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Current capsid assembly models of icosahedral nucleocytoviricota viruses.

Adv Virus Res 2020 5;108:275-313. Epub 2020 Oct 5.

Department of Chemistry and Biochemistry, The University of Texas at El Paso, El Paso, Texas, United States. Electronic address:

Nucleocytoviricota viruses (NCVs) belong to a newly established phylum originally grouped as Nucleocytoplasmic large DNA viruses. NCVs are unique because of their large and complicated genomes that contain cellular genes with homologs from all kingdoms of life, raising intensive debates on their evolutional origins. Many NCVs pack their genomes inside massive icosahedral capsids assembled from thousands of proteins. Read More

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October 2020

Metformin and cancer-specific survival among breast, colorectal, or endometrial cancer patients: a nationwide data linkage study.

Diabetes Res Clin Pract 2021 Apr 6:108755. Epub 2021 Apr 6.

Centre for Medicine Use and Safety (CMUS), Faculty of Pharmacy and Pharmaceutical Science, Monash University, Melbourne, VIC, Australia; School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Western Australia, Perth, WA, Australia.

Aims: Equivocal results of association between metformin and cancer-specific survival need more investigation. We tested the hypothesis that adherence to the drug had a lower cancer-specific mortality in a homogeneous population (i.e. Read More

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Leukemic stem cells shall be searched in the bone marrow before "tyrosine kinase inhibitor-discontinuation" in chronic myeloid leukemia.

Int J Lab Hematol 2021 Apr 9. Epub 2021 Apr 9.

Department of Hematology, Hacettepe University School of Medicine, Ankara, Turkey.

Background: Leukemic stem cells (LSCs) of chronic myeloid leukemia (CML), persisting in the bone marrow (BM) niche, could be responsible for the relapses within the patients of whom the treatment-free remission (TFR) had been attempted. We assessed the presence of the CML LSCs in the peripheral blood (PB) and concurrently in the BM in the patients with chronic-phase CML (CP CML).

Patients And Methods: Thirty-eight patients with CP CML were included into the study. Read More

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Pulmonary mycobacterium avium complex disease complicated by cancer: an 11-year survey at a single-center.

J Rural Med 2021 Apr 1;16(2):72-76. Epub 2021 Apr 1.

Division of Pulmonary Medicine, Department of Medicine, Jichi Medical University, Japan.

Pulmonary mycobacterium avium complex (MAC) disease is increasing significantly worldwide. Several studies have investigated the clinical features of pulmonary MAC disease in the setting of cancer. Here, we aimed to clarify the clinical characteristics of patients with cancer with recent onset of pulmonary MAC disease and the effect of cancer on the onset of this disease. Read More

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Individual Differences in Attentional Breadth Changes Over Time: An Event-Related Potential Investigation.

Front Psychol 2021 23;12:605250. Epub 2021 Mar 23.

Department of Psychology, Brock University, St. Catharines, ON, Canada.

Event-related potentials (ERPs) to hierarchical stimuli have been compared for global/local target trials, but the pattern of results across studies is mixed with respect to understanding how ERPs differ with local and global bias. There are reliable interindividual differences in attentional breadth biases. This study addresses two questions. Read More

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Processes of care and survival associated with treatment in specialist teenage and young adult cancer centres: results from the BRIGHTLIGHT cohort study.

BMJ Open 2021 Apr 7;11(4):e044854. Epub 2021 Apr 7.

Cancer Service, University College London Hospitals NHS Foundation Trust, London, UK.

Objective: Survival gains in teenagers and young adults (TYA) are reported to be lower than children and adults for some cancers. Place of care is implicated, influencing access to specialist TYA professionals and research.Consequently, age-appropriate specialist cancer care is advocated for TYA although systematic investigation of associated outcomes is lacking. Read More

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Investigation of the presence of carbapenemases in carbapenem-resistant Klebsiella pneumoniae strains by MALDI-TOF MS (matrix-assisted laser desorption ionization-time of flight mass spectrometry) and comparison with real-time PCR method.

Indian J Med Microbiol 2021 Apr 3. Epub 2021 Apr 3.

Ege University Faculty of Medicine, Department of Medical Microbiology, İzmir, Turkey.

Purpose: We aimed to develop a new procedure for rapid detection of the carbapenemase activity using MALDI-TOF MS, and to determine the sensitivity and specificity of the method. Also, we aimed to determine the distribution of carbapenemase genes among the K.pneumoniae strains isolated in our hospital using real-time PCR. Read More

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Cyclo[]carbons Form Strong N → C Dative/Covalent Bonds with Piperidine.

J Phys Chem A 2021 Apr 7. Epub 2021 Apr 7.

Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i., Flemingovo nám. 2, 16000 Prague 6, Czech Republic.

