31 results match your criteria involved kbs

Comparative analysis of ketone body metabolism in BALB/c mice infected with Trypanosoma evansi and Toxoplasma gondii.

Res Vet Sci 2021 Dec 20;143:134-141. Epub 2021 Dec 20.

Key Laboratory of Livestock Infectious Diseases, Ministry of Education, China; College of Animal Science and Veterinary Medicine, Shenyang Agricultural University, Shenyang 110866, China. Electronic address:

KBs (ketone bodies), i.e., acetoacetate, acetone, and (R)-3-Hydroxybutanoate, constitute the intermediate products of the incomplete oxidative degradation of fatty acids. Read More

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December 2021

Identification and Characterization of s Mutations Associated With Early Blooming in Sweet Cherry, and Validation of DNA-Based Markers for Selection.

Front Plant Sci 2021 8;12:621491. Epub 2021 Jul 8.

Unidad de Hortofruticultura, Centro de Investigación y Tecnología Agroalimentaria de Aragón, Zaragoza, Spain.

Dormancy release and bloom time of sweet cherry cultivars depend on the environment and the genotype. The knowledge of these traits is essential for cultivar adaptation to different growing areas, and to ensure fruit set in the current climate change scenario. In this work, the major sweet cherry bloom time QTL (327 Kbs; Chromosome 1) was scanned for candidate genes in the Regina cv genome. Read More

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Seizure-induced impairment in neuronal ketogenesis: Role of zinc-α2-glycoprotein in mitochondria.

J Cell Mol Med 2020 06 27;24(12):6833-6845. Epub 2020 Apr 27.

Department of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Ketone bodies (KBs) were known to suppress seizure. Untraditionally, neurons were recently reported to utilize fatty acids and produce KBs, but the effect of seizure on neuronal ketogenesis has not been researched. Zinc-α2-glycoprotein (ZAG) was reported to suppress seizure via unclear mechanism. Read More

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Ketone Bodies Promote Amyloid-β Clearance in a Human in Vitro Blood-Brain Barrier Model.

Int J Mol Sci 2020 Jan 31;21(3). Epub 2020 Jan 31.

Laboratoire de la Barrière Hémato-Encéphalique (LBHE), UR 2465, Université d'Artois, F-62300 Lens, France.

Alzheimer's disease (AD) is characterized by the abnormal accumulation of amyloid-β (Aβ) peptides in the brain. The pathological process has not yet been clarified, although dysfunctional transport of Aβ across the blood-brain barrier (BBB) appears to be integral to disease development. At present, no effective therapeutic treatment against AD exists, and the adoption of a ketogenic diet (KD) or ketone body (KB) supplements have been investigated as potential new therapeutic approaches. Read More

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January 2020

A better strategy using barbed sutures for wound closure in total knee arthroplasty.

J Comp Eff Res 2019 07 30;8(10):799-814. Epub 2019 Jul 30.

Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 30052, PR China.

The purpose of this study was to conduct a meta-analysis to systematically compare the clinical outcomes between knee barbed sutures (KBS) and knee traditional sutures (KTS) for wound closure in total knee arthroplasty (TKA). This study retrieved potential academic articles comparing the clinical outcomes between KBS and KTS in TKA from the MEDLINE database, the PubMed database, the EMBASE database and the Cochrane Library. The reference articles for the identified studies were carefully reviewed to ensure that all available documents were represented in the study. Read More

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Applying the Theoretical Domains Framework to understand knowledge broker decisions in selecting evidence for knowledge translation in low- and middle-income countries.

Health Res Policy Syst 2019 Jun 11;17(1):60. Epub 2019 Jun 11.

Department of Public Health and Primary Care, Ghent University, Campus UZ, K3, 6de verdieping, Corneel Heymanslaan 10, 9000, Ghent, Belgium.

Background: Health-related organisations disseminate an abundance of clinical and implementation evidence that has potential to improve health outcomes in low- and middle-income countries (LMICs), but little is known about what influences a user decision to select particular evidence for action. Knowledge brokers (KBs) play a part as intermediaries supporting evidence-informed health policy and practice by selecting and synthesising evidence for research users, and therefore understanding the basis for KB decisions, can help inform knowledge translation strategies. The Theoretical Domains Framework (TDF), a synthesis of psychological theories, was selected as a promising analysis approach because of its widespread use in identifying influences on decisions to act on evidence-based healthcare guidelines. Read More

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Harvesting the promise of AOPs: An assessment and recommendations.

Sci Total Environ 2018 Jul 22;628-629:1542-1556. Epub 2018 Feb 22.

