8,700 results match your criteria iron homeostasis

Loss of SDHB Promotes Dysregulated Iron Homeostasis, Oxidative Stress, and Sensitivity to Ascorbate.

Cancer Res 2021 Jun 14. Epub 2021 Jun 14.

PARCC, INSERM UMR970, Equipe Labellisée par la Ligue Contre le Cancer, Paris, France.

Succinate dehydrogenase is a key enzyme in the tricarboxylic acid cycle and the electron transport chain. All four subunits of succinate dehydrogenase are tumor suppressor genes predisposing to paraganglioma, but only mutations in the SDHB subunit are associated with increased risk of metastasis. Here we generated an knockout chromaffin cell line and compared it with deficient cells. Read More

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Effect of increased blood flow rate on renal anemia and hepcidin concentration in hemodialysis patients.

BMC Nephrol 2021 Jun 15;22(1):221. Epub 2021 Jun 15.

Department of Gastroenterological and Transplant Surgery, Applied Life Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

Background: Increasing the blood flow rate (BFR) is a useful method for increasing Kt/V and the clearance for low molecular solutes. Hemodialysis patients are often anemic due to hypoerythropoiesis and their chronic inflammatory state. Hepcidin, a hormone that regulates iron homeostasis, is considered as an indicator of iron deficiency in patients with end-stage renal disease. Read More

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Effect of Daily Iron Supplementation on Infantile Iron Homeostasis in Preterm Infants.

Front Pediatr 2021 28;9:687119. Epub 2021 May 28.

Department of Pediatric Health Care, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.

The aim of this study was to investigate the effects of unified iron supplementation and identify the factors related to the iron homeostasis among preterm infants. A total of 250 preterm infants were divided into neonatal anemic (NA, = 154) and non-neonatal anemic group (NNA, = 96). Iron supplements at a dose of 2 mg/kg per day were given from 40 weeks' gestational age to 6 months. Read More

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Iron Biofortification in Rice: An Update on Quantitative Trait Loci and Candidate Genes.

Front Plant Sci 2021 26;12:647341. Epub 2021 May 26.

Departamento de Botânica, Instituto de Biociências, e Programa de Pós-Graduação em Biologia Celular e Molecular, Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Rice is the most versatile model for cereals and also an economically relevant food crop; as a result, it is the most suitable species for molecular characterization of Fe homeostasis and biofortification. Recently there have been significant efforts to dissect genes and quantitative trait loci (QTL) associated with Fe translocation into rice grains; such information is highly useful for Fe biofortification of cereals but very limited in other species, such as maize () and wheat (). Given rice's centrality as a model for Poaceae species, we review the current knowledge on genes playing important roles in Fe transport, accumulation, and distribution in rice grains and QTLs that might explain the variability in Fe concentrations observed in different genotypes. Read More

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Adv Food Nutr Res 2021 18;96:219-250. Epub 2021 May 18.

Department of Nutritional Sciences, King's College London, London, United Kingdom.

Iron deficiency anemia affects approximately one-third of the world's population, and about half the cases are due to iron deficiency. The latest research on iron metabolism published in original articles and systematic reviews is described, and references to recent reviews provided. The topics include dietary sources and bioavailability, iron homeostasis, functions of iron in the body, and biomarkers of status. Read More

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Hepcidin contributes to Swedish mutant APP-induced osteoclastogenesis and trabecular bone loss.

Bone Res 2021 Jun 9;9(1):31. Epub 2021 Jun 9.

Department of Neurosciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.

Patients with Alzheimer's disease (AD) often have lower bone mass than healthy individuals. However, the mechanisms underlying this change remain elusive. Previously, we found that Tg2576 mice, an AD animal model that ubiquitously expresses Swedish mutant amyloid precursor protein (APP), shows osteoporotic changes, reduced bone formation, and increased bone resorption. Read More

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Role of Iron in the Molecular Pathogenesis of Diseases and Therapeutic Opportunities.

ACS Chem Biol 2021 06 9;16(6):945-972. Epub 2021 Jun 9.

