3,330 results match your criteria irritability associated


Behavioral and Cognitive Response to Selective Serotonin Reuptake Inhibitors in Frontotemporal Lobar Degeneration: A Systematic Review and Meta-analysis.

Clin Neuropharmacol 2021 Sep-Oct 01;44(5):175-183

Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, MD, TX.

Objective: This article systematically reviews current literature on the efficacy and efficiency of selective serotonin reuptake inhibitors (SSRIs) in the treatment of patients with frontotemporal lobar degeneration (FTLD), with a particular focus on behavior and cognitive functions.

Methods: A search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines using CENTRAL, MEDLINE, and Cochrane Library databases. Eleven randomized controlled trials and open-label studies looking at the effects of SSRIs on FTLD patients were included. Read More

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September 2021

Irritable bowel syndrome is strongly associated with the primary and idiopathic mast cell disorders.

Neurogastroenterol Motil 2021 Sep 17:e14265. Epub 2021 Sep 17.

University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.

Background: Mounting evidence supports a mechanistic association between irritable bowel syndrome (IBS) symptoms and mast cell hyperactivity. Yet, association between IBS and mast cell disorders (MCDs) has not been studied. We examined this association using two large databases and verified with manual chart review. Read More

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September 2021

Clinical withdrawal symptom profile of synthetic cannabinoid receptor agonists and comparison of effects with high potency cannabis.

Psychopharmacology (Berl) 2021 Sep 17. Epub 2021 Sep 17.

Addiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath, UK.

Synthetic cannabinoid receptor agonists (SCRAs) may be used as an alternative to natural cannabis; however, they may carry a greater risk of problematic use and withdrawal. This study aimed to characterise the withdrawal symptom profile of SCRAs and compare their profile of effect with high-potency herbal cannabis. Global Drug Survey data (2015 and 2016) were used to access a clinically relevant sample of people reporting use of SCRAs >10 times in the past 12-months, a previous SCRA quit attempt, and lifetime use of high-potency herbal cannabis. Read More

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September 2021

Menopause and cognitive impairment: A narrative review of current knowledge.

World J Psychiatry 2021 Aug 19;11(8):412-428. Epub 2021 Aug 19.

Department of Obstetrics and Gynecology, School of Medical Sciences, State University of Campinas, Campinas 13083-881, São Paulo, Brazil.

A severe impairment of cognitive function characterizes dementia. Mild cognitive impairment represents a transition between normal cognition and dementia. The frequency of cognitive changes is higher in women than in men. Read More

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Does food insecurity affect musculoskeletal symptoms, fatigue, and productivity of municipality cleaners? A cross-sectional study.

Work 2021 Sep 5. Epub 2021 Sep 5.

School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Municipality cleaners are exposed to food insecurity, Musculoskeletal Symptoms (MSs), and fatigue.

Objective: This study aimed to investigate the effect of food insecurity on MSs, fatigue, and productivity among municipality cleaners.

Methods: This study was conducted on 399 Iranian male municipality cleaners with at least one year of working experience. Read More

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September 2021

Associations Among Irritability, High-Sensitivity C-Reactive Protein /Interleukin-6, and Depression in Early-Stage Breast Cancer Patients Undergoing Chemotherapy: A Prospective Study.

J Acad Consult Liaison Psychiatry 2021 Sep 7. Epub 2021 Sep 7.

Professor of Psychiatry, Case Western Reserve University School of Medicine, Clinical Director of Mood Disorders Program, University Hospitals Cleveland Medical Center, 10524 Euclid Avenue, 12th Floor, Cleveland, OH, 44106.

Objectives: We examined associations among irritability (e.g., a feeling of agitation), inflammatory biomarkers, and depression during chemotherapy. Read More

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September 2021

Long-Term Neurological and Psychological Distress Symptoms among Smallholder Farmers in Costa Rica with a History of Acute Pesticide Poisoning.

Int J Environ Res Public Health 2021 Aug 26;18(17). Epub 2021 Aug 26.

Central American Institute for Studies on Toxic Substances, Universidad Nacional, Heredia 83-3000, Costa Rica.

