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Ligneous conjunctivitis associated with type I plasminogen deficiency: A rare case.

Eur J Ophthalmol 2021 Jul 24:11206721211018373. Epub 2021 Jul 24.

Opthalmology Department,"Venizeleio" General Hospital of Heraklion, Heraklion, Greece.

Ligneous conjunctivitis is a rare form of chronic, recurrent conjunctivitis characterized by wood-like, fibrinous pseudomembranes, which may be associated with systemic disease manifestations. It has been associated with congenital plasminogen (PLG) deficiency that is inherited with an autosomal recessive pattern due to mutations in the PLG gene and a variety of other genes, leading to disturbed wound healing. In this case report, we present the clinical, laboratory, and histopathological findings of a 36-year-old female patient who presented at the ophthalmology department with complaints of redness, irritation for the previous few weeks, and appearance of membranous lesions mainly on the tarsal conjunctivae. Read More

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Outcomes of MPFL reconstruction with tibial tubercle transfer for recurrent patellar instability with high grade trochlear dysplasia in Indian population.

J Clin Orthop Trauma 2021 Sep 1;20:101490. Epub 2021 Jul 1.

Institute of Advanced Orthopaedics, MOSC Medical College, Kolenchery, 682311, Ernakulam, Kerala, India.

Background: Patellar instability is a painful condition which affects the quality of life and mobility of young individuals. The aim of this study is to observe the results of medial patello-femoral ligament reconstruction with hamstring autograft along with a modified Fulkerson osteotomy, for recurrent instability of patella with high-grade trochlear dysplasia in Indian population.

Materials & Methods: We conducted a prospective observational study of 26 knees (21 patients) who attended our outpatient department from June 2014 to February 2019, with recurrent instability of the patella and high-grade trochlear dysplasia. Read More

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September 2021

Protein Causes of Urticaria and Dermatitis.

Immunol Allergy Clin North Am 2021 Aug 5;41(3):481-491. Epub 2021 Jun 5.

Department of Dermatology, University of California, San Francisco, Third and Fourth Floors, 1701 Divisadero St, San Francisco, CA 94115, USA; Department of Dermatology, Palo Alto Foundation Medical Group, 701 East El Camino Real (31-104), Mountain View, CA 94040, USA. Electronic address:

Protein contact dermatitis is a cutaneous hypersensitivity reaction after chronic, recurrent exposure or chronic irritation to animal or plant protein. Although the pathophysiological mechanisms underlying protein contact dermatitis are not well characterized, protein contact dermatitis is thought to be caused by combined type I/IV-mediated, type-1 mediated, or a Langerhans cell immunoglobulin E-mediated delayed hypersensitivity reaction. This chapter reviews the epidemiology, pathogenesis, clinical features, common protein allergens, diagnostic process, treatment options, and prognosis of protein contact dermatitis. Read More

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Successful management of recurrent irritational fibroma and associated residual soft tissue defect in the posterior teeth through single-stage surgery: A rare case report.

J Indian Soc Periodontol 2021 May-Jun;25(3):258-261. Epub 2021 May 3.

Department of Periodontology and Oral Implantology, Surendera Dental College and Research Institute, Sri Ganganagar, Rajasthan, India.

Inflammatory fibrous hyperplasia, pyogenic granuloma, peripheral ossifying fibroma, irritational fibroma (IF), peripheral giant cell granuloma, etc., are the different types of reactive gingival lesions that may occur in response to mild chronic irritation associated with subgingival factors, root remnant, iatrogenic factors, and trauma. Gingival IF is one of the most common reactive lesions and is usually sessile in nature, and its size is usually not more than 1. Read More

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Duration of total contact casting for resolution of acute Charcot foot: a retrospective cohort study.

J Foot Ankle Res 2021 Jun 15;14(1):44. Epub 2021 Jun 15.

Discipline of Podiatry, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, Victoria, 3086, Australia.

Background: Charcot neuroarthropathy (Charcot foot) is a highly destructive joint disease of the foot and ankle. If there is delayed diagnosis and treatment, it can lead to gross deformity, instability, recurrent ulceration and/or amputation. Total contact casting (TCC) is a treatment commonly used to immobilise the foot and ankle to prevent trauma, further destruction and preserve the foot structure during the inflammatory phase. Read More

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Carcinomatous meningitis from recurrent glassy cell carcinoma of the uterine cervix-A case report.

J Obstet Gynaecol Res 2021 Jun 14. Epub 2021 Jun 14.

