170,277 results match your criteria ischaemic heart

Mortality and cause of death in patients with AAV/PAN in Australia-a population-based study.

Rheumatology (Oxford) 2021 Jun 12. Epub 2021 Jun 12.

School of Medicine, University of Western Australia, Perth, Australia.

Objectives: We compared survival and causes of death in Western Australian (WA) anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and polyarteritis nodosa (PAN) patients with controls and the WA population.

Methods: In this data linkage study, we identified patients with incident AAV/PAN and age, sex and temporally matched controls 1980 - 2014 from the WA Rheumatic Disease Epidemiological Registry. Survival analyses and time-varying analyses were performed. Read More

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AIM2-driven inflammasome activation in heart failure.

Cardiovasc Res 2021 Jun 12. Epub 2021 Jun 12.

Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary.

Aims: Interleukin-1β (IL-1β) is an important pathogenic factor in cardiovascular diseases including chronic heart failure (HF). The CANTOS trial highlighted that inflammasomes as primary sources of IL-1 β are promising new therapeutic targets in cardiovascular diseases. Therefore, we aimed to assess inflammasome activation in failing hearts to identify activation patterns of inflammasome subtypes as sources of IL-1β. Read More

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Salt reduction to prevent hypertension: the reasons of the controversy.

Eur Heart J 2021 Jun 12. Epub 2021 Jun 12.

Wolfson Institute of Preventive Medicine, Barts and The London School of Medicine & Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

There is a causal relationship between dietary salt intake and blood pressure. A reduction in salt intake from the current world average of ∼10 g/day to the WHO recommended level of <5 g/day, lowers blood pressure and reduces the risk of cardiovascular disease and all-cause mortality. However, a few cohort studies have claimed that there is a J-shaped relationship between salt intake and cardiovascular risk, i. Read More

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Monocyte subset distribution and surface expression of HLA-DR and CD14 in patients after cardiopulmonary resuscitation.

Sci Rep 2021 Jun 11;11(1):12403. Epub 2021 Jun 11.

Department of Cardiology and Angiology I, University Heart Center Freiburg - Bad Krozingen, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Hugstetter Str. 55, 79106, Freiburg im Breisgau, Germany.

Systemic inflammation is a major feature of the post-cardiac arrest syndrome. The three monocyte subpopulations are thought to play an important role in this inflammatory state because they are endowed with numerous pattern recognition receptors, such as CD14, that have been associated with ischemia-reperfusion injury. By contrast, an exaggerated antiinflammatory response has also been described following cardiac arrest, which may be mediated by downregulation of antigen presentation receptor HLA-DR. Read More

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Knockdown of lncRNA Abhd11os attenuates myocardial ischemia/reperfusion injury by inhibiting apoptosis in cardiomyocytes.

J Cardiovasc Pharmacol 2021 May 31. Epub 2021 May 31.

Department of Children's Heart Center, Henan Provincial People's Hospital, Department of Children's Heart Center of Fuwai Central China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China.

Abstract: Long non-coding RNA (lncRNA) is one potential target for the treatment of various disorders. Here, we explored the role of Abhd11os in ischemia/reperfusion-induced myocardial injury, and preliminarily explored the regulatory mechanisms. Relative Abhd11os expression level was examined by qRT-PCR. Read More

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Anomalous Aortic Origin of the Coronary Arteries - State of the Art Management and Surgical Techniques.

Semin Thorac Cardiovasc Surg Pediatr Card Surg Annu 2021 ;24:85-94

Coronary Artery Anomalies Program, Texas Children's Hospital; Houston, Texas; Division of Congenital Heart Surgery, Michael E. DeBakey Department of Surgery, Texas Children's Hospital, Baylor College of Medicine; Houston, Texas. Electronic address:

Anomalous aortic origin of a coronary artery (AAOCA) can be associated with myocardial ischemia and sudden cardiac arrest. We describe and compare the management and surgical techniques for patients with AAOCA. Patients presenting to the Coronary Artery Anomalies Program are evaluated and managed following a standardized approach. Read More

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January 2021

Overexpression of PLK1 relieved the myocardial ischemia-reperfusion injury of rats through inducing the mitophagy and regulating the p-AMPK/FUNDC1 axis.

