33 results match your criteria ipfp volume


Hypoperfusion of the infrapatellar fat pad and its relationship to MRI T2* relaxation time changes in a 5/6 nephrectomy model.

Sci Rep 2021 May 11;11(1):9924. Epub 2021 May 11.

Department and Graduate Institute of Biology and Anatomy, National Defense Medical Center, No.161, Sec. 6, Minquan E. Rd., Neihu Dist., Taipei, 11490, Taiwan.

The purpose of present study was to longitudinally investigate the alterations in infrapatellar fat pad (IPFP) vascularity in 5/6 nephrectomized rats by using dynamic contrast enhanced (DCE) MRI and IPFP degeneration by using MRI T2* relaxation time. Twelve male Sprague-Dawley rats were assigned to a control group and a 5/6 nephrectomy CKD group. The right knees of all rats were longitudinally scanned by 4. Read More

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Infrapatellar fat pad volume and Hoffa-synovitis after ACL reconstruction: Association with early osteoarthritis features and pain over 5 years.

J Orthop Res 2021 Jan 17. Epub 2021 Jan 17.

La Trobe Sport and Exercise Medicine Research Centre, School of Allied Health, Human Services and Sport, La Trobe University, Bundoora, Victoria, Australia.

Infrapatellar fat pad (IPFP) morphology and Hoffa-synovitis may be relevant to the development and progression of post-traumatic osteoarthritis (OA). We aimed to compare IPFP volume and Hoffa-synovitis in participants with anterior cruciate ligament reconstruction (ACLR) and uninjured controls, and to determine their association with prevalent and worsening early knee OA features and pain in participants post-ACLR. We assessed IPFP volume and Hoffa-synovitis from magnetic resonance imaging (MRI) in 111 participants 1-year post-ACLR and 20 uninjured controls. Read More

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January 2021

Quantitative volume and dynamic contrast-enhanced MRI derived perfusion of the infrapatellar fat pad in patellofemoral pain.

Quant Imaging Med Surg 2021 Jan;11(1):133-142

Department of Radiology & Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.

Background: Patellofemoral pain (PFP) is a common knee condition and possible precursor of knee osteoarthritis (OA). Inflammation, leading to an increased perfusion, or increased volume of the infrapatellar fat pad (IPFP) may induce knee pain. The aim of the study was to compare quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters, as imaging biomarkers of inflammation, and volume of the IPFP between patients with PFP and controls and between patients with and without IPFP edema or joint effusion. Read More

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January 2021

Association of infra-patellar fat pad size with age and body weight in children and adolescents.

Ann Anat 2020 Nov 2;232:151533. Epub 2020 Jul 2.

Department of Imaging and Functional Musculoskeletal Research, Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Department of Orthopedic Surgery & Traumatology, Landesklinik Tamsweg, Paracelsus Medical University, Tamsweg, Austria.

Background: The infra-patellar fat pad (IPFP) represents a potential mediator between obesity, low grade inflammation, and knee osteoarthritis via endocrine pathways. Yet, not only in adults, but also in childhood obesity negatively impacts knee structures.

Objective: The current study therefore investigated the sex-specific growth of the IPFP with age and body weight in healthy children and adolescents. Read More

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November 2020

Partial resection of the infrapatellar fat pad during anterior cruciate ligament reconstruction has no effect on clinical outcomes including anterior knee pain.

Arch Orthop Trauma Surg 2020 Nov 22;140(11):1751-1757. Epub 2020 Jun 22.

Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa, 920-8641, Japan.

Background: Anterior knee pain (AKP) is a major complication that occurs after anterior cruciate ligament reconstruction (ACLR), even when hamstring tendon (HT) grafts are used. Damage to the infrapatellar fat pad (IPFP) during arthroscopy can cause AKP. The purpose of this study was to evaluate the influence of IPFP preservation on clinical outcomes, including AKP, in patients who underwent ACLR with HT autografts using the inside-out technique. Read More

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November 2020

Serum adipokines/related inflammatory factors and ratios as predictors of infrapatellar fat pad volume in osteoarthritis: Applying comprehensive machine learning approaches.

Sci Rep 2020 06 19;10(1):9993. Epub 2020 Jun 19.

Osteoarthritis Research Unit, University of Montreal Hospital Research Centre (CRCHUM), Montreal, Quebec, Canada.

Objective: The infrapatellar fat pad (IPFP) has been associated with knee osteoarthritis onset and progression. This study uses machine learning (ML) approaches to predict serum levels of some adipokines/related inflammatory factors and their ratios on knee IPFP volume of osteoarthritis patients.

