2,541 results match your criteria irritable mood

Aberrant Intraregional Brain Activity and Functional Connectivity in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.

Front Neurosci 2021 3;15:721822. Epub 2021 Sep 3.

Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Background And Purpose: The appearance and aggravation of diarrhea-predominant irritable bowel syndrome (IBS-D) have proven to be closely related to psychosocial factors. We aimed to measure altered spontaneous brain activity and functional connectivity (FC) in patients with IBS-D using resting-state functional magnetic resonance imaging (RS-fMRI) and to analyze the relationship between these parameters and emotional symptoms.

Methods: Thirty-six adult IBS-D patients and thirty-six demographic-matched healthy controls (HCs) underwent RS-fMRI scans. Read More

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September 2021

Irritable bowel syndrome is strongly associated with the primary and idiopathic mast cell disorders.

Neurogastroenterol Motil 2021 Sep 17:e14265. Epub 2021 Sep 17.

University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.

Background: Mounting evidence supports a mechanistic association between irritable bowel syndrome (IBS) symptoms and mast cell hyperactivity. Yet, association between IBS and mast cell disorders (MCDs) has not been studied. We examined this association using two large databases and verified with manual chart review. Read More

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September 2021

Prevalence and impact of Rome IV versus Rome III irritable bowel syndrome in patients with inflammatory bowel disease.

Neurogastroenterol Motil 2021 Sep 1:e14256. Epub 2021 Sep 1.

Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.

Background: Irritable bowel syndrome (IBS)-type symptoms are common in inflammatory bowel disease (IBD), but few studies have examined the prevalence and impact of IBS-type symptoms in IBD according to Rome IV criteria.

Methods: We collected demographic, symptom (Rome III, Rome IV, and clinical disease activity indices), psychological (anxiety, depression, and somatization), and quality of life data from 973 IBD patients. Medical records were reviewed to document disease type, extent/location, behavior, medical therapy, and antidepressant or opioid use. Read More

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September 2021

[Statics and dynamics of psychopathies in the concept of Ε. Κraepelin].

N Yu Pyatnitskiy

Zh Nevrol Psikhiatr Im S S Korsakova 2021 ;121(7):104-113

Mental Health Research Center, Moscow, Russia.

The concept of psychopathic personalities presented in the 8-th last lifetime edition of E. Kraepelin's textbook is analyzed. The special interest was guided by the fact that many types of psychopathic personalities were described by E. Read More

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September 2021

Long-term personalized low FODMAP diet improves symptoms and maintains luminal Bifidobacteria abundance in irritable bowel syndrome.

Neurogastroenterol Motil 2021 Aug 24:e14241. Epub 2021 Aug 24.

Department of Nutritional Sciences, King's College London, London, UK.

Background: Short-term trials demonstrate the low FODMAP diet improves symptoms of irritable bowel syndrome (IBS) but impacts nutrient intake and the gastrointestinal microbiota. The aim of this study was to investigate clinical symptoms, nutrient intake, and microbiota of patients with IBS 12 months after starting a low FODMAP diet.

Methods: Participants enrolled in a previous short-term clinical trial and who had been through structured FODMAP restriction, reintroduction, and personalization were invited to participate in a follow-up study at one time point at 12 months. Read More

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Efficacy of a low FODMAP diet in irritable bowel syndrome: systematic review and network meta-analysis.

Gut 2021 Aug 10. Epub 2021 Aug 10.

Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK

Objective: A diet low in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) is recommended for irritable bowel syndrome (IBS), if general lifestyle and dietary advice fails. However, although the impact of a low FODMAP diet on individual IBS symptoms has been examined in some randomised controlled trials (RCTs), there has been no recent systematic assessment, and individual trials have studied numerous alternative or control interventions, meaning the best comparator is unclear. We performed a network meta-analysis addressing these uncertainties. Read More

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The clinical utility of a comprehensive psychosomatic assessment in the program for colorectal cancer prevention: a cross-sectional study.

Sci Rep 2021 Aug 2;11(1):15575. Epub 2021 Aug 2.

Gastroenterology and Interventional Endoscopy Unit, AUSL Bologna, Bologna, Italy.