Centre for Blood Research, Life Sciences Institute, The University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3.

Iron is an essential mineral that serves as a prosthetic group for a variety of proteins involved in vital cellular processes. The iron economy within humans is highly conserved in that there is no proper iron excretion pathway. Therefore, iron homeostasis is highly evolved to coordinate iron acquisition, storage, transport, and recycling efficiently. Read More

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Role of hepcidin in physiology and pathophysiology. Emerging experimental and clinical evidence.

J Physiol Pharmacol 2021 Feb 3;72(1). Epub 2021 Jun 3.

Preventive Research Institute, The President Stanislaw Wojciechowski State University of Applied Sciences in Kalisz, Kalisz, Poland.

Normal iron metabolism is an inherent feature of maintaining homeostasis. There is a wide range of iron disorders, which arise from iron deficiency or overload. In addition, disturbances in iron metabolism are observed in the course of numerous chronic diseases. Read More

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February 2021

Calcitonin increases hepatic hepcidin expression through the BMP6 of kidney in mice.

J Trace Elem Med Biol 2021 Jun 1;68:126796. Epub 2021 Jun 1.

Laboratory of Molecular Iron Metabolism, College of Life Science, Hebei Normal University, Shijiazhuang, Hebei Province, China. Electronic address:

Background: Osteoporosis is frequently accompanied by iron disorders. Calcitonin (CT) was approved as a clinical drug to treat osteoporosis. Hepcidin is a peptide hormone that is secreted by the liver and controls body iron homeostasis. Read More

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Determination of Metal Content in Drosophila melanogaster During Metal Exposure.

Guiran Xiao

Methods Mol Biol 2021 ;2326:327-337

School of Food and Biological Engineering, Hefei University of Technology, Hefei, Anhui, China.

Trace metal elements, such as zinc, iron, copper, and manganese, play catalytic or structural roles in many enzymes and numerous proteins, and accordingly, contribute to a variety of fundamental biological processes. During the past decade, the fruit fly (Drosophila melanogaster) has become an important model organism for elucidating metal homeostasis in metazoan. We have been using Drosophila as a model to study metal metabolism for many years and have optimized simple and robust assays for determining the metal content in Drosophila, such as inductively coupled plasma mass spectrometry (ICP-MS), the activity assay of enzymes dependent on metals, and staining metal ions in tissues of Drosophila. Read More

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January 2021

Iron Reshapes the Gut Microbiome and Host Metabolism.

J Lipid Atheroscler 2021 May 10;10(2):160-183. Epub 2021 Mar 10.

Department of Biology, York University, Toronto, ON, Canada.

Compelling studies have established that the gut microbiome is a modifier of metabolic health. Changes in the composition of the gut microbiome are influenced by genetics and the environment, including diet. Iron is a potential node of crosstalk between the host-microbe relationship and metabolic disease. Read More

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The Ferroxidase Hephaestin in Lung Cancer: Pathological Significance and Prognostic Value.

Front Oncol 2021 19;11:638856. Epub 2021 May 19.

Department of Life Sciences, University of Trieste, Trieste, Italy.

Hephaestin (HEPH) belongs to a group of exocytoplasmic ferroxidases which contribute to cellular iron homeostasis by favouring its export. Down-regulation of HEPH expression, possibly by stimulating cell proliferation due to an increase in iron availability, has shown to correlate with poor survival in breast cancer. The lung is particularly sensitive to iron-induced oxidative stress, given the high oxygen tension present, however, HEPH distribution in lung cancer and its influence on prognosis have not been investigated yet. Read More

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The role of iron homeostasis and iron-mediated ROS in cancer.

Am J Cancer Res 2021 15;11(5):1895-1912. Epub 2021 May 15.

Key Laboratory of Tumor Molecular Diagnosis and Individualized Medicine of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College Hangzhou 310014, Zhejiang Province, P. R. China.

