1,205 results match your criteria irritability aggressive


Inhibitory Control in Early Childhood Aggression Subtypes: Mediation by Irritability.

Child Psychiatry Hum Dev 2021 Sep 22. Epub 2021 Sep 22.

Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY, USA.

The present study tested irritability as a mediator of inhibitory control's (IC) associations with crossed form and function aggression subtypes over one year in early childhood (N = 300, M = 44.70 months, SD = 4.38 months). Read More

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September 2021

Identifying novel mechanisms and treatment targets for irritability and aggression in psychiatric disorders.

Neuropsychopharmacology 2021 Sep 20. Epub 2021 Sep 20.

Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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September 2021

Behavioral and Cognitive Response to Selective Serotonin Reuptake Inhibitors in Frontotemporal Lobar Degeneration: A Systematic Review and Meta-analysis.

Clin Neuropharmacol 2021 Sep-Oct 01;44(5):175-183

Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, MD, TX.

Objective: This article systematically reviews current literature on the efficacy and efficiency of selective serotonin reuptake inhibitors (SSRIs) in the treatment of patients with frontotemporal lobar degeneration (FTLD), with a particular focus on behavior and cognitive functions.

Methods: A search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines using CENTRAL, MEDLINE, and Cochrane Library databases. Eleven randomized controlled trials and open-label studies looking at the effects of SSRIs on FTLD patients were included. Read More

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September 2021

Decades of Progress in the Psychopharmacology of Autism Spectrum Disorder.

J Autism Dev Disord 2021 Sep 7. Epub 2021 Sep 7.

Division of Child and Adolescent Psychiatry, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, MLC 4002, Cincinnati, OH, 45229, USA.

Recent decades have been marked by a wave drug treatment research in autism spectrum disorder (ASD). This work has resulted in improved ability to treat commonly occurring behavioral challenges associated with ASD including most prominently irritability marked by aggression, self-injurious behavior, and severe tantrums. While treatment of interfering behavior has progressed in our field, there remain several areas of unmet medical need including most prominently a lack of any approved drug therapies for the core, defining symptoms of autism. Read More

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September 2021

The Dark Triad of Personality: Is Psychopathy a Good Predictor of Workplace Stress?

Mater Sociomed 2021 Jun;33(2):100-104

Department of Psychology, Faculty of Philosophy, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.

Background: Psychopathy as an antisocial characteristic of an individual is characterized by a lack of empathy, guilt, inability to control impulsive behavior, irresponsibility, irritability and aggressive behavior. Because of the traits that underlie this factor, we hypothesized that psychopaths would experience more stress in the work environment. Stress, in this article, is operationalized within Karasek's model of stress which consider that contextual variables (excessive demands on work, lack of social support, and lack of control at work) are responsible for experiencing stress at the workplace. Read More

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Neurobiological correlates of antisociality across adolescence and young adulthood: a multi-sample, multi-method study.

Psychol Med 2021 Aug 27:1-16. Epub 2021 Aug 27.

Child and Adolescent Psychiatry and Psychosocial Care, Amsterdam UMC, Vrije Universiteit Amsterdam, de Boelelaan 1117, Amsterdam, the Netherlands.

Background: Antisociality across adolescence and young adulthood puts individuals at high risk of developing a variety of problems. Prior research has linked antisociality to autonomic nervous system and endocrinological functioning. However, there is large heterogeneity in antisocial behaviors, and these neurobiological measures are rarely studied conjointly, limited to small specific studies with narrow age ranges, and yield mixed findings due to the type of behavior examined. Read More

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The Effectiveness of Cobalamin (B12) Treatment for Autism Spectrum Disorder: A Systematic Review and Meta-Analysis.

J Pers Med 2021 Aug 11;11(8). Epub 2021 Aug 11.

Barrow Neurological Institute at Phoenix Children's Hospital, 1919 E Thomas Rd, Phoenix, AZ 85016, USA.

Autism spectrum disorder (ASD) is a common neurodevelopmental disorder affecting 2% of children in the United States. Biochemical abnormalities associated with ASD include impaired methylation and sulphation capacities along with low glutathione (GSH) redox capacity. Potential treatments for these abnormalities include cobalamin (B12). Read More

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Biochemical and Clinical Effects of Vitamin E Supplementation in Hungarian Smith-Lemli-Opitz Syndrome Patients.

