16,374 results match your criteria investigation relationships


Competitive adsorption of methanol co-solvent and dioctyl phthalate on functionalized graphene sheet: Integrated investigation by molecular dynamics simulations and quantum chemical calculations.

J Colloid Interface Sci 2021 Jul 24;605:354-363. Epub 2021 Jul 24.

School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China.

Hypothesis: Organic co-solvents, which are universally employed in adsorption studies of hydrophobic organic chemicals (HOCs), can inhibit HOC adsorption by competing for active sites on the adsorbent. The adsorbent structure can influence co-solvent interference of HOC adsorption; however, this effect remains unclear, leading to an incomplete understanding of the adsorption mechanism.

Experiments: In this study, dioctyl phthalate (DOP) was used to investigate competitive adsorption on functionalized graphene sheet in a water-methanol co-solvent system through molecular dynamics simulations and quantum chemical calculations. Read More

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Environmental sustainability of a pork and bean stew.

Sci Total Environ 2021 Jul 26;798:149203. Epub 2021 Jul 26.

School of Industrial Engineering (ETSII), C/José Gutiérrez Abascal, 2, Grupo de Agroenergética, Universidad Politécnica de Madrid, Madrid 28006, Spain.

The aim of this investigation is to quantify the environmental footprint of an industrially produced bean and pork stew produced using a combination of local/imported and fresh/ processed ingredients. The study describes 16 midpoint categories and an aggregated score, calculated following the EC Product Environmental Footprint (PEF) methodology. The carbon footprint of 1 kg of stew amounts to 2. Read More

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Application and validation of the fugitive dust source emission inventory compilation method in Xiong'an New Area, China.

Sci Total Environ 2021 Jul 18;798:149114. Epub 2021 Jul 18.

State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, College of Environmental Science and Engineering, Nankai University, Tianjin 300350, China. Electronic address:

The development of a refined fugitive dust emission inventory is vital for prevention and control of air pollution. In this study, a fugitive dust emission inventory of soil dust (SD), road dust (RD), and construction dust (CD) in Xiong'an New Area (XANA) for 2020 was developed by collecting activity data and combining remote sensing and field investigation data based on a popular compilation technology in China. The CALPUFF model was used to elucidate the contribution characteristics of dust sources to ambient particulate matter (PM), and the accuracy of the dust emission inventory compilation method was verified. Read More

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Vibrational and conformational analysis of structural phase transition in Estradiol 17β valerate with temperature.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 24;263:120219. Epub 2021 Jul 24.

Instituto de Fìsica de São Carlos, Universidade de São Paulo,C.P 369, 13560-970,São Carlos, S P, Brazil.

Estradiol 17β valerate (E2V) is a hormonal medicine widely used in hormone replacement therapy. E2V undergoes a reversible isosymmetric structural phase transition at low temperature (̴ 250 K) which results from the reorientation of the valerate chain. The reversible isosymmetric structural phase transition follows Ehrenfest's classification when described as first-order and Buerger's classification when classified as order-disorder. Read More

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Rare-earth nanoparticles induce depression, anxiety-like behavior, and memory impairment in mice.

Food Chem Toxicol 2021 Jul 28:112442. Epub 2021 Jul 28.

Department of Clinical Medicine, Fujian Medical University, Fuzhou, Fujian, 350100, China.

Rare-earth nanoparticles have been widely studied for disease diagnosis, in vivo optical imaging, biosensing, and drug delivery. However, the effects of rare-earth nanoparticles on a central nervous system remain unclear. Here, we report that the continuous exposure to rare-earth nanoparticles in mice can cause behavioral alterations including cognitive deficits, anxiety, and depression-like behavior. Read More

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Proximity of schools to roads and students' academic performance: A cross-sectional study in the Federal District, Brazil.

Environ Res 2021 Jul 28:111770. Epub 2021 Jul 28.

Department of Public Health, University of Copenhagen, Copenhagen, Denmark.

Investigations of the educational implications of children's exposure to air pollutants at school are crucial to enhance our understanding of the hazards for children. Most of the existing literature is based on studies performed in North America and Europe. Further investigation is required in low- and middle-income countries, where there are important challenges related to public health, transportation, environment, and education sector. Read More

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Investigation on enhanced mathematical morphological operators for bearing fault feature extraction.

