15,858 results match your criteria irritable bowel


Chronic stress and poor sleeping habits are associated with self-reported IBS and poor psychological well-being in the general population.

BMC Res Notes 2021 Jul 22;14(1):280. Epub 2021 Jul 22.

Department of Internal Medicine, Lund University, Skåne University Hospital, Jan Waldenström Street 15, Floor 5, 20502, Malmö, Sweden.

Objective: The present population-based study aimed to examine the association of chronic stress and sleeping difficulties with self-reported irritable bowel syndrome (IBS), gastrointestinal (GI) symptoms past 2 weeks, and psychological well-being.

Results: The Malmö Offspring Study included subjects from the general population to complete a questionnaire regarding sociodemographic factors, lifestyle factors, and medical health. Experience of chronic stress during the past or past 5 years was reported. Read More

View Article and Full-Text PDF

The food, the bug, and the ugly: A recipe for food-induced gut pain.

Allergy 2021 Jul 22. Epub 2021 Jul 22.

Department of Medicine, Farncombe Family Digestive Health Research Institute, Hamilton Health Sciences, McMaster University Medical Center, Hamilton, ON, Canada.

View Article and Full-Text PDF

Migraine and gastrointestinal disorders in middle and old age: A UK Biobank study.

Brain Behav 2021 Jul 21. Epub 2021 Jul 21.

Department of Neuroscience, Uppsala University, Uppsala, Sweden.

Introduction: Migraine is a prevalent condition causing a substantial level of disability worldwide. Despite this, the pathophysiological mechanisms are not fully understood. Migraine often co-occurs with gastrointestinal disorders, but the direction of a potential causal link is unclear. Read More

View Article and Full-Text PDF

Toward Elucidating the Physiological Impacts of Residual Stresses in the Colorectum.

J Biomech Eng 2021 Jul 21. Epub 2021 Jul 21.

Department of Mechanical Engineering, University of Connecticut, Storrs, CT, USA; Department of Biomedical Engineering, University of Connecticut, Storrs, CT, USA.

Irritable bowel syndrome afflicts 10-20% of the global population, causing visceral pain with increased sensitivity to colorectal distension and normal bowel movements. Understanding and predicting these biomechanics will further advance our understanding of visceral pain and complement the existing literature on visceral neurophysiology. We recently performed a series of experiments at three longitudinal segments (colonic, intermediate, and rectal) of the distal 30 mm of colorectums of mice. Read More

View Article and Full-Text PDF

Abdominal Pain Caused by Occlusion of the Celiac Trunk and Superior Mesenteric Artery in Addition to Irritable Bowel Syndrome: Case Series and Literature Review.

Cureus 2021 Jun 17;13(6):e15729. Epub 2021 Jun 17.

Medicine, Qatar University, Doha, QAT.

Irritable bowel syndrome (IBS) is a benign condition of the gastrointestinal tract causing abdominal pain, bloating, diarrhea, and/or constipation. Symptoms of IBS usually improve on passing flatus and defecation. There is no known identifiable underlying pathology; however, several risk factors are known to contribute to the development of IBS, which include a stressful lifestyle and certain foods such as bread, coffee, alcohol, pasta, and chocolates. Read More

View Article and Full-Text PDF

Endotrophin and C6Ma3, serological biomarkers of type VI collagen remodelling, reflect endoscopic and clinical disease activity in IBD.

Sci Rep 2021 Jul 19;11(1):14713. Epub 2021 Jul 19.

Biomarkers and Research, Nordic Bioscience, Herlev Hovedgade 205-207, 2730, Herlev, Denmark.

In inflammatory bowel disease (IBD), the chronic inflammation deeply affects the intestinal extracellular matrix. The aim of this study was to investigate if remodeling of the intestinal basement membrane type VI collagen was associated with pathophysiological changes in Crohn's disease (CD) and ulcerative colitis (UC). Serum from IBD patients (CD: n = 65; UC: n = 107; irritable bowel syndrome: n = 18; healthy subjects: n = 20) was investigated in this study. Read More

View Article and Full-Text PDF

Role of Gut Microbiota in the Pathophysiology of Stress-Related Disorders: Evidence from Neuroimaging Studies.

