Cell Mol Life Sci 2021 Jan 15;78(2):415-426. Epub 2020 Jul 15.
KU-KIST Graduate School of Converging Science and Technology, Korea University, 145 Anam-ro, Seogbuk-gu, Seoul, 02841, Republic of Korea.
μ-opioid receptor (MOR) is a class of opioid receptors that is critical for analgesia, reward, and euphoria. MOR is distributed in various brain regions, including the hippocampus, where traditionally, it is believed to be localized mainly at the presynaptic terminals of the GABAergic inhibitory interneurons to exert a strong disinhibitory effect on excitatory pyramidal neurons. However, recent intensive research has uncovered the existence of MOR in hippocampal astrocytes, shedding light on how astrocytic MOR participates in opioid signaling via glia-neuron interaction in the hippocampus. Read More