11,189 results match your criteria irritability


Seizure frequency, quality of life, behavior, cognition, and sleep in pediatric patients enrolled in a prospective, open-label clinical study with cannabidiol.

Epilepsy Behav 2021 Sep 21;124:108325. Epub 2021 Sep 21.

Department of Child Health, University of Missouri, Columbia, MO 65201, USA; Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA; Department of Pediatrics, University of Florida, Gainesville, FL 32611, USA.

Objective: To evaluate the effects of oral pharmacological cannabidiol (CBD) on seizures, side effects, quality of life, behavior, mood, and sleep in children with drug-resistant epilepsy (DRE) during a phase II, prospective, open-label clinical study.

Methods: During a phase II expanded access program (EAP) study to evaluate the safety and efficacy of using cannabidiol (CBD) for the long-term treatment of children with drug-resistant epilepsy, secondary outcome measures were also performed, including quality of life (QOLCE), behavior (aberrant behavior checklist ABC), and sleep (children's sleep habit questionnaire, CSHQ). Participants between the ages of 2 and 16 years of age with drug-resistant epilepsy (n = 35) were included in this EAP. Read More

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September 2021

Role of auricular laser acupuncture and psychological counseling in reducing nicotine dependence due to smoking: A randomized controlled trial.

Indian J Public Health 2021 Jul-Sep;65(3):243-249

Professor and Head, Department of Public Health Dentistry, Dayanand Sagar College of Dental Sciences, Bengaluru, Karnataka, India.

Background: Low level laser therapy is a novel noninvasive technology used to stimulate the acupoints recognized for tobacco cessation.

Objective: To compare the effect of laser auricular acupuncture, psychological counseling, and combination of laser acupuncture and psychological counseling in reducing nicotine dependence due to smoking.

Methods: Smokers (n = 150) fulfilling the eligibility criteria were randomly allocated to three interventional groups. Read More

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September 2021

Preliminary Efficacy of Occupational Therapy in an Equine Environment for Youth with Autism Spectrum Disorder.

J Autism Dev Disord 2021 Sep 23. Epub 2021 Sep 23.

Wyoming Institute for Disabilities, University of Wyoming, 1000 E. University Ave, Laramie, WY, 82071, USA.

The purpose of this study was to identify appropriate outcome measures and assess preliminary efficacy of occupational therapy in an equine environment (OT HORSPLAY) for youth with autism spectrum disorder (ASD). Twenty-four youth with ASD aged 6-13 were randomized to 10 weeks of OT HORSPLAY or to a waitlist control condition, occupational therapy in a garden. Youth demonstrated significantly improved goal attainment and social motivation, and decreased irritability after OT HORSPLAY. Read More

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September 2021

Inhibitory Control in Early Childhood Aggression Subtypes: Mediation by Irritability.

Child Psychiatry Hum Dev 2021 Sep 22. Epub 2021 Sep 22.

Department of Psychology, University at Buffalo, The State University of New York, Buffalo, NY, USA.

The present study tested irritability as a mediator of inhibitory control's (IC) associations with crossed form and function aggression subtypes over one year in early childhood (N = 300, M = 44.70 months, SD = 4.38 months). Read More

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September 2021

Identifying novel mechanisms and treatment targets for irritability and aggression in psychiatric disorders.

Neuropsychopharmacology 2021 Sep 20. Epub 2021 Sep 20.

Center for Depression Research and Clinical Care, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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September 2021

Behavioral and Cognitive Response to Selective Serotonin Reuptake Inhibitors in Frontotemporal Lobar Degeneration: A Systematic Review and Meta-analysis.

Clin Neuropharmacol 2021 Sep-Oct 01;44(5):175-183

Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, MD, TX.

Objective: This article systematically reviews current literature on the efficacy and efficiency of selective serotonin reuptake inhibitors (SSRIs) in the treatment of patients with frontotemporal lobar degeneration (FTLD), with a particular focus on behavior and cognitive functions.

