467 results match your criteria irisin serum

Association Between Serum Irisin and Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus: A Meta-Analysis.

Horm Metab Res 2021 May 7;53(5):293-300. Epub 2021 May 7.

Division of Nephrology, Renmin Hospital of Wuhan University, Wuhan, China.

Irisin, an emerging adipokine, has been involved in the pathogenesis of type 2 diabetes mellitus (T2DM). However, previous studies evaluating the association between irisin and diabetic nephropathy (DN) showed inconsistent results. We performed a meta-analysis to evaluate the above association. Read More

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Irisin ameliorates endoplasmic reticulum stress and liver fibrosis through inhibiting PERK-mediated destabilization of HNRNPA1 in hepatic stellate cells.

Biol Chem 2021 May 20;402(6):703-715. Epub 2021 Jan 20.

Department of Pathophysiology, Guizhou Medical University, No. 9 Beijing Road, Yunyan District, Guiyang City550004, Guizhou Province, China.

Liver fibrosis is a common consequence of chronic liver diseases involved with the activation of hepatic stellate cells (HSCs) and endoplasmic reticulum (ER) stress. Irisin is a small polypeptide hormone that shows beneficial effects on metabolic disorders. The current study aimed to investigate the biological function of irisin on hepatic fibrosis. Read More

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Associations of circulating irisin with 24-h blood pressure, total and visceral fat, and metabolic parameters in young adult hypertensives.

Arch Endocrinol Metab 2021 Feb 24. Epub 2021 Feb 24.

Division of Epidemiology, Biostatistics and Public Health Practice, University of British Columbia, Vancouver, Canada.

Objective: Some experimental and clinical studies suggest a possible role of irisin in central and peripheral regulation of blood pressure. The purpose of the study was to assess the associations between serum irisin levels, total and visceral fat, metabolic parameters, and blood pressure pattern during 24-h monitoring (ABPM).

Methods: In 206 patients with essential hypertension receiving standard antihypertensive treatments, we assessed anthropometric indices; serum irisin, blood lipids (total cholesterol, LDL-C, HDL-C, and triglycerides), glucose and insulin; body composition including lean mass and total, visceral, android and gynoid fat using a dual-energy x-ray absorptiometry; ABPM; and Homeostasis Model Assessment-Insulin Resistance (HOMA-IR). Read More

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February 2021

[Effects of irisin on lipid in mice and glycolipid metabolism in obese mice induced by diet].

Zhonghua Yi Xue Za Zhi 2021 Apr;101(16):1165-1170

Department of Radiology, Zhongda Hospital (Jiangsu Key Laboratory of Molecular and Functional Imaging), Nanjing 210009,China.

To explore the role of low-dose irisin in the browning of white adipose tissue (WAT) and activation of brown adipose tissue (BAT) in mice, and its effect on the metabolic function of diet induced obesity. A total of 22 C57/BLKS/J male mice fed with normal diet and 8 fed with high fat diet were separately divided into experimental and control group. The experimental group was given irisin (0. Read More

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Prediction of sarcopenia using a battery of circulating biomarkers.

Sci Rep 2021 Apr 21;11(1):8632. Epub 2021 Apr 21.

Department of Cardiology, Post Graduate Medical Institute, Hayatabad Medical Complex, Peshawar, Pakistan.

Loss of muscle mass and strength with aging, termed sarcopenia is accelerated in several comorbidities including chronic heart failure (CHF) and chronic obstructive pulmonary diseases (COPD). However, the effective circulating biomarkers to accurately diagnose and assess sarcopenia are not known. We recruited male healthy controls and patients with CHF and COPD (n = 81-87/group), aged 55-74 years. Read More

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Irisin induces white adipose tissue browning in mice as assessed by magnetic resonance imaging.

Exp Biol Med (Maywood) 2021 Apr 22:15353702211006049. Epub 2021 Apr 22.

Jiangsu Key Laboratory of Molecular and Functional Imaging, Department of Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, P. R. China.

