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The concentration of potentially toxic elements (PTEs) in sausages: a systematic review and meta-analysis study.

Environ Sci Pollut Res Int 2021 Jun 15. Epub 2021 Jun 15.

Department of Food Science and Nutrition, University of Campinas (UNICAMP), Rua Monteiro Lobato, 80 Caixa Postal: 6121 CEP, São Paulo, 13083-862, Campinas, Brazil.

The contamination of fresh meat and meat products like sausages with potentially toxic elements (PTEs) is a worldwide health concern. Consequently, the related investigations concerning the levels of PTEs in sausages among databases such as Scopus, Cochrane, and PubMed were investigated 1 January 2000 to 20 August 2020. Furthermore, the concentration of PTEs in sausages was meta-analyzed based on the random effect model (REM). Read More

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Fatal necrotising cutaneous mucormycosis due to novel species: a case study.

J Wound Care 2021 Jun;30(6):465-468

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

This case report describes the progressive wound infection in the left thigh of a 34-year-old man due to an old landmine explosion. The infection developed into rapidly spreading skin and soft tissue necrotising infection, despite antifungal therapy and surgical debridement. The report provides evidence that spp. Read More

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Cervical Cancer-Associated Suffering: Estimating the Palliative Care Needs of a Highly Vulnerable Population.

JCO Glob Oncol 2021 Jun;7:862-872

Department of Non-communicable Diseases, World Health Organization, Geneva, Switzerland.

Purpose: To enable design of optimum palliative care for women with cervical cancer, we studied the most common types of suffering and their severity, prevalence, and duration.

Methods: We first reviewed the literature on the major types, severity, prevalence, and duration of suffering associated with cervical cancer. We then conducted a modified Delphi process with experts in cervical cancer care to supplement the literature. Read More

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Evolutionary and Ecological Drivers Shape the Emergence and Extinction of Foot-and-Mouth Disease Virus Lineages.

Mol Biol Evol 2021 Jun 11. Epub 2021 Jun 11.

The Pirbright Institute, Ash Road, Pirbright, Woking, Surrey, United Kingdom.

Livestock farming across the world is constantly threatened by evolutionary turnover of foot-and-mouth disease virus (FMDV) strains in endemic systems, the underlying dynamics of which remain to be elucidated. Here, we map the eco-evolutionary landscape of co-circulating FMDV lineages within an important endemic virus pool encompassing Western, Central and parts of Southern Asia, reconstructing the evolutionary history and spatial dynamics over the last 20 years that shapes the current epidemiological situation. We demonstrate that new FMDV variants periodically emerge from Southern Asia, precipitating waves of virus incursions that systematically travel in a westerly direction. Read More

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PIGG variant pathogenicity assessment reveals characteristic features within 19 families.

Genet Med 2021 Jun 10. Epub 2021 Jun 10.

Sydney Children's Hospital, Centre for Clinical Genetics, Sydney Children's Hospital, High St, Randwick, UK.

Purpose: Phosphatidylinositol Glycan Anchor Biosynthesis, class G (PIGG) is an ethanolamine phosphate transferase catalyzing the modification of glycosylphosphatidylinositol (GPI). GPI serves as an anchor on the cell membrane for surface proteins called GPI-anchored proteins (GPI-APs). Pathogenic variants in genes involved in the biosynthesis of GPI cause inherited GPI deficiency (IGD), which still needs to be further characterized. Read More

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Prevalence of COVID-19 in Iran: results of the first survey of the Iranian COVID-19 Serological Surveillance program.

Clin Microbiol Infect 2021 Jun 7. Epub 2021 Jun 7.

Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Objectives: This study aims to estimate the prevalence of COVID-19 in the general population of Iran.

Methods: The target population was all Iranian people aged six years and older in the country. A stratified random sampling design was used to select 28,314 subjects from among the individuals registered in the electronic health record systems used in primary health care in Iran. Read More

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Spatio-temporal epidemiology of the tuberculosis incidence rate in Iran 2008 to 2018.

BMC Public Health 2021 06 7;21(1):1093. Epub 2021 Jun 7.

Department of Geography and Urban Planning, Faculty of Social Sciences, University of Mohaghegh Ardabili, Ardabil, Iran.

Background: Effective reduction of tuberculosis (TB) requires information on the distribution of TB incidence rate across time and location. This study aims to identify the spatio-temporal pattern of TB incidence rate in Iran between 2008 and 2018.

Methods: This cross-sectional study was conducted on aggregated TB data (50,500 patients) at the provincial level provided by the Ministry of Health in Iran between 2008 and 2018. Read More

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Risk Assessment of Covid-19 in the Iranian Health System: A Brief Report.