Methods: A search was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines using CENTRAL, MEDLINE, and Cochrane Library databases. Eleven randomized controlled trials and open-label studies looking at the effects of SSRIs on FTLD patients were included. Read More

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September 2021

Aberrant Intraregional Brain Activity and Functional Connectivity in Patients With Diarrhea-Predominant Irritable Bowel Syndrome.

Front Neurosci 2021 3;15:721822. Epub 2021 Sep 3.

Department of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, China.

Background And Purpose: The appearance and aggravation of diarrhea-predominant irritable bowel syndrome (IBS-D) have proven to be closely related to psychosocial factors. We aimed to measure altered spontaneous brain activity and functional connectivity (FC) in patients with IBS-D using resting-state functional magnetic resonance imaging (RS-fMRI) and to analyze the relationship between these parameters and emotional symptoms.

Methods: Thirty-six adult IBS-D patients and thirty-six demographic-matched healthy controls (HCs) underwent RS-fMRI scans. Read More

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September 2021

Irritable bowel syndrome is strongly associated with the primary and idiopathic mast cell disorders.

Neurogastroenterol Motil 2021 Sep 17:e14265. Epub 2021 Sep 17.

University Hospitals Cleveland Medical Center, Case Western Reserve University, Cleveland, Ohio, USA.

Background: Mounting evidence supports a mechanistic association between irritable bowel syndrome (IBS) symptoms and mast cell hyperactivity. Yet, association between IBS and mast cell disorders (MCDs) has not been studied. We examined this association using two large databases and verified with manual chart review. Read More

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September 2021

Clinical withdrawal symptom profile of synthetic cannabinoid receptor agonists and comparison of effects with high potency cannabis.

Psychopharmacology (Berl) 2021 Sep 17. Epub 2021 Sep 17.

Addiction and Mental Health Group (AIM), Department of Psychology, University of Bath, Bath, UK.

Synthetic cannabinoid receptor agonists (SCRAs) may be used as an alternative to natural cannabis; however, they may carry a greater risk of problematic use and withdrawal. This study aimed to characterise the withdrawal symptom profile of SCRAs and compare their profile of effect with high-potency herbal cannabis. Global Drug Survey data (2015 and 2016) were used to access a clinically relevant sample of people reporting use of SCRAs >10 times in the past 12-months, a previous SCRA quit attempt, and lifetime use of high-potency herbal cannabis. Read More

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September 2021

Efficacy of Brivaracetam in children with epilepsy.

Epilepsy Res 2021 Sep 10;177:106757. Epub 2021 Sep 10.

Hospital Universitario Niño Jesús, Madrid, Neuropediatría, Spain. Electronic address:

Background And Objectives: To determine the efficacy, tolerance, and safety of BRV in children with epilepsy.

Methods: A retrospective study of patients with epilepsy who received treatment with BRV before age 16 years and underwent a minimum follow-up of 3 months.

Method And Results: Sixty-six patients were included in the study. Read More

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September 2021

Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Protracted Alcohol Withdrawal Symptoms in Male Alcohol-Dependent Patients.

Front Psychiatry 2021 30;12:678594. Epub 2021 Aug 30.

Department of Nursing, Affiliated Psychological Hospital of Anhui Medical University, Hefei, China.

Protracted alcohol withdrawal symptoms (PAWS), characterized by the presence of substance-specific signs and symptoms (including anxiety, irritability, mood instability, insomnia, and cravings), make alcohol abstinence difficult and increase the risk of relapse in recovering alcoholics. The goal of this study was to evaluate the effect of transcutaneous auricular vagus nerve stimulation (taVNS) on PAWS and plasma brain-derived neurotrophic factor (BDNF), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and leptin levels in patients with alcohol dependency. A total of 114 patients with alcohol dependence were randomly divided into two groups: the treatment group and the control group. Read More

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Predicting the gender of individuals with tinnitus based on daily life data of the TrackYourTinnitus mHealth platform.

Sci Rep 2021 Sep 15;11(1):18375. Epub 2021 Sep 15.