Department of Obstetrics and Gynecology, St. Mary's Hospital, Kurume, Japan.

Carcinomatous meningitis presents with a variety of neurological symptoms and has a poor prognosis. We encountered a case of carcinomatous meningitis from cervical cancer. A 30-year-old patient was diagnosed with cervical cancer (glassy cell carcinoma), stage IIB. Read More

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A novel treatment of intertrigo in athletes and overweight subjects.

J Cosmet Dermatol 2021 Apr;20 Suppl 1:23-27

Dermatology Clinic, University of Catania, Catania, Italy.

Background: Intertrigo is a recurrent inflammatory dermatosis involving large/small body folds. Skin barrier products represent the mainstay of treatment in uncomplicated mild/moderate intertrigo.

Aims: To assess by clinical and instrumental evaluation the efficacy and tolerability of a new barrier spray containing zinc gluconate-taurine complex and zinc oxide combined with panthenol, glycerin, and Shea (Butyrospermum parkii) butter in mild-to-moderate intertrigo in athletes and overweight subjects. Read More

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Arthroscopic bone block stabilisation procedures for glenoid bone loss in anterior glenohumeral instability: A systematic review of clinical and radiological outcomes.

Orthop Traumatol Surg Res 2021 Apr 29:102949. Epub 2021 Apr 29.

Kansas City University of Medicine and Biosciences, Kansas City, MO, USA.

Introduction: Recurrent shoulder instability is frequently associated with glenohumeral bone loss. Recently there has been a surge of interest in arthroscopically performed bone block procedures. The aim of this systematic review was to determine the clinical and radiological outcomes of arthroscopic glenoid bone block stabilisation for recurrent anterior dislocation. Read More

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The Influence of Irrigation during the Finishing and Polishing of Composite Resin Restorations-A Systematic Review of In Vitro Studies.

Materials (Basel) 2021 Mar 29;14(7). Epub 2021 Mar 29.

Institute of Integrated Clinical Practice, Faculty of Medicine, University of Coimbra, 3000-075 Coimbra, Portugal.

The surface smoothness of composite restorations affects not only their esthetic appearance but also other properties. Thus, rough surfaces can lead to staining, plaque accumulation, gingival irritation, recurrent caries, abrasiveness, wear kinetics, and tactile perception by the patient. The aim of this study was to evaluate the influence of irrigation during the finishing and polishing of composite resin restorations. Read More

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Hyperuricosuria, hematuria, and novel bladder images with IgA nephropathy.

Proc (Bayl Univ Med Cent) 2020 Dec 23;34(2):294-296. Epub 2020 Dec 23.

Department of Pediatrics, Texas A&M Health Science Center, Baylor Scott & White McLane Children's Medical Center, Temple, Texas.

Episodic (recurrent) macroscopic hematuria in patients with IgA nephropathy is usually associated with a benign prognosis, although some patients experience a transient fall in glomerular filtration rate during the episodes. We present a 15-year-old girl with mild IgA nephropathy who had multiple episodes of macroscopic hematuria associated with severe but transient decreases in estimated glomerular filtration rate, low levels of serum uric acid, and marked increases in fractional excretion of uric acid. Ultrasound studies showed marked inflammatory changes in the bladder, especially involving the trigone. Read More

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December 2020

[A case of nasal discharge resulting in recurrent bacterial meningitis].

Rinsho Shinkeigaku 2021 Mar 23;61(3):177-181. Epub 2021 Feb 23.

Division of Neurology, Department of Internal Medicine, St. Marianna University School of Medicine.

A 47-year-old man who was previously hospitalized three times due to bacterial meningitis experienced a headache and posterior neck pain in May. He was admitted to our hospital because of a fever 3 h later. He was fully conscious and febrile, with a headache and signs of meningeal irritation. Read More

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Spontaneous unscarred uterine rupture in a twin pregnancy complicated by adenomyosis: A case report.

Medicine (Baltimore) 2021 Jan;100(3):e24048

Department of Obstetrics and Gynecology, the First Affiliated Hospital of Anhui Medical University.

Introduction: Uterine rupture during pregnancy is a serious obstetric complication accompanied by a high incidence of maternal morbidity and mortality, and the presence of uterine scars is the main risk factor. In the present case, uterine rupture occurred in an unscarred uterus in a nonlaboring primigravida woman with adenomyosis and twin pregnancy in the third trimester.

