Front Chem 2020 17;8:182. Epub 2020 Mar 17.
The Key Laboratory of Life-Organic Analysis, Key Laboratory of Pharmaceutical Intermediates and Analysis of Natural Medicine, School of Chemistry and Chemical Engineering, Institute of Anticancer Agents Development and Theranostic Application, Qufu Normal University, Qufu, China.
Herein, we report the synthesis, characterization and anticancer activity of a series of half-sandwich iridium imidazole and benzimidazole -heterocyclic carbene (NHC) anticancer complexes, and the general formula of which can be expressed as [(η-Cp)Ir(CN)Cl]Cl (Cp: pentamethylcyclopentadienyl (Cp) or biphenyl derivatives (Cp); CN: imidazole and benzimidazole NHC chelating ligands). Compared with -platin, these complexes showed interesting antitumor activity against A549 cells. Complexes could bind to bovine serum albumin (BSA) by means of static quenching mode, catalyze the oxidation of nicotinamide adenine dinucleotide (NADH) and increase the levels of reactive oxygen species (ROS). Read More