Ann Nutr Metab 2021 Jul 19:1-7. Epub 2021 Jul 19.

Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Background: The brain and gut communicate bidirectionally via immune, neurological, and endocrine pathways, which is termed the "brain-gut interaction." Recent studies of gut microbiota as a mediator of this interaction have provided a growing body of scientific evidence that suggests that the gut microbiota influences stress and emotional responses and stress-related disorders.

Summary: Major advances in analytical methods have led to an increased number of studies that combine gut microbiota and neuroimaging, mainly magnetic resonance imaging, to elucidate the mechanisms. Read More

View Article and Full-Text PDF

IBS Therapeutic has Broad Spectrum Antimicrobial Activity.

Antimicrob Agents Chemother 2021 Jul 19:AAC0044321. Epub 2021 Jul 19.

Department of Molecular Biosciences, University of Texas at Austin, Austin TX USA.

Otilonium bromide is a poorly absorbed oral medication used to control irritable bowel syndrome. It is thought to act as a muscle relaxant in the intestine. Here we show that otilonium bromide has broad-spectrum antibacterial and antifungal activity, including against multi-drug resistant strains. Read More

View Article and Full-Text PDF

Neuro-Immune Modulation Effects of Sacral Nerve Stimulation for Visceral Hypersensitivity in Rats.

Front Neurosci 2021 2;15:645393. Epub 2021 Jul 2.

Division of Gastroenterology and Hepatology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Visceral hypersensitivity (VH) is one of the underlying pathophysiologies of irritable bowel syndrome. Mast cell overactivation has been found to be one of the main causes of VH. We investigated the effects and mechanisms of actions of sacral nerve stimulation (SNS) on visceral pain in a rodent model of VH. Read More

View Article and Full-Text PDF

Comparative effectiveness of 5-hydroxytryptamine 3 receptor antagonists in irritable bowel syndrome: a network meta-analysis of randomized controlled studies.

Ann Gastroenterol 2021 Jul-Aug;34(4):535-546. Epub 2021 Apr 2.

Tel Aviv University, Ministry of Health, Israel (Yaron Niv).

Background: There is evidence demonstrating the beneficial effects of 5-hydroxytryptamine 3 receptor antagonists (5-HT) for the treatment of non-constipated irritable bowel syndrome (NC-IBS). We aimed to determine the comparative effectiveness of 5-HT antagonists in NC-IBS, as evidenced by the results of a network meta-analysis (NWM) of published relevant randomized controlled trials (RCTs).

Methods: We searched the PubMed/Medline, EMBASE, and Cochrane Library databases for relevant RCTs through September 2020 and data from each selected RCT were extracted. Read More

View Article and Full-Text PDF

Illness perception and health care use in individuals with irritable bowel syndrome: results from an online survey.

BMC Fam Pract 2021 Jul 19;22(1):154. Epub 2021 Jul 19.

Institute of Occupational and Social Medicine and Health Services Research, University Hospital Tübingen, Wilhelmstraße 27, 72074, Tübingen, Germany.

Background: Individual illness perception is known to influence a range of outcome variables. However, little is known regarding illness perception in irritable bowel syndrome (IBS) and its relation to the use of the health care system. This study hypothesised a relationship between illness perception and inappropriate health care use (under-, over- and misuse). Read More

View Article and Full-Text PDF

Is Regular Probiotic Practice Safe for Management of Sepsis?

Chin J Integr Med 2021 Jul 16. Epub 2021 Jul 16.

Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Lucknow (UP), India.

