302 results match your criteria iron oxide-based


Stimuli responsive and receptor targeted iron oxide based nanoplatforms for multimodal therapy and imaging of cancer: Conjugation chemistry and alternative therapeutic strategies.

J Control Release 2021 Mar 22;333:188-245. Epub 2021 Mar 22.

Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat 382481, India. Electronic address:

Cancer being one of the most precarious and second most fatal diseases evokes opportunities for multimodal delivery platforms which will act synergistically for efficient cancer treatment. Multifunctional iron oxide magnetic nanoparticles (IONPs) are being studied for few decades and still attracting increasing attention for several biomedical applications owing to their multifunctional design and intrinsic magnetic properties that provide a multimodal theranostic platform for cancer therapy, monitoring and diagnosis. The review article aims to provide brief information on various surface chemistries involved in modulating IONPs properties to exhibit potential therapy in cancer treatment. Read More

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Biodistribution of poly clustered superparamagnetic iron oxide nanoparticle labeled mesenchymal stem cells in aminoglycoside induced ototoxic mouse model.

Biomed Eng Lett 2021 Feb 8;11(1):39-53. Epub 2021 Jan 8.

Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, Wonju, 26426 South Korea.

Recently, application of stem cell therapy in regenerative medicine has become an active field of study. Mesenchymal stem cells (MSCs) are known to have a strong ability for homing. MSCs labeled with superparamagnetic iron oxide nanoparticles (SPIONs) exhibit enhanced homing due to magnetic attraction. Read More

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February 2021

Nanoparticles exhibiting self-regulating temperature as innovative agents for Magnetic Fluid Hyperthermia.

Nanotheranostics 2021 15;5(3):333-347. Epub 2021 Mar 15.

Department of Computer Science, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy.

During the last few years, for therapeutic purposes in oncology, considerable attention has been focused on a method called magnetic fluid hyperthermia (MFH) based on local heating of tumor cells. In this paper, an innovative, promising nanomaterial, M48 composed of iron oxide-based phases has been tested. M48 shows self-regulating temperature due to the observable second order magnetic phase transition from ferromagnetic to paramagnetic state. Read More

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Biomineralized iron oxide-polydopamine hybrid nanodots for contrast-enhanced -weighted magnetic resonance imaging and photothermal tumor ablation.

J Mater Chem B 2021 02;9(7):1781-1786

Jiangsu Key Laboratory of Neuropsychiatric Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China.

Iron oxide nanoparticles (IO NPs) have become the focus of molecular imaging probes for contrast enhanced magnetic resonance (MR) imaging due to their intrinsic magnetic and biodegradable properties, as well as long blood half-lives and low toxicity. Massive efforts have been made to explore the IO NPs as T2-weighted MR contrast agents, which have high susceptibility to induce a long-range magnetic field that interferes with diagnosis. Thus, the development of IO NPs with potent T1 relaxivity might help in providing an alternative for clinically applied gadolinium chelates. Read More

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February 2021

Bioevaluation methods for iron-oxide-based magnetic nanoparticles.

Int J Pharm 2021 Mar 3;597:120348. Epub 2021 Feb 3.

University of Ljubljana, Faculty of Pharmacy, The Chair of Pharmaceutical Technology, Aškerčeva cesta 7, 1000 Ljubljana, Slovenia. Electronic address:

Despite the intensive development and unique properties of iron-oxide-based magnetic nanoparticles (MNPs), their use as drug delivery systems has not yet entered clinical practice. There also remains a lack of data on their toxicity profile and behavior in the bioenvironment. A number of in-vitro studies have been performed, but these were carried out with various MNPs using various methods of bioevaluation and various cell lines, so they are not universally applicable. Read More

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Targeted Molecular Imaging of Cardiovascular Diseases by Iron Oxide Nanoparticles.

Arterioscler Thromb Vasc Biol 2020 Dec 24:ATVBAHA120315404. Epub 2020 Dec 24.