Patient Concerns: In this case, the patient suspected to have a history of endometriosis have got twin pregnancies following intracytoplasmic sperm injection, and complained of recurrent lower abdominal pain from 16 weeks to 29 weeks of gestation. Read More

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January 2021

The genitourinary syndrome of menopause.

Menopause 2021 02 1;28(5):579-588. Epub 2021 Feb 1.

Department Obstetrics, Gynecology and Reproductive Sciences, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

Abstract: Genitourinary syndrome of menopause (GSM) refers to a collection of symptoms resulting from diminished hormonal, primarily estrogenic stimulation to the vulvovaginal or lower urinary tract and may affect up to 50% of postmenopausal women. Symptoms, which are typically progressive and unlikely to resolve spontaneously, may include, but are not limited to, vulvovaginal dryness, burning or irritation, dyspareunia, or urinary symptoms of urgency, dysuria or recurrent urinary tract infection. These symptoms are typically progressive and unlikely to resolve spontaneously. Read More

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February 2021

Acceptable Long-Term Outcomes of Arthroscopic Bone Grafting for Recurrent Posterior Shoulder Instability: Minimum Follow-Up of 5 Years.

Arthroscopy 2021 03 29;37(3):816-823. Epub 2020 Dec 29.

Alps Surgery Institute, Clinique Générale Annecy, Annecy, France.

Purpose: To examine the long-term clinical outcome associated with arthroscopically placed autologous iliac crest bone graft (ICBG) for recurrent posterior shoulder instability.

Methods: From January 2008 to December 2013, patients treated with posterior ICBG and a minimum follow-up of 5 years were included. Clinical outcome of patients operated with a posterior ICBG was analyzed with multiple patient-reported outcome measures included Constant (CS), American Shoulder and Elbow Surgeons (ASES), Walch-Duplay, and Rowe scores, shoulder subjective value, and pain visual analog score. Read More

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Treatment of vulvovaginitis.

Cate Sheppard

Aust Prescr 2020 12 1;43(6):195-199. Epub 2020 Dec 1.

Vulvovaginitis is a commonly encountered problem in general practice. It usually presents with irritation and vaginal discharge A thorough examination is essential in order not to miss the less common causes. Investigations may be needed to confirm the diagnosis Candidiasis and bacterial vaginosis are the most common causes. Read More

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December 2020

Incidental squamous cell carcinoma of renal pelvis presenting as skin invasion: a case report.

J Med Case Rep 2020 Dec 15;14(1):244. Epub 2020 Dec 15.

Department of Oncology Radiotherapy, Affiliated the 900th Hospital of PLA, Fujian Medical University, 156 Xi Er Huan Road, Fuzhou City, Fujian Province, 350025, People's Republic of China.

Introduction: Squamous cell carcinoma of the renal pelvis is a rare neoplasm, accounting for less than 0.8% of malignant renal tumors. Chronic irritation is believed to be the primary pathogenic cause for squamous cell carcinoma of the renal pelvis. Read More

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December 2020

A custom-made brachytherapy applicator for recurrent endometrial and vaginal cancer: A dental technique for prosthesis fabrication.

J Prosthet Dent 2020 Nov 5. Epub 2020 Nov 5.

Junior Associate Professor, Department of Maxillofacial Prosthetics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. Electronic address:

The role of the prosthodontist in radiation therapy includes fabrication of radiation therapy prosthetic applicators. Brachytherapy is a form of cancer treatment that involves direct insertion of radioactive implants into the tissue. In the case of vaginal cancer, brachytherapy requires the radiation oncologist to use a device called an applicator. Read More

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November 2020

Examining 15% Azelaic Acid Foam for the Treatment of Folliculitis: A Pilot Study.

J Clin Aesthet Dermatol 2020 Apr 1;13(4):36-38. Epub 2020 Apr 1.

Dr. Draelos is with Dermatology Consulting Services, PLLC in High Point, North Carolina.

Folliculitis is a frequently recurrent skin condition characterized by inflammatory papules and pustules on numerous body areas arising from follicular irritation induced by shaving or trauma but might also arise in the presence of bacterial or fungal organisms. Oral and topical antibiotics remain the mainstay of treatment, but the chronicity of the condition requires a safe maintenance therapy. The objective of this study was to examine the off-label use of 15% azelaic acid foam in the treatment of folliculitis. Read More

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Sodium bicarbonate gels: a new promising strategy for the treatment of vulvovaginal candidosis.

Eur J Pharm Sci 2021 Feb 26;157:105621. Epub 2020 Oct 26.

