452,215 results match your criteria involving mtor


Characteristics and progression-free survival of Afro-Caribbean men with metastatic hormone-sensitive prostate cancer at the time of diagnosis.

Prostate 2021 Jul 28. Epub 2021 Jul 28.

CHU de Pointe-à-Pitre, Univ Antilles, Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), Pointe-à-Pitre, France.

Introduction And Objectives: Metastatic hormone-sensitive prostate cancer (mHSPC) accounts for 12% of prostate cancers diagnosed in Guadeloupe according to the Guadeloupean cancer registry. Most published studies have been conducted on the Caucasian population, whereas data concerning mHSPC in the Afro-Caribbean population are lacking. We aimed to describe the patient characteristics and estimate the progression-free survival of men with mHSPC in an Afro-Caribbean population according to the available treatment. Read More

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Comparative effectiveness and safety of 32 pharmacological interventions recommended by guidelines for coronavirus disease 2019: a systematic review and network meta-analysis combining 66 trials.

Chin Med J (Engl) 2021 Jul 27. Epub 2021 Jul 27.

Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing 100191, China Department of Clinical Epidemiology and EBM, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China National Clinical Research Center of Digestive Diseases, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China Primary Care Unit, Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge CB18RN, UK Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton L8S4K1, Canada Department of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing 100191, China.

Background: The global pandemic coronavirus disease 2019 (COVID-19) has become a major public health problem and presents an unprecedented challenge. However, no specific drugs were currently proven. This study aimed to evaluate the comparative efficacy and safety of pharmacological interventions in patients with COVID-19. Read More

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Unusual Variants of Teratoma Involving the Gynecologic Tract.

Int J Gynecol Pathol 2021 Jul 28. Epub 2021 Jul 28.

Department of Pathology, University of Miami/Jackson Health System, Miami, Florida.

Teratomas are tumors of germ cell origin, and in the female genital tract are subclassified in immature or mature based on the presence or absence, respectively, of immature elements. Somatic tumors may also develop in association with teratomas, and most commonly include thyroid tumors, carcinoids and carcinomas. We report herein 2 rare forms of gynecologic teratomas: 1 case of immature teratoma of the uterus and 1 case of a benign follicular hamartoma arising in association with mature cystic teratoma of the ovary. Read More

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How Can eHealth Meet the Hearing and Communication Needs of Adults With Hearing Impairment and their Significant Others? A Group Concept Mapping Study.

Ear Hear 2021 Jul 27. Epub 2021 Jul 27.

HEARing CRC, Melbourne, VIC, Australia School of Health and Rehabilitation Sciences, University of Queensland, Brisbane, QLD, Australia Department of Audiology and Speech Pathology, University of Melbourne, Melbourne, VIC, Australia.

Objectives: To seek the perspectives of key stakeholders regarding: (1) how eHealth could help meet the hearing and communication needs of adults with hearing impairment and their significant others; and (2) how helpful each aspect of eHealth would be to key stakeholders personally.

Design: Group concept mapping, a mixed-methods participatory research method, was used to seek the perspectives of key stakeholders: adults with hearing impairment (n = 39), significant others (n = 28), and hearing care professionals (n = 56). All participants completed a short online survey before completing one or more of the following activities: brainstorming, sorting, and rating. Read More

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Desmoplastic Small Round Cell Tumor of the Submandibular Gland: A Case Report and Literature Review.

ORL J Otorhinolaryngol Relat Spec 2021 Jul 28:1-6. Epub 2021 Jul 28.

Department of Pathology, Maoming People's Hospital, Maoming, China.

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressively malignant tumor mostly occurring in the abdominal and pelvic cavity of young patients. However, few cases had been reported concerning DSRCT occurring in the head and neck region. We presented a rare case of DSRCT of the right submandibular in a 25-year-old man. Read More

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Associations between exercise, inflammation and symptom severity in those with mental health disorders.

Cytokine 2021 Jul 25;146:155648. Epub 2021 Jul 25.

School of Exercise Science, Sport and Health, Charles Sturt University, Bathurst, NSW, Australia.

Aim: This study aimed to investigate the effects of 6-weeks of moderate intensity aerobic exercise on markers of inflammation and symptom severity in those undergoing management of a mental health disorder.

Method: Twenty six participants were allocated into two groups, those reporting as apparently healthy (AH, n = 13) or those undergoing the management of a mental health disorder (MI, n = 13). Following a baseline testing and familiarization session, participants commenced the 6-week aerobic training intervention, involving stationary cycling at 65% heart rate reserve for 35 min progressing to 70% for 40 min. Read More

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Chronic neuroleptic treatment combined with a high fat diet elevated [3H] flunitrazepam binding in the cerebellum.