This study aimed to track and evaluate the effect of low-dose irisin on the browning of white adipose tissue (WAT) in mice using magnetic resonance imaging (MRI) noninvasively . Mature white adipocytes extracted from mice were cultured, induced and characterized before being treated by irisin. The volume and fat fraction of WAT were quantified using MRI in normal chow diet and high fat mice after injection of irisin. Read More

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Serum sclerostin concentration is associated with specific adipose, muscle and bone tissue markers in lean adolescent females with increased physical activity.

J Pediatr Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.

Objectives: Sclerostin is an important regulator of bone mass involving the Wnt/β-catenin signalling pathway. Relatively few studies have investigated the relationships of circulating sclerostin levels with adiposity-related and muscle-related biochemical factors in individuals with increased energy metabolism. The aim of this study was to investigate the associations of circulating sclerostin with adipokines, myokines, osteokines and body composition values in lean adolescent females with increased physical activity. Read More

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Irisin Regulating Skeletal Response to Endurance Exercise in Ovariectomized Mice by Promoting Akt/β-Catenin Pathway.

Front Physiol 2021 25;12:639066. Epub 2021 Mar 25.

College of Physical Education, Yangzhou University, Yangzhou, China.

Thought irisin is recognized as a pivotal modulator for bone formation, its role in regulating skeletal response to exercise training remains unknown. Therefore, we aimed to determine the change of irisin in response to 8-week exercise training and its role in regulating the effects of exercise on bone loss in ovariectomized (Ovx) mice. Forty 3-month old female C57BL/6 mic were randomly allocated into four groups: (1) Sham-operated (Sham); (2) ovariectomized; (3) Ovx plus 8-week downhill running exercise (Ex); (4) Ovx plus exercise and received twice weekly injection of cyclo RGDyk protein (a putative anti-irisin receptor agents) (ExRg). Read More

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Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration.

Sci Rep 2021 Mar 29;11(1):7097. Epub 2021 Mar 29.

Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland.

The study investigated the effect of single and chronic (10 sessions) whole-body cryotherapy (WBC; 3-min, - 110 °C) on amino acid (AA) profile, myostatin, fibroblast growth factor 21 (FGF21), and concentrations of brain-derived neurotrophic factor (BDNF), irisin and adiponectin in relation to glucose homeostasis. Thirty-five, healthy men were randomly split into experimental (young: 28 ± 7 years and middle-aged: 51 ± 3 years) and control groups. Blood samples were taken before and 1 h after the first and last (10th) WBC session. Read More

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Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice.

Neuropathol Appl Neurobiol 2021 Mar 26. Epub 2021 Mar 26.

Department of Pharmaceutical Sciences, Northeast Ohio Medical University, Rootstown, OH, USA.

Aims: Irisin is a hormone cleaved from fibronectin type-III domain-containing protein 5 in response to exercise and may be therapeutic in Alzheimer's disease (AD). Irisin is shown to repair damage caused by midlife cardiometabolic risk factors for AD (i.e. Read More

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Ameliorative effects of garlic oil on FNDC5 and irisin sensitivity in liver of streptozotocin-induced diabetic rats.

J Pharm Pharmacol 2021 Apr;73(6):824-834

Department of Anatomy, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey.

Objectives: This study was aimed to investigate the effects of garlic oil (GO), an important natural constituent used in alleviating diabetes and its complications, on the expression levels of irisin and related genes.

Methods: Thirty-two rats were divided into four groups: Control, Diabetes-Control, Diabetes+GO 100 mg/kg/day and Control+GO 100 mg/kg/day for 45 days. The measurements included: changes in liver Peroxisome proliferator-activated receptor-gamma-coactivator (PGC)-1α, Fibronectin Type-III-Domain-Containing5 (FNDC5), irisin expression, mRNA expression of p38 and TNF-α (Tumour necrosis factor-α), total-antioxidant-status (L-TAS; S-TAS), total-oxidant-status (L-TOS; S-TOS) in liver and serum, respectively. Read More

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The Influence of Exercise Training on Endothelial Function, Serum Irisin and Inflammatory Markers in the Elderly with Metabolic Syndrome.