Bioengineered 2021 Dec;12(1):2676-2687

Department of Cardiovascular Internal Medicine, The Second Affiliated Hospital of Guizhou Medical University, Kaili City, Guizhou Province, China.

Myocardial cell injury caused by myocardial ischemia and reperfusion is one of the main causes of the occurrence and development of heart disease. Recent study has shown that inducing mitophagy of cardiomyocytes is a crucial method to alleviate ischemia-reperfusion injury. While, Polo-like kinase 1 (PLK1) can induce the mitophagy of breast cancer cells. Read More

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December 2021

Reperfused vs. Non-reperfused Myocardial Infarction: When to Use Which Model.

Am J Physiol Heart Circ Physiol 2021 Jun 11. Epub 2021 Jun 11.

Department of Pharmacology, Faculty of Medicine, Dalhousie University, Saint John, NB E2L 4L5, Canada.

There is a lack of understanding in the cardiac remodeling field regarding the use of non-reperfused MI and reperfused MI in animal models of myocardial infarction (MI). This Perspectives summarizes the consensus of the authors regarding how to select the optimum model for your experiments and is a part of ongoing efforts to establish rigor and reproducibility in cardiac physiology research. Read More

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Impact Of Chronic Kidney Disease On The Pharmacodynamic And Pharmacokinetic Effects Of Ticagrelor In Patients With Diabetes Mellitus And Coronary Artery Disease.

Eur Heart J Cardiovasc Pharmacother 2021 Jun 11. Epub 2021 Jun 11.

University of Florida College of Medicine-Jacksonville, Jacksonville, FL, USA.

Aims: Patients with diabetes mellitus (DM) and chronic kidney disease (CKD) are at increased risk of atherothrombotic events. Ticagrelor reduces ischaemic events compared to clopidogrel, with the greatest risk reduction in patients with both DM and CKD. How CKD status affects the pharmacodynamic (PD) and pharmacokinetic (PK) profiles of different ticagrelor maintenance dose regimens in patients with DM is unknown. Read More

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Progress in cardiac research - from rebooting cardiac regeneration to a complete cell atlas of the heart.

Cardiovasc Res 2021 Jun 11. Epub 2021 Jun 11.

Institute for Cardiovascular Prevention (IPEK), LMU Munich, DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, and Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

We review some of the important discoveries and advances made in basic and translational cardiac research in 2020. For example, in the field of myocardial infarction (MI), new aspects of autophagy and the importance of eosinophils were described. Novel approaches such as a glycocalyx mimetic were used to improve cardiac recovery following MI. Read More

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Current Updates on Potential Role of Flavonoids in Hypoxia/Reoxygenation Cardiac Injury Model.

Cardiovasc Toxicol 2021 Jun 10. Epub 2021 Jun 10.

Programme of Biomedicine, School of Health Sciences (PPSK), Universiti Sains Malaysia, Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia.

Clinically, timely reperfusion strategies to re-establish oxygenated blood flow in ischemic heart diseases seem to salvage viable myocardium effectively. Despite the remarkable improvement in cardiac function, reperfusion therapy could paradoxically trigger hypoxic cellular injury and dysfunction. Experimental laboratory models have been developed over the years to explain better the pathophysiology of cardiac ischemia-reperfusion injury, including the in vitro hypoxia-reoxygenation cardiac injury model. Read More

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Endovascular treatment of coronary subclavian steal syndrome: a case series highlighting the diagnostic usefulness of a multimodality imaging approach.

Eur Heart J Case Rep 2021 Mar 29;5(3):ytab056. Epub 2021 Mar 29.

Department of Cardiology, Instituto Cardiovascular, Hospital Clínico San Carlos, C/Profesor Martín Lagos S/N, 28040 Madrid, Spain.