Methods: Serum and MRI were from the OAI at baseline. Read More

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Movement and volume of infrapatellar fat pad and knee kinematics during quasi-static knee extension at 30 and 0° flexion in young healthy individuals.

Knee 2020 Jan 7;27(1):71-80. Epub 2020 Jan 7.

Department of Rehabilitation, Hiroshima International University, 555-36, Kurosegakuenndai, Higashihiroshimashi, Hiroshima, Japan. Electronic address:

Introduction: The purpose of this study was to determine the changes in the shape and volume of the infrapatellar fat pad (IPFP) associated with knee flexion angle in young healthy individuals.

Methods: Young, healthy individuals without a history of knee injuries participated in this cross-sectional study. Behavior of the IPFP was quantified using three-dimensional (3D) models of the IPFP, patella, patellar tendon, femur, and tibia obtained from MRI taken at 0° and 30° flexion. Read More

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January 2020

Higher Serum Levels of Resistin Are Associated With Knee Synovitis and Structural Abnormalities in Patients With Symptomatic Knee Osteoarthritis.

J Am Med Dir Assoc 2019 10 20;20(10):1242-1246. Epub 2019 Aug 20.

Clinical Research Centre, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. Electronic address:

Objective: Resistin acts as an endogenous ligand of Toll-like receptor (TLR)-4 that triggers major inflammatory pathways and mediates inflammatory processes. The role of resistin in osteoarthritis (OA) pathogenesis is unclear. The aim of this study is to describe the longitudinal associations of serum levels of resistin with knee synovitis measures and structural abnormalities in patients with knee OA. Read More

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October 2019

Patellar tendon enthesis abnormalities and their association with knee pain and structural abnormalities in older adults.

Osteoarthritis Cartilage 2019 03 5;27(3):449-458. Epub 2018 Dec 5.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. Electronic address:

Objective: To describe associations between presence of patellar tendon enthesis (PTE) abnormalities and symptoms, structural abnormalities, and total knee replacement (TKR) in older adult cohort.

Methods: PTE abnormalities (presence of abnormal bone signal and/or bone erosion), were measured on T2-weighted magnetic resonance (MR) images at baseline in 961 community-dwelling older adults. Knee pain and function limitation were assessed using Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Read More

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MRI-detected osteophytes of the knee: natural history and structural correlates of change.

Arthritis Res Ther 2018 Oct 23;20(1):237. Epub 2018 Oct 23.

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia.

Backgroud: The natural history of semi-quantitative magnetic resonance imaging (MRI)-detected osteophytes (MRI-detected OPs) has not been described and it is unknown whether knee structural abnormalities can predict MRI-detected OP change over time. Thus, the aim of current study is to describe the natural history of knee MRI-detected OP, and to determine if knee structural abnormalities are associated with change of MRI-detected OP in a longitudinal study of older adults.

Methods: Randomly selected older adults (n = 837, mean age 63 years) had MRI at baseline and 413 of them had MRI 2. Read More

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October 2018

Association Between Quantitatively Measured Infrapatellar Fat Pad High Signal-Intensity Alteration and Magnetic Resonance Imaging-Assessed Progression of Knee Osteoarthritis.

Arthritis Care Res (Hoboken) 2019 05;71(5):638-646

University of Tasmania, Hobart, Tasmania, and Monash University, Melbourne, Victoria, Australia, and Zhujiang Hospital, Southern Medical University, Guangzhou, China.

Objective: To describe the cross-sectional and longitudinal associations between quantitative measures of infrapatellar fat pad (IPFP) signal-intensity alteration and knee structural abnormalities in patients with symptomatic knee osteoarthritis (OA).

Methods: A total of 261 patients (mean ± SD age 63.0 ± 7. Read More

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Signal intensity alteration within infrapatellar fat pad predicts knee replacement within 5 years: data from the Osteoarthritis Initiative.

Osteoarthritis Cartilage 2018 10 26;26(10):1345-1350. Epub 2018 May 26.

Department of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Australia.

Objective: To investigate whether infrapatellar fat pad (IPFP) signal intensity (SI) alteration predicts the occurrence of knee replacement (KR) in knee osteoarthritis (OA) patients over 5 years.

Design: The subjects were selected from Osteoarthritis Initiative (OAI) study. Case knees (n = 127) were defined as those who received KR during 5 years follow-up visit. Read More

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October 2018

Associations between knee structural measures, circulating inflammatory factors and MMP13 in patients with knee osteoarthritis.

Osteoarthritis Cartilage 2018 08 22;26(8):1063-1069. Epub 2018 May 22.