Australian Institute for Bioengineering and Nanotechnology, the University of Queensland, Australia (K.X.V.-P., Z.P.X., H.T.T.).

Cardiovascular disease is one of the major contributors to global disease burden. Atherosclerosis is an inflammatory process that involves the accumulation of lipids and fibrous elements in the large arteries, forming an atherosclerotic plaque. Rupture of unstable plaques leads to thrombosis that triggers life-threatening complications such as myocardial infarction. Read More

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December 2020

Advanced Functional Nanostructures based on Magnetic Iron Oxide Nanomaterials for Water Remediation: A Review.

Water Res 2021 Feb 30;190:116693. Epub 2020 Nov 30.

Center of Nanoscience, Nanotechnology and Innovation - CeNano(2)I, Department of Metallurgical and Materials Engineering, Federal University of Minas Gerais - UFMG, Av. Antônio Carlos, 6627 - Belo Horizonte/MG, Brazil. Electronic address:

The fast growth of industrialization combined with the increasing population has led to an unparalleled demand for providing water in a safe, reliable, and cost-effective way, which has become one of the biggest challenges of the twenty-first century faced by global society. The application of nanotechnology in water treatment and pollution cleanup is a promising alternative in order to overcome the current limitations. In particular, the application of magnetic iron oxide nanoparticles (MIONs) for environmental remediation has currently received remarkable attention due to its unique combination of physicochemical and magnetic properties. Read More

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February 2021

Microdistribution of Magnetic Resonance Imaging Contrast Agents in Atherosclerotic Plaques Determined by LA-ICP-MS and SR-μXRF Imaging.

Mol Imaging Biol 2020 Dec 7. Epub 2020 Dec 7.

Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.

Purpose: Contrast-enhanced magnetic resonance imaging (MRI) has the potential to replace angiographic evaluation of atherosclerosis. While studies have investigated contrast agent (CA) uptake in atherosclerotic plaques, exact CA spatial distribution on a microscale is elusive. The purpose of this study was to investigate the microdistribution of gadolinium (Gd)- and iron (Fe) oxide-based CA in atherosclerotic plaques of New Zealand White rabbits. Read More

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December 2020

Iron Dysregulation in Human Cancer: Altered Metabolism, Biomarkers for Diagnosis, Prognosis, Monitoring and Rationale for Therapy.

Cancers (Basel) 2020 Nov 26;12(12). Epub 2020 Nov 26.

Institute for Advanced Biosciences, UGA INSERM U1209 CNRS UMR5309, 38700 La Tronche, France.

Iron (Fe) is a trace element that plays essential roles in various biological processes such as DNA synthesis and repair, as well as cellular energy production and oxygen transport, and it is currently widely recognized that iron homeostasis is dysregulated in many cancers. Indeed, several iron homeostasis proteins may be responsible for malignant tumor initiation, proliferation, and for the metastatic spread of tumors. A large number of studies demonstrated the potential clinical value of utilizing these deregulated proteins as prognostic and/or predictive biomarkers of malignancy and/or response to anticancer treatments. Read More

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November 2020

Organ-specific toxicity of magnetic iron oxide-based nanoparticles.

Nanotoxicology 2021 03 20;15(2):167-204. Epub 2020 Nov 20.

SCAMT Institute, ITMO University, Peterburg, Russian Federation.

The unique properties of magnetic iron oxide nanoparticles determined their widespread use in medical applications, the food industry, textile industry, which in turn led to environmental pollution. These factors determine the long-term nature of the effect of iron oxide nanoparticles on the body. However, studies in the field of chronic nanotoxicology of magnetic iron particles are insufficient and scattered. Read More

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Reduced Graphene Oxide-Based Foam as an Endocrine Disruptor Adsorbent in Aqueous Solutions.

Membranes (Basel) 2020 Nov 13;10(11). Epub 2020 Nov 13.