Background: Coronary subclavian steal syndrome (CSSS) is an uncommon complication observed in patients after coronary artery bypass surgery with left internal mammary artery (LIMA) grafts. It is defined as coronary ischaemia due to reversal flow from the LIMA to the left subclavian artery (SA) when a proximal left SA stenosis is present. In practice, the entire clinical spectrum of ischaemic heart disease, ranging from asymptomatic patients to acute myocardial infarction, may be encountered. Read More

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A case report of takotsubo syndrome complicated by ischaemic stroke: the clinical dilemma of anticoagulation.

Eur Heart J Case Rep 2021 Mar 15;5(3):ytab051. Epub 2021 Mar 15.

Cardiothoracic and Vascular Department, Cardiology Unit, University Hospital "San Giovanni di Dio e Ruggi d'Aragona", Heart Tower-Room 807, Largo Città d'Ippocrate, 84131 Salerno, Italy.

Background: Takotsubo syndrome (TTS) is an acute and transient heart failure syndrome due to reversible myocardial dysfunction characterized by a wide spectrum of possible clinical scenarios. About one-fifth of TTS patients experience adverse in-hospital events. Thromboembolic complications, especially stroke, have been reported, albeit in a minority of patients. Read More

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Current Developments on the Role of α-Adrenergic Receptors in Cognition, Cardioprotection, and Metabolism.

Dianne M Perez

Front Cell Dev Biol 2021 25;9:652152. Epub 2021 May 25.

The Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, United States.

The α-adrenergic receptors (ARs) are G-protein coupled receptors that bind the endogenous catecholamines, norepinephrine, and epinephrine. They play a key role in the regulation of the sympathetic nervous system along with β and α-AR family members. While all of the adrenergic receptors bind with similar affinity to the catecholamines, they can regulate different physiologies and pathophysiologies in the body because they couple to different G-proteins and signal transduction pathways, commonly in opposition to one another. Read More

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The use of near-infrared spectroscopy in the diagnosis of peripheral artery disease: A systematic review.

Vascular 2021 Jun 10:17085381211025174. Epub 2021 Jun 10.

70309Kaunas University of Technology, Kaunas, Lithuania.

Background: Peripheral arterial disease is a stenosis or occlusion of peripheral arteries that results in compromised blood flow and muscle ischemia. The available diagnostic methods are mostly used to measure and visualize blood flow and are not useful in the evaluation of perfusion, especially in diabetic patients, which is now considered to be a research priority by most of the vascular societies around the world as this is still a relatively poorly studied phenomenon.

Objective: The aim of this review is to explore the clinical significance of muscle tissue oxygenation monitoring in lower-extremity peripheral artery disease diagnosis using the near-infrared spectroscopy method. Read More

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Activation of the ATF6 (Activating Transcription Factor 6) Signaling Pathway in Neurons Improves Outcome After Cardiac Arrest in Mice.

J Am Heart Assoc 2021 Jun 11:e020216. Epub 2021 Jun 11.

Department of Anesthesiology Center for Perioperative Organ Protection Duke University Medical Center Durham NC.

Background Ischemia/reperfusion injury impairs proteostasis, and triggers adaptive cellular responses, such as the unfolded protein response (UPR), which functions to restore endoplasmic reticulum homeostasis. After cardiac arrest (CA) and resuscitation, the UPR is activated in various organs including the brain. However, the role of the UPR in CA has remained largely unknown. Read More

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Levels of bioactive adrenomedullin in plasma and cerebrospinal fluid in relation to delayed cerebral ischemia in patients after aneurysmal subarachnoid hemorrhage: A prospective observational study.

J Neurol Sci 2021 Jun 5;427:117533. Epub 2021 Jun 5.

Department of Neurosurgery, RWTH Aachen University Hospital, Aachen, Germany. Electronic address:

Objectives: Adrenomedullin (ADM) has been identified as a promising biomarker of mortality and outcome in sepsis, heart failure and after major surgery. A recently developed assay specific for bioactive adrenomedullin (bio-ADM) has not yet been assessed in aneurysmal subarachnoid hemorrhage (aSAH). The objective of this prospective trial was to assess the time course of bio-ADM after aSAH in relation to the development of delayed cerebral ischemia (DCI) and its association with clinical outcome. Read More

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Extracellular vesicles from patients with Acute Coronary Syndrome impact on ischemia-reperfusion injury.