Clin Lab 2021 Mar;67(3)

Background: Although exercise has beneficial effects on metabolic syndrome (Mets), the effects of exercise training on endothelial function and irisin level in the elderly with MetS remain controversial. The aim of this study is to evaluate the influence of exercise training on endothelial function and serum irisin level in the elderly with MetS.

Methods: Volunteers with MetS were recruited (n = 30). Read More

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Diagnostic and Prognostic Relevance of Serum Irisin Level in Patients with Pulmonary Embolism.

Clin Lab 2021 Mar;67(3)

Background: We aimed to determine the diagnostic and prognostic value of serum irisin level in patients with acute pulmonary embolism (PE) admitted to the emergency department.

Methods: Ninety patients who underwent computed tomography pulmonary angiography (CTPA) due to suspected PE were included in the study. Demographic data, PE risk factors, and associated diseases, vital signs, Wells score, Revised Geneva score, pulmonary embolism severity index (PESI), and simplified PESI (sPESI) were recorded. Read More

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Circulating Myonectin and Irisin Levels in Gestational Diabetes Mellitus - A Case-control Study.

Z Geburtshilfe Neonatol 2021 Mar 16. Epub 2021 Mar 16.

Medical Biology, Bozok University Faculty of Medicine, Yozgat, Turkey.

Objective: The objective of this study was to assess the levels of serum myonectin and irisin in pregnant women with and without gestational diabetes mellitus (GDM).

Method: A total of 80 pregnant women participated in our study (which consisted of 40 patients with GDM, 40 participants as the control group). Myonectin and irisin levels were analyzed through the ELISA technique, in addition to metabolic parameters in the serum samples of the participants. Read More

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Serum Levels of Irisin and Omentin-1 in Breast Neoplasms and Their Association with Tumor Histology.

Int J Endocrinol 2021 22;2021:6656671. Epub 2021 Feb 22.

First Department of Pharmacology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece.

Breast cancer is associated with obesity, possibly due to direct effects of adipokines and myokines, such as omentin-1 and irisin. In this study, we aimed to evaluate omentin-1 and irisin levels in women with benign and/or malignant breast neoplasms vs. healthy controls. Read More

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February 2021

Early Post-Stroke Electroacupuncture Promotes Motor Function Recovery in Post-Ischemic Rats by Increasing the Blood and Brain Irisin.

Neuropsychiatr Dis Treat 2021 1;17:695-702. Epub 2021 Mar 1.

Department of Rehabilitation Medicine, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.

Objective: Recent studies have shown that irisin, a novel peptide hormone derived from muscles, could be used as a potential therapeutic drug against ischemic stroke. Moreover, electroacupuncture (EA) is widely used in the treatment of ischemic stroke. Yet, whether irisin is involved in the EA neuroprotection remains unclear. Read More

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Effects of increased physical activity and/or weight loss diet on serum myokine and adipokine levels in overweight adults with impaired glucose metabolism.

J Diabetes Complications 2021 May 25;35(5):107892. Epub 2021 Feb 25.

Hacettepe University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkey. Electronic address:

Aim: The purpose of this study was to investigate the changes in serum irisin, fibroblast growth factor-21 (FGF21), visfatin, follistatin like protein-1 (FSTL1), and meteorin-like protein (Metrnl) levels in response to increased physical activity and/or diet interventions in overweight subjects with impaired glucose metabolism (IGM).

Methods: A total of 60 subjects (BMI > 25.0 kg/m) with IGM were recruited in this single-centered interventional study. Read More

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Effects of competitive physical activity on serum irisin levels and bone turnover markers.

J Endocrinol Invest 2021 Mar 6. Epub 2021 Mar 6.

Department of Clinical and Experimental Medicine, University of Catania, AOU Policlinico "G. Rodolico - San Marco", Via S. Sofia 78, 95123, Catania, Italy.

Background: Irisin, a myokine, is a polypeptide derived from the cleavage of the extracellular domain of fibronectin domain-containing protein 5, a receptor that is present on different tissues (skeletal muscle, pericardium, myocardium, and brain), whose functions are not yet fully defined.

Purpose: The main aim of our study was to evaluate the effect of competitive physical activity on serum irisin levels and bone turnover markers.