As an important trace element, iron plays an essential role in many biology processes like cell proliferation, metabolism, and mitochondrial function. However, the disruption of iron homeostasis tends to cells death and human diseases due to it servers as mediator to promote the production of reactive oxygen species (ROS). In this review, first we introduced the mechanism of complex iron-mediated ROS involved in apoptosis, necroptosis, ferroptosis and pyroptosis. Read More

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Prenatal alcohol-related alterations in maternal, placental, neonatal, and infant iron homeostasis.

Am J Clin Nutr 2021 Jun 5. Epub 2021 Jun 5.

Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.

Background: Prenatal alcohol exposure (PAE) is associated with postnatal iron deficiency (ID), which has been shown to exacerbate deficits in growth, cognition, and behavior seen in fetal alcohol spectrum disorders. However, the mechanisms underlying PAE-related ID remain unknown.

Objectives: We aimed to examine biochemical measures of iron homeostasis in the mother, placenta, neonate, and 6. Read More

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Increased iron content in the heart of the Fmr1 knockout mouse.

Biometals 2021 Jun 5. Epub 2021 Jun 5.

Faculty of Medicine, Physiology, University of Helsinki, P.O. Box 63, 00290, Helsinki, Finland.

Trace elements have important functions in several processes involved in cellular homeostasis and survival. Dysfunctional metal ion homeostasis can make an important impact on cellular defence mechanisms. We assessed the concentrations of 23 trace minerals in different tissues (brain, spleen, heart and liver) of Fmr1 knockout (KO) mice that display the main phenotype of Fragile X syndrome (FXS), an intellectual disability syndrome and the best-known monogenic model of autism spectrum disorder (ASD). Read More

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Emerging Applications for Quantitative Susceptibility Mapping in the Detection of Traumatic Brain Injury Pathology.

Neuroscience 2021 Jun 2. Epub 2021 Jun 2.

Curtin University, Faculty of Health Sciences, Curtin Health Innovation Research Institute, Bentley, WA Australia; Perron Institute for Neurological and Translational Science, Nedlands, WA Australia. Electronic address:

Traumatic brain injury (TBI) is a common but heterogeneous injury underpinned by numerous complex and interrelated pathophysiological mechanisms. An essential trace element, iron is abundant within the brain and involved in many fundamental neurobiological processes, including oxygen transportation, oxidative phosphorylation, myelin production and maintenance, as well as neurotransmitter synthesis and metabolism. Excessive levels of iron are neurotoxic and thus iron homeostasis is tightly regulated in the brain, however, many details about the mechanisms by which this is achieved are yet to be elucidated. Read More

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Approaches to Understanding Mechanisms of Dentilisin Protease Complex Expression in .

Front Cell Infect Microbiol 2021 18;11:668287. Epub 2021 May 18.

Department of Biologic and Materials Sciences & Prosthodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, United States.

The oral spirochete is a keystone periodontal pathogen that, in association with members of a complex polymicrobial oral biofilm, contributes to tissue damage and alveolar bone loss in periodontal disease. Virulence-associated behaviors attributed to include disruption of the host cell extracellular matrix, tissue penetration and disruption of host cell membranes accompanied by dysregulation of host immunoregulatory factors. dentilisin is associated with several of these behaviors. Read More

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Interplay between central carbon metabolism and metal homeostasis in mycobacteria and other human pathogens.

Agnese Serafini

Microbiology (Reading) 2021 Jun;167(6)

Independent researcher 00012 Guidonia Montecelio, Rome, Italy.

Bacterial nutrition is a fundamental aspect of pathogenesis. While the host environment is in principle nutrient-rich, hosts have evolved strategies to interfere with nutrient acquisition by pathogens. In turn, pathogens have developed mechanisms to circumvent these restrictions. Read More

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Expression profiles and prognostic values of BolA family members in ovarian cancer.

J Ovarian Res 2021 Jun 2;14(1):75. Epub 2021 Jun 2.

Department of Nursing, Shengjing Hospital of China Medical University, No.36 Sanhao Street, Shenyang, Liaoning, 110004, People's Republic of China.