ISA Trans 2021 Jul 19. Epub 2021 Jul 19.

State Key Laboratory of Traction Power, Southwest Jiaotong University, Chengdu 610031, China. Electronic address:

Morphological filtering has been extensively applied to rotating machinery diagnostics, whereas traditional morphological operators cannot effectively extract fault-triggered transient impulse components from noisy mechanical vibration signal. In this paper, a framework of generalized compound morphological operator (GCMO) is presented to enhance the extraction ability of impulsive fault features. Further, several new compound morphological operators are developed for transient impulse extraction by introducing the product, convolution, and cross-correlation operations into the GCMO framework. Read More

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Cyclodextrin based bone regenerative inclusion complex for Resveratrol in Postmenopausal Osteoporosis.

Eur J Pharm Biopharm 2021 Jul 27. Epub 2021 Jul 27.

Pharmaceutics and Pharmacokinetics Division, CSIR-Central Drug Research Institute, Lucknow 226 031, India. Electronic address:

Recent preclinical studies have shown that resveratrol (RSV), is a promising remedy for osteoporosis owing to its estrogenic, anti-inflammatory, and antioxidant properties. However, RSV has met limited success due to its poor oral bioavailability and inefficient systemic delivery. In this study, we prepared the inclusion complex of RSV with sulfo-butyl ether β-cyclodextrin (SBE-β-CD) to enhance the aqueous solubility of RSV. Read More

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SARS-CoV-2 specific memory T cell epitopes identified in COVID-19-recovered subjects.

Virus Res 2021 Jul 27:198508. Epub 2021 Jul 27.

Center of Excellence for Inflammation, Infectious Disease and Immunity, Quillen College of Medicine, East Tennessee State University, Johnson City, Tennessee 37614; Division of Infectious Diseases, Department of Internal Medicine, Quillen College of Medicine, ETSU, Johnson City, Tennessee 37614; Hepatitis (HCV/HBV/HIV) Program, James H. Quillen VA Medical Center, Department of Veterans Affairs, Johnson City, Tennessee 37614. Electronic address:

The COVID-19 pandemic caused by SARS-CoV-2 infection poses a serious threat to public health. An explicit investigation of COVID-19 immune responses, particularly the host immunity in recovered subjects, will lay a foundation for the rational design of therapeutics and/or vaccines against future coronaviral outbreaks. Here, we examined virus-specific T cell responses and identified T cell epitopes using peptides spanning SARS-CoV-2 structural proteins. Read More

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Response of metabolic and lipid synthesis gene expression changes in Camellia oleifera to mulched ecological mat under drought conditions.

Sci Total Environ 2021 Jul 2;795:148856. Epub 2021 Jul 2.

Key Laboratory for Silviculture and Conservation, Ministry of Education, Beijing Forestry University, Beijing 100083, PR China. Electronic address:

Plants respond to adverse conditions by activating defense mechanisms that alter metabolism and impact agricultural crop yield. Organic mulching of Camellia oleifera leads to increased oil yield compared to control. In this study, multi-platform untargeted metabolomics and qRT-PCR were used to measure the effects of organic mulching on seed kernel metabolism. Read More

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Does work-family conflict play a role in the relationship between work-related hazards and musculoskeletal pain?

Am J Ind Med 2021 Jul 29. Epub 2021 Jul 29.

Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.

Background: Previous research identified an association between work-family conflict and musculoskeletal pain. This study explores how conflict arising from participating in both the work and nonwork domains might influence the relationships between musculoskeletal pain experienced by workers and particular work-related hazards.

Methods: A cross-sectional survey of data was collected from 401 workers in Belgium across seven organizations in the service and production sector. Read More

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Risk factor control across the spectrum of cardiovascular risk: Findings from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).

Am J Prev Cardiol 2021 Mar 13;5:100147. Epub 2021 Jan 13.

Department of Hospital Medicine, San Francisco VA Medical Center, San Francisco, CA, USA.

Background: Presence of cardiovascular disease (CVD) risk factors (RFs) should prompt patients and their providers to work aggressively towards controlling those that are modifiable. The extent to which a greater CVD RF burden is related to CVD RF control in a contemporary and diverse Hispanic/Latino population is not well-understood.