For decades, the gut has been thought to play an important role in sepsis pathogenesis. Sepsis is a serious life-threatening, chronic condition of an infection caused by dysregulated host immune response in most of the intensive care unit patients. Probiotics have dual roles in polymicrobial sepsis i. Read More

View Article and Full-Text PDF

Influence of low FODMAP-gluten free diet on gut microbiota alterations and symptom severity in Iranian patients with irritable bowel syndrome.

BMC Gastroenterol 2021 Jul 14;21(1):292. Epub 2021 Jul 14.

Celiac Disease Department, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background And Objective: Recently, dietary restriction of fermentable carbohydrates (a low-FODMAP diet) in combination with a gluten-free diet (GFD) has been proposed to reduce the symptoms in irritable bowel syndrome (IBS) patients. Different studies reported that IBS has been associated with dysbiosis in the gut microbiota. Additionally, a few studies have reported inflammation in the gastrointestinal (GI) system of adults with IBS. Read More

View Article and Full-Text PDF

The role of bile acids and their TGR5 receptor in irritable bowel syndrome and diarrhoea.

Dig Liver Dis 2021 Jul 11. Epub 2021 Jul 11.

Department of Gastroenterology, Imperial College Healthcare NHS Trust and Division of Digestive Diseases, Imperial College London, Hammersmith Hospital, London W12 0NN, UK. Electronic address:

This commentary looks at recent findings relating to bile acids in patients with irritable bowel syndrome with diarrhoea (IBS-D). Bile acid diarrhoea is recognised to be a frequent, treatable cause of chronic diarrhoea, with a clinical picture which overlaps IBS-D. In the study - by Wei and colleagues, a large proportion of IBS-D patients were shown to have increased faecal bile acids, and an increase in primary bile acids, reflecting changes in bacterial metabolism. Read More

View Article and Full-Text PDF

Return on investment of internet delivered exposure therapy for irritable bowel syndrome: a randomized controlled trial.

BMC Gastroenterol 2021 Jul 13;21(1):289. Epub 2021 Jul 13.

Department of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Nobels väg 9, 171 65, Stockholm, Sweden.

Background: Irritable bowel syndrome (IBS) is a debilitating and costly disorder. Cognitive behavior therapy (CBT) is effective in the treatment of IBS, both when delivered over the internet and in face-to-face settings. CBT consists of different components and little is known about their relative importance. Read More

View Article and Full-Text PDF

Irritable bowel syndrome and subsequent risk of Parkinson's disease: a nationwide population-based matched-cohort study.

J Neurol 2021 Jul 13. Epub 2021 Jul 13.

Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro Seodaemun-gu, Seoul, 03722, Republic of Korea.

Background: Gastrointestinal dysfunction (GI) is the most prevalent non-motor symptom of Parkinson's disease (PD), and its role in the risk of PD has been studied. In this study, we tried to evaluate whether irritable bowel syndrome (IBS) increased the risk of PD development stratified by sex, age, and IBS duration using a large nationwide cohort in Korea.

Methods: Patients aged ≥ 20 years with a primary diagnosis of IBS (ICD-10 codes: G56) more than three times were selected. Read More

View Article and Full-Text PDF

A Review of Irritable Bowel Syndrome.

JAMA 2021 07;326(2):189

Laboratory for Brain-Gut Axis Studies, KU Leuven, Leuven, Belgium.

View Article and Full-Text PDF

A Review of Irritable Bowel Syndrome-Reply.

JAMA 2021 07;326(2):189-190

Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota.

View Article and Full-Text PDF

Sensory Adaptation Training or Escitalopram for IBS With Constipation and Rectal Hypersensitivity: A Randomized Controlled Trial.

Clin Transl Gastroenterol 2021 Jul 13;12(7):e00381. Epub 2021 Jul 13.

Department of Population Health Sciences, Augusta University, Augusta, Georgia, USA.

Introduction: Rectal hypersensitivity is an important pathophysiological dysfunction in irritable bowel syndrome with predominant constipation (IBS-C), whose treatment remains challenging. In a randomized controlled trial, we compared the efficacy and safety of a novel sensori-behavioral treatment, sensory adaptation training (SAT) with escitalopram.