Prog Neuropsychopharmacol Biol Psychiatry 2021 Jul 25:110407. Epub 2021 Jul 25.

Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions (BNNLA), Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; Department of Psychology, University at Buffalo, Buffalo, NY, USA. Electronic address:

Clinical and preclinical studies have shown dysfunctions in genetic expression and neurotransmission of γ-Aminobutyric acid (GABA), GABA receptor subunits, and GABA-synthesizing enzymes GAD and GAD in schizophrenia. It is well documented that there is significant weight gain after chronic neuroleptic treatment in humans. While there are limited studies on the effects of diet on GABA signaling directly, a change in diet has been used clinically as an adjunct to treatment for schizophrenic relief. Read More

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Rituximab for the Treatment of Refractory Cardiac Sarcoidosis-A Single Center Experience.

J Card Fail 2021 Jul 25. Epub 2021 Jul 25.

Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA; Division of Epidemiology, Department of Health Sciences Research, Rochester, MN, USA.

Objective: To examine the effect of anti-B cell therapy (rituximab) on cardiac inflammation and function in corticosteroid-refractory cardiac sarcoidosis.

Background: Cardiac sarcoidosis (CS) is a rare cause of cardiomyopathy characterized by granulomatous inflammation involving the myocardium. While typically responsive to corticosteroid treatment, there is a critical need for identifying effective steroid-sparing agents for disease control. Read More

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A switch in species dominance of a recovering pelagic ecosystem.

Curr Biol 2021 Jul 21. Epub 2021 Jul 21.

School of Biological Sciences, University of Aberdeen, Aberdeen AB24 2TZ, UK.

Although many marine ecosystems have been adversely impacted by human activities, some are now recovering due to reductions in fishing pressure. Here, we document the recovery of an ecosystem subjected to intense anthropogenic activity for over 200 years, the Clyde Sea. This region once had productive fisheries for herring (Clupea harengus) and other fish, but these disappeared at the turn of the century. Read More

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Molecular noise filtering in the β-adrenergic signaling network by phospholamban pentamers.

Cell Rep 2021 Jul;36(4):109448

Randall Centre for Cell and Molecular Biophysics, King's College London, SE1 1UL London, UK.

Phospholamban (PLN) is an important regulator of cardiac calcium handling due to its ability to inhibit the calcium ATPase SERCA. β-Adrenergic stimulation reverses SERCA inhibition via PLN phosphorylation and facilitates fast calcium reuptake. PLN also forms pentamers whose physiological significance has remained elusive. Read More

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Enantioselective Copper-Catalyzed Synthesis of Trifluoromethyl-Cyclopropylboronates.

Org Lett 2021 Jul 28. Epub 2021 Jul 28.

Universidad de Alcalá, Departamento de Química Orgánica y Química Inorgánica,, Alcalá de Henares 28805, Spain.

A copper-catalyzed enantioselective cyclopropanation involving trifluorodiazoethane in the presence of alkenyl boronates has been developed. This transformation enables the preparation of 2-substituted-3-(trifluoromethyl)cyclopropylboronates with high levels of stereocontrol. The products are valuable synthetic intermediates by transformation of the boronate group. Read More

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Risdiplam-Treated Infants with Type 1 Spinal Muscular Atrophy versus Historical Controls.

N Engl J Med 2021 Jul;385(5):427-435

From the Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston (B.T.D.); the Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan (R.M., G.B.), and the Center of Translational and Experimental Myology, IRCCS Istituto Giannina Gaslini, Genoa (C.B.) - both in Italy; the Department of Developmental Neurology, Medical University of Gdańsk, Gdańsk, Poland (M.M.-B.); the Paediatric Gait Analysis Service of New South Wales, the Children's Hospital at Westmead and the University of Sydney, Sydney (K.R.); the Department of Pediatrics, Peking University First Hospital, Beijing (H.X.), and Children's Hospital of Fudan University, Shanghai (Y.W.) - both in China; the Department of Neurology, Faculdade de Medicina, Universidade de São Paulo, São Paulo (E.Z.); the Dubowitz Neuromuscular Centre, National Institute for Health Research Great Ormond Street Hospital Biomedical Research Centre, University College London Great Ormond Street Institute of Child Health, and Great Ormond Street Hospital for Children NHS Foundation Trust, London (G.B.), Roche Products, Welwyn Garden City (M.E.-K.), and the Muscular Dystrophy UK Oxford Neuromuscular Centre, the Department of Paediatrics, University of Oxford, Oxford (L.S.) - all in the United Kingdom; Russian Children Neuromuscular Center, Veltischev Clinical Pediatric Research Institute, Pirogov Russian National Research Medical University, Moscow (D.V.); Pharma Development, Safety (M.G.), Product Development Medical Affairs - Neuroscience and Rare Disease (K.G., P.F.), and Pharma Development Neurology (R.S.S.), F. Hoffmann-La Roche, and Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel (O.K., H.K.) - both in Basel, Switzerland; the Division of Child Neurology, Centre de Références des Maladies Neuromusculaires, the Department of Pediatrics, University Hospital Liege, University of Liege, Liege, Belgium (L.S.); and I-Motion, Institut de Myologie, Assistance Publique Hôpitaux de Paris, Hôpital Armand Trousseau, Paris (L.S.).

