42 results match your criteria iran's pharmaceutical

Impact of PCSK9 Immunization on Glycemic Indices in Diabetic Rats.

J Diabetes Res 2021 30;2021:4757170. Epub 2021 Aug 30.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Methods: To prepare the anti-PCSK9 vaccine, a peptide construct called Immunogenic Fused PCSK9-Tetanus (IFPT) was linked to the surface of nanoliposome carriers. Healthy rats received four subcutaneous injections of the vaccine at biweekly intervals. Two weeks after the last vaccination, anti-PCSK9 antibody titers, PCSK9 targeting, and inhibition of PCSK9-low-density lipoprotein receptor (LDLR) interaction were evaluated. Read More

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Pre-Clinical Evaluation of the Nanoliposomal antiPCSK9 Vaccine in Healthy Non-Human Primates.

Vaccines (Basel) 2021 Jul 6;9(7). Epub 2021 Jul 6.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad 9177948564, Iran.

Background: Our previous studies showed the safe preventive and therapeutic effects of immunization using the nanoliposomal antiPCSK9 vaccine called "Liposomal Immunogenic Fused PCSK9-Tetanus plus Alum adjuvant" (L-IFPTA), in mouse models of atherosclerosis. Here we aimed to ascertain the immunogenicity and safety of the L-IFPTA vaccine in a pre-clinical study in healthy non-human primates.

Methods: Five male rhesus macaque monkeys were subcutaneously immunized with the L-IFPTA vaccine, four times with bi-weekly intervals. Read More

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Phosphatidylserine-containing liposomes: Therapeutic potentials against hypercholesterolemia and atherosclerosis.

Eur J Pharmacol 2021 Oct 7;908:174308. Epub 2021 Jul 7.

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran; School of Medicine, The University of Western Australia, Perth, Australia; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address:

Liposomes have been suggested as potential tools for cholesterol deposit mobilization from atherosclerotic lesions. Here, we explored the anti-atherosclerotic effects of phosphatidylserine (PS)-containing liposomes in vivo. High-fat diet-fed New Zealand white rabbits which were divided into groups receiving weekly intravenous injections of PS liposomes, atorvastatin-loaded PS (PSA) liposomes (100 μg phospholipid/kg), or control buffer for four weeks. Read More

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October 2021

PCSK9 vaccine: so near, yet so far!

Eur Heart J 2021 Jun 21. Epub 2021 Jun 21.

Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Lodz, Poland.

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Opium tincture-assisted treatment for opioid use disorder: A systematic review.

J Subst Abuse Treat 2021 10 4;129:108519. Epub 2021 Jun 4.

HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran; School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, BC, Canada. Electronic address:

Background: Some countries have used opioid agonist medications other than methadone and buprenorphine as a strategy to increase treatment diversity. In Iran and other countries where opium use is common and culturally tolerated, opium tincture (OT) has gained growing popularity and been approved to treat opioid use disorder (OUD). Given the increasing interest in this intervention, we conducted a systematic review of the literature to evaluate the safety and efficacy of OT-assisted treatment for OUD. Read More

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October 2021

Assessment of Antibiotic Dispensing Practice in Community Pharmacies of Tehran, for 2 Common Infectious Symptoms, Using Simulated Patient Method.

Iran J Pharm Res 2020 ;19(4):35-43

Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Resistance to antibiotics is a worldwide concern and community pharmacies can play a strategic role in controlling this issue through rationalizing antibiotic consumption. Considering that dispensing any type of antibiotics without a prescription is prohibited according to Iran's regulations, this study was conducted to quantify the rate of antibiotic dispensing without a prescription by pharmacists in Tehran, Iran. A descriptive cross-sectional study was conducted from September 2016 through May 2017. Read More

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January 2020

Coupling Microplate-Based Antibacterial Assay with Liquid Chromatography for High-Resolution Growth Inhibition Profiling of Crude Extracts: Validation and Proof-of-Concept Study with .

Molecules 2021 Mar 11;26(6). Epub 2021 Mar 11.

Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK-2100 Copenhagen, Denmark.

With the identification of novel antibiotics from nature being pivotal in the fight against human pathogenic bacteria, there is an urgent need for effective methodologies for expedited screening of crude extracts. Here we report the development and validation of a simple and dye-free antimicrobial assay in 96-well microplate format, for both determination of IC values and high-resolution inhibition profiling to allow pin-pointing of bioactive constituents directly from crude extracts. While commonly used antimicrobial assays visualize cell viability using dyes, the developed and validated assay conveniently uses OD measurements directly on the fermentation broth. Read More

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Iran, sanctions, and the COVID-19 crisis.

Amir Abdoli

J Med Econ 2020 Dec 16;23(12):1461-1465. Epub 2020 Dec 16.

Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran.

With an over 80 million population, Iran is the second-largest country in the Middle East. The coronavirus disease 2019 (COVID-19) has spread over all 31 provinces of Iran, leading to the most cases and death among the Eastern Mediterranean countries. At the same time, Iran is under the United States political and economic sanctions that compromised Iran's health system. Read More

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December 2020

An application of analytic network process model in supporting decision making to address pharmaceutical shortage.

BMC Health Serv Res 2020 Jul 8;20(1):626. Epub 2020 Jul 8.

Pharmacoeconomics and Pharma Management, School of Pharmacy, Shahid Beheshti University of MedicalSciences, Tehran, Iran.

Background: The present study aimed to develop an Analytic Network Process (ANP) model to assist policymakers in identifying and prioritizing allocation indicators, which are being used or should be used to distribute drugs in short supply among different provinces.

Methods: The model encompasses the interactions between various indicators and efficiency, equity, and effectiveness paradigms. Accordingly, a set of clusters and elements, which were associated with the allocation of drugs in short supply in Iran's pharmaceutical system, were detected to develop the model and were then compared in pairs in terms of a specified factor to show the priorities. Read More

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Effect of two major health reforms on health care cost and utilization in Fars Province of Iran: family physician program and health transformation plan.

BMC Health Serv Res 2020 May 6;20(1):382. Epub 2020 May 6.

Health Human Resources Research Center, School of Management and Information Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Family physician program (FPP) and health transformation plan (HTP) are two major reforms that have been implemented in Iran's health system in recent. The present study was aimed at evaluating the impact of these two reforms on the level of service utilization and cost of health care services.

Methods: This longitudinal study was conducted on people insured by social security organization in Fars province during 2009-2016. Read More

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The Study of Effective Factors on Iran's Pharmaceutical Export Supply and Demand.

Iran J Pharm Res 2019 ;18(4):2226-2232

Department of Health Economics and Management, School of Health, Urmia University of Medical Sciences, Urmia, Iran.

The importance of drug as a valuable export product in the global economy becomes clearer every day. Understanding the problems of exports and factors affecting it, can be an important step to keep Iran's position in the world markets and further export development of this product. In this study, Iranian pharmaceutical exports' supply and demand functions were calculated using co-integration and error correction techniques through time series quarterly data of 2000-2014 in order to identify the factors affecting pharmaceutical exports (short run and long run relationships among the variables) and price and income elasticities. Read More

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January 2019

The Globalization of Biological Psychiatry and the Rise of Bipolar Spectrum Disorder in Iran.

Cult Med Psychiatry 2020 Sep;44(3):404-432

Division of Social and Transcultural Psychiatry, Department of Psychiatry, McGill University, Montreal, Canada.

In recent years, psychiatry in Iran witnessed a dramatic increase in the use of the diagnosis of bipolar spectrum disorder (BSD). This qualitative study maps the journey of the BSD diagnosis from the West to Iran, examines the controversy surrounding the diagnosis and its treatment, and explores some of the structural factors that facilitate and maintain the widespread use of the BSD diagnosis in Iran and related practices of prescribing neuroleptic and mood stabilizers. The study methods include archival research and semi-structured interviews with 25 prominent Iranian psychiatrists in the field of mood disorders. Read More

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September 2020

Policy Analysis Of Iranian Pharmaceutical Sector; A Qualitative Study.

Risk Manag Healthc Policy 2019 7;12:199-208. Epub 2019 Nov 7.

School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Introduction: Improving public health through providing affordable and accessible pharmaceuticals is among the concerns of governments worldwide. This study aimed to analyze Iran's pharmaceutical sector policies in order to identify the challenges and suggest some strategic solutions to overcome such challenges.

Methods: Top managers (15), middle managers (10), and operational managers (5) working in the Food and Drug Administration of Iranian Ministry of Health along with community pharmacists (5) participated in a qualitative study using semi-structured in-depth interviews. Read More

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November 2019

The Scarce Drugs Allocation Indicators in Iran: A Fuzzy Delphi Method Based Consensus.

Iran J Pharm Res 2019 ;18(2):1126-1135

School of Industrial Engineering, Iran University of Sciences and Technology, Tehran, Iran.

Almost all countries are affected by a variety of drug-supply problems and spend a considerable amount of time and resources to address shortages. The current study aims to reach a consensus on the scarce drug allocation measures to improve the allocation process of scarce drugs in Iran by a population needs-based approach. To achieve the objective, two phases were conducted. Read More

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January 2019

Direct and indirect cost of managing Alzheimer's disease in the Islamic Republic of Iran.