Methods: Fifteen male footballers and an equal number of subjects of the same age and gender, but with a predominantly sedentary lifestyle, had their serum levels of irisin and bone turnover markers measured. Read More

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The Acute Effects of Swimming Exercise on PGC-1α-FNDC5/Irisin-UCP1 Expression in Male C57BL/6J Mice.

Metabolites 2021 Feb 16;11(2). Epub 2021 Feb 16.

Division of Sport Science, College of Arts & Physical Education, Incheon National University, Incheon 22012, Korea.

Irisin is a myokine primarily secreted by skeletal muscles and is known as an exercise-induced hormone. The purpose of this study was to determine whether the PGC-1α -FNDC5 /Irisin-UCP1 expression which is an irisin-related signaling pathway, is activated by an acute swimming exercise. Fourteen to sixteen weeks old male C57BL/6J mice ( = 20) were divided into control (CON, = 10) and swimming exercise groups (SEG, = 10). Read More

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February 2021

Asprosin, a novel glucogenic adipokine: a potential therapeutic implication in diabetes mellitus.

Arch Physiol Biochem 2021 Mar 4:1-7. Epub 2021 Mar 4.

Department of Biophysics, Faculty of Medicine, Firat University, Elazig, Turkey.

Objectives: We aimed to investigate the effects of asprosin on diabetes with a focus on serum glucose, irisin, ghrelin, leptin levels and hepatic levels of triglycerides (TG), cholesterol, low-density lipoprotein (LDL).

Methods: Asprosin (10 µg/kg) was administered intraperitoneally four times at 3-day intervals and then blood and hepatic parameters above mentioned were investigated in control and diabetic mice.

Results: The administration of asprosin increased blood glucose level in healthy animals ( = . Read More

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Cord blood and maternal serum preptin and irisin concentrations are regulated independently in GDM.

S S Ersahin A Yurci

Eur Rev Med Pharmacol Sci 2021 Feb;25(4):1954-1958

Department of Obstetrics and Gynecology, Altınbas University, Istanbul, Turkey.

Objective: The aim of this study is to examine the maternal serum and cord blood irisin and preptin levels in gestational diabetes mellitus (GDM) and correlate their levels with demographic and biochemical parameters.

Patients And Methods: A total of 21 pregnant women with GDM and 21 BMI and age-matched pregnant women without GDM were included in the study. They underwent 50 g glucose challenge test (GCT) between 24-28th gestational weeks. Read More

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February 2021

The genetic background and vitamin D supplementation can affect irisin levels in Prader-Willi syndrome.

J Endocrinol Invest 2021 Mar 3. Epub 2021 Mar 3.

Department of Emergency and Organ Transplantation, University of Bari 'A. Moro', Piazza Giulio Cesare, 11, 70124, Bari, Italy.

Background: Prader-Willi syndrome (PWS) is associated to distinctive clinical symptoms, including obesity, cognitive and behavioral disorders, and bone impairment. Irisin is a myokine that acts on several target organs including brain adipose tissue and bone. The present study was finalized to explore circulating levels of irisin in children and adult PWS patients. Read More

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Basal myokine levels are associated with quality of life and depressed mood in older adults.

Psychophysiology 2021 May 2;58(5):e13799. Epub 2021 Mar 2.

Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria.

In an aging society, late-life depression has become an increasing problem. There is evidence that physical activity ameliorates depressive symptoms and increases the quality of life (QoL). However, the underlying mechanisms are still poorly understood. Read More

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Association of Circulating Irisin Levels and the Characteristics and Prognosis of Coronary Artery Disease.

Am J Med Sci 2021 Feb 26. Epub 2021 Feb 26.

Department of Cardiology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, No. 639 Zhizaoju Road, Shanghai 200011, People's Republic of China. Electronic address:

Background: Irisin is a new muscle factor discovered in recent years that shows a strong association with metabolic diseases. However, its role in coronary artery disease (CAD) is still controversial. We performed this study to determine the relationship of serum irisin with the characteristics and prognosis of CAD. Read More

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February 2021

The Specific Judo Training Program Combined With the Whole Body Cryostimulation Induced an Increase of Serum Concentrations of Growth Factors and Changes in Amino Acid Profile in Professional Judokas.