Background: Type 1 spinal muscular atrophy (SMA) is a progressive neuromuscular disease characterized by an onset at 6 months of age or younger, an inability to sit without support, and deficient levels of survival of motor neuron (SMN) protein. Risdiplam is an orally administered small molecule that modifies pre-messenger RNA splicing and increases levels of functional SMN protein in blood.

Methods: We conducted an open-label study of risdiplam in infants with type 1 SMA who were 1 to 7 months of age at enrollment. Read More

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Endoplasmic reticulum stress inhibits 3D Matrigel-induced vasculogenic mimicry of breast cancer cells via TGF-β1/Smad2/3 and β-catenin signaling.

FEBS Open Bio 2021 Jul 28. Epub 2021 Jul 28.

Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Endoplasmic reticulum (ER) stress is a cellular stress condition involving disturbance in the folding capacity of the ER caused by endogenous and exogenous factors. ER stress signaling pathways affect tumor malignant growth, angiogenesis and progression, and promote the anti-tumor effects of certain drugs. However, the impact of ER stress on the vasculogenic mimicry (VM) phenotype of cancer cells has not been well addressed. Read More

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Application of the Bethesda system for reporting thyroid cytopathology for classification of thyroid nodules: A clinical and cytopathological characteristics in Bhutanese population.

Diagn Cytopathol 2021 Jul 28. Epub 2021 Jul 28.

Department of Pathology and Laboratory Medicine, Jigme Dorji Wangchuck National Referral Hospital, Thimphu, Bhutan.

Introduction: The existence of baseline data on the spectrum of thyroid nodules in Bhutanese patients is unknown. Fine-needle aspiration cytology (FNAC) is regarded as the gold standard diagnostic test for pre-op assessment of thyroid lesions.

Materials And Methods: We conducted a retrospective study, involving 765 patients who underwent FNAC of the thyroid gland, at Jigme Dorji Wangchuck National Referral Hospital, Thimphu, between January-2018 to December-2020. Read More

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Factors associated with unprotected sex in people who consume sexually explicit media.

Rev Bras Enferm 2021 26;74(6):e20210061. Epub 2021 Jul 26.

Universidade NOVA de Lisboa. Lisboa, Portugal.

Objective: To analyze the factors associated with sex without the use of condoms in consumers of sexually explicit media (SEM).

Methods: Cross-sectional study, with a sample of 172 participants selected and collected through social media. To assess the predictors of unprotected sexual practices, the Poisson regression model was used. Read More

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Distribution of HLA-DRB1 alleles in BRICS countries with a high tuberculosis burden: a systematic review and meta-analysis.

Rev Soc Bras Med Trop 2021 23;54:e00172021. Epub 2021 Jul 23.

Fundação Oswaldo Cruz, Instituto Gonçalo Moniz, Salvador, BA, Brasil.

Introduction: Tuberculosis (TB) is the leading cause of death worldwide caused by a single infectious disease agent. Brazil, Russia, India, China, and South Africa (BRICS) account for more than half of the world's TB cases. Bacillus Calmette-Guérin (BCG) remains the only vaccine available despite its variable efficacy. Read More

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Temporal Trend of Mortality Due to Ischemic Heart Diseases in Northeastern Brazil (1996-2016): An Analysis According to Gender and Age Group.

Arq Bras Cardiol 2021 Jul;117(1):51-60

Universidade Federal de Alagoas, Maceió, AL - Brasil.

Background: Ischemic heart disease (IHD) is the leading cause of death among cardiovascular diseases (CVD).

Objective: To describe the sociodemographic profile and analyze the trend in the mortality rate due to IHD, according to sex and by age group, in the states of the Northeast region of Brazil, from 1996 to 2016.