Department of Rheumatology and Immunology, Arthritis Research Institute, The First Affiliated Hospital of Anhui Medical University, Hefei, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; Translational Research Centre, Academy of Orthopaedics, Guangdong Province, China; School of Basic Medical Sciences, Southern Medical University, Guangzhou, China; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address:

Objective: To investigate cross-sectional associations between serum level of Matrix metalloproteinase (MMP)13 and knee structural measures and circulating inflammatory factors in patients with symptomatic knee osteoarthritis (OA).

Design: A total of 149 subjects with symptomatic knee OA were included. Magnetic resonance imaging was used to measure infrapatellar fat pad (IPFP) volume, IPFP signal intensity alternation, cartilage volume and cartilage defects. Read More

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Responsiveness of Infrapatellar Fat Pad Volume Change to Body Weight Loss or Gain: Data from the Osteoarthritis Initiative.

Cells Tissues Organs 2018 1;205(1):53-62. Epub 2018 Feb 1.

Obesity is a potent risk factor for knee osteoarthritis (OA) that is driven by mechanical and potentially endocrine mechanisms, and it affects women more frequently than men. The infrapatellar fat pat (IPFP) represents a potential link between obesity, intra-articular inflammation and structural pathology. Here we investigate whether the IPFP is responsive to body weight loss/gain in women and how its responsiveness to weight change compares to that of subcutaneous fat (SCF) of the thigh. Read More

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Knee Fat Pad Volumes in Patients with Hemophilia and Their Relationship with Osteoarthritis.

Arthritis 2017 5;2017:1578623. Epub 2017 Dec 5.

Radiology Service, VA San Diego Healthcare System, San Diego, CA, USA.

Hemophilic arthropathy is a progressive, disabling condition with poorly understood pathobiology. Since there is an emerging interest to study the role of intra-articular fat pad size and biology in arthritic conditions, we explored fat pad volume changes in hemophilic arthropathy and to what extent they differed from osteoarthritis. We matched a cohort of 13 adult patients with hemophilic arthropathy of the knee with age- and gender-matched cohorts without osteoarthritis ("control cohort") and with the same degree of radiographic osteoarthritis ("OA cohort") in 1 : 2 fashion. Read More

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December 2017

Associations between serum ghrelin and knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee osteoarthritis.

Osteoarthritis Cartilage 2017 09 15;25(9):1428-1435. Epub 2017 Jun 15.

Department of Rheumatology and Immunology, Arthritis Research Institute, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Street, Hefei, China; Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, Tasmania 7000, Australia; Institute of Bone & Joint Translational Research, Southern Medical University, Guangzhou, China. Electronic address:

Objective: The roles of ghrelin in knee osteoarthritis (OA) are unclear. This study aimed to examine cross-sectional associations of ghrelin with knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee OA.

Methods: This study included 146 patients with symptomatic knee OA. Read More

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September 2017

Variance in infra-patellar fat pad volume: Does the body mass index matter?-Data from osteoarthritis initiative participants without symptoms or signs of knee disease.

Ann Anat 2017 Sep 25;213:19-24. Epub 2017 May 25.

Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany.

The infra-patellar fat pad (IPFP) has been proposed to represent an endocrine link between obesity and knee osteoarthritis (OA). The purpose of the current study has been to explore the extent to which IPFP volume is related to body mass index (BMI). A total of 152 participants (age 56±7 years) without knee OA were studied. Read More

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September 2017

Impact of Diet and/or Exercise Intervention on Infrapatellar Fat Pad Morphology: Secondary Analysis from the Intensive Diet and Exercise for Arthritis (IDEA) Trial.

Cells Tissues Organs 2017 22;203(4):258-266. Epub 2017 Feb 22.

Institute of Anatomy, Paracelsus Medical University Salzburg and Nuremberg, Salzburg, Austria.

Objectives: The infrapatellar fat pad (IPFP) represents intra-articular adipose tissue that may contribute to intra-articular inflammation and pain by secretion of proinflammatory cytokines. Here we examined the impact of weight loss by diet and/or exercise interventions on the IPFP volume.

Methods: Intensive Diet and Exercise for Arthritis (IDEA) was a single-blinded, single-center, 18-month, prospective, randomized controlled trial that enrolled 454 overweight and obese older adults with knee pain and radiographic osteoarthritis. Read More

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Between-group differences in infra-patellar fat pad size and signal in symptomatic and radiographic progression of knee osteoarthritis vs non-progressive controls and healthy knees - data from the FNIH Biomarkers Consortium Study and the Osteoarthritis Initiative.