Iran J Neurol 2019 Jan;18(1):7-12

Department of Pharmacoeconomics and Pharmaceutical Administration, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Alzheimer's disease (AD) affects a large number of adults annually all around the world. The monetary cost of this disorder is huge. This study aims to estimate the cost of AD in Iran by considering stages of disease. Read More

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January 2019

The Structure of the World Pharmaceutical Market: Prioritizing Iran's Target Export Markets.

Iran J Pharm Res 2019 ;18(1):546-555

Department of Health Information Technology, School of Allied Medical Sciences, Urmia Medical Sciences University, Urmia, Iran.

Iran`s pharmaceutical products market has faced fluctuations over time. Suitable market selection is necessary for stability of pharmaceutical exports. This study aimed to determine the structure of the world pharmaceutical market and to identify the target of Iranian pharmaceutical export. Read More

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January 2019

Pattern of Antidepressant Utilization and Cost in Iran from 2006 to 2013 in Comparison with Other Countries.

J Epidemiol Glob Health 2018 12;8(3-4):213-219

Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Antidepressant prescribing patterns have changed globally over the past few years, with conventional drugs including tricyclic antidepressants and monoamine oxidase inhibitors being replaced by selective serotonin reuptake inhibitors (SSRIs) and novel antidepressants. The objective of this study was to assess antidepressant utilization in Iran from 2006 to 2013 and to show Iran's situation in antidepressant consumption compared with other countries. A cross-sectional study was undertaken using prescription claims data from Iranian insurance agencies. Read More

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December 2018

Medication Errors Associated With Adverse Drug Reactions in Iran (2015-2017): A P-Method Approach.

Int J Health Policy Manag 2018 12 1;7(12):1090-1096. Epub 2018 Dec 1.

Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.

Medication errors are the second most common cause of adverse patient safety incidents and the single most common preventable cause of adverse events in medical practice. Given the high human fatalities and financial burden of medication errors for healthcare systems worldwide, reducing their occurrence is a global priority. Therefore, appropriate policies to reduce medication errors, using national data and valid statistics are required. Read More

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December 2018

A Comparative Study on Different Pharmaceutical Industries and Proposing a Model for the Context of Iran.

Iran J Pharm Res 2018 ;17(4):1593-1603

Department of Health Services Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.

Medication is known as the main and the most effective factor in improving public health. On the other hand, having a strong and effective pharmaceutical industry will, to a very large extent, guarantee people's health. Therefore, this study was prospected to review the different pharmaceutical industries around the world and propose a model for the context of Iran. Read More

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January 2018

Inputs of Iranian health system reform plan from health sector managers and policy-makers' points of view.

J Educ Health Promot 2018 29;7:126. Epub 2018 Oct 29.

School of Management and Medical Information Sciences, Health Management and Economics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Context: Health system reform plan refers to conducting some fundamental, systematic, and sustainable changes.

Aims: The aim of the present study was to evaluate different required inputs of Iran Health Transformation Plan from experts' viewpoints.

Settings And Design: The data of this qualitative study were collected using semi-structured interviews. Read More

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October 2018

Promoting Role of MXene Nanosheets in Biomedical Sciences: Therapeutic and Biosensing Innovations.

Adv Healthc Mater 2019 01 25;8(1):e1801137. Epub 2018 Oct 25.

Department of Mechanical Engineering, Texas A&M University, College Station, TX, 77483, USA.

MXene nanosheets have emerged as biocompatible transition metal structures, which illustrate desirable performance for various applications due to their unique structural, physicochemical, and compositional features. MXenes are currently expanding their usage territory from mechanical, optical, chemical, and electronic fields toward biomedical areas. This is mainly originated from their large surface area and strong absorbance in near-infrared region, which in combination with their facile surface functionalization with various polymers or nanoparticles, make them promising nanoplatforms for drug delivery, cancer therapy, precise biosensing and bioimaging. Read More

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January 2019

Setting research priorities to achieve long-term health targets in Iran.

J Glob Health 2018 Dec;8(2):020702

Population Health Research Group, Health Metrics Research Center, Institute for Health Sciences Research, ACECR. Tehran, Iran.

Background: In 2015, it was estimated that the burden of disease in Iran comprised of 19 million disability-adjusted life years (DALYs), 74% of which were due to non-communicable diseases (NCDs). The observed leading causes of death were cardiovascular diseases (41.9%), neoplasms (14. Read More

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December 2018

The Texture of Psychoactive Illicit Drugs in Iran: Adulteration with Lead and other Active Pharmaceutical Ingredients.

J Psychoactive Drugs 2018 Nov-Dec;50(5):451-459. Epub 2018 Aug 21.

c Department of Medicinal Chemistry, Faculty of Pharmacy , Pharmaceutical Sciences Branch, Islamic Azad University , Tehran , Iran.