Methods: Ecological study involving IHD mortality in the northeastern states. Read More

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Alternatives to Traditional Pedicle Screws for Posterior Fixation of the Degenerative Lumbar Spine.

JBJS Rev 2021 Jul 28;9(7). Epub 2021 Jul 28.

San Francisco Orthopaedic Residency Program, St. Mary's Medical Center, San Francisco, California.

Background: Traditional pedicle screws are currently the gold standard to achieve stable 3-column fixation of the degenerative lumbar spine. However, there are cases in which pedicle screw fixation may not be ideal. Due to their starting point lateral to the pars interarticularis, pedicle screws require a relatively wide dissection along with a medialized trajectory directed toward the centrally located neural elements and prevertebral vasculature. Read More

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A Rare Collecting Duct Carcinoma With Widespread Metastasis Visualized by 18F-FDG PET/CT.

Clin Nucl Med 2021 Jul 23. Epub 2021 Jul 23.

From the Departments of Pulmonary and Critical Care Medicine Nuclear Medicine, Henan Provincial People's Hospital, Zhengzhou University People's Hospital, Zhengzhou, Henan, China.

Abstract: Collecting duct carcinoma is a rare and highly aggressive renal tumor with a poor prognosis. The presence of metastasis is common at collecting duct carcinoma diagnosis, but widespread metastases involving multiple soft tissues are extremely unusual. Here, we describe a 65-year-old man presenting with fever and lower leg pain as the first and main manifestations. Read More

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Current Techniques Used for Practical Blood Flow Restriction Training: A Systematic Review.

J Strength Cond Res 2021 Jul 26. Epub 2021 Jul 26.

Department of Sport Science, Institute III, Otto von Guericke University Magdeburg, Magdeburg, Germany; and Department of Orthopedics, University Medicine Rostock, Rostock, Germany.

Abstract: Bielitzki, R, Behrendt, T, Behrens, M, and Schega, L. Current techniques used for practical blood flow restriction training: a systematic review. J Strength Cond Res XX(X): 000-000, 2021-The purpose of this article was to systematically review the available scientific evidence on current methods used for practical blood flow restriction (pBFR) training together with application characteristics as well as advantages and disadvantages of each technique. Read More

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Dexmedetomidine Ameliorates Perioperative Neurocognitive Disorders by Suppressing Monocyte-Derived Macrophages in Mice With Preexisting Traumatic Brain Injury.

Anesth Analg 2021 Jul 28. Epub 2021 Jul 28.

From the Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Background: Traumatic brain injury (TBI) initiates immune responses involving infiltration of monocyte-derived macrophages (MDMs) in the injured brain tissue. These MDMs play a key role in perioperative neurocognitive disorders (PNDs). We tested the hypothesis that preanesthetic treatment with dexmedetomidine (DEX) could suppress infiltration of MDMs into the hippocampus of TBI model mice, ameliorating PND. Read More

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Emerging therapeutics in Huntington's Disease.

Expert Opin Emerg Drugs 2021 Jul 28. Epub 2021 Jul 28.

NYU Langone's Fresco Institute for Parkinson's & Movement Disorders.

Introduction: Huntington's Disease is a neurodegenerative disease that is characterized by motor dysfunction, behavioral/psychiatric symptoms, and cognitive impairment. Because of the lack of availability of curative or disease modifying treatments, much of clinical practice in HD care to date has focused on symptomatic treatment. Recent work has created optimism surrounding possible emerging disease modifying therapeutics. Read More

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Simultaneous determination of drug resistance and single nucleotide polymorphism genotype using nested multiplex PCR with amplicon sequencing.

J Clin Microbiol 2021 Jul 28:JCM0081421. Epub 2021 Jul 28.

Department of Mycobacteriology, Leprosy Research Center, National Institute of Infectious Diseases, 4-2-1 Aoba-cho, Higashimurayama, Tokyo 189-0002, Japan.

is the predominant cause of leprosy worldwide, and its genotypes can be classified into four single nucleotide polymorphism (SNP) types and 16 subtypes. Determining drug resistance and genotype is typically done by PCR and Sanger DNA sequencing, which require substantial effort. Here we describe a rapid method involving multiplex PCR in combination with nested amplification and next generation sequence analysis that allows simultaneous determination of drug resistance and SNP genotype directly from clinical specimens. Read More

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Pathological fracture in paediatric bone tumours and tumour-like lesions: A predictor of benign lesions?

Br J Radiol 2021 Jul 28:20201341. Epub 2021 Jul 28.

