1,558 results match your criteria investigation successive

Systematic, Modifying Group-Assisted Strategy Expanding Coverage of Metabolite Annotation in Liquid Chromatography-Mass Spectrometry-Based Nontargeted Metabolomics Studies.

Anal Chem 2021 Jul 30. Epub 2021 Jul 30.

CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

From microbes to human beings, nontargeted metabolic profiling by liquid chromatography (LC)-mass spectrometry (MS) has been commonly used to investigate metabolic alterations. Still, a major challenge is the annotation of metabolites from thousands of detected features. The aim of our research was to go beyond coverage of metabolite annotation in common nontargeted metabolomics studies by an integrated multistep strategy applying data-dependent acquisition (DDA)-based ultrahigh-performance liquid chromatography (UHPLC)-high-resolution mass spectrometry (HRMS) analysis followed by comprehensive neutral loss matches for characteristic metabolite modifications and database searches in a successive manner. Read More

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Feasibility and effectiveness of endoscopic irreversible electroporation for the upper gastrointestinal tract: an experimental animal study.

Sci Rep 2021 Jul 28;11(1):15353. Epub 2021 Jul 28.

Department of Veterinary Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St. Paul, MN, USA.

Irreversible electroporation (IRE) is a local non-thermal ablative technique currently used to treat solid tumors. Here, we investigated the clinical potency and safety of IRE with an endoscope in the upper gastrointestinal tract. Pigs were electroporated with recently designed endoscopic IRE catheters in the esophagus, stomach, and duodenum. Read More

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Joint language production: An electrophysiological investigation of simulated lexical access on behalf of a task partner.

J Exp Psychol Learn Mem Cogn 2021 Jul 22. Epub 2021 Jul 22.

Department of Psychology.

This study investigates in a joint action setting a well-established effect in speech production, cumulative semantic interference, an increase in naming latencies when naming a series of semantically related pictures. In a joint action setting, two task partners take turns naming pictures. Previous work in this setting has demonstrated that naming latencies increase not only with each semantically related picture speakers named themselves, but also with each picture named by the partner (Hoedemaker et al. Read More

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Asymptomatic Carriage of Type D/C in Broiler Flocks as the Source of Contamination of a Massive Botulism Outbreak on a Dairy Cattle Farm.

Front Microbiol 2021 29;12:679377. Epub 2021 Jun 29.

ANSES, French Agency for Food, Environmental and Occupational Health Safety, Hygiene and Quality of Poultry and Pig Products Unit, Ploufragan, France.

In winter 2018, a massive type D/C cattle botulism outbreak occurred on a mixed dairy and broiler farm in France. An investigation was conducted based on the hypothesis of asymptomatic carriage in poultry. We set out to identify the source of contamination of the dairy cattle and to monitor the contamination of broilers over time, including the hatchery delivering chicks to the farm. Read More

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Clinical profile of hospitalized COVID-19 patients in first & second wave of the pandemic: Insights from an Indian registry based observational study.

Indian J Med Res 2021 Jul 14. Epub 2021 Jul 14.

Indian Council of Medical Research, New Delhi,, India.

Background & Objectives: : India witnessed a massive second surge of COVID-19 cases since March 2021 after a period of decline from September 2020. Data collected under the National Clinical Registry for COVID-19 (NCRC) were analysed to describe the differences in demographic and clinical features of COVID-19 patients recruited during these two successive waves.

Methods: : The NCRC, launched in September 2020, is an ongoing multicentre observational initiative, which provided the platform for the current investigation. Read More

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Weight gain during twin pregnancy with favorable pregnancy outcomes in Japan: A retrospective investigation for new criteria based on perinatal registry data.

PLoS One 2021 2;16(7):e0253596. Epub 2021 Jul 2.

Perinatal Center for Maternity and Neonates, Yokohama City University Medical Center, Yokohama, Japan.

In 2009, the United States Institute of Medicine (IOM) reported the optimal gestational weight gain (GWG) during twin pregnancy based on the pre-pregnancy body mass index (BMI). However, there are ethnic variations in the relationship between GWG and pregnancy outcomes. We aimed to establish the criteria for optimal GWG during twin pregnancy in Japan. Read More

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Evaluation of Anticonvulsant Activity of 80% Methanolic Root Bark Extract and Solvent Fractions of (A. Rich.) Vatke (Rubiaceae) in Swiss Albino Mice.