Pharmacol Res 2021 Jun 7;170:105715. Epub 2021 Jun 7.

Department of Medical Sciences, University of Turin, Turin, Italy. Electronic address:

The relevance of extracellular vesicles (EV) as mediators of cardiac damage or recovery upon Ischemia Reperfusion Injury (IRI) and Remote Ischemic PreConditioning (RIPC) is controversial. This study aimed to investigate whether serum-derived EV, recovered from patients with Acute Coronary Syndrome (ACS) and subjected to the RIPC or sham procedures, may be a suitable therapeutic approach to prevent IRI during Percutaneous-Coronary-Intervention (PCI). A double-blind, randomized, sham-controlled study (NCT02195726) has been extended, and EV were recovered from 30 patients who were randomly assigned (1:1) to undergo the RIPC- (EV-RIPC) or sham-procedures (EV-naive) before PCI. Read More

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Large, Hormonally Active Primary Cardiac Paraganglioma: Diagnosis and Management.

Ann Thorac Surg 2021 Jun 7. Epub 2021 Jun 7.

Department of Cardiovascular Surgery, Houston Methodist Hospital. Electronic address:

We describe a 26-year-old woman presenting with chest pain and evidence of coronary ischemia. Echocardiography revealed a large left ventricular mass initially deemed unresectable at her initial institution. Investigation revealed a dopamine-secreting primary cardiac paraganglioma (PCP) encompassing vital cardiac architecture. Read More

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Contemporary Medical Management of Peripheral Artery Disease.

Circ Res 2021 Jun 10;128(12):1868-1884. Epub 2021 Jun 10.

Heart and Vascular Center, Dartmouth-Hitchcock Medical Center, Geisel School of Medicine at Dartmouth, Lebanon, NH (M.A.C.).

Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis. Modifiable risk factors including cigarette smoking, dyslipidemia, diabetes, poor diet quality, obesity, and physical inactivity, along with underlying genetic factors contribute to lower extremity atherosclerosis. Patients with PAD often have coexistent coronary or cerebrovascular disease, and increased likelihood of major adverse cardiovascular events, including myocardial infarction, stroke and cardiovascular death. Read More

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Prognostic Role of High Sensitivity C-Reactive Protein in Patients With Acute Myocardial Infarction.

Front Cardiovasc Med 2021 24;8:659446. Epub 2021 May 24.

Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.

High sensitivity CRP (hs-CRP) has attracted intense interest in risk assessment. We aimed to explore its prognostic value in patients with acute myocardial infarction (AMI). We enrolled 4,504 consecutive AMI patients in this prospective cohort study. Read More

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Postoperative low molecular weight heparin bridging treatment for patients at high risk of arterial thromboembolism (PERIOP2): double blind randomised controlled trial.

BMJ 2021 06 9;373:n1205. Epub 2021 Jun 9.

Department of Medicine, McGill University, Montreal, QC, Canada.

Objective: To determine the efficacy and safety of dalteparin postoperative bridging treatment versus placebo for patients with atrial fibrillation or mechanical heart valves when warfarin is temporarily interrupted for a planned procedure.

Design: Prospective, double blind, randomised controlled trial.

Setting: 10 thrombosis research sites in Canada and India between February 2007 and March 2016. Read More

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Remote Ischemic Preconditioning Protects Against Endothelial Dysfunction in a Human Model of Systemic Inflammation: A Randomized Clinical Trial.

Arterioscler Thromb Vasc Biol 2021 Jun 10:ATVBAHA121316388. Epub 2021 Jun 10.

Periodontology Unit, UCL Eastman Dental Institute and Hospital, University College London, United Kingdom. (M.O., Y.L., F.D.).