The newly synthesized C ring is demonstrated as the smallest all-carbon acceptor that exhibits strong electron acceptance. This study provides a quantum-chemical investigation of the electron-acceptance behavior of monocyclic carbon rings with a particular emphasis on C through the formation of a dative bond with piperidine. The results show that C rings form strong dative bonds with piperidine, whereas the respective van der Waals (vdW) complexes are higher in energy. Read More

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Ranking the risk of animal-to-human spillover for newly discovered viruses.

Proc Natl Acad Sci U S A 2021 Apr;118(15)

One Health Institute and Karen C. Drayer Wildlife Health Center, School of Veterinary Medicine, University of California, Davis, CA 95616;

The death toll and economic loss resulting from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic are stark reminders that we are vulnerable to zoonotic viral threats. Strategies are needed to identify and characterize animal viruses that pose the greatest risk of spillover and spread in humans and inform public health interventions. Using expert opinion and scientific evidence, we identified host, viral, and environmental risk factors contributing to zoonotic virus spillover and spread in humans. Read More

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Transmission analysis of COVID-19 with discrete time imported cases: Tianjin and Chongqing as cases.

Infect Dis Model 2021 31;6:618-631. Epub 2021 Mar 31.

Complex Systems Research Center, Shanxi University, Taiyuan, Shan'xi, 030006, China.

In 2020, an unexpectedly large outbreak of the coronavirus disease 2019 (COVID-19) epidemic was reported in mainland China. As we known, the epidemic was caused by imported cases in other provinces of China except for Hubei in 2020. In this paper, we developed a differential equation model with tracing isolation strategy with close contacts of newly confirmed cases and discrete time imported cases, to perform assessment and risk analysis for COVID-19 outbreaks in Tianjin and Chongqing city. Read More

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Interlaboratory validation of a hanging pendulum thrust balance for electric propulsion testing.

Rev Sci Instrum 2021 Mar;92(3):034502

Department of Aeronautics, Imperial College London, South Kensington, London SW72AZ, United Kingdom.

A hanging pendulum thrust balance has been developed by Imperial College London in collaboration with the European Space Agency (ESA) to characterize a wide range of static fire electric propulsion and chemical micro-propulsion devices with thrust in the range of 1 mN to 1 N. The thrusters under investigation are mounted on a pendulum platform, which is suspended from the support structure using stainless steel flexures. The displacement of the platform is measured using an optical laser triangulation sensor. Read More

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Modeling the dynamics of novel coronavirus (COVID-19) via stochastic epidemic model.

Results Phys 2021 Mar 27:104004. Epub 2021 Mar 27.

Department of Mathematical Sciences, UAE University, Al-Ain, P.O. Box 15551, United Arab Emirates.

In this article we propose a stochastic model to discuss the dynamics of novel corona virus disease. We formulate the model to study the long run behavior in varying population environment. For this purposes we divided the total human population into three epidemiological compartments: the susceptible, covid-19 infected, recovered and recovered along with one class of reservoir. Read More

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Iron Accumulation and Lipid Peroxidation in the Aging Retina: Implication of Ferroptosis in Age-Related Macular Degeneration.

Aging Dis 2021 Apr 1;12(2):529-551. Epub 2021 Apr 1.

1Department of Ophthalmology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Iron is an essential component in many biological processes in the human body. It is critical for the visual phototransduction cascade in the retina. However, excess iron can be toxic. Read More

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Spectral, Molecular Modeling, and Biological Activity Studies on New Schiff's Base of Acenaphthaquinone Transition Metal Complexes.

Bioinorg Chem Appl 2021 22;2021:6674394. Epub 2021 Mar 22.

Department of Chemistry, Umm-Al-Qura University, Makkah, Saudi Arabia.

The newly synthesized Schiff's base derivative, N-allyl-2-(2-oxoacenaphthylen-1(2H)-ylidene)hydrazine-1-carbothioamide, has been characterized by different spectral techniques. Its reaction with Co(II), Ni(II), and Zn(II) acetate led to the formation of 1 : 1 (M:L) complexes. The IR and NMR spectral data revealed keto-thione form for the free ligand. Read More

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Social cognitive impairment in early Parkinson's disease: A novel "mild impairment"?

Parkinsonism Relat Disord 2021 Mar 4. Epub 2021 Mar 4.

Sorbonne Université, Inserm, CNRS, Institut du Cerveau - Paris Brain Institute - ICM, Paris, France; Department of Neurology, Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris (APHP), Paris, France; Institute of Memory and Alzheimer's Disease (IM2A), Pitié-Salpêtrière Hospital, Assistance Publique Hôpitaux de Paris (APHP), Paris, France.

Introduction: Social cognition (SC) deficit has recently been described in the early stages of Parkinson's disease (PD), but findings remain unclear. Our objective was to determine the frequency of SC impairment in newly-diagnosed PD patients and whether it is independent of Mild Cognitive Impairment (MCI).