Disaster Med Public Health Prep 2021 Jun 7:1-12. Epub 2021 Jun 7.

Iran Ministry of Health and Medical Education, National Medical Emergency Organization Tehran, Tehran, IR.

Objective: The outbreak of Covid-19 has exerted unprecedented pressure on healthcare systems throughout the world. This study was designed to develop a national health emergency management program based on risk assessment for COVID-19.

Method: Mixed-methods research was used. Read More

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Antioxidant and anticancer potentials of edible flowers: where do we stand?

Crit Rev Food Sci Nutr 2021 Jun 7:1-57. Epub 2021 Jun 7.

Department of Pharmacy, Abdul Wali Khan University Mardan, Mardan, Pakistan.

Edible flowers are attracting special therapeutic attention and their administration is on the rise. Edible flowers play pivotal modulatory roles on oxidative stress and related interconnected apoptotic/inflammatory pathways toward the treatment of cancer. In this review, we highlighted the phytochemical content and therapeutic applications of edible flowers, as well as their modulatory potential on the oxidative stress pathways and apoptotic/inflammatory mediators, resulting in anticancer effects. Read More

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Subtyping β-lactamase-producing strains isolated from patients with UTI by MLVA and PFGE methods.

Iran J Basic Med Sci 2021 Apr;24(4):437-443

Department of Microbiology, Research Center of Reference Health Laboratory, Ministry of Health and Medical Education, Tehran, Iran.

Objectives: Strain subtyping is an important epidemiological tool to trace contamination, determine clonal relationships between different strains, and the cause of outbreaks. Current subtyping methods, however, yield less than optimal subtype discrimination. Pulsed-field gel electrophoresis is the gold standard method for and Multiple-Locus Variable-number tandem repeat Analysis is a rapid PCR-based method. Read More

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Designing, implementation, and evaluation of internship comprehensive system for assessment and monitoring.

J Educ Health Promot 2021 31;10:93. Epub 2021 Mar 31.

Medical Education Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: During the past decade, the benefits of using portfolios, especially electronic portfolios, were recognized. Due to the lack of using portfolios and especially electronic portfolio in the clinical evaluations of internship training in medical schools of Iran, this study has designed, implemented, and evaluated a comprehensive system for monitoring and evaluating the activities of interns.

Materials And Methods: This study was a software development study in the three phases of design, implementation, and evaluation. Read More

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Evaluating Community-Based Programs in Promoting Traffic Behaviors and Safe Road Crossing Behaviors in Youth: An Application on Theory of Planned Behavior.

Int J Prev Med 2021 19;12:11. Epub 2021 Jan 19.

Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Background: Today, one of the most serious causes of mortality and disability among youth is the traffic accidents. Regarding its importance, this paper aimed to investigate the community-based program to promote the safe traffic behaviors among youth.

Methods: This was a quasi-experimental conducted on 5000 youth in five Iranian cities named Lanjan, Gomishan, Fasa, Tehran, and Zahedan in 2015-2016. Read More

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January 2021

Food Insecurity and Dietary Intake Among Elderly Population: A Systematic Review.

Int J Prev Med 2021 19;12. Epub 2021 Jan 19.

Department of Health Sciences, Liverpool Hope University, Hope Park, United Kingdom.

Background: This review seeks to determine the relationship between food insecurity among elderly people over the past decades and nutrient deficiency, which is rather unclear. We aim to systematically review the relationship between food insecurity and dietary intake among elderly population.

Methods: In this systematic review, we systematically searched the international databases including PubMed, Web of Sciences, and Scopus for scientifically related papers which have been published up until January 2018. Read More

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January 2021

Epidemiological characteristics and mortality risk factors among COVID-19 patients in Ardabil, Northwest of Iran.

BMC Emerg Med 2021 06 2;21(1):67. Epub 2021 Jun 2.

Department of Public Health, School of Health, Ardabil University of Medical Sciences, Ardabil, Iran.

Background: Coronavirus disease highly contagious, is prevalent in all age and sex groups infecting the respiratory system. The present study seeks to investigate the epidemiology and effective factors in mortality of patients with COVID-19 in Ardabil province, northwestern Iran.

Methods: In a retrospective study, the hospitalized patients with laboratory-diagnosed COVID-19 between February to August 2020 were enrolled. Read More

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Rodent-Related Zoonotic Pathogens at the Human-Animal-Environment Interface in Qatar: A Systematic Review and Meta-Analysis.

Int J Environ Res Public Health 2021 May 31;18(11). Epub 2021 May 31.