Methods: Using multicenter community-based data from the Hispanic Community Health Study/Study of Latinos, we assessed the self-reported prevalence of hypertension, hypercholesterolemia, diabetes, and prevalent CVD (ischemic heart disease or stroke). Read More

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Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications.

Front Cell Dev Biol 2021 13;9:661802. Epub 2021 Jul 13.

The First Medical Center, Chinese PLA General Hospital, Institute of Orthopedics, Beijing, China.

Knee menisci are structurally complex components that preserve appropriate biomechanics of the knee. Meniscal tissue is susceptible to injury and cannot heal spontaneously from most pathologies, especially considering the limited regenerative capacity of the inner avascular region. Conventional clinical treatments span from conservative therapy to meniscus implantation, all with limitations. Read More

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Uncovering Transcriptional Regulators and Targets of sRNAs Using an Integrative Data-Mining Approach: H-NS-Regulated RseX as a Case Study.

Front Cell Infect Microbiol 2021 13;11:696533. Epub 2021 Jul 13.

McKetta Department of Chemical Engineering, University of Texas at Austin, Austin, TX, United States.

Bacterial small RNAs (sRNAs) play a vital role in pathogenesis by enabling rapid, efficient networks of gene attenuation during infection. In recent decades, there has been a surge in the number of proposed and biochemically-confirmed sRNAs in both Gram-positive and Gram-negative pathogens. However, limited homology, network complexity, and condition specificity of sRNA has stunted complete characterization of the activity and regulation of these RNA regulators. Read More

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Fasting biochemical hypoglycemia and related-factors in non-diabetic population: Kanagawa Investigation of Total Check-up Data from National Database-8.

World J Diabetes 2021 Jul;12(7):1131-1140

School of Nutrition and Dietetics, Faculty of Health and Social Services, Kanagawa University of Human Services, Yokosuka 238-8522, Japan.

Background: In healthy people, the lowest daily blood glucose concentration is usually observed in the early morning, after overnight fasting. However, the clinical relevance and the prevalence of fasting biochemical hypoglycemia (FBH) are poorly understood in people who do not have diabetes, although the clinical implications of such hypoglycemia have been extensively studied in patients with diabetes. FBH can be influenced by many factors, including age, sex, body mass, smoking, alcohol drinking, exercise levels, medications, and eating behaviors, such as breakfast skipping and late-night eating. Read More

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Genomic Characterization of Strains From a Cluster of Infant Botulism Type A in a Small Town in Colorado, United States.

Front Microbiol 2021 13;12:688240. Epub 2021 Jul 13.

National Botulism Laboratory, Enteric Diseases Laboratory Branch, Division of Foodborne, Waterborne and Environmental Diseases, National Center for Emerging Zoonotic and Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States.

Three cases of infant botulism were reported in a small Colorado town between 1981 and 1984. The first two cases occurred in 1981, 6 months apart, and the third case occurred in 1984. type A was isolated from stool of all three case patients and from environmental samples of the patient's homes. Read More

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"No Way Out Except From External Intervention": First-Hand Accounts of Autistic Inertia.

Front Psychol 2021 13;12:631596. Epub 2021 Jul 13.

Body, Eye and Movement Lab, Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, United Kingdom.

This study, called for by autistic people and led by an autistic researcher, is the first to explore 'autistic inertia,' a widespread and often debilitating difficulty acting on their intentions. Previous research has considered initiation only in the context of social interaction or experimental conditions. This study is unique in considering difficulty initiating tasks of any type in real life settings, and by gathering qualitative data directly from autistic people. Read More

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Cognitive Biases in Blood-Injection-Injury Phobia: A Review.

Front Psychiatry 2021 13;12:678891. Epub 2021 Jul 13.

School of Psychological Sciences, University of Haifa, Haifa, Israel.

Blood-injection-injury (BII) phobia can lead to avoidance of crucial medical procedures and to detrimental health consequences, even among health workers. Yet unlike other specific phobias, BII phobia has been understudied. Specifically, while cognitive biases have been extensively investigated in other anxiety disorders, little is known about the same biases in BII phobia. Read More

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Mineralocorticoid Receptor Antagonist Improves Cardiac Structure in Type 2 Diabetes: Data From the MIRAD Trial.