US Environmental Protection Agency, 6201 Congdon Blvd, Duluth, MN 55804, USA. Electronic address:

The Adverse Outcome Pathway (AOP) concept is a knowledge assembly and communication tool to facilitate the transparent translation of mechanistic information into outcomes meaningful to the regulatory assessment of chemicals. The AOP framework and associated knowledgebases (KBs) have received significant attention and use in the regulatory toxicology community. However, it is increasingly apparent that the potential stakeholder community for the AOP concept and AOP KBs is broader than scientists and regulators directly involved in chemical safety assessment. Read More

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How Can a Ketogenic Diet Improve Motor Function?

Front Mol Neurosci 2018 26;11:15. Epub 2018 Jan 26.

INSERM 1083, CNRS, Equipe Mitolab, Institut MITOVASC, UMR 6015, Université d'Angers, Angers, France.

A ketogenic diet (KD) is a normocaloric diet composed by high fat (80-90%), low carbohydrate, and low protein consumption that induces fasting-like effects. KD increases ketone body (KBs) production and its concentration in the blood, providing the brain an alternative energy supply that enhances oxidative mitochondrial metabolism. In addition to its profound impact on neuro-metabolism and bioenergetics, the neuroprotective effect of specific polyunsaturated fatty acids and KBs involves pleiotropic mechanisms, such as the modulation of neuronal membrane excitability, inflammation, or reactive oxygen species production. Read More

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January 2018

Sanger Brown and Edward Schäfer before Heinrich Klüver and Paul Bucy: their observations on bilateral temporal lobe ablations.

Neurosurg Focus 2017 Sep;43(3):E2

Department of Neurosurgery, NYU Langone Medical Center, New York, New York.

Fifty years before a report on the complete bitemporal lobectomy syndrome in primates, known as the Klüver-Bucy syndrome, was published, 2 talented investigators working at the University College in London, England-neurologist Sanger Brown and physiologist Edward Schäfer-also made this discovery. The title of their work was "An investigation into the functions of the occipital and temporal lobes of the monkey's brain," and it involved excisional brain surgery in 12 monkeys. They were particularly interested in the then-disputed primary cortical locations relating to vision and hearing. Read More

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September 2017

Metabolism and acetylation contribute to leucine-mediated inhibition of cardiac glucose uptake.

Am J Physiol Heart Circ Physiol 2017 Aug 23;313(2):H432-H445. Epub 2017 Jun 23.

Université catholique de Louvain, Institut de Recherche Expérimentale et Clinique, Pole of Cardiovascular Research, Brussels, Belgium;

High plasma leucine levels strongly correlate with type 2 diabetes. Studies of muscle cells have suggested that leucine alters the insulin response for glucose transport by activating an insulin-negative feedback loop driven by the mammalian target of rapamycin/p70 ribosomal S6 kinase (mTOR/p70S6K) pathway. Here, we examined the molecular mechanism involved in leucine's action on cardiac glucose uptake. Read More

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Genome-wide Regulatory Roles of the C2H2-type Zinc Finger Protein ZNF764 on the Glucocorticoid Receptor.

Sci Rep 2017 01 31;7:41598. Epub 2017 Jan 31.

Division of Translational Medicine, Sidra Medical and Research Center, Doha 26999, Qatar.

The C2H2-type zinc finger protein ZNF764 acts as an enhancer for several steroid hormone receptors, and haploinsufficiency of this gene may be responsible for tissue resistance to multiple steroid hormones including glucocorticoids observed in a patient with 16p11.2 microdeletion. We examined genome-wide regulatory actions of ZNF764 on the glucocorticoid receptor (GR) in HeLa cells as a model system. Read More

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January 2017

Virtual Knowledge Brokering: Describing the Roles and Strategies Used by Knowledge Brokers in a Pediatric Physiotherapy Virtual Community of Practice.

J Contin Educ Health Prof 2016 ;36(3):186-94

Ms. Hurtubise: Doctoral Student, Faculté de médecine et sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada. Dr. Rivard: Postdoctoral fellow, School of Rehabilitation Science, Faculty of Health Sciences, and CanChild Centre for Childhood Disability Research, McMaster University, Hamilton, ON, Canada. Ms. Héguy: Research Assistant, Faculté de médecine et sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada. Ms. Berbari: Research Coordinator, Centre de recherche du centre hospitalier universitaire de Sherbrooke, QC, Canada. Dr. Camden: Assistant Professor, École de réadaptation, Faculté de médecine et sciences de la santé, Université de Sherbrooke, Sherbrooke, QC, Canada, CanChild Centre for Childhood Disability Research, McMaster University, Hamilton, ON, Canada, and Centre de recherche du centre hospitalier universitaire de Sherbrooke, QC, Canada.