Studies suggest that acute pesticide poisonings (APP) may be linked with long-term neurological effects. To examine long-term neurological and psychological distress symptoms associated with having experienced an APP, we conducted a cross-sectional study of 300 conventional and organic smallholder farmers from Zarcero County, Costa Rica, May-August 2016. We collected self-reported data on sociodemographic characteristics, occupational history, pesticide exposure, APPs, neurological and psychological distress symptoms (using the Brief Symptom Inventory (BSI)). Read More

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Screening male prisoners for depression and anxiety with the PHQ-9 and GAD-7 at NHS Healthcheck: patterns of symptoms and caseness threshold.

BMC Psychiatry 2021 09 9;21(1):446. Epub 2021 Sep 9.

Psychiatry, Institute of Mental Health, University of Nottingham, Nottingham, NG7 2DU, UK.

Background: Screening for depression and anxiety disorders has been proposed in prison populations but little is known about caseness thresholds on commonly used self-report measures in relation to core symptoms, risk factors and symptom patterns.

Method: A cross-sectional prevalence survey measured depression and anxiety caseness (threshold scores > 10 and > 15 on PHQ-9 and GAD-7 and diagnostic algorithm on PHQ-9) in 1205 male prisoners aged 35-74 years eligible for an NHS Healthcheck from six English prisons. Caseness scores were compared with the presence or absence of daily core symptoms of depression and generalised anxiety disorder (GAD), demographic, prison and cardiovascular risk factors. Read More

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September 2021

Age and sex-related variability in the presentation of generalized anxiety and depression symptoms.

Depress Anxiety 2021 Sep 8. Epub 2021 Sep 8.

Institute of Psychiatry, Psychology and Neuroscience, King's College London, Denmark Hill, Camberwell, London, UK.

Background: Generalized anxiety and depression are extremely prevalent and debilitating. There is evidence for age and sex variability in symptoms of depression, but despite comorbidity it is unclear whether this extends to anxiety symptomatology. Studies using questionnaire sum scores typically fail to address this phenotypic complexity. Read More

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September 2021

Exercise behavior patterns and associations with subjective well-being during the COVID-19 pandemic: A cross-sectional study in Brazil.

Eur J Integr Med 2021 Sep 28;46:101374. Epub 2021 Aug 28.

Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, RN, Brazil.

Introduction: The COVID-19 pandemic has affected the behavior and practice of planned and structured physical exercises. This study aimed to investigate the association between changes in physical exercise behavior and subjective well-being during the COVID-19 pandemic in Brazil.

Methods: This cross-sectional study was performed in Brazil and included a total of 595 individuals recruited through social media platforms, personal and professional contacts. Read More

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September 2021

Decades of Progress in the Psychopharmacology of Autism Spectrum Disorder.

J Autism Dev Disord 2021 Sep 7. Epub 2021 Sep 7.

Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 4002, Cincinnati, OH, 45229, USA.

Recent decades have been marked by a wave drug treatment research in autism spectrum disorder (ASD). This work has resulted in improved ability to treat commonly occurring behavioral challenges associated with ASD including most prominently irritability marked by aggression, self-injurious behavior, and severe tantrums. While treatment of interfering behavior has progressed in our field, there remain several areas of unmet medical need including most prominently a lack of any approved drug therapies for the core, defining symptoms of autism. Read More

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September 2021

Cognitive and Affective Empathy in Huntington's Disease.

J Huntingtons Dis 2021 Aug 30. Epub 2021 Aug 30.

Movement Disorders Unit, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Background: Empathy is a multidimensional construct and a key component of social cognition. In Huntington's disease (HD), little is known regarding the phenomenology and the neural correlates of cognitive and affective empathy, and regarding how empathic deficits interact with other behavioral and cognitive manifestations.

Objective: To explore the cognitive and affective empathy disturbances and related behavioral and neural correlates in HD. Read More

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The Dark Triad of Personality: Is Psychopathy a Good Predictor of Workplace Stress?