Department of Chemistry and Biochemistry, Université du Québec à Montréal, Montréal, QC H3C 3P8, Canada.

A stable and magnetic graphene oxide (GO) foam-polyethyleneimine-iron nanoparticle (GO-PEI-FeNPs) composite has been fabricated for removal of endocrine disruptors-bisphenol A, progesterone and norethisterone-from aqueous solution. The foam with porous and hierarchical structures was synthesized by reduction of graphene oxide layers coupled with co-precipitation of iron under a hydrothermal system using polyethyleneimine as a cross linker. The presence of magnetic iron nanoparticles facilitates the separation process after decontamination. Read More

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November 2020

Activating Iron Based Materials for Overall Electrochemical Water Splitting via the Incorporation of Noble Metals.

Chem Asian J 2020 Dec 17;15(24):4339-4346. Epub 2020 Nov 17.

School of Chemistry and Physics, Queensland University of Technology (QUT), Brisbane, QLD 4001, Australia.

Although the presence of iron in mixed metal oxide based catalysts has shown significant performance improvement in the oxygen evolution reaction (OER), iron oxides themselves demonstrate much poorer activity. In this study, we investigate improving the performance of iron catalysts via surface decoration with gold or platinum for not only the OER but also the hydrogen evolution reaction (HER) for overall water splitting in an alkaline electrolyte. Two types of iron catalysts were synthesised, iron nanocubes and iron oxide via electrochemical deposition methods which were decorated with either Au or Pt via galvanic replacement. Read More

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December 2020

Simultaneous molecular MRI of extracellular matrix collagen and inflammatory activity to predict abdominal aortic aneurysm rupture.

Sci Rep 2020 09 16;10(1):15206. Epub 2020 Sep 16.

Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität Zu Berlin, and Berlin Institute of Health, Charitéplatz 1, 10117, Berlin, Germany.

Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease with an up to 80% mortality in case of rupture. Current biomarkers fail to account for size-independent risk of rupture. By combining the information of different molecular probes, multi-target molecular MRI holds the potential to enable individual characterization of AAA. Read More

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September 2020

Developments in the Application of Nanomaterials for Water Treatment and Their Impact on the Environment.

Nanomaterials (Basel) 2020 Sep 7;10(9). Epub 2020 Sep 7.

Center for Advanced Materials (CAM), Qatar University, P.O. Box 2713 Doha, Qatar.

Nanotechnology is an uppermost priority area of research in several nations presently because of its enormous capability and financial impact. One of the most promising environmental utilizations of nanotechnology has been in water treatment and remediation where various nanomaterials can purify water by means of several mechanisms inclusive of the adsorption of dyes, heavy metals, and other pollutants, inactivation and removal of pathogens, and conversion of harmful materials into less harmful compounds. To achieve this, nanomaterials have been generated in several shapes, integrated to form different composites and functionalized with active components. Read More

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September 2020

Yttrium iron garnet for hyperthermia applications: Synthesis, characterization and in-vitro analysis.

Mater Sci Eng C Mater Biol Appl 2020 Nov 6;116:111163. Epub 2020 Jun 6.

Bio-Interface & Environmental Engineering Lab, Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. Electronic address:

Exclusive magnetocaloric properties of orthoferrites offer advantages for their application in the magnetic hyperthermia as well as imaging applications. In the present study, the effect of yttrium concentration on the magnetic characteristics of the iron oxide based nanomaterials was analyzed to assess their potential for the hyperthermia applications. The Sol-gel method was used to synthesize the Yttrium Iron Garnet (YIG) based nanoparticles, using different molar ratios of Fe and Y precursors, followed by the calcination at 900, 1000 and 1100 °C. Read More

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November 2020

Surface Modification of Iron Oxide-Based Magnetic Nanoparticles for Cerebral Theranostics: Application and Prospection.