Introduction: Knowledge transfer in pediatric rehabilitation is challenging and requires active, multifaceted strategies. The use of knowledge brokers (KBs) is one such strategy noted to promote clinician behavior change. The success of using KBs to transfer knowledge relies on their ability to adapt to ever-changing clinical contexts. Read More

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February 2018

The Human Capital of Knowledge Brokers: An analysis of attributes, capacities and skills of academic teaching and research faculty at Kenyan schools of public health.

Health Res Policy Syst 2016 Aug 2;14(1):58. Epub 2016 Aug 2.

Department of International Health, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD, 21205, United States of America.

Background: Academic faculty involved in public health teaching and research serve as the link and catalyst for knowledge synthesis and exchange, enabling the flow of information resources, and nurturing relations between 'two distinct communities' - researchers and policymakers - who would not otherwise have the opportunity to interact. Their role and their characteristics are of particular interest, therefore, in the health research, policy and practice arena, particularly in low- and middle-income countries. We investigated the individual attributes, capacities and skills of academic faculty identified as knowledge brokers (KBs) in schools of public health (SPH) in Kenya with a view to informing organisational policies around the recruitment, retention and development of faculty KBs. Read More

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Mesiotemporal Disconnection and Hypoactivity in Klüver-Bucy Syndrome: Case Series and Literature Review.

J Clin Psychiatry 2016 08;77(8):e982-8

Neurological Institute, Department of Psychiatry and Psychology, Cleveland Clinic Foundation, Ohio, USA.

Objective: Klüver-Bucy syndrome (KBS) is often perceived as rare and limited to cases with bilateral amygdala destruction. In fact, various alternate mechanisms may be involved, warranting exploration of the syndrome's presentation, pathophysiology, prognosis, and management.

Data Sources: Clinical management and the electronic medical records were examined for 2 patients diagnosed with partial KBS (ICD-10 F07. Read More

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Diabetic and dyslipidaemic morbidly obese exhibit more liver alterations compared with healthy morbidly obese.

BBA Clin 2016 Jun 8;5:54-65. Epub 2016 Jan 8.

Biochemistry and Molecular Biology Department, Biology Faculty, Barcelona University, Spain.

Background & Aims: To study the origin of fat excess in the livers of morbidly obese (MO) individuals, we analysed lipids and lipases in both plasma and liver and genes involved in lipid transport, or related with, in that organ.

Methods: Thirty-two MO patients were grouped according to the absence (healthy: DM - DL -) or presence of comorbidities (dyslipidemic: DM - DL +; or dyslipidemic with type 2 diabetes: DM + DL +) before and one year after gastric bypass.

Results: The livers of healthy, DL and DM patients contained more lipids (9. Read More

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Krüppel Homolog 1 Inhibits Insect Metamorphosis via Direct Transcriptional Repression of Broad-Complex, a Pupal Specifier Gene.

J Biol Chem 2016 Jan 30;291(4):1751-1762. Epub 2015 Oct 30.

From the Insect Growth Regulation Research Unit, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki 305-8634, Japan.

The Broad-Complex gene (BR-C) encodes transcription factors that dictate larval-pupal metamorphosis in insects. The expression of BR-C is induced by molting hormone (20-hydroxyecdysone (20E)), and this induction is repressed by juvenile hormone (JH), which exists during the premature larval stage. Krüppel homolog 1 gene (Kr-h1) has been known as a JH-early inducible gene responsible for repression of metamorphosis; however, the functional relationship between Kr-h1 and repression of BR-C has remained unclear. Read More

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January 2016

Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.

Diabetes 2013 Oct 4;62(10):3618-26. Epub 2013 Apr 4.

Department of Medicine, University of Eastern Finland, Kuopio, Finland.

We investigated the association of the levels of ketone bodies (KBs) with hyperglycemia and with 62 genetic risk variants regulating glucose levels or type 2 diabetes in the population-based Metabolic Syndrome in Men (METSIM) study, including 9,398 Finnish men without diabetes or newly diagnosed type 2 diabetes. Increasing fasting and 2-h plasma glucose levels were associated with elevated levels of acetoacetate (AcAc) and β-hydroxybutyrate (BHB). AcAc and BHB predicted an increase in the glucose area under the curve in an oral glucose tolerance test, and AcAc predicted the conversion to type 2 diabetes in a 5-year follow-up of the METSIM cohort. Read More

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October 2013

DNA methylation profile dynamics of tissue-dependent and differentially methylated regions during mouse brain development.