Mater Sociomed 2021 Jun;33(2):100-104

Department of Psychology, Faculty of Philosophy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Background: Psychopathy as an antisocial characteristic of an individual is characterized by a lack of empathy, guilt, inability to control impulsive behavior, irresponsibility, irritability and aggressive behavior. Because of the traits that underlie this factor, we hypothesized that psychopaths would experience more stress in the work environment. Stress, in this article, is operationalized within Karasek's model of stress which consider that contextual variables (excessive demands on work, lack of social support, and lack of control at work) are responsible for experiencing stress at the workplace. Read More

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Role of age at onset in the clinical presentation of bipolar disorder in Indian population.

Ind Psychiatry J 2021 Jan-Jun;30(1):41-46. Epub 2021 Jun 17.

Department of Community Medicine, Dr. S.N. Medical College, Jodhpur, Rajasthan, India.

Objective: The objective of this study was to determine any association of age at onset (AAO) with clinical presentation of bipolar disorder (BD) and family history of illness.

Materials And Methods: A hospital-based cross-sectional observational study was conducted including 162 patients having a diagnosis of BD current episode manic. Individuals were divided into three subgroups according to AAO, i. Read More

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Safety and Tolerability of Transdermal Cannabidiol Gel in Children With Developmental and Epileptic Encephalopathies: A Nonrandomized Controlled Trial.

JAMA Netw Open 2021 Sep 1;4(9):e2123930. Epub 2021 Sep 1.

Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.

Importance: Developmental and epileptic encephalopathies (DEEs) are the most severe group of drug-resistant epilepsies. Alternatives to oral therapies are urgently needed to reduce seizures and improve developmental outcomes and comorbidities in this medically complex population.

Objective: To assess the safety and tolerability of cannabidiol (CBD) transdermal gel in children with DEEs and to evaluate seizure frequency, sleep, and quality of life. Read More

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September 2021

Prevalence and impact of Rome IV versus Rome III irritable bowel syndrome in patients with inflammatory bowel disease.

Neurogastroenterol Motil 2021 Sep 1:e14256. Epub 2021 Sep 1.

Leeds Gastroenterology Institute, St. James's University Hospital, Leeds, UK.

Background: Irritable bowel syndrome (IBS)-type symptoms are common in inflammatory bowel disease (IBD), but few studies have examined the prevalence and impact of IBS-type symptoms in IBD according to Rome IV criteria.

Methods: We collected demographic, symptom (Rome III, Rome IV, and clinical disease activity indices), psychological (anxiety, depression, and somatization), and quality of life data from 973 IBD patients. Medical records were reviewed to document disease type, extent/location, behavior, medical therapy, and antidepressant or opioid use. Read More

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September 2021

Dysfunction in differential reward-punishment responsiveness in conduct disorder relates to severity of callous-unemotional traits but not irritability.

Psychol Med 2021 Sep 1:1-11. Epub 2021 Sep 1.

Center for Neurobehavioral Research, Boys Town National Research Hospital, Boys Town, NE, USA.

Background: Conduct disorder (CD) has been associated with dysfunction in reinforcement-based decision-making. Two forms of affective traits that reflect the components of CD severity are callous-unemotional (CU; reduced guilt/empathy) traits and irritability. The form of the reinforcement-based decision-making dysfunction with respect to CD and CU traits remains debated and has not been examined with respect to irritability in cases with CD. Read More

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September 2021

The Impact of COVID-19 on Adolescents' Daily Lives: The Role of Parent-Child Relationship Quality.

J Res Adolesc 2021 Sep;31(3):623-644

KU Leuven.

COVID-19 lockdown measures have profoundly impacted adolescent' daily life, with research suggesting an increase in irritability, stress, loneliness, and family conflict. A potential protective factor is parent-child relationship quality; however, no studies have investigated this. We used data from SIGMA, a longitudinal, experience sampling cohort study, in which N = 173 adolescents aged 11 to 20 were tested before and during COVID-19. Read More

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September 2021

The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.

J Pers Med 2021 Aug 11;11(8). Epub 2021 Aug 11.

Barrow Neurological Institute at Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ 85016, USA.