Nanomaterials (Basel) 2020 Jul 24;10(8). Epub 2020 Jul 24.

National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing 100190, China.

Combining diagnosis with therapy, magnetic iron oxide nanoparticles (INOPs) act as an important vehicle for drug delivery. However, poor biocompatibility of INOPs limits their application. To improve the shortcomings, various surface modifications have been developed, including small molecules coatings, polymers coatings, lipid coatings and lipopolymer coatings. Read More

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High-resolution ICP-MS approach for characterization of magnetic nanoparticles for biomedical applications.

J Pharm Biomed Anal 2020 Sep 16;189:113479. Epub 2020 Jul 16.

Vernadsky Institute of Geochemistry and Analytical Chemistry, Kosygin St. 19, 119991, Moscow, Russian Federation. Electronic address:

The potential of iron oxide-based nanoparticles (IONs) as theranostic agents is believed to be in a great part due to non-invasive diagnosis and therapeutic applications. However, there is still a lack of well-recognized methodology to assess bioresistance, hypotoxicity, reactivity toward pertinent biomolecules, as well as an eventual dose of IONs as prerequisites for their clinical use. In this study, we demonstrate how application of high-resolution ICP-MS in combination with conventional ultrafiltration can address these important issues in a simple and high-throughput way. Read More

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September 2020

Hydrothermal synthesis and characterization of magnetic FeO and APTS coated FeO nanoparticles: physicochemical investigations of interaction with DNA.

J Mater Sci Mater Med 2020 Jul 23;31(8):68. Epub 2020 Jul 23.

Nano-bioconjugate Chemistry Lab, Cluster Innovation Centre, University of Delhi, Delhi, India.

Magnetic nanoparticles (MNPs) especially iron oxide (FeO) NPs have quite extensively been used for in vivo delivery of biomolecules and drugs because of their high bioconjugation efficiency. In this study, FeO NPs and (3-Aminopropyl) triethoxysilane (APTS) coated FeO NPs were synthesized and their interaction with Calf thymus (Ct) DNA has been studied in order to understand their usage in biomedical applications. Hydrothermal method was used for the NPs synthesis. Read More

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A highly selective iron oxide-based imaging nanoparticle for long-term monitoring of drug-induced tumor cell apoptosis.

Biomater Sci 2021 Jan;9(2):471-481

Department of Materials Sciences and Engineering, University of Washington, Seattle, Washington 98195, USA. and Department of Neurological Surgery, University of Washington, Seattle, Washington 98195, USA.

The ability to visualize and quantify apoptosis in vivo is critical to monitoring the disease response to treatment and providing prognostic information. However, the application of current apoptosis labeling probes faces significant challenges including nonspecific tissue uptake, inefficient apoptotic cell labeling and short monitoring windows. Here we report a highly specific apoptosis labeling nanoparticle (NP) probe with Pisum sativum agglutinin (PSA) as a tumor targeting ligand for prolonged in vivo apoptosis imaging. Read More

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January 2021

Exploring precision polymers to fine-tune magnetic resonance imaging properties of iron oxide nanoparticles.

J Colloid Interface Sci 2020 Nov 10;579:401-411. Epub 2020 Jun 10.

Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK. Electronic address:

The use of bio-polymers as stabilising agents for iron oxide-based negative magnetic resonance imaging (MRI) contrast agents has become popular in recent years, however the wide polydispersity of biologically-derived and commercially available polymers limits the ability to produce truly tuneable and reproducible behaviour, a major challenge in this area. In this work, stable colloids of iron oxide nanoparticles were prepared utilising precision-engineered bio-polymer mimics, poly(2-acrylamido-2-methylpropane sodium sulfonate) (P(AMPS)) polymers, with controlled narrow polydispersity molecular weights, as templating stabilisers. In addition to producing magnetic colloids with excellent MRI contrast capabilities (r values reaching 434. Read More

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November 2020

Simultaneous in vivo PET/MRI using fluorine-18 labeled FeO@Al(OH) nanoparticles: comparison of nanoparticle and nanoparticle-labeled stem cell distribution.