Adv Pharmacol Pharm Sci 2021 7;2021:6689879. Epub 2021 Jun 7.

Department of Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.

Background: Epilepsy is one of the most common serious neurological disorders, responsible for substantial morbidity and mortality due to limited efficacy and negative properties of antiepileptic drugs. Medicinal plants are believed to be an important source of new chemical substances with potential therapeutic effects. (A. Read More

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The dome of Rotunda in Thessaloniki: Investigation of a multi-pictorial phase wall painting through analytical methods.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Dec 24;262:120101. Epub 2021 Jun 24.

School of Physics, Faculty of Sciences, Aristotle University of Thessaloniki, GR-54124 Thessaloniki, Greece.

The present study focuses on the investigation of the successive pictorial phases of the wall painting which survives on the missing eastern part of the magnificent mosaic composition in the interior of Rotunda, Thessaloniki, Greece. Rotunda, a circular domed monumental building, was constructed in the early 4th century AD and it is included in the UNESCO World Heritage List. Characterization analysis was performed by means of microscopic, spectroscopic and crystallographic techniques, in order to identify the technological features of the wall painting and the materials used, to document the initial Byzantine pictorial phase -known from the archaeological research- along with the overpaintings attributed to the 19th and 20th centuries. Read More

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December 2021

Investigation of endolymphatic hydrops positivity rates in patients with recurrent audiovestibular symptoms using inner ear magnetic resonance imaging.

Auris Nasus Larynx 2021 Jun 17. Epub 2021 Jun 17.

Department of Otolaryngology, Takai Hospital, Nara, Japan.

Objectives: This study aimed to investigate the endolymphatic hydrops (EH)-positivity rates among patients with recurrent audiovestibular symptoms using intravenous injection of gadolinium-enhanced inner ear magnetic resonance imaging (ieMRI).

Methods: We reviewed 710 successive patients with recurrent audiovestibular symptoms at the Vertigo/Dizziness Center of Nara Medical University and other related hospitals, between May 2014 and April 2020. We performed ieMRI on 153 patients with unilateral recurrent cochleovestibular symptoms (rCV), 51 with recurrent vertigo symptoms (rVO), and 84 with unilateral recurrent cochlear symptoms (rCO). Read More

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Digital holographic microscopy for real-time investigation of 3D microstructural dynamics of starch-kefiran-based nanocomposite.

Appl Opt 2021 Jun;60(16):4706-4715

Investigating real-time phenomena in bio-polymers has received much attention because of their increasing demands in polymer substitution. The 3D morphometry of polymer surfaces may be very impactful in such studies. Here, digital holographic microscopy (DHM) is applied for quantitative measurement of the rare morphological changes of UV-A and UV-C exposed nanocomposites during their incubation with excess water. Read More

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J Zoo Wildl Med 2021 Jun;52(2):795-805

Binder Park Zoo, Battle Creek, MI 49014, USA,

High neonatal mortality among red pandas () challenges the long-term sustainability of the Species Survival Plan population. Congenital hypothyroidism (CH) is a rare condition in domestic animals, typically due to an inherited genetic defect. Nongoitrous CH was presumptively diagnosed in 75% ( = 6/8) of red panda neonates from four successive litters, with a common sire and two closely related dams. Read More

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Acupuncture at the auricular branch of the vagus nerve enhances heart rate variability in humans: An exploratory study.

Heart Rhythm O2 2020 Aug 9;1(3):215-221. Epub 2020 Jun 9.

Department of Cardiology, St. Josefs-Hospital Wiesbaden, Wiesbaden, Germany.

Background: Recent animal and human studies have shown antiarrhythmic effects inhibiting inducibility of atrial fibrillation through low-level transcutaneous electrical stimulation at the auricular branch of the vagus nerve (ABVN).

Objective: The present study investigated effects of acupuncture at the ABVN on the autonomic cardiac nervous system in humans through analysis of heart rate and heart rate variability (HRV) parameters.