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder affecting 2% of children in the United States. Biochemical abnormalities associated with ASD include impaired methylation and sulphation capacities along with low glutathione (GSH) redox capacity. Potential treatments for these abnormalities include cobalamin (B12). Read More

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Biochemical and Clinical Effects of Vitamin E Supplementation in Hungarian Smith-Lemli-Opitz Syndrome Patients.

Biomolecules 2021 08 17;11(8). Epub 2021 Aug 17.

Division of Clinical Genetics, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

Smith-Lemli-Opitz syndrome (SLOS) is a severe monogenic disorder resulting in low cholesterol and high 7-dehydrocholesterol (7-DHC) levels. 7-DHC-derived oxysterols likely contribute to disease pathophysiology, and thus antioxidant treatment might be beneficial because of high oxidative stress. In a three-year prospective study, we investigated the effects of vitamin E supplementation in six SLOS patients already receiving dietary cholesterol treatment. Read More

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Understanding Irritability in Relation to Anger, Aggression, and Informant in a Pediatric Clinical Population.

J Am Acad Child Adolesc Psychiatry 2021 Aug 23. Epub 2021 Aug 23.

Pediatric Mental Health Institute, Children's Hospital Colorado, University of Colorado, Anschutz Medical Campus, Aurora.

Objective: Despite its clinical relevance to pediatric mental health, the relationship of irritability with anger and aggression remains unclear. We aimed to quantify the relationships between well-validated, commonly used measurements of these constructs and informant effects in a clinically relevant population.

Method: A total of 195 children with primary diagnoses of attention-deficit/hyperactivity disorder, disruptive mood dysregulation disorder, or no major disorder and their parents rate irritability, anger, and aggression on measures of each construct. Read More

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Neuropsychiatric Manifestations of Wilson Disease: Correlation with MRI and Glutamate Excitotoxicity.

Mol Neurobiol 2021 Aug 26. Epub 2021 Aug 26.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India.

This study aims to identify neuropsychiatric manifestations in neurological Wilson disease (NWD), and their correlation with MRI changes and glutamate excitotoxicity. Forty-three consecutive patients with NWD from a tertiary care teaching hospital were evaluated prospectively who fulfilled the inclusion criteria. The neuropsychiatric evaluation was done using Neuropsychiatric Inventory (NPI) battery that assesses 12 domains including delusion, hallucination, agitation/aggression, dysphoria/depression, anxiety, euphoria, apathy, disinhibition, irritability, aberrant motor activity, appetite change, and abnormal nighttime behavior. Read More

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Effectiveness of Early Physiotherapy in an Infant With a High Risk of Developmental Delay.

Cureus 2021 Jul 23;13(7):e16581. Epub 2021 Jul 23.

Physiotherapy, Ravi Nair Physiotherapy College (RNPC), Wardha, IND.

Premature birth is the most common cause for a stay in the neonatal intensive care unit (NICU) among neonates. Premature birth leads to prematurity, which is associated with complications such as respiratory distress syndrome (RDS), hyperbilirubinemia, gastroesophageal reflux (GERD), intraventricular hemorrhage (periventricular leukomalacia), retinopathy of prematurity (ROP), and so on. These secondary complications are of great concern and need to be handled with care to prevent the further deterioration of the quality of life of the baby as he grows. Read More

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Acute Lymphoblastic Leukemia Following Incomplete Kawasaki Disease.

J Med Cases 2020 Nov 23;11(11):352-354. Epub 2020 Sep 23.

Department of Clinical Immunology, Hospital de Especialidades, UMAE 25 IMSS, Monterrey, Mexico.

Kawasaki disease (KD) is a multisystemic vasculitis of unknown etiology, typically affecting children younger than 5 years of age. A direct relationship between KD and the development of malignant tumors has not been demonstrated, however, the immunological alterations of KD could be associated with its development. An 11-month-old male was diagnosed with incomplete KD. Read More

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November 2020

Safety and Efficacy of Medical Cannabis in Autism Spectrum Disorder Compared with Commonly Used Medications.

Cannabis Cannabinoid Res 2021 Aug 24. Epub 2021 Aug 24.