Institute of Clinical Epidemiology and Biometry, University of Wuerzburg, Wuerzburg, Germany.

Tinnitus is an auditory phantom perception in the absence of an external sound stimulation. People with tinnitus often report severe constraints in their daily life. Interestingly, indications exist on gender differences between women and men both in the symptom profile as well as in the response to specific tinnitus treatments. Read More

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September 2021

Iron supplementation for hypoferritinemia-related psychological symptoms in children and adolescents.

J Nippon Med Sch 2021 Sep 14. Epub 2021 Sep 14.

Department of Psychiatry, Tokai University School of Medicine.

Background: Although some studies have described the association between serum ferritin levels and specific disorders in child and adolescent psychiatry, few have focused on mental health with low serum ferritin levels in children and adolescents. This study examined the effects of iron administration on psychological state of children and adolescents with reduced serum ferritin concentration.

Methods: This prospective study evaluated 19 participants aged 6-15 years with serum ferritin levels <30 ng/mL who visited a mental health clinic and received oral iron administration for 12 weeks. Read More

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September 2021

Treatment of a Case of Toe Hair-Thread Tourniquet Syndrome With Hirasè Technique.

Pediatr Emerg Care 2021 Sep 14. Epub 2021 Sep 14.

From the Division of Plastic Surgery, Department of Biotechnologies and Life Sciences, University of Insubria, ASST Sette Laghi, Varese, Italy.

Abstract: Hair-thread tourniquet syndrome (HTTS) is an uncommon condition that affects mostly babies, usually a few months old. It happens when a strand of hair or cloth fiber encircles an appendage causing a condition of total or subtotal ischemia (West J Med 1976;125:335-336). This condition has been described several times in the recent literature. Read More

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September 2021

Viridans Group Streptococcus Meningitis in an Immunocompetent Child: A Case Report.

Am J Case Rep 2021 Sep 14;22:e933089. Epub 2021 Sep 14.

Department of Pediatrics, Umm Al Qura University, Mecca, Saudi Arabia.

BACKGROUND Viridans group streptococci (VGS) are commensal organisms in humans that are considered contaminants when isolated from culture specimens. However, VGS can be pathogenic when recovered multiple times from blood cultures or when in immunocompromised hosts. VGS are the leading cause of dental abscesses and infective endocarditis in children with underlying congenital heart diseases. Read More

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September 2021

Protocol of controlled odorant stimulation for reducing apnoeic episodes in premature newborns: a randomised open-label Latin-square study with independent evaluation of the main endpoint (PREMODEUR).

BMJ Open 2021 Sep 13;11(9):e047141. Epub 2021 Sep 13.

Service de néonatologie et de réanimation néonatale, Hospices Civils de Lyon, Hôpital Femme Mère Enfant, Bron, France.

Introduction: Apnoea affects 85% of premature infants under 34 weeks of age and would be an important risk factor for subsequent neuropsychological disorders. Currently, premature children with life-threatening apnoeas receive stimulants such as methylxanthines (mainly, caffeine) or doxapram (an analeptic unlicensed in children under 15). However, these products have undesirable effects (hyperarousal, irritability, sleep disorders, tachycardia) and are not always effective because apnoea does persist in some premature newborns. Read More

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September 2021

Retrospective analysis of the effects of a hyaluronic-based gum gel to counteract signs and symptoms of teething in infants.

Minerva Pediatr (Torino) 2021 Sep 13. Epub 2021 Sep 13.

Department of Digestive Endoscopy, Fondazione, Poliambulanza, Brescia, Italy.

Background: Teething discomfort is a widespread disorder affecting a very high percentage of infants. It creates anxiety in parents, who look for help in pediatric clinics. The use of hyaluronic acid gels has been shown in the last 20 years to be an effective tool, generally devoid of side effects, in reducing oral mucosal inflammation in adults. Read More

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September 2021

Personality traits beyond Neuroticism predict post-concussive symptomatology in the post-acute period after mild traumatic brain injury in premorbidly healthy adults.

