2 results match your criteria iridiumiii complexes

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Insights into the antiproliferative mechanism of (C^N)-chelated half-sandwich iridium complexes.

Dalton Trans 2020 Dec;49(48):17635-17641

Institut Parisien de Chimie Moléculaire (IPCM), Sorbonne Université, CNRS, 4 place Jussieu, F-75005 Paris, France.

Transition metal-based anticancer compounds, as an alternative to platinum derivatives, are raising scientific interest as they may present distinct although poorly understood mechanisms of action. We used a structure-activity relationship-based methodology to investigate the chemical and biological features of a series of ten (C^N)-chelated half-sandwich iridiumIII complexes of the general formula [IrCp*(phox)Cl], where (phox) is a 2-phenyloxazoline ligand forming a 5-membered metallacycle. This series of compounds undergoes a fast exchange of their chlorido ligand once solubilised in DMSO. Read More

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December 2020

Imidazole and Benzimidazole Modified Half-Sandwich Iridium -Heterocyclic Carbene Complexes: Synthesis, Anticancer Application, and Organelle Targeting.

Front Chem 2020 17;8:182. Epub 2020 Mar 17.

The Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Institute of Anticancer Agents Development and Theranostic Application, Qufu Normal University, Qufu, China.

Herein, we report the synthesis, characterization and anticancer activity of a series of half-sandwich iridium imidazole and benzimidazole -heterocyclic carbene (NHC) anticancer complexes, and the general formula of which can be expressed as [(η-Cp)Ir(CN)Cl]Cl (Cp: pentamethylcyclopentadienyl (Cp) or biphenyl derivatives (Cp); CN: imidazole and benzimidazole NHC chelating ligands). Compared with -platin, these complexes showed interesting antitumor activity against A549 cells. Complexes could bind to bovine serum albumin (BSA) by means of static quenching mode, catalyze the oxidation of nicotinamide adenine dinucleotide (NADH) and increase the levels of reactive oxygen species (ROS). Read More

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