CICS-UBI, Health Sciences Research Center, Faculty of Health Sciences, University of Beira Interior, Avenida Infante D. Henrique, 6200-506 Covilhã, Portugal; Labfit-HPRD Health Products Research and Development, Lda Edifício UBIMedical, Estrada Municipal 506, 6200-281 Covilhã, Portugal; CNC-Center for Neuroscience and Cell Biology, University of Coimbra, Rua Larga, Faculty of Medicine, Pólo I, 3004-504 Coimbra, Portugal. Electronic address:

Vulvovaginal candidosis (VVC), caused mainly by the yeast Candida albicans, is the second most prevalent vaginal infection. It has been found to have a large impact on women's quality of life, self-esteem and routines. The prevalence of recurrent vulvovaginal candidosis (RVVC) remains high so the development of alternative treatments is needed. Read More

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February 2021

Recurrent Irritation Fibroma-"What Lies Beneath": A Multidisciplinary Treatment Approach.

Int J Clin Pediatr Dent 2020 May-Jun;13(3):306-309

Department of Pediatric and Preventive Dentistry, RUHS College of Dental Sciences, Jaipur, Rajasthan, India.

Irritation fibroma is a benign, exophytic reactive oral lesion that develops secondary to injury. Its recurrence rate is rare but may happen in case of repeated trauma at the same site. This case report describes a recurrent fibroma in the anterior region of the hard palate in a 13-year-old male patient, which recurred in less than 1 year of surgical excision of the previous lesion. Read More

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September 2020

Identification of A Novel TGFBI Gene Mutation (p.Serine524Cystine) Associated with Late Onset Recurrent Epithelial Erosions and Bowman Layer Opacities.

Ophthalmic Genet 2020 12 3;41(6):639-644. Epub 2020 Sep 3.

Stein Eye Institute, David Geffen School of Medicine at UCLA , Los Angeles, CA, USA.

Background: Most transforming growth factor beta-induced () corneal dystrophies are associated with a characteristic phenotype, clinical course, and a conserved mutation in the gene. However, we report a novel missense mutation associated with a late-onset, variant Bowman layer dystrophy.

Methods: Participants underwent slit-lamp examination and multimodal imaging. Read More

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December 2020

A rare case of intestinal obstruction: Sclerosing encapsulating peritonitis of unknown cause.

Jeong Ho Kang

Turk J Emerg Med 2020 Jul-Sep;20(3):152-155. Epub 2020 Jul 18.

Department of Emergency Medicine, Jeju National University School of Medicine, Jeju-do, Republic of Korea.

Sclerosing encapsulating peritonitis (SEP) is characterized by the partial or complete enclosing of the small intestines by a thick fibro-collagenous membrane, which can cause recurrent intestinal obstruction. SEP is a clinically rare disease, and the major risk factor is peritoneal dialysis (PD). Early diagnosis of SEP is an important factor in the patient's prognosis, but it is clinically difficult. Read More

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Migratory serpiginous corneal epitheliopathy (MSCE)- details of 4 cases.

Ocul Surf 2020 10 18;18(4):742-747. Epub 2020 Aug 18.

Cornea and Anterior Segment Services, L. V. Prasad Eye Institute, Bhubaneswar, Odisha, India. Electronic address:

Background And Objective: To describe four cases of recurrent, fleeting corneal epithelial lesion, migratory serpiginous corneal epitheliopathy (MSCE).

Method: Description of cases, histopathology and discussion of treatment outcome.

Results: The study included 4 consecutive male patients; mean age was 21. Read More

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October 2020

An aggressive pyogenic granuloma masquerading as a vascular neoplasm.

J Indian Soc Periodontol 2020 May-Jun;24(3):276-279. Epub 2020 Jan 27.

Department of Oral and Maxillofacial Surgery, SDM College of Dental Sciences and Hospital, A Constituent Unit of Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.

Pyogenic granuloma (PG) is a benign lesion, with a female predilection, commonly associated with local irritation or trauma. We report an unusual, destructive case of PG, displaying excessive loss of blood and destruction of alveolar bone leading to the loss of maxillary anterior teeth in an 18-year-old female, compromising function and esthetics. The incisional and excisional biopsy specimen of this recurrent lesion obtained during a 5-year span was studied, which revealed an increase in vascularity and extensive proliferation of endothelial cells admixed with varying degree of inflammatory cell infiltrate. Read More

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January 2020

Posterior reversible encephalopathy syndrome and reversible cerebral vasoconstriction syndrome associated spinal subdural hematoma: A case report.