Background: The BOLA gene family, comprising three members, is mainly involved in regulating intracellular iron homeostasis. Emerging evidence suggests that BolA family member 2 plays a vital role in tumorigenesis and hepatic cellular carcinoma progression. However, there was less known about its role in ovarian cancer. Read More

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Daily Oral Supplementation with 60 mg of Elemental Iron for 12 Weeks Alters Blood Mitochondrial DNA Content, but Not Leukocyte Telomere Length in Cambodian Women.

Nutrients 2021 May 31;13(6). Epub 2021 May 31.

Food, Nutrition and Health, University of British Columbia, 2205 East Mall, Vancouver, BC V6T 1Z4, Canada.

There is limited evidence regarding the potential risk of untargeted iron supplementation, especially among individuals who are iron-replete or have genetic hemoglobinopathies. Excess iron exposure can increase the production of reactive oxygen species, which can lead to cellular damage. We evaluated the effect of daily oral supplementation on relative leukocyte telomere length (rLTL) and blood mitochondrial DNA (mtDNA) content in non-pregnant Cambodian women (18-45 years) who received 60 mg of elemental iron as ferrous sulfate ( = 190) or a placebo ( = 186) for 12 weeks. Read More

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Erythrocytes: Central Actors in Multiple Scenes of Atherosclerosis.

Int J Mol Sci 2021 May 29;22(11). Epub 2021 May 29.

Diabète athérothrombose Thérapies Réunion Océan Indien (DéTROI), INSERM, UMR 1188, Université de La Réunion, 97400 Saint Denis, France.

The development and progression of atherosclerosis (ATH) involves lipid accumulation, oxidative stress and both vascular and blood cell dysfunction. Erythrocytes, the main circulating cells in the body, exert determinant roles in the gas transport between tissues. Erythrocytes have long been considered as simple bystanders in cardiovascular diseases, including ATH. Read More

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Chorioamnionitis Precipitates Perinatal Alterations of Heme-Oxygenase-1 (HO-1) Homeostasis in the Developing Rat Brain.

Int J Mol Sci 2021 May 28;22(11). Epub 2021 May 28.

Department of Pediatrics, Neonatal-Perinatal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Chorioamnionitis (CHORIO), placental insufficiency, and preterm birth are well-known antecedents of perinatal brain injury (PBI). Heme-oxygenase-1 (HO-1) is an important inducible enzyme in oxidative and inflammatory conditions. In the brain, HO-1 and the iron regulatory receptor, transferrin receptor-1 (TfR1), are known to be involved in iron homeostasis, oxidative stress, and cellular adaptive mechanisms. Read More

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EnvIRONmental Aspects in Myelodysplastic Syndrome.

Int J Mol Sci 2021 May 14;22(10). Epub 2021 May 14.

Department of Internal Medicine V, Medical University of Innsbruck, Anichstraße 35, 6020 Innsbruck, Austria.

Systemic iron overload is multifactorial in patients suffering from myelodysplastic syndrome (MDS). Disease-immanent ineffective erythropoiesis together with chronic red blood cell transfusion represent the main underlying reasons. However, like the genetic heterogeneity of MDS, iron homeostasis is also diverse in different MDS subtypes and can no longer be generalized. Read More

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Harnessing the Physiological Functions of Cellular Prion Protein in the Kidneys: Applications for Treating Renal Diseases.

Biomolecules 2021 May 22;11(6). Epub 2021 May 22.

Stembio, Ltd., Entrepreneur 306, Soonchunhyang-ro 22, Sinchang-myeon, Asan 31538, Korea.

A cellular prion protein (PrP) is a ubiquitous cell surface glycoprotein, and its physiological functions have been receiving increased attention. Endogenous PrP is present in various kidney tissues and undergoes glomerular filtration. In prion diseases, abnormal prion proteins are found to accumulate in renal tissues and filtered into urine. Read More

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A Synthetic SOD/Catalase Mimic Compound for the Treatment of ALS.

Antioxidants (Basel) 2021 May 22;10(6). Epub 2021 May 22.

Schulich Faculty of Chemistry, Technion-Israel Institute of Technology, Haifa 32000, Israel.