EJNMMI Res 2020 Jun 30;10(1):73. Epub 2020 Jun 30.

Biomedical MRI, Department of Imaging and Pathology, KU Leuven, 3000, Leuven, Belgium.

Background: Mesenchymal stem cells (MSCs) have shown potential for treatment of different diseases. However, their working mechanism is still unknown. To elucidate this, the non-invasive and longitudinal tracking of MSCs would be beneficial. Read More

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Quantification of Synergistic Effects of Ceragenin CSA-131 Combined with Iron Oxide Magnetic Nanoparticles Against Cancer Cells.

Int J Nanomedicine 2020 24;15:4573-4589. Epub 2020 Jun 24.

Department of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Bialystok 15-222, Poland.

Background: Therapeutic efficiency of ceragenins against cancers may be limited by lack of their hemocompatibility when high concentrations of molecules are required to reach a desired result. Synergistic effects observed upon administration of anticancer agents and metal nanoparticles may provide an opportunity to limit toxicity of immobilized ceragenins on the surface of metal nanoparticles and to improve their therapeutic efficiency at the same time. The aim of present work is to investigate the anticancer activities and hemocompatibility of nanoformulations consisting of ceragenin CSA-131 united with aminosilane-modified iron oxide-based magnetic nanoparticles (MNP) and prepared by 1) covalent bonding (MNP@CSA-131) or 2) by combining CSA-131 with MNP in 1:1 ratio (CSA-131 + MNP). Read More

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Efficient uptake and retention of iron oxide-based nanoparticles in HeLa cells leads to an effective intracellular delivery of doxorubicin.

Sci Rep 2020 06 29;10(1):10530. Epub 2020 Jun 29.

Heidelberg University, Medical Faculty Mannheim, Universitätsmedizin Mannheim, Department of Radiation Oncology, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

The purpose of this study was to construct and characterize iron oxide nanoparticles (IONP) for intracellular delivery of the anthracycline doxorubicin (DOX; IONP) in order to induce tumor cell inactivation. More than 80% of the loaded drug was released from IONP within 24 h (100% at 70 h). Efficient internalization of IONP and IONP in HeLa cells occurred through pino- and endocytosis, with both IONP accumulating in a perinuclear pattern. Read More

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A Graphdiyne Oxide-Based Iron Sponge with Photothermally Enhanced Tumor-Specific Fenton Chemistry.

Adv Mater 2020 Aug 28;32(31):e2000038. Epub 2020 Jun 28.

CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing, 100190, P. R. China.

Fenton reaction-mediated oncotherapy is an emerging strategy which uses iron ions to catalytically convert endogenous hydrogen peroxide into hydroxyl radicals, the most reactive oxygen species found in biology, for efficient cancer therapy. However, Fenton reaction efficiency in tumor tissue is typically limited due to restrictive conditions. One strategy to overcome this obstacle is to increase the temperature specifically at the tumor site. Read More

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Insights into Ion Occupancy Manipulation of Fe-Co Oxide Free-Standing Cathodes for Li-O Batteries with Enhanced Deep Charge Capability and Long-Term Capability.

ACS Appl Mater Interfaces 2020 Jul 26;12(27):30268-30279. Epub 2020 Jun 26.

Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, China.

The merits of Li-O batteries due to the huge energy density are shadowed by the sluggish kinetics of oxygen redox and massive side reactions caused by conductive carbon and a binder. Herein, Fe-Co inverse spinel oxide nanowires grown on Ni foam are fabricated as carbon-free and binder-free cathodes for Li-O batteries. Superior high rate cycle durability and deep charge capability are obtained. Read More

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Iron Oxide Nanoparticle-Induced Autophagic Flux Is Regulated by Interplay between p53-mTOR Axis and Bcl-2 Signaling in Hepatic Cells.