Osteoarthritis Cartilage 2017 07 12;25(7):1114-1121. Epub 2017 Feb 12.

Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria; Chondrometrics GmbH, Ainring, Germany. Electronic address:

Objective: To examine cross-sectional and longitudinal between-group differences of infra-patellar fat pad (IPFP) size and magnetic resonance imaging (MRI) signal from fat-suppressed intermediate-weighted images with clinically relevant symptomatic and radiographic progression of knee osteoarthritis (OA), vs healthy references.

Methods: We studied 110 case knees (Kellgren-Lawrence Grade [KLG1-3]) with radiographic (≥0.7 mm loss in joint space width [JSW]) and symptomatic progression (≥+9/100 units on the Western Ontario and McMasters Universities Osteoarthritis Index [WOMAC] knee pain subscale) vs 118 control knees without progression from the Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium cohort. Read More

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A novel method for assessing signal intensity within infrapatellar fat pad on MR images in patients with knee osteoarthritis.

Osteoarthritis Cartilage 2016 11 18;24(11):1883-1889. Epub 2016 Jun 18.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia; Arthritis Research Institute, 1st Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China; Institute of Bone and Joint Research, Kolling Institute, University of Sydney; Rheumatology Department, Royal North Shore Hospital, Sydney, NSW, Australia. Electronic address:

Purpose: To assess reliability and validity of a semi-automated quantitative method to measure infrapatellar fat pad (IPFP) signal intensity in patients with knee osteoarthritis (OA).

Methods: Hundred patients with knee OA were selected. Sagittal planes of fat-saturated T2-weighted images obtained on 1. Read More

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November 2016

Hypointense signals in the infrapatellar fat pad assessed by magnetic resonance imaging are associated with knee symptoms and structure in older adults: a cohort study.

Arthritis Res Ther 2016 10 12;18(1):234. Epub 2016 Oct 12.

Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7000, Australia.

Background: There are few clinical and epidemiological studies reporting the association between abnormal changes within the IPFP and knee osteoarthritic changes. This study aims to describe the associations between hypointense signals in the infrapatellar fat pad (IPFP) and knee structural change and symptoms in older adults.

Methods: Participants (n = 874) were selected randomly from local community and followed up 2. Read More

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October 2016

Serum levels of interleukin-17 and adiponectin are associated with infrapatellar fat pad volume and signal intensity alteration in patients with knee osteoarthritis.

Arthritis Res Ther 2016 08 26;18:193. Epub 2016 Aug 26.

Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University, 218 Jixi Street, Hefei, China.

Background: In the present study, we sought to generate hypotheses regarding the associations of serum levels of interleukin (IL)-17, adiponectin, and resistin with magnetic resonance imaging-measured infrapatellar fat pad (IPFP) size and signal intensity alterations in patients with knee osteoarthritis (OA).

Methods: A total of 170 subjects with symptomatic knee OA (mean age 55.4 years, range 34-74, 88. Read More

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Signal intensity alteration in the infrapatellar fat pad at baseline for the prediction of knee symptoms and structure in older adults: a cohort study.

Ann Rheum Dis 2016 10 26;75(10):1783-8. Epub 2015 Nov 26.

Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia Arthritis Research Institute, 1st Affiliated Hospital, Anhui Medical University, Hefei, Anhui, China.

Objective: To describe the associations between infrapatellar fat pad (IPFP) signal intensity alteration at baseline and knee symptoms and structural changes in older adults.

Methods: A total of 874 subjects (mean 62.1 years, 50. Read More

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October 2016

Intra- and inter-observer reliability of quantitative analysis of the infra-patellar fat pad and comparison between fat- and non-fat-suppressed imaging--Data from the osteoarthritis initiative.

Ann Anat 2016 Mar 10;204:29-35. Epub 2015 Nov 10.

Paracelsus Medical University Salzburg & Nuremberg, Institute of Anatomy, Strubergasse 21, A-5020 Salzburg, Austria.

The infra-patellar fat pad (IPFP), as intra-articular adipose tissue represents a potential source of pro-inflammatory cytokines and its size has been suggested to be associated with osteoarthritis (OA) of the knee. This study examines inter- and intra-observer reliability of fat-suppressed (fs) and non-fat-suppressed (nfs) MR imaging for determination of IPFP morphological measurements as novel biomarkers. The IPFP of nine right knees of healthy Osteoarthritis Initiative participants was segmented by five readers, using fs and nfs baseline sagittal MRIs. Read More

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A large infrapatellar fat pad protects against knee pain and lateral tibial cartilage volume loss.