Biomolecules 2021 08 17;11(8). Epub 2021 Aug 17.

Division of Clinical Genetics, Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, 4032 Debrecen, Hungary.

Smith-Lemli-Opitz syndrome (SLOS) is a severe monogenic disorder resulting in low cholesterol and high 7-dehydrocholesterol (7-DHC) levels. 7-DHC-derived oxysterols likely contribute to disease pathophysiology, and thus antioxidant treatment might be beneficial because of high oxidative stress. In a three-year prospective study, we investigated the effects of vitamin E supplementation in six SLOS patients already receiving dietary cholesterol treatment. Read More

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Understanding Irritability in Relation to Anger, Aggression, and Informant in a Pediatric Clinical Population.

J Am Acad Child Adolesc Psychiatry 2021 Aug 23. Epub 2021 Aug 23.

Pediatric Mental Health Institute, Children's Hospital Colorado, University of Colorado, Anschutz Medical Campus, Aurora.

Objective: Despite its clinical relevance to pediatric mental health, the relationship of irritability with anger and aggression remains unclear. We aimed to quantify the relationships between well-validated, commonly used measurements of these constructs and informant effects in a clinically relevant population.

Method: A total of 195 children with primary diagnoses of attention-deficit/hyperactivity disorder, disruptive mood dysregulation disorder, or no major disorder and their parents rate irritability, anger, and aggression on measures of each construct. Read More

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Neuropsychiatric Manifestations of Wilson Disease: Correlation with MRI and Glutamate Excitotoxicity.

Mol Neurobiol 2021 Aug 26. Epub 2021 Aug 26.

Department of Neurology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Raebareli Road, Lucknow, 226014, India.

This study aims to identify neuropsychiatric manifestations in neurological Wilson disease (NWD), and their correlation with MRI changes and glutamate excitotoxicity. Forty-three consecutive patients with NWD from a tertiary care teaching hospital were evaluated prospectively who fulfilled the inclusion criteria. The neuropsychiatric evaluation was done using Neuropsychiatric Inventory (NPI) battery that assesses 12 domains including delusion, hallucination, agitation/aggression, dysphoria/depression, anxiety, euphoria, apathy, disinhibition, irritability, aberrant motor activity, appetite change, and abnormal nighttime behavior. Read More

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Safety and Efficacy of Medical Cannabis in Autism Spectrum Disorder Compared with Commonly Used Medications.

Cannabis Cannabinoid Res 2021 Aug 24. Epub 2021 Aug 24.

Colorado Department of Public Health and Environment, Marijuana Health Monitoring and Research, Denver, Colorado, USA.

The objective of this study was to evaluate the safety and efficacy of medications commonly used in autism spectrum disorder (ASD) and compare this to what current research has shown regarding medical cannabis use in this population. Searches were performed to collect information surrounding currently used medications and their safety and efficacy profiles, biologic plausibility of cannabis use for symptoms of ASD, and studies detailing cannabis' safety and efficacy profile for use in the ASD population. Results were used to compare medications to cannabis as a proposed treatment. Read More

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Parent Description of Anxiety in Angelman Syndrome.

J Autism Dev Disord 2021 Aug 20. Epub 2021 Aug 20.

Lurie Center for Autism, Massachusetts General Hospital, One Maguire Road, Lexington, MA, 02421, USA.

Anxiety is being increasingly identified in Angelman syndrome (AS). Qualitative questions and quantitative assessments were used to evaluate for anxiety in 50 subjects with AS. In-person evaluations assessed behaviors concerning for anxiety and circumstances wherein they occurred. Read More

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Adjunctive Therapy to Manage Neuropsychiatric Symptoms in Moderate and Severe Dementia: Randomized Clinical Trial Using an Outpatient Version of Tailored Activity Program.

J Alzheimers Dis 2021 ;83(1):475-486

Laboratorio de Neurociencias (LIM-27), Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Brazil.

Background: Neuropsychiatric symptoms (NPS) such as aggression, apathy, agitation, and wandering may occur in up to 90%of dementia cases. International guidelines have suggested that non-pharmacological interventions are as effective as pharmacological treatments, however without the side effects and risks of medications. An occupational therapy method, called Tailored Activity Program (TAP), was developed with the objective to treat NPS in the elderly with dementia and has been shown to be effective. Read More

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January 2021

Unhealthy family functioning is associated with health-related quality of life among military spouse caregivers.