JACC Heart Fail 2021 Aug;9(8):550-558

Department of Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. Electronic address:

Objectives: This study investigated the impact of the MR antagonist (MRA) eplerenone on LVM in type 2 diabetes patients at high risk for cardiovascular disease (CVD).

Background: MRA activation is associated with cardiac fibrosis and increased left ventricular mass (LVM), which is an independent predictor of adverse CVD, including heart failure in patients with type 2 diabetes.

Methods: A prespecified analysis of secondary endpoints in a randomized, double-blinded clinical trial of 140 patients with type 2 diabetes at high risk of or established CVD. Read More

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Molecular Aspects of Lifestyle and Environmental Effects in Patients With Diabetes: JACC Focus Seminar.

J Am Coll Cardiol 2021 Aug;78(5):481-495

Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Diabetes is characterized as an integrated condition of dysregulated metabolism across multiple tissues, with well-established consequences on the cardiovascular system. Recent advances in precision phenotyping in biofluids and tissues in large human observational and interventional studies have afforded a unique opportunity to translate seminal findings in models and cellular systems to patients at risk for diabetes and its complications. Specifically, techniques to assay metabolites, proteins, and transcripts, alongside more recent assessment of the gut microbiome, underscore the complexity of diabetes in patients, suggesting avenues for precision phenotyping of risk, response to intervention, and potentially novel therapies. Read More

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Greenhouse gas budgets of severely polluted urban lakes in India.

Sci Total Environ 2021 Jul 12;798:149019. Epub 2021 Jul 12.

UK Centre for Ecology & Hydrology, Edinburgh, UK.

Inland waters are important sources of greenhouse gases and emissions from polluted subtropical systems may be contributing to the observed global increase in atmospheric methane concentrations. Here we detail a scoping study where dissolved concentrations of greenhouse gases methane (CH), carbon dioxide (CO) and nitrous oxide (NO) were measured in two contrasting urban lakes in Bangalore (Bengaluru), Karnataka, India, from June 2018 to February 2020. Bellandur Lake is a severely polluted system whilst Jakkur Lake has been subject to partial restoration via treatment of organic matter inputs. Read More

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Cadmium-induced transgenerational effects on tomato plants: A gift from parents to progenies.

Sci Total Environ 2021 May 21;789:147885. Epub 2021 May 21.

Departamento de Genética, Escola Superior de Agricultura "Luiz de Queiroz"/Universidade de São Paulo (ESALQ/USP), Avenida Pádua Dias, 11, 13418-900, Piracicaba, SP, Brazil. Electronic address:

The present study aimed to investigate the Cd-induced transgenerational effects on plants. Grafted tomato plants, which exhibited the same cultivar as scion and distinct cultivars with contrasting Cd-tolerance as rootstocks, were grown in soil without and with artificial addition of Cd (less than 2.0, and 6. Read More

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An investigation into the biological effects of indirect potable reuse water using zebrafish embryos.

Sci Total Environ 2021 May 24;789:147981. Epub 2021 May 24.

Brunel University London, Institute for Environment Health and Societies, UB8 3PH, UK. Electronic address:

Advanced treatment technologies are being assessed as a proactive measure to assist with the transformation of treated wastewater into a source of water for potable water production. We investigated the biological effects along an advanced water treatment pilot plant, using zebrafish embryos throughout early development. The study compared phenotypic observations with global transcriptome responses, enabling us to keep an open mind about the chemicals that might influence the biological activity. Read More

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Detection of SARS-CoV-2 variants by genomic analysis of wastewater samples in Israel.

Sci Total Environ 2021 May 24;789:148002. Epub 2021 May 24.

Central Virology Laboratory, Ministry of Health, Chaim Sheba Medical Center, Ramat Gan, Israel. Electronic address:

Investigation of SARS-CoV-2 spread and identification of variants in sewers has been demonstrated to accurately detect prevalence of viral strains and is advantageous to clinical sampling in population catchment size. Herein, we utilized an established nationwide system of wastewater sampling and viral concentration approaches to perform large-scale surveillance of SARS-CoV-2 variants in nine different locations across Israel that were sampled from August 2020 to February 2021 and sequenced (n = 58). Viral sequences obtained from the wastewater samples had high coverages of the genome, and mutation analyses successfully identified the penetration of the B. Read More

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Rethinking the causes of extreme heavy winter PM pollution events in northern China.