Few studies have investigated psychosocial characteristics and lifestyle behaviors of participants at programs for secondary prevention of colorectal cancer (CRC). This study aimed, through a comprehensive psychosomatic assessment based on clinimetric principles, to evaluate psychosocial characteristics and lifestyle behaviors in participants at CRC secondary prevention program, and to investigate the associations between these variables and endoscopic outcomes. In this cross-sectional study, the first 150 consecutive asymptomatic participants at the CRC prevention program who resulted positive to fecal occult blood test (FOBT) and were thus referred to colonoscopy, underwent a psychosomatic assessment including psychiatric diagnoses (DSM-5), psychosomatic syndromes (DCPR-R), psychological distress, psychological well-being and lifestyle behaviors. Read More

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Dynamics of data-driven microstates in bipolar disorder.

J Psychiatr Res 2021 09 16;141:370-377. Epub 2021 Jul 16.

Department of Population Health Sciences, 610 Walnut Street, 707 WARF Building, University of Wisconsin, Madison, WI, 53706, USA; Department of Mathematics, Van Vleck Hall, 480 Lincoln Drive, University of Wisconsin, Madison, WI, 53706, USA. Electronic address:

Many of the existing models of mood in bipolar disorder can largely be divided into two camps, tracking mood as either a discrete or continuous variable. Both groups rely upon certain assumptions, with most considering only aggregate scores on clinical instruments. In this study, we propose a novel framework that combines elements from both discrete and continuous mood models, using a machine learning pipeline to detect subtle patterns across individuals. Read More

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September 2021

Differences in emotional state and autistic symptoms before and during confinement due to the COVID-19 pandemic.

Res Dev Disabil 2021 Sep 16;116:104038. Epub 2021 Jul 16.

Department of Health Psychology, Miguel Hernández University of Elche, Edificio Altamira, Avda. de la Universidad, s/n Elche, Alicante, 03202, Spain.

Background: The COVID-19 pandemic has generated a global crisis that has affected the emotional health of both the general and the clinical population.

Method: The present study aimed to analyze the differences between the emotional states of a group of individuals with ASD and a neurotypical group both during and after the COVID-19 confinement. The study also examined the changes in autistic symptoms between a group of individuals with ASD who were confined during the COVID-19 pandemic and another group of individuals with ASD who were studied prior to the COVID-19 pandemic period. Read More

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September 2021

CYP2D6 genotype predicts tamoxifen discontinuation and drug response: a secondary analysis of the KARISMA trial.

Ann Oncol 2021 Oct 18;32(10):1286-1293. Epub 2021 Jul 18.

Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.

Background: Guidelines regarding whether tamoxifen should be prescribed based on women's cytochrome P450 2D6 (CYP2D6) genotypes are conflicting and have caused confusion. This study aims to investigate if CYP2D6 metabolizer status is associated with tamoxifen-related endocrine symptoms, tamoxifen discontinuation, and mammographic density change.

Patients And Methods: We used data from 1440 healthy women who participated the KARISMA dose determination trial. Read More

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October 2021

Behavioural and physiological response to frustration in autistic youth: associations with irritability.

J Neurodev Disord 2021 07 19;13(1):27. Epub 2021 Jul 19.

Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Background: Irritability is a common and impairing occurrence in autistic youth, yet the underlying mechanisms are not well-known. In typically developing populations, differences in frustration response have been suggested as important driver of the behavioural symptoms of irritability. Research exploring the role of frustration response as a risk factor for irritability in autistic populations is limited and often uses parent report or observer ratings; objective measures of frustration response appropriate for use in autistic populations are required to advance the field. Read More

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Network of depression and anxiety symptoms in patients with epilepsy.

Epilepsy Res 2021 Sep 23;175:106696. Epub 2021 Jun 23.

Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, People's Republic of China. Electronic address:

Purpose: Depression and anxiety are often comorbid in people with epilepsy. Network models consider this comorbidity as an interacting system of depressive and anxiety symptoms. The present study investigates the network structure of depressive and anxiety symptoms in people with epilepsy and aims to identify the central and bridge symptoms to provide suggestions for the prevention of and intervention for depression-anxiety comorbidity in patients with epilepsy. Read More

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September 2021

Migraine and the development of additional psychiatric and pain disorders in the transition from adolescence to adulthood.

Cephalalgia 2021 Jun 23:3331024211021792. Epub 2021 Jun 23.

LMU University Hospital Munich, Dr. von Hauner Children's Hospital, Department for Pediatric Neurology & Developmental Medicine, LMU Center for Munich, Germany Development and Children with Medical Complexity - iSPZ Hauner.

Introduction: The transition from childhood to adolescence and from adolescence to adulthood are vulnerable phases in life. In these phases, late or insufficient treatment of diseases may lead to chronification and favor development of additional disorders. In adolescents, migraine often has a highly negative impact on school performance and everyday life. Read More

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Case 19-2021: A 54-Year-Old Man with Irritability, Confusion, and Odd Behaviors.