Methods: Patients with IBS-C (Rome III) with rectal hypersensitivity received 6 biweekly sessions of SAT or escitalopram 10 mg daily for 3 months. Read More

View Article and Full-Text PDF

Narrative review: Risk of eating disorders and nutritional deficiencies with dietary therapies for irritable bowel syndrome.

Neurogastroenterol Motil 2021 Jul 13:e14188. Epub 2021 Jul 13.

College of Pharmacy & Health Sciences, Campbell University, Buies Creek, NC, USA.

Background And Aims: Dietary treatments are growing in popularity as interventions for chronic digestive conditions. Patients with irritable bowel syndrome (IBS) often change their eating behaviors to mitigate symptoms. This can occur under the direction of their physician, a dietitian, or be self-directed. Read More

View Article and Full-Text PDF

Sleep disturbances in the irritable bowel syndrome and functional dyspepsia are independent of psychological distress: a population-based study of 1322 Australians.

Aliment Pharmacol Ther 2021 Jul 11. Epub 2021 Jul 11.

College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia.

Background: Psychological distress, strongly associated with functional gastrointestinal disorders (FGIDS), likely plays a central role in the pathophysiology. The role of sleep disturbances in FGIDs is unclear, and an association with psychological factors is uncertain.

Aim: To determine whether sleep disturbances are associated with irritable bowel syndrome (IBS) and functional dyspepsia (FD) and if a potential association is explained by psychological distress. Read More

View Article and Full-Text PDF

Irritable Bowel Syndrome prevalence and work ability in a sample of healthcare workers exposed to occupational stress.

J Psychosom Res 2021 Sep 2;148:110566. Epub 2021 Jul 2.

Gastrointestinal Unit, Department of Translational Sciences and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.

Objective: Occupational stress represents a significant precipitating factor in different diseases but its role in Irritable Bowel Syndrome (IBS) needs to be clarified. The present cross-sectional study aimed at investigating the prevalence of IBS diagnosis in a sample of health workers and exploring the potential relationships between IBS, work-related stress levels and work ability.

Methods: 653 health workers undergoing periodical occupational health surveillance at the Occupational and Preventive Medicine Unit of a major University Hospital in central Italy, were consecutively recruited and screened for IBS diagnosis, according to ROMA IV criteria. Read More

View Article and Full-Text PDF
September 2021

Multi-omics analyses show disease, diet, and transcriptome interactions with the virome.

Gastroenterology 2021 Jul 7. Epub 2021 Jul 7.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, 55905, USA. Electronic address:

Background And Aims: The gut virome includes eukaryotic viruses and bacteriophages that can shape the gut bacterial community and elicit host responses. The virome may be implicated in diseases such as irritable bowel syndrome (IBS), where gut bacteria play an important role in pathogenesis. Herein we provide a comprehensive and longitudinal characterization of the virome including DNA and RNA viruses and paired multi-omics data in a cohort of healthy subjects and patients with IBS. Read More

View Article and Full-Text PDF

Tongxie Anchang Decoction Relieves Visceral Hypersensitivity in Diarrhea-Predominant Irritable Bowel Syndrome Rats by Regulating the NGF/TrkA Signaling Pathway.

Evid Based Complement Alternat Med 2021 18;2021:6679348. Epub 2021 Jun 18.

Department of Gastroenterology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, China.

Irritable bowel syndrome (IBS) is a functional gastrointestinal disease characterized by visceral hypersensitivity-related abdominal pain, in which diarrhea-predominant IBS (IBS-D) is the main subtype and has a high clinical incidence. Tongxie Anchang Decoction (TXACD) has been proved to significantly improve abdominal pain in patients with IBS-D, but its underlying therapeutic mechanism still remains unclear. In the present study, IBS-D model rats were induced by neonatal maternal separation (NMS) combined with restraint stress (RS). Read More

View Article and Full-Text PDF

Disorders of the brain-gut interaction and eating disorders.