Medicine (Baltimore) 2020 Jul;99(31):e21522

Department of Neurology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.

Rationale: Posterior reversible encephalopathy syndrome (PRES) and reversible cerebral vasoconstriction syndrome (RCVS) are separate clinical entities with distinct pathophysiological features. But in some special conditions PRES and RCVS can occur simultaneously.

Patient Concerns: We report the unique case of a 40-year-old female presented with crescendo headache, blurred vision, and recurrent generalized tonic-clonic seizure. Read More

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Recurrent Vulvovaginal Candidosis and Cluster Analysis of Clinical Signs and Symptoms: A Laboratory-Based Investigation.

J Fungi (Basel) 2020 Jul 22;6(3). Epub 2020 Jul 22.

Public Health Institute Niš, 18000 Niš, Serbia.

Recurrent vulvovaginal candidosis (RVVC) represents a major health problem that significantly affects a patient's quality of life (QoL). This infection presents with a plethora of clinical manifestation, and this is the first study that carries out a cluster analysis of these signs and symptoms (SS). The goals are to evaluate the distribution of species causing RVVC, their in-vitro susceptibility to antifungals, and the patient's QoL. Read More

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Dysethesia due to irritation of the dorsal root ganglion following lumbar transforaminal endoscopy: Analysis of frequency and contributing factors.

Clin Neurol Neurosurg 2020 10 13;197:106073. Epub 2020 Jul 13.

Clinical Professor of Endoscopic Surgery, University of New Mexico School of Medicine Department of Neurosurgery Albuquerque, NM, United States; Desert Institute for Spine Care, Phoenix, AZ, USA.

Background: New onset of acute dysethetic leg pain due to irritation of the dorsal root ganglion (DRG) following uneventful recovery from an expertly executed lumbar transforaminal endoscopic decompression is a common problem. Its incidence and relation to any risk factors that could be mitigated preoperatively are not well understood.

Methods: We performed a multicenter frequency analysis of DRG irritation dysesthesia in 451 patients who underwent lumbar transforaminal endoscopic decompression for herniated disc and foraminal stenosis. Read More

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October 2020

Countertransference Processes in Psychodynamic Therapy with Dependent (Anaclitic) Depressed Patients: A Qualitative Study Using Supervision Data.

Psychodyn Psychiatry 2020 ;48(2):170-200

Department of Psychoanalysis and Clinical Consulting, Ghent University, Ghent, Belgium.

Although Blatt's two-polarity model of depression has suggested that patients' interpersonal styles may shape countertransference phenomena in psychotherapy, empirical research on this topic has remained scarce. This article provides an in-depth study of countertransference processes in clinical work with dependent (anaclitic) depressed patients using a qualitative methodology. Thematic analysis of narrative material of psychodynamic therapists discussing patient cases during supervision ( = 7) resulted in four recurrent themes: "empathy, compassion, and support," "anxiety, feeling overwhelmed, and protection," "frustration, irritation, and confrontation," and "inadequacy, incompetence, and fatalism. Read More

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Estrogen for the prevention of recurrent urinary tract infections in postmenopausal women: a meta-analysis of randomized controlled trials.

Int Urogynecol J 2021 Jan 20;32(1):17-25. Epub 2020 Jun 20.

Department of Medicine, Mackay Medical College, New Taipei, Taiwan.

Introduction And Hypothesis: Recurrent urinary tract infections (rUTIs) are commonly encountered in postmenopausal women. Optimal non-antimicrobial prophylaxis for rUTIs is an important health issue. The aim of this study was to evaluate the use of estrogen in the prevention of rUTIs versus placebo. Read More

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January 2021

Global post-marketing safety surveillance of Tumor Treating Fields (TTFields) in patients with high-grade glioma in clinical practice.

J Neurooncol 2020 Jul 13;148(3):489-500. Epub 2020 Jun 13.

Division of Clinical Neurooncology, Department of Neurology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Introduction: Tumor Treating Fields (TTFields; antimitotic treatment) delivers low-intensity, intermediate-frequency, alternating electric fields through skin-applied transducer arrays. TTFields (200 kHz) was FDA-approved in glioblastoma (GBM), based on the phase 3 EF-11 (recurrent GBM, rGBM) and EF-14 (newly diagnosed GBM, ndGBM) trials. The most common TTFields-related adverse event (AE) in both trials was array-associated skin irritation. Read More

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