Methods: We enrolled 24 healthy male volunteers and compared acupuncture at the ABVN to placebo-acupuncture performed at the Ma-35 point (an acupuncture point used in traditional Chinese medicine to treat pain caused by gonarthrosis). Read More

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Bispectral Index Alterations and Associations With Autonomic Changes During Hypnosis in Trauma Center Researchers: Formative Evaluation Study.

JMIR Form Res 2021 May 26;5(5):e24044. Epub 2021 May 26.

St Elizabeth Youngstown Hospital, Youngstown, OH, United States.

Background: Previous work performed by our group demonstrated that intermittent reductions in bispectral index (BIS) values were found during neurofeedback following mindfulness instructions. Hypnosis was induced to enhance reductions in BIS values.

Objective: This study aims to assess physiologic relaxation and explore its associations with BIS values using autonomic monitoring. Read More

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Predicting Semantic Similarity Between Clinical Sentence Pairs Using Transformer Models: Evaluation and Representational Analysis.

JMIR Med Inform 2021 May 26;9(5):e23099. Epub 2021 May 26.

Institute of Electronics, Communications & Information Technology, School of Electronics, Electrical Engineering and Computer Science, Queen's University Belfast, Belfast, United Kingdom.

Background: Semantic textual similarity (STS) is a natural language processing (NLP) task that involves assigning a similarity score to 2 snippets of text based on their meaning. This task is particularly difficult in the domain of clinical text, which often features specialized language and the frequent use of abbreviations.

Objective: We created an NLP system to predict similarity scores for sentence pairs as part of the Clinical Semantic Textual Similarity track in the 2019 n2c2/OHNLP Shared Task on Challenges in Natural Language Processing for Clinical Data. Read More

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Improving Asthma Symptoms Among Inner-City Women During Pregnancy: A Prospective Cohort Intervention.

J Allergy Clin Immunol Pract 2021 May 24. Epub 2021 May 24.

Division of Pulmonary, Critical Care, and Sleep Medicine, Drexel University College of Medicine, Philadelphia, Pa.

Background: It is unknown how active asthma management influences symptom control among inner-city pregnant women who have unique exposures and socioeconomic limitations affecting their care.

Objective: To assess the impact of an integrated subspecialty intervention composed of education and monitoring on asthma control among underserved women in an antenatal clinic setting.

Methods: We conducted a prospective cohort study of pregnant asthmatic patients participating in a subspecialty clinic integrated into routine prenatal care. Read More

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HPLC Quantification of Thymoquinone Extracted from L. () Seeds and Antibacterial Activity of Its Extracts against Species.

Evid Based Complement Alternat Med 2021 20;2021:6645680. Epub 2021 Apr 20.

Department of Biotechnology, Kinnaird College for Women, 93-Jail Road, Lahore, Pakistan.

The medicinal importance of seeds for treating various ailments is portrayed by its traditional uses. Owing to its immense pharmacological importance, the thymoquinone phytoconstituent of can prove beneficial for the South Asian countries including Pakistan, where this seed is commonly produced and healthcare facilities are limited. In this study, the antibacterial activity of various extracts of seeds, extracted thymoquinone, and oil samples have been investigated against and using well and disc diffusion assay. Read More

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On the relevance of modulation transfer function measurements in digital mammography quality control.

J Med Imaging (Bellingham) 2021 Mar 27;8(2):023505. Epub 2021 Apr 27.

KU Leuven, Department of Imaging and Pathology, Leuven, Belgium.

The relevance of presampling modulation transfer function (MTF) measurements in digital mammography (DM) quality control (QC) is examined. Two studies are presented: a case study on the impact of a reduction in MTF on the technical image quality score and analysis of the robustness of routine QC MTF measurements. In the first study, two needle computed radiography (CR) plates with identical sensitivities were used with differences in the 50% point of the MTF ( ) larger than the limiting value in the European guidelines ( change between successive measurements). Read More

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Has Muslim Got Benefited from the National Health Mission? A Situational Analysis of Maternal Health Services in India.

Ethiop J Health Sci 2020 Sep;30(5):785-794

International Institute for Population Sciences, Mumbai, India.

Background: It is a marked recognition that when the population is disaggregated by religion, wide disparities in the utilization of maternal health care services can be observed. The study was aimed to analyze the levels and trends of maternal health services among Muslims in India. The study also delineated the investigation of confounding factors attributed to maternal health services among the selected population. Read More

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September 2020

Systematic simplification of the Anaerobic Digestion Model No. 1 (ADM1) - Model development and stoichiometric analysis.