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease affecting motor neurons. To date, the etiology of the disease is still unclear, with evidence of reactive oxygen species, mitochondrial dysfunction, iron homeostasis perturbation, protein misfolding and protein aggregation as key players in the pathology of the disease. Twenty percent of familial ALS and two percent of sporadic ALS instances are due to a mutation in Cu/Zn superoxide dismutase (SOD1). Read More

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Patterns and Associations of Essential Trace Elements (Cu, Fe and Zn) in Saudi Adults with Varying Levels of Glycemia.

Metabolites 2021 May 6;11(5). Epub 2021 May 6.

Chair for Biomarkers of Chronic Diseases, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.

The homeostasis of trace elements were observed to contribute to certain diabetic outcomes. This cross-sectional study determined the differences and associations between serum levels of copper (Cu), iron (Fe) and zinc (Zn) in Saudi patients with and without type 2 diabetes mellitus (T2DM) as well as those with prediabetes. Anthropometrics were measured, and fasting blood samples were collected from 119 patients with T2DM (aged 41-64 years), 95 non-T2DM (aged 27-55 years) and 80 with prediabetes (aged 35-57 years). Read More

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Higher Hepcidin Levels in Adolescents with Obesity Are Associated with Metabolic Syndrome Dyslipidemia and Visceral Fat.

Antioxidants (Basel) 2021 May 9;10(5). Epub 2021 May 9.

Glycation, Oxidation and Disease Laboratory, Department of Research, College of Osteopathic Medicine, Touro University California, Vallejo, CA 94592, USA.

Tightly regulated iron metabolism prevents oxidative stress. Hepcidin is a hormone that regulates iron flow in plasma; its production is induced by an iron overload and by inflammation. It inhibits iron entry into the circulation by blocking dietary absorption in the duodenum, the release of recycled iron from macrophages and the exit of stored iron from hepatocytes. Read More

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Skeletal Lipocalin-2 Is Associated with Iron-Related Oxidative Stress in ob/ob Mice with Sarcopenia.

Antioxidants (Basel) 2021 May 11;10(5). Epub 2021 May 11.

Department of Anatomy and Convergence Medical Science, Bio Anti-Aging Medical Research Center, Institute of Health Sciences, College of Medicine, Gyeongsang National University, Jinju 52777, Gyeongnam, Korea.

Obesity and insulin resistance accelerate aging-related sarcopenia, which is associated with iron load and oxidative stress. Lipocalin-2 (LCN2) is an iron-binding protein that has been associated with skeletal muscle regeneration, but details regarding its role in obese sarcopenia remain unclear. Here, we report that elevated LCN2 levels in skeletal muscle are linked to muscle atrophy-related inflammation and oxidative stress in leptin-deficient ob/ob mice. Read More

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Oral Administration of Ginger-Derived Lipid Nanoparticles and Dmt1 siRNA Potentiates the Effect of Dietary Iron Restriction and Mitigates Pre-Existing Iron Overload in KO Mice.

Nutrients 2021 May 15;13(5). Epub 2021 May 15.

Food Science & Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.

Intestinal iron transport requires an iron importer (Dmt1) and an iron exporter (Fpn1). The hormone hepcidin regulates iron absorption by modulating Fpn1 protein levels on the basolateral surface of duodenal enterocytes. In the genetic, iron-loading disorder hereditary hemochromatosis (HH), hepcidin production is low and Fpn1 protein expression is elevated. Read More

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Risk of Iron Overload in Obesity and Implications in Metabolic Health.

Nutrients 2021 May 2;13(5). Epub 2021 May 2.

UCD Institute of Food & Health, University College Dublin, Belfield, D04 V1W8 Dublin, Ireland.

Excessive adiposity is associated with several metabolic perturbations including disturbances in iron homeostasis. Increased systemic inflammation in obesity stimulates expression of the iron regulatory hormone hepcidin, which can result in a maldistribution of bodily iron, which may be implicated in metabolic dysfunction. This study aimed to investigate the effect of adiposity and any associated inflammation on iron homeostasis and the potential implications of dysregulated iron metabolism on metabolic health. Read More

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