BMC Genomics 2013 Feb 6;14:82. Epub 2013 Feb 6.

Laboratory of Cellular Biochemistry, Department of Animal Resource Sciences/Veterinary Medical Sciences, The University of Tokyo, Yayoi 1-1-1, Bunkyo-ku, Tokyo 113-8657, Japan.

Background: Tissues and their component cells have unique DNA methylation profiles comprising DNA methylation patterns of tissue-dependent and differentially methylated regions (T-DMRs). Previous studies reported that DNA methylation plays crucial roles in cell differentiation and development. Here, we investigated the genome-wide DNA methylation profiles of mouse neural progenitors derived from different developmental stages using HpyCH4IV, a methylation-sensitive restriction enzyme that recognizes ACGT residues, which are uniformly distributed across the genome. Read More

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February 2013

School-based strategies for oral health education of adolescents--a cluster randomized controlled trial.

BMC Oral Health 2012 Dec 18;12:54. Epub 2012 Dec 18.

Department of Oral Health Sciences, Federal Postgraduate Medical Institute, Shaikh Zayed Medical Complex, Lahore, Pakistan.

Background: Oral health education (OHE) in schools has largely been imparted by dental professionals. Considering the substantial cost of this expert-led approach, the strategies relying on teachers, peer-leaders and learners themselves have also been utilized. However the evidence for comparative effectiveness of these strategies is lacking in the dental literature. Read More

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December 2012

A knowledge management methodology for the integrated assessment of WWTP configurations during conceptual design.

Water Sci Technol 2012 ;66(1):165-72

Catalan Institute for Water Research, Scientific and technological Park, Girona, Spain.

The current complexity involved in wastewater management projects is arising as the XXI century sets new challenges leading towards a more integrated plant design. In this context, the growing number of innovative technologies, stricter legislation and the development of new methodological approaches make it difficult to design appropriate flow schemes for new wastewater projects. Thus, new tools are needed for the wastewater treatment plant (WWTP) conceptual design using integrated assessment methods in order to include different types of objectives at the same time i. Read More

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September 2012

P120-catenin isoforms 1 and 3 regulate proliferation and cell cycle of lung cancer cells via β-catenin and Kaiso respectively.

PLoS One 2012 20;7(1):e30303. Epub 2012 Jan 20.

Department of Pathology, First Affiliated Hospital and College of Basic Medical Sciences, China Medical University, Shenyang, China.

Background: The different mechanisms involved in p120-catenin (p120ctn) isoforms' 1/3 regulation of cell cycle progression are still not elucidated to date.

Methods And Findings: We found that both cyclin D1 and cyclin E could be effectively restored by restitution of p120ctn-1A or p120ctn-3A in p120ctn depleted lung cancer cells. When the expression of cyclin D1 was blocked by co-transfection with siRNA-cyclin D1 in p120ctn depleted cells restoring p120ctn-1A or 3A, the expression of cyclin E was slightly decreased, not increased, implying that p120ctn isoforms 1 and 3 cannot up-regulate cyclin E directly but may do so through up-regulation of cyclin D1. Read More

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Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions.

Mutat Res 2009 Jul 17;667(1-2):4-14. Epub 2008 Jul 17.

Department of Laboratory Medicine, Section of Occupational and Environmental Medicine, Lund University, Lund, Sweden.

Objectives: The susceptibility to arsenic (As)-induced diseases differs greatly between individuals, probably to a large extent due to genetic differences in arsenic metabolism. The aim for this study was to identify genetic variants affecting arsenic metabolism.

Methods: We evaluated the association between urinary metabolite pattern and polymorphisms in three gene-groups related to arsenic metabolism: (1) methyltransferases, (2) other genes involved in one-carbon metabolism and (3) genes involved in reduction reactions. Read More

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Sexually selected signals are not similar to sports handicaps.

Thomas Getty

Trends Ecol Evol 2006 Feb 14;21(2):83-8. Epub 2005 Nov 14.

Department of Zoology & Kellogg Biological Station, Michigan State University, Hickory Corners, MI 49060-9516, USA.

The handicap principle is a simple but powerful metaphor that has had a major impact on how biologists study and understand sexual selection. Here, I show that its application to signalling in sexual selection is not a valid generalization from its roots in economics. Although some signalling systems, with additive costs and benefits, have solutions that resemble sports handicaps, the signalling in sexual selection has multiplicative costs and benefits, and solutions that do not resemble sports handicaps. Read More

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February 2006

Using NetMeeting for remote configuration of the Otto Bock C-Leg: technical considerations.