Psychoactive illicit drugs are widely used all over the world. Due to the high demand for illicit drugs, adulteration of substances with poisonous and active pharmaceutical ingredients is a common phenomenon in some countries. Lead and other active pharmaceutical ingredients are among adulterants added to illicit drugs intentionally. Read More

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October 2019

The concentration and probabilistic health risk assessment of pesticide residues in commercially available olive oils in Iran.

Food Chem Toxicol 2018 Oct 3;120:32-40. Epub 2018 Jul 3.

Department of Food Science, Faculty of Food Engineering, University of Campinas, Campinas, SP, Brazil. Electronic address:

This study was undertaken to analyze 29 pesticides residues in 37 commercially olive oil collected samples from Iran's markets using Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) approach along with acetonitrile for the extraction, surface adsorbents for clean-up procedure, following with a gas chromatography-mass spectroscopy (GC-MS). In order to eliminate the matrix effect, the calibration curves were drawn using spiked samples with the Area under curve (AUC) portion calculation of pesticide residue to AUC internal standard (Triphenyl Methane (TPM)). Moreover, the probabilistic health risk assessment includes non-carcinogenic and carcinogenic risk were estimated by target hazard quotient (THQ), total target hazard quotient (TTHQ) and cancer risk (CR) using the Monte Carlo Simulation (MCS) method. Read More

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October 2018

Determinants of Iran's in Pharmaceutical Industry.

Iran J Pharm Res 2018 ;17(2):822-828

Department of Public Heath, School of Health, Social Determinants of Health Research Center, Urmia Medical Sciences University, Urmia, Iran.

Among non-oil and in trade arena, drug has always been strategic importance and most government especially industrialized countries pay special attention to its production and trade issues. Thus, having a comprehensive view from economic perspective to this section is essential for suggesting intervention. This was a descriptive-analytical and panel study. Read More

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January 2018

Impact assessment of Iran's health technology assessment programme.

Health Res Policy Syst 2018 Feb 22;16(1):15. Epub 2018 Feb 22.

Shaheed Beheshti University of Medical Sciences, Tehran, Iran.

Background: Following approximately 10 years from the beginning of Iran's national Health Technology Assessment (HTA) programme, the present study aims to evaluate its success by examining the impact of HTA and identifying the determinant factors leading to the implementation of HTA report results.

Methods: The triangulation method was employed herein. HTA reports were initially identified and their impact and determinant factors were then examined from the perspectives of both researchers (by preparing a questionnaire according to the Payback model and sending it to HTA principle investigators) and stakeholders (semi-structured interviews held with each HTA stakeholder). Read More

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February 2018

Death-specific rate due to asthma and chronic obstructive pulmonary disease in Iran.

Clin Respir J 2018 Jun 16;12(6):2075-2083. Epub 2018 Apr 16.

Non-Communicable Diseases Research Center Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background And Objective: Asthma and chronic obstructive pulmonary disease (COPD) could be considered as a major health problem in industrialized and developing countries. This study was designed to analyze the trends of mortality from asthma and COPD at national and subnational levels in Iran based on National Death Registry, from 2001 to 2015.

Materials And Methods: We used Death Registration System (DRS) as the basic source of data. Read More

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Epidemiology and outcome of 2,590 burned patients in Northwest Iran.

Ann Burns Fire Disasters 2017 Jun;30(2):85-90

Department of Surgery, Ayatollah Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran.

Burns are calamities with considerable morbidity and mortality rates. We attempted to examine the epidemiology of burns in Zanjan city, in northwest Iran, by a systematic study of existing information. The medical files of 2,590 thermal burn patients treated in our hospital in Zanjan city, Iran, from December 2010 to November 2016 were studied. Read More

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Addressing the impact of economic sanctions on Iranian drug shortages in the joint comprehensive plan of action: promoting access to medicines and health diplomacy.

Global Health 2016 06 8;12(1):31. Epub 2016 Jun 8.

Department of Anesthesiology, University of California, San Diego School of Medicine, San Diego, CA, USA.

Background: The U.S Congress initiated sanctions against Iran after the 1979 U.S. Read More

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The impact of international economic sanctions on Iranian cancer healthcare.

Health Policy 2015 Oct 22;119(10):1309-18. Epub 2015 Aug 22.

Seton Hall University School of Law, Newark, USA.

Background: In 2012, Iranian's economy collapsed under strain from sanctions instituted to stop Iran from violating the International Nuclear Non-Proliferation Treaty. Sanctions have indirectly led to serious healthcare concerns, specifically cancer treatment. This is the first report to evaluate Iranian cancer healthcare while under international economic sanctions. Read More

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October 2015