Immunol Allergy Clin North Am 2021 Aug 5;41(3):481-491. Epub 2021 Jun 5.
Department of Dermatology, University of California, San Francisco, Third and Fourth Floors, 1701 Divisadero St, San Francisco, CA 94115, USA; Department of Dermatology, Palo Alto Foundation Medical Group, 701 East El Camino Real (31-104), Mountain View, CA 94040, USA. Electronic address:
Protein contact dermatitis is a cutaneous hypersensitivity reaction after chronic, recurrent exposure or chronic irritation to animal or plant protein. Although the pathophysiological mechanisms underlying protein contact dermatitis are not well characterized, protein contact dermatitis is thought to be caused by combined type I/IV-mediated, type-1 mediated, or a Langerhans cell immunoglobulin E-mediated delayed hypersensitivity reaction. This chapter reviews the epidemiology, pathogenesis, clinical features, common protein allergens, diagnostic process, treatment options, and prognosis of protein contact dermatitis. Read More