Front Physiol 2021 9;12:627657. Epub 2021 Feb 9.

Department of Physical Culture Gorzow Wielkopolski, Poznań University of Physical Education, Poznań, Poland.

This study aimed to evaluate the effect of a specific training program, supported by 10 sessions of whole body cryostimulation, on growth factors concentrations, amino acids profile and motor abilities in professional judokas. Ultimately, twelve athletes took part in the study. They were randomly assigned to the cryostimulation group (CRY, = 6) or the control group (CON, = 6). Read More

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February 2021

[Effect of 4-week electroacupuncture intervention on "Browning" of white fat in rats and its mechanism].

Zhongguo Ying Yong Sheng Li Xue Za Zhi 2020 Sep;36(5):471-477

School of Sport Science, Beijing Sport University, Beijing 100084, China.

To investigate the effects of 4-week electroacupuncture intervention on "Browning" of white fat in rats, and to explore its molecular mechanisms. Twenty-four 8-week-old male SD rats were randomly divided into sedentary group (Sed), aerobic exercise group (Exe) and electroacupuncture group (ElA), 8 rats in each group. Exe group used 65% Max oxygen uptake intensity treadmill exercise, 1 h/d,6 d/w, while the ElA group used electric acupuncture to stimulate "zusanli" and "tianshu" points, 20 min/d,6 d/w, and the weight of rats was recorded every week. Read More

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September 2020

Effect of Sitagliptin on Serum Irisin Levels in Patients with Newly Diagnosed Type 2 Diabetes Mellitus.

Diabetes Ther 2021 Apr 24;12(4):1029-1039. Epub 2021 Feb 24.

Department of Endocrinology, Beijing Chao-yang Hospital, Capital Medical University, Beijing, 100020, China.

Introduction: Irisin is a unique myokine with striking effects on regulating insulin sensitivity and energy metabolism. This study aimed to investigate the changes in serum irisin in patients with newly diagnosed type 2 diabetes mellitus (T2DM) following sitagliptin treatment.

Methods: Thirty-two patients with T2DM were treated with 100 mg/day sitagliptin for 16 weeks. Read More

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Irisin deletion induces a decrease in growth and fertility in mice.

Reprod Biol Endocrinol 2021 Feb 13;19(1):22. Epub 2021 Feb 13.

Reproductive Endocrinology and Regulation Laboratory West China Second University Hospital, Sichuan University, #20 Section 3, Ren Min Nan Road, Chengdu, 610041, Sichuan, China.

Background: Irisin, which is cleaved from fibronectin type III domain-containing protein 5 (Fndc5), plays an important role in energy homeostasis. The link between energy metabolism and reproduction is well known. However, the biological actions of irisin in reproduction remain largely unexplored. Read More

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February 2021

Serum Irisin Level Is Positively Associated with Bone Mineral Density in Patients on Maintenance Hemodialysis.

Int J Endocrinol 2021 25;2021:8890042. Epub 2021 Jan 25.

School of Medicine, Tzu Chi University, Hualien, Taiwan.

Background: Irisin is a circulating hormone-like myokine that plays an important role in bone metabolism. We performed a cross-sectional study to investigate whether serum irisin levels correlated with bone mineral density (BMD) in patients on maintenance hemodialysis (MHD).

Methods: Blood samples were obtained from 80 patients on MHD, and serum irisin concentrations were determined using a commercially available enzyme-linked immunosorbent assay. Read More

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January 2021

Effects of marathon race on selected myokines and sclerostin in middle-aged male amateur runners.

Sci Rep 2021 Feb 2;11(1):2813. Epub 2021 Feb 2.

Department of Physical Therapy and Sports Recovery, Poznan University of Physical Education, Poznań, Poland.

In recent years, there has been increasing interest in the homeostatic response to extreme exercises, especially in the integrated function of muscle and bone. The aim of this study was to evaluate the effects of a marathon race on selected myokines and sclerostin in 10 male recreational runners (mean age 41 ± 7.7 years). Read More

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February 2021