Appl Neuropsychol Adult 2021 Sep 11:1-10. Epub 2021 Sep 11.

Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Australia.

There is growing evidence that an individual's personality traits are related to post-concussion symptomatology beyond the acute period after mild traumatic brain injury (mTBI). Few studies, however, have analyzed this impact beyond the personality trait of Neuroticism. We examined the impact of personality traits on post-concussion symptoms (PCS) by measuring the Big Five personality domains and their lower-order aspects in 87 pre-morbidly healthy participants assessed 6-12 weeks post-mTBI ( = 53) or physical trauma ( = 34). Read More

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September 2021

Hypomanic/manic switch after transcranial magnetic stimulation in mood disorders: A systematic review and meta-analysis.

World J Psychiatry 2021 Aug 19;11(8):477-490. Epub 2021 Aug 19.

Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University of Chieti, Chieti 66100, Italy.

Background: Nowadays there is an increasing use of transcranial magnetic stimulation (TMS) both in neurological and psychiatric fields. After Food and Drug Administration approval of TMS for the therapy of treatment-resistant depression, TMS has been widely used in the context of mood disorders (MD). However, growing reports regarding the possibility of developing hypomanic/manic switch (HMS) have generated concern regarding its use in MDs. Read More

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Menopause and cognitive impairment: A narrative review of current knowledge.

World J Psychiatry 2021 Aug 19;11(8):412-428. Epub 2021 Aug 19.

Department of Obstetrics and Gynecology, School of Medical Sciences, State University of Campinas, Campinas 13083-881, São Paulo, Brazil.

A severe impairment of cognitive function characterizes dementia. Mild cognitive impairment represents a transition between normal cognition and dementia. The frequency of cognitive changes is higher in women than in men. Read More

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An Observational Study on Arrhythmia During Cesarean Section Under Spinal Anesthesia: Incidence, Risk Factors, and Effects on Immediate Post-delivery Neonatal Outcome.

Cureus 2021 Aug 5;13(8):e16898. Epub 2021 Aug 5.

Anesthesiology and Critical Care, North Eastern Indira Gandhi Regional Institute of Health & Medical Sciences, Shillong, IND.

Introduction: Various types of arrhythmia have been reported during cesarean section under spinal anesthesia. But the possible causative factors and the effects of arrhythmia on immediate post-delivery neonatal outcome are not well established.

Methods: This prospective observational study was conducted over a period of one year in a tertiary care hospital on women undergoing cesarean section under spinal anesthesia. Read More

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Does food insecurity affect musculoskeletal symptoms, fatigue, and productivity of municipality cleaners? A cross-sectional study.

Work 2021 Sep 5. Epub 2021 Sep 5.

School of Nutrition & Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Municipality cleaners are exposed to food insecurity, Musculoskeletal Symptoms (MSs), and fatigue.

Objective: This study aimed to investigate the effect of food insecurity on MSs, fatigue, and productivity among municipality cleaners.

Methods: This study was conducted on 399 Iranian male municipality cleaners with at least one year of working experience. Read More

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September 2021

Examining the influence of irritability and ADHD on domains of parenting stress.

Eur Child Adolesc Psychiatry 2021 Sep 12. Epub 2021 Sep 12.

University of Louisville, Louisville, USA.

Parents of children with ADHD typically report higher levels of parenting stress than parents of typically developing children. Children with ADHD display developmentally inappropriate levels of hyperactivity, impulsivity, and inattention. Some children with ADHD are also prone to particularly high levels of tonic irritability that may explain some of the impairments typically found in ADHD. Read More

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September 2021

Nutritional Formulation for Patients with Angelman Syndrome: A Randomized, Double-Blind, Placebo-Controlled Study of Exogenous Ketones.

J Nutr 2021 Sep 11. Epub 2021 Sep 11.

Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.

Background: Angelman syndrome (AS) patients often respond to low glycemic index therapy to manage refractory seizures. These diets significantly affect quality of life and are challenging to implement. These formulations may have benefits in AS even in the absence of biomarkers suggesting ketosis. Read More

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September 2021

Symptom structure of posttraumatic stress disorder after parental bereavement - a network analysis of Chinese parents who have lost their only child.