School of Life Sciences, College of Agriculture, Engineering & Science, University of KwaZulu Natal, Durban 4000, South Africa.

Rodents are one of the most diversified terrestrial mammals, and they perform several beneficial activities in nature. These animals are also important as carriers of many pathogens with public health importance. The current systematic review was conducted to formulate a true depiction of rodent-related zoonoses in Qatar. Read More

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Application of Advanced Nanomaterials for Kidney Failure Treatment and Regeneration.

Materials (Basel) 2021 May 29;14(11). Epub 2021 May 29.

Pharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz 5166614756, Iran.

The implementation of nanomedicine not only provides enhanced drug solubility and reduced off-target adverse effects, but also offers novel theranostic approaches in clinical practice. The increasing number of studies on the application of nanomaterials in kidney therapies has provided hope in a more efficient strategy for the treatment of renal diseases. The combination of biotechnology, material science and nanotechnology has rapidly gained momentum in the realm of therapeutic medicine. Read More

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Redox Regulation in Diazotrophic Bacteria in Interaction with Plants.

Antioxidants (Basel) 2021 May 30;10(6). Epub 2021 May 30.

Université Côte d'Azur, INRAE, CNRS, ISA, 06903 Sophia Antipolis, France.

Plants interact with a large number of microorganisms that greatly influence their growth and health. Among the beneficial microorganisms, rhizosphere bacteria known as Plant Growth Promoting Bacteria increase plant fitness by producing compounds such as phytohormones or by carrying out symbioses that enhance nutrient acquisition. Nitrogen-fixing bacteria, either as endophytes or as endosymbionts, specifically improve the growth and development of plants by supplying them with nitrogen, a key macro-element. Read More

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Seasonal Variations of Rosmarinic Acid and Its Glucoside and Expression of Genes Related to Their Biosynthesis in Two Medicinal and Aromatic Species of subg. .

Biology (Basel) 2021 May 22;10(6). Epub 2021 May 22.

Department of Pharmaceutical Biology and Biotechnology, Wroclaw Medical University, Borowska 211, 50-556 Wroclaw, Poland.

Kar. and B.T. Read More

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Tissue-Specific Microparticles Improve Organoid Microenvironment for Efficient Maturation of Pluripotent Stem-Cell-Derived Hepatocytes.

Cells 2021 May 21;10(6). Epub 2021 May 21.

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran 1665659911, Iran.

Liver organoids (LOs) are receiving considerable attention for their potential use in drug screening, disease modeling, and transplantable constructs. Hepatocytes, as the key component of LOs, are isolated from the liver or differentiated from pluripotent stem cells (PSCs). PSC-derived hepatocytes are preferable because of their availability and scalability. Read More

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Altered expression of STAT genes in periodontitis.

Hum Antibodies 2021 May 19. Epub 2021 May 19.

Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Signal Transducer and Activator of Transcription (STAT) pathway is functionally located downstream of Janus kinases proteins and can integrate signals from diverse pathways, thus regulating several aspects of immune responses. Although contribution of STAT proteins in the pathogenesis of several inflammatory conditions has been confirmed, their role in the development of periodontitis has been less appraised. Thus, we assessed levels of STAT transcripts in the periodontal tissues and circulation of affected individuals compared with the corresponding controls. Read More

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Hepcidin Gene Cloning and Expression Pattern in Turbot () after Infection.

Iran J Biotechnol 2020 Oct 1;18(4):e2767. Epub 2020 Oct 1.

First Institute of Oceanography, Ministry of Natural Resources (MNR), Qingdao, China.

Background: Antimicrobial peptides play crucial roles in organisms as the first line of defense against invading pathogens.

Objective: To isolate the hepcidin () gene from the liver of turbot () challenged with (GenBank accession number: AM113708), characterize it, and assess its expression level in various tissues.

Materials And Methods: The DNA sequence of hepcidin from was determined from the total RNA extracted and reverse transcribed from this fish. Read More

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October 2020

Distributing and assessing fluoride health risk in urban drinking water resources in Fars Province, Iran, using the geographical information system.

Environ Geochem Health 2021 May 30. Epub 2021 May 30.

School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran.

Excessive fluoride intake has been reported in many studies, which can lead to diseases such as autism, mental retardation, low birth weight, reproductive disorder, as well as dental and bone fluorosis. The potential risk assessment of fluoride intake for the health of people living in Fars Province, Iran, is investigated. Hence, 1700 drinking water samples were taken from April 2018 to March 2020 in four seasons in 29 cities of Fars Province and were analyzed. Read More

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Competitive anxiety or Coronavirus anxiety? The psychophysiological responses of professional football players after returning to competition during the COVID-19 pandemic.