N Engl J Med 2021 Jun;384(25):2438-2445

From the Departments of Psychiatry (N.K., M.W.P.), Neurology (A.B.), and Radiology (R.G.G.), Massachusetts General Hospital, and the Departments of Psychiatry (N.K., M.W.P.), Neurology (A.B.), and Radiology (R.G.G.), Harvard Medical School - both in Boston.

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The association of phasic irritability (aggressive outbursts) and tonic irritability (irritable mood) to depression occurrences, symptoms, and subtypes.

J Affect Disord 2021 10 11;293:9-18. Epub 2021 Jun 11.

Vanderbilt University, Nashville, Tennessee.

Background: Research among adults has rarely differentiated between tonic irritability (i.e., irritable mood) and phasic irritability (i. Read More

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October 2021

Antidepressants in bipolar disorder: Analysis of correlates overall, and in BD-I and BD-II subsamples.

J Affect Disord 2021 09 26;292:352-358. Epub 2021 May 26.

Department of Psychiatry and Behavioural Sciences, Stanford University, CA, United States.

Background: Clinical therapeutic approaches to Bipolar Disorders (BDs) include diverse pharmacotherapies, targeting different symptomatic BD presentations. To date, guidelines about pharmacological treatment of BDs have focused on short-term treatment of mood episodes, at the expense of longer-term treatment, especially for (the most common) predominantly depressive polarity patients.

Methods: A database of BD-I and BD-II patients was collected between 2013 and 2019 at the University Psychiatric Clinic of Ospedale Policlinico and Ospedale Luigi Sacco of Milan. Read More

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September 2021

Neural correlates of irritability in a community sample of children.

J Affect Disord 2021 09 5;292:223-226. Epub 2021 Jun 5.

Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, University of Melbourne, Melbourne, Australia; School of Psychology, Deakin University, Geelong, Australia.

Irritability has been associated with aberrant patterns of neural activation, yet little is known about structural brain correlates of irritability. As such, we aimed to investigate associations between irritability and gray matter volume (GMV) in a community sample of children enriched for irritability. The sample comprised children (n=162) aged 9-11 years with and without Attention-Deficit/Hyperactivity Disorder (ADHD), participating in a cohort study with magnetic resonance imaging data available. Read More

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September 2021

Irritable Bowel Syndrome: Questions and Answers for Effective Care.

Am Fam Physician 2021 06;103(12):727-736

Mayo Clinic College of Medicine and Science, Rochester, MN, USA.

Irritable bowel syndrome (IBS) is a heterogeneous group of conditions related to specific biologic and cellular abnormalities that are not fully understood. Psychological factors do not cause IBS, but many people with IBS also have anxiety or depressed mood, a history of adverse life events, or psychosocial stressors. Physicians must understand the fears and expectations of patients and how they think about their symptoms and should also respond empathetically to psychosocial cues. Read More

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Identifying the Inter-Domain Relations Among ODD, CD, and CU Traits in Preschool Children Using Network Analysis.

Res Child Adolesc Psychopathol 2021 10 14;49(10):1289-1301. Epub 2021 Jun 14.

University of Kentucky, Lexington, KY, 40506, USA.

Oppositional defiant disorder (ODD) and conduct disorder (CD) are two of the most common forms of disruptive behavior disorders during childhood. Callous-unemotional (CU) traits are an important factor in understanding the presentation of these externalizing forms of psychopathology. ODD, CD, and CU traits are highly related constructs, yet little work has examined how these externalizing forms of psychopathology are related at the domain level. Read More

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October 2021

Dynamics of amygdala connectivity in bipolar disorders: a longitudinal study across mood states.

Neuropsychopharmacology 2021 08 7;46(9):1693-1701. Epub 2021 Jun 7.

Laboratory for Behavioral Neurology and Imaging of Cognition, Department of Fundamental Neurosciences, University of Geneva, Geneva, Switzerland.

Alterations in activity and connectivity of brain circuits implicated in emotion processing and emotion regulation have been observed during resting-state for different clinical phases of bipolar disorders (BD), but longitudinal investigations across different mood states in the same patients are still rare. Furthermore, measuring dynamics of functional connectivity patterns offers a powerful method to explore changes in the brain's intrinsic functional organization across mood states. We used a novel co-activation pattern (CAP) analysis to explore the dynamics of amygdala connectivity at rest in a cohort of 20 BD patients prospectively followed-up and scanned across distinct mood states: euthymia (20 patients; 39 sessions), depression (12 patients; 18 sessions), or mania/hypomania (14 patients; 18 sessions). Read More

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Diagnostic Trends and Prescription Patterns in Disruptive Mood Dysregulation Disorder and Bipolar Disorder.