Sci Total Environ 2021 Jun 24;794:148637. Epub 2021 Jun 24.

Key Lab of Marine Environment and Ecology, Ministry of Education, Ocean University of China, Qingdao 266100, China; Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao 266100, China; Institute for Advanced Ocean Study, Ocean University of China, Qingdao 266100, China. Electronic address:

It has been reported that air quality models largely underestimate PM concentrations during severe pollution events in China. In this study, the Models-3 Community Multi-scale Air Quality model (CMAQ) was employed to simulate PM concentrations in May-June (non-heating period) and in November-December (heating period) of 2013 in northern China, with a particular focus on determining the causes of the underestimation. Modeling results reproduced the mass concentrations of PM in approximately 50% of the non-heating and heating periods in Qingdao (referred to as the good periods), while the model performance was unsatisfactory during the remaining periods (the poor periods). Read More

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Intensification of supercritical water oxidation (ScWO) by ion exchange with zeolite for the reuse of landfill leachates.

Sci Total Environ 2021 Jun 26;794:148584. Epub 2021 Jun 26.

Department of Chemical Engineering, State University of Maringá, 5790 Colombo Avenue, Jd. University, 87020900 Maringá, Parana, Brazil.

The disposal of solid residues in sanitary landfills results in the formation of a complex, variable, and recalcitrant wastewater, known as leachates. Supercritical water oxidation (ScWO) can be applied to treat leachates although most studies are based on removing the most relevant contaminants, such as organic matter and ammonia. Therefore, comprehensive analysis of this process is essential for large-scale applications. Read More

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Greenspace Inversely Associated with the Risk of Alzheimer's Disease in the Mid-Atlantic United States.

Earth (Basel) 2021 Feb;2(1):140-150

US EPA, Office of Research and Development, Center for Public Health and Environmental Assessment, Research Triangle Park, Durham, NC 27711, USA.

Alzheimer's disease (AD) is a chronic neurodegenerative disease and the most common form of dementia in older adults. Treatment of AD symptoms is very challenging and expensive. Appropriate diet as well as mental and physical activity may delay or reduce the occurrence of AD. Read More

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February 2021

Human-to-Cattle Complex Transmission in the United States.

Front Vet Sci 2021 12;8:691192. Epub 2021 Jul 12.

United States Department of Agriculture: Animal and Plant Health Inspection Service, Veterinary Services, National Veterinary Services Laboratories, Ames, IA, United States.

The complex (MTBC) species includes both , the primary cause of human tuberculosis (TB), and , the primary cause of bovine tuberculosis (bTB), as well as other closely related species. Zoonotic transmission of from cattle to humans was recognized more than a century ago, but transmission of MTBC species from humans to cattle is less often recognized. Within the last decade, multiple published reports from around the world describe human-to-cattle transmission of MTBC. Read More

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Seasonal Patterns in Incidence and Antimicrobial Resistance of Common Bacterial Pathogens in Nursing Home Patients and Their Rooms.

Front Public Health 2021 12;9:671428. Epub 2021 Jul 12.

Division of Geriatric and Palliative Care Medicine, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MI, United States.

Colonization is the main precursor to infection, which may lead to adverse clinical outcomes among older adults in nursing homes (NHs). Understanding seasonal changes in the local burden of common bacterial pathogens is key to implementing appropriate and cost-effective infection prevention measures in this resource-constrained healthcare environment. It is thus surprising that seasonal trends in patient and environmental colonization with major bacterial pathogens are presently unknown in the expanding NH setting. Read More

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Biallelic -Variants Leading to Developmental Regression With Progressive Spasticity and Brain Atrophy in a Chinese Patient.

Front Genet 2021 12;12:685035. Epub 2021 Jul 12.

Department of Neurology, National Center for Children's Health, Beijing Children's Hospital, Capital Medical University, Beijing, China.

Objective: The cytochrome c oxidase assembly factor 7 ( gene encodes a protein localized to mitochondria that is involved in the assembly of mitochondrial respiratory chain complex IV. Here, we report the clinical, genetic and biochemical analysis of a female patient with suspected mitochondrial disorder and novel variants in , that presented with a considerably different phenotype and age of onset than the five patients reported to date.

Methods: We performed trio-exome sequencing in the affected patient and both parents. Read More

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