Colorado Department of Public Health and Environment, Marijuana Health Monitoring and Research, Denver, Colorado, USA.

The objective of this study was to evaluate the safety and efficacy of medications commonly used in autism spectrum disorder (ASD) and compare this to what current research has shown regarding medical cannabis use in this population. Searches were performed to collect information surrounding currently used medications and their safety and efficacy profiles, biologic plausibility of cannabis use for symptoms of ASD, and studies detailing cannabis' safety and efficacy profile for use in the ASD population. Results were used to compare medications to cannabis as a proposed treatment. Read More

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Acute encephalitis in pediatric multisystem inflammatory syndrome associated with COVID-19.

Eur J Paediatr Neurol 2021 Aug 5;34:84-90. Epub 2021 Aug 5.

Vittore Buzzi Children's Hospital, Pediatric Neurology Unit, Via Castelvetro, 32, 20154, Milan, Italy. Electronic address:

Objective: To characterize neurological involvement in multisystem inflammatory syndrome in children (MIS-C) related to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Methods: Retrospective analysis of the clinical, electroencephalographic, CSF and neuroradiological parameters recorded in seven children (3 males, aged 3-10 years) affected by MIS-C with acute neurological involvement.

Results: All cases presented acute encephalopathy with drowsiness, irritability, mood deflection and diffuse EEG slowing with periodic posterior complexes. Read More

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Child, parent, and family mental health and functioning in Australia during COVID-19: comparison to pre-pandemic data.

Eur Child Adolesc Psychiatry 2021 Aug 21. Epub 2021 Aug 21.

Centre for Social and Early Emotional Development, School of Psychology, Deakin University, 221 Burwood Highway, Geelong, VIC, 3216, Australia.

The COVID-19 pandemic presents significant risks to population mental health. Despite evidence of detrimental effects for adults, there has been limited examination of the impact of COVID-19 on parents and children specifically. We aim to examine patterns of parent and child (0-18 years) mental health, parent substance use, couple conflict, parenting practices, and family functioning during COVID-19, compared to pre-pandemic data, and to identify families most at risk of poor outcomes according to pre-existing demographic and individual factors, and COVID-19 stressors. Read More

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Covariance Between Parent and Child Symptoms Before and During the COVID-19 Pandemic.

J Pediatr Psychol 2021 Aug 18. Epub 2021 Aug 18.

Department of Psychology, University of New Orleans, USA.

Objective: COVID-19 has had unprecedented effects on American families, including increases in depression, anxiety, and irritability for both parents and children. While parents and children influence each other's psychological functioning during non-disaster times, this effect may be amplified during times of disaster. The current study investigated how COVID-19 influenced covariance of depressive symptoms and irritability in children and their parents. Read More

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Neuropsychological and Psychosocial Consequences of the COVID-19 Pandemic.

Neurophysiology 2021 Aug 12:1-10. Epub 2021 Aug 12.

Idaho State University College of Pharmacy, Pocatello, Idaho USA.

The coronavirus disease designated as COVID-19 reached the level of a pandemic, affecting countries all across the world. Widespread outbreaks of COVID-19 are associated with psychological distress and symptoms of mental disorders. This article is a narrative review of the existing scientific literature on mental health of the society and interventions relevant to the COVID-19 pandemic. Read More

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Correlates of Lifetime Physical Abuse Among Schoolchildren Aged 15 Years in Post-communist Albania.

Front Public Health 2021 28;9:607493. Epub 2021 Jul 28.

Faculty of Medicine, University of Medicine, Tirana, Albania.

Our aim was to assess the prevalence and correlates of lifetime physical abuse among schoolchildren in Albania, a post-communist country in South Eastern Europe which is currently undergoing a rapid socioeconomic transition. The third wave of Health Behavior in School-Aged Children (HBSC) in Albania was conducted in 2017-18 including a nationwide representative sample of 1,708 schoolchildren aged 15 years (54% girls; response rate: 95%). Children were asked to report on lifetime physical abuse and a wide range of socio-demographic factors, lifestyle factors and health status characteristics. Read More

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