J Am Acad Child Adolesc Psychiatry 2021 Jun 3. Epub 2021 Jun 3.

Pfizer Global Product Development, Pfizer Inc, Groton, Connecticut.

Objective: Disruptive mood dysregulation disorder (DMDD) was introduced in DSM-5 to distinguish a subset of chronically irritable youth who may be incorrectly diagnosed and/or treated for pediatric bipolar disorder (BPD). This study characterized the rate of new treatment episodes and treated prevalence of BPD and DMDD from a longitudinal electronic health record database and examined the impact of DMDD on prescription trends.

Method: A retrospective cohort study using 2008-2018 Optum electronic health record data was conducted. Read More

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Network structure of depression and anxiety symptoms in Chinese female nursing students.

BMC Psychiatry 2021 05 31;21(1):279. Epub 2021 May 31.

Department of Military Medical Psychology, Air Force Medical University, Xi'an, 710032, China.

Background: Comorbidity between depressive and anxiety disorders is common. From network perspective, mental disorders arise from direct interactions between symptoms and comorbidity is due to direct interactions between depression and anxiety symptoms. The current study investigates the network structure of depression and anxiety symptoms in Chinese female nursing students and identifies the central and bridge symptoms as well as how other symptoms in present network are related to depression symptom "thoughts of death". Read More

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The Role of Epigenomic Regulatory Pathways in the Gut-Brain Axis and Visceral Hyperalgesia.

Cell Mol Neurobiol 2021 May 31. Epub 2021 May 31.

Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.

The gut-brain axis (GBA) is broadly accepted to describe the bidirectional circuit that links the gastrointestinal tract with the central nervous system (CNS). Interest in the GBA has grown dramatically over past two decades along with advances in our understanding of the importance of the axis in the pathophysiology of numerous common clinical disorders including mood disorders, neurodegenerative disease, diabetes mellitus, non-alcohol fatty liver disease (NAFLD) and enhanced abdominal pain (visceral hyperalgesia). Paralleling the growing interest in the GBA, there have been seminal developments in our understanding of how environmental factors such as psychological stress and other extrinsic factors alter gene expression, primarily via epigenomic regulatory mechanisms. Read More

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The Irritable and Oppositional Dimensions of Oppositional Defiant Disorder: Integral Factors in the Explanation of Affective and Behavioral Psychopathology.

Child Adolesc Psychiatr Clin N Am 2021 07;30(3):637-647

Department of Psychological Sciences, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA.

Oppositional defiant disorder includes distinct but inseparable dimensions of chronic irritability and oppositional behavior. The dimensions have been identified in early childhood to adulthood, and show discriminant associations with internalizing and externalizing psychopathology. The introduction of disruptive mood dysregulation disorders and the requirements that it take precedence over oppositional defiant disorder diagnostically are not supported by evidence and introduce confusion about the structure and linkages of irritability and oppositional behavior, and obscure the importance of the behavioral dimension in explaining and predicting poor outcomes. Read More

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Psychosocial risk factors associated with esophageal cancer in Chinese cohort: A systematic review and meta-analysis.

Medicine (Baltimore) 2021 May;100(21):e26029

Department of Cardiothoracic Surgery, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, China.

Abstract: Previous studies were controversial about the role of psychosocial factors in the pathogenesis of esophageal cancer (EC). This study aimed to systematically evaluate the effect size of psychosocial risk factors for EC in Chinese cohort.A literature search was conducted in both English and Chinese databases, and odds ratios (OR) with the corresponding 95% confidence intervals (CI) were pooled using a random-effects model. Read More

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Irritability in Mood Disorders: Neurobiological Underpinnings and Implications for Pharmacological Intervention.

CNS Drugs 2021 Jun 21;35(6):619-641. Epub 2021 May 21.

Department of Psychiatry, Faculty of Medicine and Health, Northern Clinical School, The University of Sydney, Sydney, NSW, Australia.

Feeling irritable is a common experience, both in health and disease. In the context of psychiatric illnesses, it is a transdiagnostic phenomenon that features across all ages, and often causes significant distress and impairment. In mood disorders, irritability is near ubiquitous and plays a central role in diagnosis and yet, despite its prevalence, it remains poorly understood. Read More

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