Arthritis Res Ther 2015 Nov 10;17:318. Epub 2015 Nov 10.

Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Alfred Hospital, Melbourne, VIC, 3004, Australia.

Introduction: The infrapatellar fat pad (IPFP) is commonly resected during knee joint arthroplasty, but the ramifications of doing so are unclear. This longitudinal study determined whether the size of the IPFP (maximum cross-sectional area (CSA)) was associated with knee cartilage loss and the development of knee pain in adults without knee osteoarthritis (OA).

Methods: A total of 297 adults without American College of Rheumatology clinical criteria for a diagnosis of knee OA were recruited. Read More

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November 2015

Magnetic resonance imaging of Hoffa's fat pad and relevance for osteoarthritis research: a narrative review.

Osteoarthritis Cartilage 2016 Mar 9;24(3):383-97. Epub 2015 Oct 9.

Quantitative Imaging Center (QIC), Department of Radiology, Boston University School of Medicine, Boston, MA, USA.

Objective: To give an illustrative overview of Hoffa's fat pad pathology with a radiologic emphasis on the anatomy, on technical considerations, and on imaging differential diagnoses in the context of osteoarthritis (OA) imaging research.

Design: A PubMed database search including only English literature and covering a 20 year period was performed. The search was based on but no limited to the query terms "Hoffa", "Hoffa's fat pad" or "infrapatellar fat pad (IPFP)" in combination with "synovitis", "OA", and "magnetic resonance imaging (MRI)". Read More

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Effects of body mass index, infrapatellar fat pad volume and age on patellar cartilage defect.

Acta Orthop Belg 2015 Mar;81(1):41-6

The aim of this study was to evaluate the associations between patellar cartilage defects and body mass index (BMI), infrapatellar fat pad (IPFP) volume and age. 100 patients who met the inclusion criteria and were aged 18 to 60, were evaluated retrospectively. For detecting and measuring patellar cartilage defects, axial sequences were used and sagittal sequences were used to evaluate IPFP volumes. Read More

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Association Between Infrapatellar Fat Pad Volume and Knee Structural Changes in Patients with Knee Osteoarthritis.

J Rheumatol 2015 Oct 15;42(10):1878-84. Epub 2015 Aug 15.

From the Department of Rheumatology and Immunology, Arthritis Research Institute, and the Department of Medical Images, the First Affiliated Hospital of Anhui Medical University, Hefei, China; Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia.J. Cai, MMed; J. Xu, MD; K. Wang, MD; S. Zheng, MMed; F. He, MMed; S. Huan, MMed; S. Xu, MD, Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University; H. Zhang, MMed, Department of Medical Image, the First Affiliated Hospital of Anhui Medical University; L. Laslett, MD, Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University; C. Ding, MD, Department of Rheumatology and Immunology, Arthritis Research Institute, the First Affiliated Hospital of Anhui Medical University, and Menzies Institute for Medical Research, University of Tasmania.

Objective: The function of the infrapatellar fat pad (IPFP) in knee osteoarthritis (OA) remains uncertain. This study aimed to examine cross-sectional associations between IPFP volume and knee structures in patients with knee OA.

Methods: The study included 174 patients with clinical knee OA (mean age, 55. Read More

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October 2015

Infrapatellar fat pad volume is greater in individuals with patellofemoral joint osteoarthritis and associated with pain.

Rheumatol Int 2015 Aug 18;35(8):1439-42. Epub 2015 Mar 18.

Department of Physiotherapy, St Vincent's Hospital, 41 Victoria Parade, Fitzroy, VIC, 3065, Australia,

There is relatively little research specifically investigating patellofemoral joint osteoarthritis (PFJ OA). In particular, the source of pain in PFJ OA has not been established. One structure that may be an important contributor is the infrapatellar fat pad (IPFP). Read More

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Sex-differences of the healthy infra-patellar (Hoffa) fat pad in relation to intermuscular and subcutaneous fat content--data from the Osteoarthritis Initiative.

Ann Anat 2015 Jul 31;200:30-6. Epub 2015 Jan 31.

Institute of Anatomy, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria. Electronic address:

The infra-patellar fat pad (IPFP) is composed of intra-articular adipose tissue; it represents a potential source of pro-inflammatory cytokines and has been associated with osteoarthritis of the knee. Yet, to what extent the size of the IPFP differs between healthy men and women, and how sex differences compare to those in inter-muscular and subcutaneous fat tissue content is unknown. We studied healthy reference subjects from the Osteoarthritis Initiative, without knee pain, without radiographic signs or without risk factors of femorotibial osteoarthritis. Read More

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