Psychol Trauma 2021 Jul 29. Epub 2021 Jul 29.

Research Department.

Objective: The current study examines health-related quality of life (HRQOL) and family functioning in a sample of spouse caregivers assisting post-9/11 service members and veterans (SMV) following traumatic brain injury (TBI).

Method: Participants were 316 spouse (and partner) caregivers of SMVs following a mild, moderate, severe, or penetrating TBI. Caregivers completed the Family Assessment Device General Functioning subscale, 24 HRQOL questionnaires, and the Mayo-Portland Adaptability Inventory (4th ed. Read More

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Editorial: Safer Use of Antipsychotics in Youth (SUAY): Should Treatment Be Guided by Symptoms?

J Am Acad Child Adolesc Psychiatry 2021 Jul 23. Epub 2021 Jul 23.

Icahn School of Medicine at Mount Sinai, New York, and New York City Health + Hospitals/Elmhurst, New York.

Child and adolescent psychiatrists have company as they wrestle with clinical decision making regarding when it is appropriate to prescribe an antipsychotic. Pediatricians face a similar challenge in trying to determine under what circumstances to prescribe an antibiotic. Both classes of medications are powerful and can be lifesaving, but they are not without the risk of associated adverse events and cumulative exposure. Read More

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Clinical profiles of people with dementia exhibiting with neuropsychiatric symptoms admitted to mental hospitals: A multicenter prospective survey in Japan.

Geriatr Gerontol Int 2021 Sep 26;21(9):825-829. Epub 2021 Jul 26.

Department of Neuropsychiatry, Kochi Medical School, Kochi University, Kochi, Japan.

Aims: Patients with severe behavioral and psychological symptoms of dementia (BPSD) are often admitted to mental hospitals, while, inpatient care could also lead to prolonged hospital stay. The present study aims to survey clinical profiles of patients who required inpatient treatment for BPSD, and then establish the criteria for introducing inpatient treatment through assessment by certified psychiatrists.

Methods: We performed a prospective survey about clinical characteristics of people with dementia who required treatment of BPSD at 12 mental medical institutions. Read More

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September 2021

Dynamics of data-driven microstates in bipolar disorder.

J Psychiatr Res 2021 09 16;141:370-377. Epub 2021 Jul 16.

Department of Population Health Sciences, 610 Walnut Street, 707 WARF Building, University of Wisconsin, Madison, WI, 53706, USA; Department of Mathematics, Van Vleck Hall, 480 Lincoln Drive, University of Wisconsin, Madison, WI, 53706, USA. Electronic address:

Many of the existing models of mood in bipolar disorder can largely be divided into two camps, tracking mood as either a discrete or continuous variable. Both groups rely upon certain assumptions, with most considering only aggregate scores on clinical instruments. In this study, we propose a novel framework that combines elements from both discrete and continuous mood models, using a machine learning pipeline to detect subtle patterns across individuals. Read More

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September 2021

Differences in emotional state and autistic symptoms before and during confinement due to the COVID-19 pandemic.

Res Dev Disabil 2021 Sep 16;116:104038. Epub 2021 Jul 16.

Department of Health Psychology, Miguel Hernández University of Elche, Edificio Altamira, Avda. de la Universidad, s/n Elche, Alicante, 03202, Spain.

Background: The COVID-19 pandemic has generated a global crisis that has affected the emotional health of both the general and the clinical population.

Method: The present study aimed to analyze the differences between the emotional states of a group of individuals with ASD and a neurotypical group both during and after the COVID-19 confinement. The study also examined the changes in autistic symptoms between a group of individuals with ASD who were confined during the COVID-19 pandemic and another group of individuals with ASD who were studied prior to the COVID-19 pandemic period. Read More

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September 2021

Kamishoyosan (a Japanese traditional herbal formula), which effectively reduces the aggressive biting behavior of male and female mice, and potential regulation through increase of Tph1, Tph2, and Esr2 mRNA levels.

Brain Res 2021 Oct 11;1768:147580. Epub 2021 Jul 11.