World J Gastroenterol 2021 Jun;27(24):3668-3681

Department of The Second Medical, "Iuliu Hatieganu" University of Medicine and Pharmacy Cluj-Napoca, Cluj-Napoca RO 400174, Cluj, Romania.

Background: Eating disorders (ED) involve both the nervous system and the gastrointestinal tract. A similar double involvement is also found in disorders of the brain-gut interaction (DGBI) and symptoms are sometimes similar.

Aim: To find out where there is an association and a cause-effect relationship, we looked for the comorbidity of DGBI and ED. Read More

View Article and Full-Text PDF

Irritable bowel syndrome.

Med Clin (Barc) 2021 Jul 5. Epub 2021 Jul 5.

Servicio de Aparato Digestivo, Hospital Royo Villanova, Zaragoza, España. Electronic address:

Irritable bowel syndrome is one of the most common functional bowel disorders, and has a substantial impact on patients' daily lives, as well as a big economic impact on society. It is characterised by abdominal pain, bloating and abdominal distention and altered bowel movements, with a predominance of diarrhoea, constipation, or alternation of these signs, which cannot be explained by a structural or biochemical abnormality. Its aetiopathogenesis and pathophysiological mechanism are unknown. Read More

View Article and Full-Text PDF

Lipidomics As Tools For Finding Biomarkers Of Intestinal Pathology: From Irritable Bowel Syndrome To Colorectal Cancer.

Curr Drug Targets 2021 Jul 7. Epub 2021 Jul 7.

Department of Basic Health Sciences, Faculty of Health Sciences, Universidad Rey Juan Carlos (URJC), Campus de Alcorcón, Avda. de Atenas s/n, 28022 Madrid. Spain.

Lipidomics is an emerging and promising branch that analyses the different lipid mole-cules in a biological sample. It is considered a branch of metabolomics, which is defined as the comprehensive analysis of metabolites in a biological specimen. Nonetheless, in recent years lipidomics is becoming a distinct discipline in the biomedicine field. Read More

View Article and Full-Text PDF

High consumption of Nickel-containing foods and IBS-like disorders: late events in a gluten-free diet.

Ecotoxicol Environ Saf 2021 Oct 6;222:112492. Epub 2021 Jul 6.

Department of Translational and Precision Medicine, Sapienza University of Rome, Italy. Electronic address:

As reported in the recent literature, Nickel has become an important part of our daily life since the last decades. We can find it in skincare products, occupational exposures and foods. Only recently, research has started to show a link between Nickel and many health disorders, including adverse reactions to food containing nickel. Read More

View Article and Full-Text PDF
October 2021

Electro-hydrodynamic assisted synthesis of lecithin-stabilized peppermint oil-loaded alginate microbeads for intestinal drug delivery.

Int J Biol Macromol 2021 Jul 5;185:861-875. Epub 2021 Jul 5.

Wuya College of Innovation, Shenyang Pharmaceutical University, Wenhua Road 103, 110016 Shenyang, China.

Peppermint oil (PO) is the most prominent oil using in pharmaceutical formulations with its significant therapeutic value. In this sense, this oil is attracting considerable attention from the scientific community due to its traditional therapeutic claim, biological and pharmacological potential in recent research. An organic solvent-free and environment-friendly electrohydrodynamic assisted (EHDA) technique was employed to prepared PO-loaded alginate microbeads. Read More

View Article and Full-Text PDF

Current status of fecal microbiota transplantation for irritable bowel syndrome.

Neurogastroenterol Motil 2021 Jul 8:e14157. Epub 2021 Jul 8.

Department of Clinical Medicine, University of Bergen, Bergen, Norway.

Background: Irritable bowel syndrome (IBS) is a common gastrointestinal functional disorder. Although IBS is a benign condition, it reduces the quality of life considerably. While there is currently no effective treatment for this disorder, fecal microbiota transplantation (FMT) seems to be promising. Read More

View Article and Full-Text PDF