Bioresour Technol 2021 Aug 6;333:125124. Epub 2021 Apr 6.

Biochemical Conversion Department, Deutsches Biomasseforschungszentrum gemeinnützige GmbH, Torgauer Straße 116, 04347 Leipzig, Germany; Faculty of Agricultural and Environmental Sciences, Chair of Waste and Resource Management, University of Rostock, Justus-von-Liebig-Weg 6, 18059 Rostock, Germany.

Rigorous process models provide a reliable basis for model-based monitoring and control of anaerobic digestion plants. Due to the complex model structure and non-linear system characteristics, the established Anaerobic Digestion Model No. 1 (ADM1) is rarely applied in industrial plant operation. Read More

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Equilibrium between tri- and tetra-coordinate chalcogenuranes is critical for cysteine protease inhibition.

J Comput Chem 2021 Jun 19;42(17):1225-1235. Epub 2021 Apr 19.

ABCSim - Laboratório de simulação e modelagem, Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, Brazil.

There have been significant advances in the biological use of hypervalent selenium and tellurium compounds as cysteine protease inhibitors. However, the full understanding of their reaction mechanisms for and cysteine proteases inhibition is still elusive. Kinetic studies suggest an irreversible inhibition mechanism, which was explained by forming a covalent bond between the enzyme sulfhydryl group and the chalcogen atom at its hypervalent state (+4). Read More

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Low Heart Rate Variability Predicts Stroke and Other Complications in the First Six Postoperative Months After a Hip Fracture Operation.

Front Cardiovasc Med 2021 22;8:640970. Epub 2021 Mar 22.

Section of Cardiovascular and Renal Research, University of Oslo, Oslo, Norway.

One-year mortality after hip fractures is underestimated and is reported as 25%. An improved risk stratifying could contribute to a better follow up of these patients. Heart Rate Variability (HRV) is an easy point-of-care investigation and is been used in cardiology, endocrinology, and perioperative care. Read More

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Sex-Specific Autonomic Responses to Acute Resistance Exercise.

Medicina (Kaunas) 2021 Mar 24;57(4). Epub 2021 Mar 24.

Cardiovascular Dynamics Laboratory, Exercise Science/Physiology, Kent State University, Kent, OH 44242, USA.

Acute resistance exercise (RE) reduces vagal modulation and increases sympathovagal balance, which increases the risk for arrythmias. Few studies have examined sex differences in autonomic modulation after acute RE. The purpose of this investigation was to examine sex-specific responses to acute RE on autonomic modulation. Read More

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Marine-Derived Natural Products as ATP-Competitive mTOR Kinase Inhibitors for Cancer Therapeutics.

Pharmaceuticals (Basel) 2021 Mar 21;14(3). Epub 2021 Mar 21.

Division of Life Sciences, Department of Bio & Medical Big Data (BK21 Program), Research Institute of Natural Science (RINS), Gyeongsang National University (GNU), 501 Jinju-daero, Jinju 52828, Korea.

The mammalian target of rapamycin (mTOR) is a serine/threonine kinase portraying a quintessential role in cellular proliferation and survival. Aberrations in the mTOR signaling pathway have been reported in numerous cancers including thyroid, lung, gastric and ovarian cancer, thus making it a therapeutic target. To attain this objective, an in silico investigation was designed, employing a pharmacophore modeling approach. Read More

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Rainfall Influences Occurrence of Pharmaceutical and Personal Care Products in Landfill Leachates: Evidence from Seasonal Variations and Extreme Rainfall Episodes.

Environ Sci Technol 2021 04 1;55(8):4822-4830. Epub 2021 Apr 1.

Catalan Institute for Water Research (ICRA), C/Emili Grahit 101, Girona 17003, Spain.

Unused or expired pharmaceutical and personal care products (PPCPs) are usually discharged into municipal solid wastes, then travel to landfills, and eventually percolate into leachates. However, knowledge of their occurrence and temporal dynamics in leachates is limited, making landfill leachate an underappreciated emission source of PPCPs. Furthermore, the differences in PPCP variations in landfill leachates emphasize the necessity for identifying the influencing factors and elucidating the mechanisms for PPCP fluctuations. Read More

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A Detailed Investigation of the Onion Structure of Exchanged Coupled Magnetic [email protected]@FeO Nanoparticles.