Department of Applied Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8544, Japan. Electronic address:

Kamishoyosan (KSS), a Japanese traditional herbal formula, is used to treat symptoms related to the autonomic nervous system in men and women; it is especially known for improving the symptoms of irritability (e.g., bad temper and persistent anger). Read More

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October 2021

Extrapyramidal Side Effects in a Patient with Alcohol Withdrawal Symptoms: A Reflection of Quality of the Mental Health Care System.

Risk Manag Healthc Policy 2021 1;14:2789-2795. Epub 2021 Jul 1.

CHINTA Research Bangladesh (Centre for Health Innovation, Networking, Training, Action and Research - Bangladesh), Dhaka, Bangladesh.

Background: The burden of substance use disorders is increasing in most countries in sub-Saharan Africa. Individuals with substance use disorders (eg, alcohol use disorder) are at high risk of manifesting extrapyramidal side effects or extrapyramidal symptoms (EPS) during treatment of alcohol-induced mental illness symptoms especially psychosis. EPS management poses a challenge since some of the drugs used for treating EPS have addictive properties. Read More

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The association of phasic irritability (aggressive outbursts) and tonic irritability (irritable mood) to depression occurrences, symptoms, and subtypes.

J Affect Disord 2021 10 11;293:9-18. Epub 2021 Jun 11.

Vanderbilt University, Nashville, Tennessee.

Background: Research among adults has rarely differentiated between tonic irritability (i.e., irritable mood) and phasic irritability (i. Read More

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October 2021

A Randomized Controlled Trial of Computerized Interpretation Bias Training for Disruptive Mood Dysregulation Disorder: A Fast-Fail Study.

J Am Acad Child Adolesc Psychiatry 2021 Jun 17. Epub 2021 Jun 17.

National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland.

Objective: To examine targeted, mechanism-based interventions is the next generation of treatment innovation. Biased threat labeling of ambiguous face emotions (interpretation bias) is a potential behavioral treatment target for anger, aggression, and irritability. Changing biases in face-emotion labeling may improve irritability-related outcomes. Read More

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Identifying the Inter-Domain Relations Among ODD, CD, and CU Traits in Preschool Children Using Network Analysis.

Res Child Adolesc Psychopathol 2021 10 14;49(10):1289-1301. Epub 2021 Jun 14.

University of Kentucky, Lexington, KY, 40506, USA.

Oppositional defiant disorder (ODD) and conduct disorder (CD) are two of the most common forms of disruptive behavior disorders during childhood. Callous-unemotional (CU) traits are an important factor in understanding the presentation of these externalizing forms of psychopathology. ODD, CD, and CU traits are highly related constructs, yet little work has examined how these externalizing forms of psychopathology are related at the domain level. Read More

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October 2021

The Challenge of Managing Patients Suffering from TBI: The Utility of Multiparametric MRI.

CNS Spectr 2021 04;26(2):178-179

Western University of Health Sciences, Pomona, CA, USA.

Traumatic brain injury (TBI) is a complex phenomenon affecting multiple areas of the brain in multiple ways. Both right and left hemispheres are affected as well as supratentorial and infratentorial compartments. These multifocal injuries are caused by many factors including acute mechanical injury, focal intracranial hemorrhage, blunt and rotational forces, epidural and subdural hematoma, hypoxemia, hypotension, edema, axonal damage, neuronal death, gliosis and blood brain barrier disruption. Read More

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Effects of the Great East Japan Earthquake and the Fukushima Daiichi Nuclear Power Plant accident on behavioural and psychological symptoms of dementia among patients.

Psychogeriatrics 2021 Sep 5;21(5):709-715. Epub 2021 Jun 5.

Department of Neuropsychiatry, Aizu Medical Centre, Fukushima Medical University, Aizuwakamatsu, Japan.

Background: The Great East Japan Earthquake triggered accidents at the Fukushima Daiichi Nuclear Power Plant, becoming the first complex disaster that included both a natural and a nuclear power disaster. This study examines how complex disasters affect patients with dementia.

Methods: Participants included the 331 people diagnosed with dementia out of the 2482 new patients (between January 2008 and December 2015) at a psychiatric hospital located in the indoor sheltering zones nearby mandatory evacuation zones. Read More

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September 2021

Forest Manners Exchange: Forest as a Place to Remedy Risky Behaviour of Adolescents: Mixed Methods Approach.