Cells 2020 04 18;9(4). Epub 2020 Apr 18.

Institute of Physics of the Czech Academy of Sciences, Prague, 18221, Czech Republic.

Iron oxide-based nanoparticles have been repeatedly shown to affect lysosomal-mediated signaling. Recently, nanoparticles have demonstrated an ability to modulate autophagic flux via lysosome-dependent signaling. However, the precise underlying mechanisms of such modulation as well as the impact of cellular genetic background remain enigmatic. Read More

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Coarse-graining in micromagnetic simulations of dynamic hysteresis loops.

J Phys Condens Matter 2020 Apr 23;32(35):35LT01. Epub 2020 Apr 23.

Department of Physics and Physical Oceanography, Memorial University of Newfoundland, St. John's, Newfoundland and Labrador, Canada, A1B 3X7. Department of Applied Mathematics, University of Western Ontario, London, Ontario, Canada, N6A 3K7.

We use micromagnetic simulations based on the stochastic Landau-Lifshitz-Gilbert equation to calculate dynamic magnetic hysteresis loops at finite temperature that are invariant with simulation cell size. As a test case, we simulate a magnetite nanorod, the building block of magnetic nanoparticles that have been employed in preclinical studies of hyperthermia. With the goal to effectively simulate loops for large iron-oxide-based systems at relatively slow sweep rates on the order of 1 Oe ns or less, we modify and employ a previously derived renormalization group approach for coarse-graining (Grinstein and Koch 2003 Phys. Read More

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A novel intratumoral pH/redox-dual-responsive nanoplatform for cancer MR imaging and therapy.

J Colloid Interface Sci 2020 Aug 7;573:263-277. Epub 2020 Apr 7.

Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, Hubei University, Wuhan 430062, China. Electronic address:

The integration of diagnostic and therapeutic functions in a nanoplatform has been a rapidly emerging method in the management of cancer. The application of imaging technology paves the way to track the pharmacokinetics of the nanoplatforms, to guide the treatment, and to monitor the therapeutic processes and outcomes. Herein, we reported a novel type of monodisperses mesoporous silica-coated superparamagnetic iron oxide-based multifunctional nanoplatform (DOX@MMSN-SS-PEI-cit) for the diagnosis and treatment of cancer. Read More

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Facile CO separation and subsequent H production via chemical-looping combustion over ceria-zirconia solid solutions.

Phys Chem Chem Phys 2020 Apr;22(16):8545-8556

Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, 32611, USA.

A novel chemical-looping combustion scheme is proposed, where facile gas separation via steam condensation enables the production of sequestrable CO2 from alkanes, such as CH4, and pure H2 from H2O. This cycle consists of two steps, namely, (1) the endothermic reduction of a ceria-based solid solution via the complete oxidation of CH4, followed by (2) the exothermic oxidation of the reduced metal oxide via H2O splitting. Relative to iron oxide-based materials and undoped ceria, ceria-zirconia solid solutions possess favorable partial molar enthalpic and entropic properties; this promotes selective production of complete combustion products, H2O and CO2, during the reforming reaction. Read More

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Shape Anisotropic Iron Oxide-Based Magnetic Nanoparticles: Synthesis and Biomedical Applications.

Int J Mol Sci 2020 Apr 1;21(7). Epub 2020 Apr 1.

Centre of Physics (CFUM), University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

Research on iron oxide-based magnetic nanoparticles and their clinical use has been, so far, mainly focused on the spherical shape. However, efforts have been made to develop synthetic routes that produce different anisotropic shapes not only in magnetite nanoparticles, but also in other ferrites, as their magnetic behavior and biological activity can be improved by controlling the shape. Ferrite nanoparticles show several properties that arise from finite-size and surface effects, like high magnetization and superparamagnetism, which make them interesting for use in nanomedicine. Read More

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