Psychoneuroendocrinology 2021 Jul 14;129:105269. Epub 2021 May 14.

Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark; Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. Electronic address:

Objective: This study aimed to examine the relationship between competitive anxiety, fear/anxiety of COVID-19, and autonomic and endocrine stress responses in professional football players after returning to competition during the COVID-19 pandemic.

Methods: Ninety male professional football players (age: 26.33 ± 2. Read More

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DITAS: An Integrated Gateway to E-health Communications.

Stud Health Technol Inform 2021 May;281:452-456

Center for Statistics & Information Technology, Ministry of Health and Medical Education, Tehran, Iran.

Today, the demand for health-oriented systems to facilitate and improve treatment processes is growing. For different information systems with different structures and technologies to be able to communicate with each other, a single gateway is required. The gateway acts as an interface between information systems and unifies protocols, rules, and standards related to communication processes. Read More

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The Iranian Integrated Care Electronic Health Record.

Stud Health Technol Inform 2021 May;281:654-658

Center for Statistics and Information Technology, Ministry of Health and Medical Education.

E-health plays a crucial role in E-government by proposing healthcare services based on information technology. However, the way to administer these services by using E-health solutions is one of the challenging issues. One of these significant challenges is how one integrates heterogeneous healthcare information of the different point of care systems. Read More

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Trend and epidemiological patterns of animal bites in Golestan province (Northern Iran) between 2017 and 2020.

PLoS One 2021 25;16(5):e0252058. Epub 2021 May 25.

Department of Healthcare Services Management, School of Health Management & Information Sciences, Iran University of Medical Sciences, Tehran, Iran.

Background: Rabies is one of the oldest zoonosis viral diseases, which still remains as one of the most important threats to public health in the 21st century.

Methods: This cross-sectional study examined epidemiologic features of all 33,996 cases of persons bitten by animals and referred to the rabies prophylaxis centers in Golestan province between March 2017 and March 2020. Factors included demographic information of the victim (age, gender, and occupation), type of invasive animals (dog, cat, and other types), time of bite (year, month, and hour), place of residence (urban or rural), and injury and treatment statuses. Read More

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Economic inequality in prevalence of underweight and short stature in children and adolescents: the weight disorders survey of the CASPIAN-IV study.

Arch Endocrinol Metab 2021 May;64(5):548-558

Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran,

Objective: The aim of this study was to determine the determinants of socio-economic inequality in the prevalence of short stature and underweight in Iranian children and adolescents.

Methods: This cross-sectional nationwide study was conducted on 36,486 participants, aged 6-18 years. This school-based surveillance (CASPIAN- IV) program and its complementary part on weight disorders evaluation was conducted in urban and rural areas of 30 provinces in Iran. Read More

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Root vacuolar sequestration and suberization are prominent responses of spp. rootstocks during salinity stress.

Plant Direct 2021 May 19;5(5):e00315. Epub 2021 May 19.

Department of Plant Sciences University of California Davis Davis CA USA.

Understanding the mechanisms of stress tolerance in diverse species is needed to enhance crop performance under conditions such as high salinity. Plant roots, in particular in grafted agricultural crops, can function as a boundary against external stresses in order to maintain plant fitness. However, limited information exists for salinity stress responses of woody species and their rootstocks. Read More

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Taurine mitigates bile duct obstruction-associated cholemic nephropathy: effect on oxidative stress and mitochondrial parameters.

Clin Exp Hepatol 2021 Mar 25;7(1):30-40. Epub 2021 Mar 25.

Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Aim Of The Study: Cholestasis is a serious complication affecting other organs such as the liver and kidney. Oxidative stress and mitochondrial impairment are proposed as the primary mechanisms for cholestasis-induced organ injury. Taurine (TAU) is the most abundant free amino acid in the human body, which is not incorporated in the structure of proteins. Read More

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Iran COVID-19 Epidemiology Committee: A Review of Missions, Structures, Achievements, and Challenges.

J Res Health Sci 2021 Mar 7;21(1):e00505. Epub 2021 Mar 7.

Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.

Background: Since the beginning of the coronavirus disease 2019 (COVID-19) epidemic in Iran, the control and management of the epidemic were headed by the National Headquarter for the Control of COVID-19 Epidemic through setting up different scientific committees, including the COVID-19 National Epidemiology Committee. The present study reviews the missions, structures, achievements, and challenges of the Epidemiology Committee.

Study Design: A rapid review . Read More

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