Int J Environ Res Public Health 2021 05 26;18(11). Epub 2021 May 26.

Department of Forestry and Wood Economics, Czech University of Life Sciences Prague, Faculty of Forestry and Wood Sciences, Kamýcká 129, 6-Suchdol, 16500 Praha, Czech Republic.

This paper evaluates the impact of the forest environment on aggressive manifestations in adolescents. A remedial educative programme was performed with 68 teenagers from institutions with substitute social care with diagnoses F 30.0 (affective disorders) and F 91. Read More

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Measuring Irritability in Early Childhood: A Psychometric Evaluation of the Affective Reactivity Index in a Clinical Sample of 3- to 8-Year-Old Children.

Assessment 2021 Jun 1:10731911211020078. Epub 2021 Jun 1.

Florida International University, Miami, FL, USA.

The parent-report Affective Reactivity Index (ARI-P) is the most studied brief scale specifically developed to assess irritability, but relatively little is known about its performance in early childhood (i.e., ≤8 years). Read More

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Low Dose Lithium Treatment of Behavioral Complications in Alzheimer's Disease: Lit-AD Randomized Clinical Trial.

Am J Geriatr Psychiatry 2021 May 12. Epub 2021 May 12.

Division of Geriatric Psychiatry (DPD, LSP, EDH, DAD, GHP), New York State Psychiatric Institute, NY; Department of Psychiatry (DPD, SL, HA, EDH, BAD, GHP), Columbia University Medical Center, NY; Department of Neurology and Taub Institute for Research on Alzheimer's Disease and the Aging Brain, (DPD, EDH), Columbia University Medical Center, NY; Center for Cognitive Neuroscience and Aging, Department of Psychiatry and Behavioral Sciences (EC, LL), University of Miami Miller School of Medicine Miami, FL; Division of Geriatric Psychiatry (BPF, IVV), McLean Hospital, Harvard Medical School, MA; Departments of Psychiatry and Neurology (MMH, NI), University of Texas Southwestern Medical Center, TX; Mental Health Data Science, Department of Psychiatry (SL, HA), Columbia University Medical Center and New York State Psychiatric Institute, NY.

Background: A case series suggested efficacy for lithium to treat agitation in dementia, but no placebo-controlled trials have been conducted.

Objectives: To evaluate low-dose lithium treatment of agitation in Alzheimer's disease (AD).

Method: In a four-site trial, patients with AD and agitation/aggression score ≥4 on the Neuropsychiatric Inventory (NPI) were randomized, double-blind, to lithium carbonate 150-600 mg daily or placebo for 12 weeks. Read More

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The association of sleep quality and aggression: A systematic review and meta-analysis of observational studies.

Sleep Med Rev 2021 Oct 12;59:101500. Epub 2021 May 12.

Department of Epidemiology and Data Science, Amsterdam Public Health Research Institute, Amsterdam University Medical Centres, Location VUMC, Amsterdam, the Netherlands.

Poor sleep quality is closely related to aggression, but despite the promise of new therapeutic possibilities, a systematic synthesis of observational research on the association between sleep quality and aggression is lacking. This systematic review and meta-analysis examined the association between sleep quality and aggression, using the academic databases PubMed and PsycINFO. Subjective and objective measures of sleep quality were included, as well as multiple measures of aggression, assessing aggressive and externalizing behavior, anger, hostility and irritability. Read More

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October 2021

The Irritable and Oppositional Dimensions of Oppositional Defiant Disorder: Integral Factors in the Explanation of Affective and Behavioral Psychopathology.

Child Adolesc Psychiatr Clin N Am 2021 07;30(3):637-647

Department of Psychological Sciences, University of Connecticut, 406 Babbidge Road, Storrs, CT 06269, USA.

Oppositional defiant disorder includes distinct but inseparable dimensions of chronic irritability and oppositional behavior. The dimensions have been identified in early childhood to adulthood, and show discriminant associations with internalizing and externalizing psychopathology. The introduction of disruptive mood dysregulation disorders and the requirements that it take precedence over oppositional defiant disorder diagnostically are not supported by evidence and introduce confusion about the structure and linkages of irritability and oppositional behavior, and obscure the importance of the behavioral dimension in explaining and predicting poor outcomes. Read More

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