20). Epub 2021 Oct 18.

Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul 06125, Korea.

Preeclampsia is a complex hypertensive disorder in pregnancy which can be lethal and is responsible for more than 70,000 maternal deaths worldwide every year. Besides the higher risk of unfavorable obstetric outcomes in women with preeclampsia, another crucial aspect that needs to be considered is the association between preeclampsia and the postpartum cardiovascular health of the mother. Currently, preeclampsia is classified as one of the major risk factors of cardiovascular disease (CVD) in women, which doubles the risk of venous thromboembolic events, stroke, and ischemic heart disease. Read More

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October 2021

Mitochondrial Strokes: Diagnostic Challenges and Chameleons.

Genes (Basel) 2021 Oct 19;12(10). Epub 2021 Oct 19.

Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology and The National Hospital for Neurology and Neurosurgery, London WC1N 3BG, UK.

Mitochondrial stroke-like episodes (SLEs) are a hallmark of mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS). They should be suspected in anyone with an acute/subacute onset of focal neurological symptoms at any age and are usually driven by seizures. Suggestive features of an underlying mitochondrial pathology include evolving MRI lesions, often originating within the posterior brain regions, the presence of multisystemic involvement, including diabetes, deafness, or cardiomyopathy, and a positive family history. Read More

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October 2021

Isolation of RNA from Acute Ischemic Stroke Clots Retrieved by Mechanical Thrombectomy.

Genes (Basel) 2021 Oct 14;12(10). Epub 2021 Oct 14.

Canon Stroke and Vascular Research Center, University at Buffalo, Buffalo, NY 14203, USA.

Mechanical thrombectomy (MT) for large vessel acute ischemic stroke (AIS) has enabled biologic analyses of resected clots. While clot histology has been well-studied, little is known about gene expression within the tissue, which could shed light on stroke pathophysiology. In this methodological study, we develop a pipeline for obtaining useful RNA from AIS clots. Read More

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October 2021

Overview of Acute Ischemic Stroke Evaluation and Management.

Biomedicines 2021 Oct 16;9(10). Epub 2021 Oct 16.

Department of Neurology, Ochsner Louisiana State University Health Sciences Center, Shreveport, LA 71103, USA.

Stroke is a major contributor to death and disability worldwide. Prior to modern therapy, post-stroke mortality was approximately 10% in the acute period, with nearly one-half of the patients developing moderate-to-severe disability. The most fundamental aspect of acute stroke management is "time is brain". Read More

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October 2021

Histone Deacetylases and Their Isoform-Specific Inhibitors in Ischemic Stroke.

Biomedicines 2021 Oct 11;9(10). Epub 2021 Oct 11.

Laboratory of Molecular Neurobiology, Academy of Biology and Biotechnology, Southern Federal University, pr. Stachki 194/1, Rostov-on-Don 344090, Russia.

Cerebral ischemia is the second leading cause of death in the world and multimodal stroke therapy is needed. The ischemic stroke generally reduces the gene expression due to suppression of acetylation of histones H3 and H4. Histone deacetylases inhibitors have been shown to be effective in protecting the brain from ischemic damage. Read More

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October 2021

Relationships of Ischemic Stroke Occurrence and Outcome with Gene Variants Encoding Enzymes of Tryptophan Metabolism.

Biomedicines 2021 Oct 11;9(10). Epub 2021 Oct 11.

Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, H-6725 Szeged, Hungary.

Ischemic stroke is among the leading causes of mortality and long-term disability worldwide. Among stroke risk factors the importance of genetic background is gaining interest. There is a growing body of evidence of changes of metabolite levels and enzyme activities involved in the conversion of Trp during the course of cerebral ischemia. Read More

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October 2021

Treatment Efficacy Analysis in Acute Ischemic Stroke Patients Using In Silico Modeling Based on Machine Learning: A Proof-of-Principle.

Biomedicines 2021 Sep 29;9(10). Epub 2021 Sep 29.

Department of Radiology, University of Calgary, Calgary, AB T2N 2T9, Canada.

Interventional neuroradiology is characterized by engineering- and experience-driven device development with design improvements every few months. However, clinical validation of these new devices requires lengthy and expensive randomized controlled trials. This contribution proposes a machine learning-based in silico study design to evaluate new devices more quickly with a small sample size. Read More

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September 2021

Identifying Thrombus on Non-Contrast CT in Patients with Acute Ischemic Stroke.

Diagnostics (Basel) 2021 Oct 16;11(10). Epub 2021 Oct 16.

Department of Clinical Neurosciences, University of Calgary, Calgary, AB T2N 1N4, Canada.

The hyperdense sign is a marker of thrombus in non-contrast computed tomography (NCCT) datasets. The aim of this work was to determine optimal Hounsfield unit (HU) thresholds for thrombus segmentation in thin-slice non-contrast CT (NCCT) and use these thresholds to generate 3D thrombus models. Patients with thin-slice baseline NCCT (≤2. Read More

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October 2021

Machine Learning-Based Three-Month Outcome Prediction in Acute Ischemic Stroke: A Single Cerebrovascular-Specialty Hospital Study in South Korea.

Diagnostics (Basel) 2021 Oct 15;11(10). Epub 2021 Oct 15.

Department of Neurosurgery, Pohang Stroke and Spine Hospital, Pohang 37659, Korea.

Background: Functional outcomes after acute ischemic stroke are of great concern to patients and their families, as well as physicians and surgeons who make the clinical decisions. We developed machine learning (ML)-based functional outcome prediction models in acute ischemic stroke.

Methods: This retrospective study used a prospective cohort database. Read More

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October 2021

Metabolomic Profiles of Men and Women Ischemic Stroke Patients.

Diagnostics (Basel) 2021 Sep 28;11(10). Epub 2021 Sep 28.

School of Medicine Greenville, University of South Carolina, Greenville, SC 29605, USA.

Background: Stroke is known to affect both men and women; however, incidence and outcomes differ between them. Therefore, the discovery of novel, sex-specific, blood-based biomarkers for acute ischemic stroke (AIS) patients has the potential to enhance the understanding of the etiology of this deadly disease in the content of sex. The objective of this study was to identify serum metabolites associated with male and female AIS patients. Read More

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September 2021