Department of Radiology, Royal National Orthopaedic Hospital, Stanmore, UK.

Objective: To determine the incidence and causes of pathological fractures in paediatric bone tumours and tumour-like lesions, and to determine if they are predictive of benign lesions.

Methods And Materials: Retrospective review of children with suspected bone tumours referred to a specialist musculoskeletal oncology service between September 2019 and August 2020. Data recorded included patient age and gender, lesion location, the presence of a pathological fracture on the initial plain radiograph, and the final diagnosis made either by image-guided biopsy/curettage or based on typical imaging features. Read More

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Examination of How Well Long-Range-Corrected Density Functionals Satisfy the Ionization Energy Theorem.

J Chem Theory Comput 2021 Jul 28. Epub 2021 Jul 28.

Department of Chemistry, Chemical Theory Center, and Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota 55455-0431, United States.

We calculated the vertical ionization energies (VIE) of 99 species in two ways to examine the accuracy of several long-range-corrected (LC) hybrid meta functionals in comparison with a gradient approximation (GA), global hybrids, and doubly hybrids. In the category of LC functionals, we examined both those with meta ingredients (i.e. Read More

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Vertical maxillary excess associated with altered passive eruption: a case report with an interdisciplinary approach.

Int J Esthet Dent 2021 Aug;16(3):350-363

A smile is a symbol of beauty and wellbeing in our modern society, human facial expression transcending language, culture, race, gender, time, and socioeconomic differences. An esthetic smile consists of three main components: the teeth, the lip framework, and the gingival scaffold. In some patients, the altered relationship between the teeth, the alveolar bone, and the soft tissue may result in the clinical condition known as gummy smile. Read More

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Neuromuscular Blockade and Reversal Agent Practice Variability in the US Inpatient Surgical Settings.

Adv Ther 2021 Jul 28. Epub 2021 Jul 28.

Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA, 02115, USA.

Introduction: The management of neuromuscular blockade (NMB) has evolved over time and remains a critical component of general anesthesia. However, NMB use varies by patient and procedural characteristics, clinical practices, protocols, and drug access. National utilization patterns are unknown. Read More

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The role of collaborative, multistakeholder partnerships in reshaping the health management of patients with noncommunicable diseases during and after the COVID-19 pandemic.

Aging Clin Exp Res 2021 Jul 28. Epub 2021 Jul 28.

Viatris, London, UK.

Background: Policies to combat the COVID-19 pandemic have disrupted the screening, diagnosis, treatment, and monitoring of noncommunicable (NCD) patients while affecting NCD prevention and risk factor control.

Aims: To discuss how the first wave of the COVID-19 pandemic affected the health management of NCD patients, identify which aspects should be carried forward into future NCD management, and propose collaborative efforts among public-private institutions to effectively shape NCD care models.

Methods: The NCD Partnership, a collaboration between Upjohn and the European Innovation Partnership on Active and Healthy Ageing, held a virtual Advisory Board in July 2020 with multiple stakeholders; healthcare professionals (HCPs), policymakers, researchers, patient and informal carer advocacy groups, patient empowerment organizations, and industry experts. Read More

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Examining the barriers of influenza vaccine hesitancy in persons with dementia: a literature review.

Aging Clin Exp Res 2021 Jul 28. Epub 2021 Jul 28.

Faculty of Health Sciences, Ontario Tech University, 2000 Simcoe Street North, Oshawa, ON, L1G 0C5, Canada.

Background/aims: Despite the proven benefits of vaccine prevention and the continuous development of this important public health measure, vaccine hesitancy is among the top ten threats to global health according to the World Health Organization in 2019. Those who contract the influenza virus will typically develop a mild illness. However, for populations at a higher risk, including those diagnosed with dementia, influenza is proven to be more detrimental. Read More

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The Function and Regulation of Platelet P2Y12 Receptor.

Cardiovasc Drugs Ther 2021 Jul 28. Epub 2021 Jul 28.

Department of Pharmacology, School of Pharmacy, Jilin University, Fujin Road, Changchun, 130021, Jilin, China.

In addition to the key role in hemostasis and thrombosis, platelets have also been wildly acknowledged as immune regulatory cells and involving in the pathogenesis of inflammation-related diseases. Since purine receptor P2Y12 plays a crucial role in platelet activation, P2Y12 antagonists such as clopidogrel, prasugrel, and ticagrelor have been widely used in cardiovascular diseases worldwide in recent decades due to their potent antiplatelet and antithrombotic effects. Meanwhile, the role of P2Y12 in inflammatory diseases has also been extensively studied. Read More

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