ACS Appl Mater Interfaces 2021 Apr 29;13(14):16784-16800. Epub 2021 Mar 29.

Université de Strasbourg, CNRS, Institut de Physique et Chimie des Matériaux de Strasbourg, UMR 7504, Strasbourg F-67000, France.

Nanoparticles that combine several magnetic phases offer wide perspectives for cutting edge applications because of the high modularity of their magnetic properties. Besides the addition of the magnetic characteristics intrinsic to each phase, the interface that results from core-shell and, further, from onion structures leads to synergistic properties such as magnetic exchange coupling. Such a phenomenon is of high interest to overcome the superparamagnetic limit of iron oxide nanoparticles which hampers potential applications such as data storage or sensors. Read More

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Estrogen cholestasis induces gut and liver injury in rats involving in activating PI3K/Akt and MAPK signaling pathways.

Life Sci 2021 Jul 26;276:119367. Epub 2021 Mar 26.

Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. Electronic address:

Backgrounds: Estrogen and its metabolites often lead to intrahepatic cholestasis in susceptible women with pregnancy, administration of oral contraceptives and postmenopausal hormone replacement therapy. Recently, dysfunction of the gut-liver axis has been suggested to play a pivotal role in the progression of cholestasis, but details about estrogen cholestasis (EC)-induced gut and liver injury are still largely unknown. This study aims to gain insight into EC-induced gut and liver injury and cell signaling implicated. Read More

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A New Superconducting 3R-WS Phase at High Pressure.

J Phys Chem Lett 2021 Apr 26;12(13):3321-3327. Epub 2021 Mar 26.

State Key Laboratory of Superhard Materials, College of Physics, Jilin University, Changchun 130012, China.

High-pressure investigation has been shown to be of paramount significance for changing the conventional lattice or bringing fascinating properties, especially inducing superconducting phases. Here we studied the application of pressure to the recently synthesized 2M-WS with the record (8.8 K) among transition metal dichalcogenides (TMDs) at ambient pressure by electrical resistance investigations, synchrotron X-ray studies, and theoretical calculations. Read More

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Associations between self-reported spontaneous thought and temporal sequences of EEG microstates.

Brain Cogn 2021 06 8;150:105696. Epub 2021 Mar 8.

Department of Psychology, University of Miami, United States.

Thought dynamically evolves from one moment to the next even in the absence of external stimulation. The extent to which patterns of spontaneous thought covary with time-varying fluctuations in intrinsic brain activity is of great interest but remains unknown. We conducted novel analyses of data originally reported by Portnova et al. Read More

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Application of the mixing of the field of low amplitude AC bias with a strong field of linear slow varying to investigate the magnetic properties of materials.

Andrzej Nowrot

Heliyon 2021 Feb 19;7(2):e06258. Epub 2021 Feb 19.

Department of Electrical Engineering and Automation in Industry, Silesian University of Technology, PL-44100 Gliwice, Poland.

The paper presents a new experimental method of the magnetic hysteresis loop investigation and the constructed measurement instrument. The principle of operation is to mix two magnetic fields: the first of these fields has a very low amplitude, a shape of sine wave (AC bias) and the frequency range order of 10-10 Hz. The second field has a very low frequency (order 10 Hz), a high amplitude and forms approximately a triangle wave. Read More

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February 2021

The investigation of surface composition of nitrogen-doped niobium for superconducting RF cavities.

Nanotechnology 2021 Mar 3. Epub 2021 Mar 3.

Sichuan University, Chengdu, Sichuan, CHINA.

Systematic analysis of the surface morphology, crystalline phase, chemical composition and elemental distribution along depth for nitrogen-doped niobium was carried out through different ways of characterization, including SEM, AFM, GIXRD, RBS and layer-by-layer XPS analysis. The results showed that, after nitrogen doping, the surface was covered by densely distributed trigonal precipitates with average crystallite size of 32 ± 8 nm, in line with the calculation result (29.9 nm) of nitrogen-enriched β-Nb2N from GIXRD, demonstrating the phase composion of trigonal precipitates. Read More

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