Prosthet Orthot Int 2002 Aug;26(2):154-8

The Rehabilitation Centre, Ottawa, Ontario, Canada.

Telehealth has the potential to be a valuable tool for technical and clinical support of computer controlled prosthetic devices. This pilot study examined the use of Internet-based, desktop video conferencing for remote configuration of the Otto Bock C-Leg. Laboratory tests involved connecting two computers running Microsoft NetMeeting over a local area network (IP protocol). Read More

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Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.

J Am Coll Cardiol 2001 Nov;38(5):1554-63

Cardiopulmonary Division, Department of Internal Medicine, Tokyo, Japan.

Objectives: We sought to determine whether potassium (K(+)) channel blockers (KBs) can activate extracellular signal-regulated kinase (ERK) and to characterize the upstream signals leading to ERK activation in cardiomyocytes.

Background: Because KBs attenuate K(+) outward current, they may possibly prolong the duration of action potentials, leading to an increase in calcium (Ca(2+)) transient ([Ca(2+)](i)) in cardiomyocytes. Elevation of intracellular Ca(2+) levels can trigger various signaling events. Read More

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November 2001

A study of PROforma, a development methodology for clinical procedures.

Artif Intell Med 1999 Oct;17(2):195-221

Department of Computer Science and Mathematics, Vrije Universiteit Amsterdam, Boelelaan 1081a, 1081HV, Amsterdam, The Netherlands.

Knowledge engineering has shown that besides the general methodologies from software engineering it is useful to develop special purpose methodologies for knowledge based systems (KBS). PROforma is a newly developed methodology for a specific type of knowledge based systems. PROforma is intended for decision support systems and in particular for clinical procedures in the medical domain. Read More

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October 1999

Performance trade-off across a natural resource gradient.

Oecologia 1999 Jul;120(1):137-146

W.K. Kellogg Biological Station and Department of Zoology, Michigan State University, 3700 E Gull Lake Dr., Hickory Corners, MI 49060, USA e-mail: Fax: +1-616-671-2104, , , , , , US.

An important environmental factor determining both phytoplankton and zooplankton community composition is lake depth and thermal stratification. However, there is little information on how the interaction between zooplankton grazers and their phytoplankton food changes along an environmental gradient of lake depth. We contrasted resource availability for daphniid zooplankton populations living in two shallow, unstratified lakes and in two deep, stratified lakes using a novel growth bioassay. Read More

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Effects of larval mosquitoes (Aedes triseriatus) and stemflow on microbial community dynamics in container habitats.

Appl Environ Microbiol 1999 Jun;65(6):2661-73

W. K. Kellogg Biological Station, Michigan State University, Hickory Corners, Michigan 49060, USA.

The dynamics of the microbial food sources for Aedes triseriatus larvae in microcosms were found to be strongly influenced by larval presence. The total abundance of bacteria in water samples generally increased in response to larvae, including populations of cultivable, facultatively anaerobic bacteria. Additionally, a portion of the community shifted from Pseudomonaceae to Enterobacteriaceae. Read More

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[Atrioventricular reciprocating tachycardia with QRS type left branch block in patients undergoing radiofrequency catheter ablation: analysis of the substrate and mechanism of tachycardia].

G Ital Cardiol 1994 Jun;24(6):707-21

Divisione di Cardiologia, IRCCS Policlinico S. Matteo, Università degli Studi, Pavia.

Background: Among patients (pts) with atrioventricular accessory pathway (AP), some cases show wide complex arrhythmias with different QRS morphology. In a subset of these pts, an atrioventricular reentrant tachycardia with left bundle branch block morphology (LBBBM-AVRT) is observed. The aim of this study is: 1) to identify the substrate and the reentrant mechanism underlying the LBBBM-AVRT in pts undergoing radiofrequency catheter ablation (RFCA) of AP; 2) to report the results achieved by RFCA of the identified substrate. Read More

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Changes in lipogenic capacity and activities of ketolytic and lipogenic enzymes in brain regions of developing rats.

J Neurochem 1983 Jan;40(1):99-105

Oxidation of ketone bodies (KBs) generates acetyl coenzyme A (AcCoA), which can be further incorporated into fatty acid. We have determined the rates of lipogenesis from ketone bodies in developing rats and their relation to the activities of enzymes involved in the production of cytoplasmic AcCoA via different pathways in brain regions. In the cerebrum (Cbr), rates of fatty acid synthesis from [3-14C]acetoacetate ([3-14C]AcAc) were high during the early postnatal period but decreased rapidly thereafter until weaning. Read More

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January 1983