Objective: Inflammation, oxidative stress, and endothelial dysfunction are known to contribute to ischemia-reperfusion injury. Remote ischemic preconditioning (RIPC) protects from endothelial dysfunction and the damage induced by ischemia-reperfusion. Using intensive periodontal treatment (IPT), an established human model of acute systemic inflammation, we investigated whether RIPC prevents endothelial dysfunction and modulates systemic levels of inflammation and oxidative stress. Read More

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Therapeutic Properties of Highly Selective β-blockers With or Without Additional Vasodilator Properties: Focus on Bisoprolol and Nebivolol in Patients With Cardiovascular Disease.

Cardiovasc Drugs Ther 2021 Jun 9. Epub 2021 Jun 9.

Cardiometabolic Care, GCC Medical Affairs, Merck Serono Middle East FZ-LLC, Riyadh, Saudi Arabia.

Bisoprolol and nebivolol are highly selective β-adrenoceptor antagonists, with clinical indications in many countries within the management of heart failure with reduced left ventricular ejection fraction (HFrEF), ischaemic heart disease (IHD), and hypertension. Nebivolol has additional vasodilator actions, related to enhanced release of NO in the vascular wall. In principle, this additional mechanism compared with bisoprolol might lead to more potent vasodilatation, which in turn might influence the effectiveness of nebivolol in the management of HFrEF, IHD and hypertension. Read More

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[Current aspects of heart-kidney interactions : Summary of important clinical studies from 2020].

Herz 2021 Jun 9. Epub 2021 Jun 9.

Klinik für Innere Medizin III, Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin, IMED, Universitätsklinikum des Saarlandes, Homburg, Deutschland.

Patients with chronic kidney diseases show an increased cardiovascular morbidity and mortality. Last year a number of important studies on heart-kidney interaction were published, which are summarized and discussed in this article. In the DAPA-CKD study and the SCORED study two different sodium-glucose linked transporter 2 (SGLT2) inhibitors (dapagliflozin and sotagliflozin) were found to improve the prognosis of patients with chronic kidney diseases with and without diabetes. Read More

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A Novel Multiparameter Scoring Model for Noninvasive Early Prediction of Ischemic Colitis: A Multicenter, Retrospective, and Real-World Study.

Clin Transl Gastroenterol 2021 Jun 9;12(6):e00370. Epub 2021 Jun 9.

Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Introduction: Ischemic colitis (IC) is a common gastrointestinal ischemic disease caused by hypoperfusion or reperfusion injury. However, there are few studies on risk factors associated with poor prognoses of the disease. This study aimed to determine the predictors of poor prognoses in patients with IC and establish a prognostic scoring method with good internal and external validity for identifying severe cases in an early stage. Read More

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Stress myocardial blood flow and revascularization in chronic coronary artery disease.

J Nucl Cardiol 2021 Jun 8. Epub 2021 Jun 8.

Turku PET Centre, Turku University Hospital and University of Turku, Turku, Finland.

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Myocardial hypoxic stress mediates functional cardiac extracellular vesicle release.

Eur Heart J 2021 Jun 9. Epub 2021 Jun 9.

DZHK, Munich Partner Site, Ismaninger Str. 22, 81675 Munich, Germany.

Aims : Increased shedding of extracellular vesicles (EVs)-small, lipid bilayer-delimited particles with a role in paracrine signalling-has been associated with human pathologies, e.g. atherosclerosis, but whether this is true for cardiac diseases is unknown. Read More

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A novel Danshensu/tetramethylpyrazine protects against Myocardial Ischemia Reperfusion Injury in rats.

Int J Med Sci 2021 13;18(12):2716-2724. Epub 2021 May 13.

Department of Pharmacology, Harbin Medical University-Daqing, Daqing, 163319, China.

A new Danshensu/tetramethylpyrazine derivative (ADTM) with cardio-protection effects such as antioxidant, arterial relaxation, pro-angiogenesis and antiplatelet activities. Platelet activating factor receptor (PAFR) plays a key role in myocardial ischemia reperfusion (MIR) injury. This study aims to investigate the protective role of ADTM in MIR injury and clarify the potential role of PAFR. Read More

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