J Affect Disord 2021 Sep 2;295:673-680. Epub 2021 Sep 2.

CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China. Electronic address:

Background: The death of a child is a highly traumatic event and often leads to mental health problems, including posttraumatic stress disorder (PTSD). Previous studies have focused on overall PTSD after the loss of an only child; however, little attention has been given to PTSD at the symptom level. This study aims to identify the network structure of PTSD symptoms in bereaved parents who have lost their only child, known as Shidu parents in Chinese society. Read More

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September 2021

Associations Among Irritability, High-Sensitivity C-Reactive Protein /Interleukin-6, and Depression in Early-Stage Breast Cancer Patients Undergoing Chemotherapy: A Prospective Study.

J Acad Consult Liaison Psychiatry 2021 Sep 7. Epub 2021 Sep 7.

Professor of Psychiatry, Case Western Reserve University School of Medicine, Clinical Director of Mood Disorders Program, University Hospitals Cleveland Medical Center, 10524 Euclid Avenue, 12th Floor, Cleveland, OH, 44106.

Objectives: We examined associations among irritability (e.g., a feeling of agitation), inflammatory biomarkers, and depression during chemotherapy. Read More

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September 2021

Long-Term Neurological and Psychological Distress Symptoms among Smallholder Farmers in Costa Rica with a History of Acute Pesticide Poisoning.

Int J Environ Res Public Health 2021 Aug 26;18(17). Epub 2021 Aug 26.

Central American Institute for Studies on Toxic Substances, Universidad Nacional, Heredia 83-3000, Costa Rica.

Studies suggest that acute pesticide poisonings (APP) may be linked with long-term neurological effects. To examine long-term neurological and psychological distress symptoms associated with having experienced an APP, we conducted a cross-sectional study of 300 conventional and organic smallholder farmers from Zarcero County, Costa Rica, May-August 2016. We collected self-reported data on sociodemographic characteristics, occupational history, pesticide exposure, APPs, neurological and psychological distress symptoms (using the Brief Symptom Inventory (BSI)). Read More

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Impacts of the Goldmining and Chronic Methylmercury Exposure on the Good-Living and Mental Health of Munduruku Native Communities in the Amazon Basin.

Int J Environ Res Public Health 2021 Aug 26;18(17). Epub 2021 Aug 26.

Departamento de Endemias Samuel Pessoa, Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz (ENSP/Fiocruz), Rua Leopoldo Bulhões, 1480, Manguinhos, Rio de Janeiro 21041-210, Brazil.

This paper is an exploratory study that examines the illegal goldmining impacts on Munduruku communities' "Good-Living" () and explores the possible relationship between chronic methylmercury (MeHg) exposure and the worsening mental health conditions in three villages in the Middle-Tapajós River, Brazilian Amazon. The region has been experiencing a long-lasting threat of goldminers' invasions. A total of 109 people were interviewed and evaluated. Read More

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Screening male prisoners for depression and anxiety with the PHQ-9 and GAD-7 at NHS Healthcheck: patterns of symptoms and caseness threshold.

BMC Psychiatry 2021 09 9;21(1):446. Epub 2021 Sep 9.

Psychiatry, Institute of Mental Health, University of Nottingham, Nottingham, NG7 2DU, UK.

Background: Screening for depression and anxiety disorders has been proposed in prison populations but little is known about caseness thresholds on commonly used self-report measures in relation to core symptoms, risk factors and symptom patterns.

Method: A cross-sectional prevalence survey measured depression and anxiety caseness (threshold scores > 10 and > 15 on PHQ-9 and GAD-7 and diagnostic algorithm on PHQ-9) in 1205 male prisoners aged 35-74 years eligible for an NHS Healthcheck from six English prisons. Caseness scores were compared with the presence or absence of daily core symptoms of depression and generalised anxiety disorder (GAD), demographic, prison and cardiovascular risk factors. Read More

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September 2021