Methods: We enrolled 109 patients with idiopathic PD diagnosed within the previous four years (ICEBERG cohort) and 39 healthy participants. Read More

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Thinking Small: Small Molecules as Potential Synergistic Adjuncts to Checkpoint Inhibition in Melanoma.

Int J Mol Sci 2021 Mar 22;22(6). Epub 2021 Mar 22.

Department of Surgery, University of Rochester Medical Center, Rochester, NY 14642, USA.

Metastatic melanoma remains the deadliest form of skin cancer. Immune checkpoint inhibition (ICI) immunotherapy has defined a new age in melanoma treatment, but responses remain inconsistent and some patients develop treatment resistance. The myriad of newly developed small molecular (SM) inhibitors of specific effector targets now affords a plethora of opportunities to increase therapeutic responses, even in resistant melanoma. Read More

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Acute MDPV Binge Paradigm on Mice Emotional Behavior and Glial Signature.

Pharmaceuticals (Basel) 2021 Mar 16;14(3). Epub 2021 Mar 16.

Institute of Pharmacology and Experimental Therapeutics/IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal.

3,4-Methylenedioxypyrovalerone (MDPV), a widely available synthetic cathinone, is a popular substitute for classical controlled drugs of abuse, such as methamphetamine (METH). Although MDPV poses public health risks, its neuropharmacological profile remains poorly explored. This study aimed to provide evidence on that direction. Read More

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Chromatography-Independent Fractionation and Newly Identified Molecular Features of the Adzuki Bean ( Willd.) β-vignin Protein.

Int J Mol Sci 2021 Mar 16;22(6). Epub 2021 Mar 16.

Department of Bromatological Analysis, School of Pharmacy, Federal University of Bahia, 40170-115 Salvador, Brazil.

Adzuki seed β-vignin, a vicilin-like globulin, has proven to exert various health-promoting biological activities, notably in cardiovascular health. A simple scalable enrichment procedure of this protein for further nutritional and functional studies is crucial. In this study, a simplified chromatography-independent protein fractionation procedure has been optimized and described. Read More

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A Multi-Country, Single-Blinded, Phase 2 Study to Evaluate a Point-of-Need System for Rapid Detection of Leishmaniasis and Its Implementation in Endemic Settings.

Microorganisms 2021 Mar 12;9(3). Epub 2021 Mar 12.

Department of Animal Science, Division of Microbiology and Animal Hygiene, Georg-August-University of Goettingen, D-37077 Goettingen, Germany.

With the advancement of isothermal nucleic acid amplification techniques, detection of the pathogenic DNA in clinical samples at point-of-need is no longer a dream. The newly developed recombinase polymerase amplification (RPA) assay incorporated in a suitcase laboratory has shown promising diagnostic efficacy over real-time PCR in detection of DNA from clinical samples. For broader application of this point-of-need system, we undertook a current multi-country diagnostic evaluation study towards establishing this technique in different endemic settings which would be beneficial for the ongoing elimination programs for leishmaniasis. Read More

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Large Scale Molecular Studies of Pituitary Neuroendocrine Tumors: Novel Markers, Mechanisms and Translational Perspectives.

Cancers (Basel) 2021 Mar 19;13(6). Epub 2021 Mar 19.

Latvian Biomedical Research and Study Centre, Ratsupites Str. 1-k1, LV-1067 Riga, Latvia.

Pituitary neuroendocrine tumors (PitNETs) are non-metastatic neoplasms of the pituitary, which overproduce hormones leading to systemic disorders, or tumor mass effects causing headaches, vertigo or visual impairment. Recently, PitNETs have been investigated in large scale (exome and genome) molecular analyses (transcriptome microarrays and sequencing), to uncover novel markers. We performed a literature analysis on these studies to summarize the research data and extrapolate overlapping gene candidates, biomarkers, and molecular mechanisms. Read More

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Greek Tulips: Worldwide Electronic Trade over the Internet, Global Ex Situ Conservation and Current Sustainable Exploitation Challenges.

Plants (Basel) 2021 Mar 19;10(3). Epub 2021 Mar 19.

Institute of Plant Breeding and Genetic Resources (IPBGR), Hellenic Agricultural Organization (HAO) Demeter, 57001 Thessaloniki, Greece.

From an ornamental viewpoint, tulips are famous clonally propagated crops. This research focuses on 15 wild-growing Greek tulip species including 11 range-restricted species, i.e. Read More

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Kinetics of Austenite Phase Transformations in Newly-Developed 0.17C-2Mn-1Si-0.2Mo Forging Steel with Ti and V Microadditions.

Materials (Basel) 2021 Mar 30;14(7). Epub 2021 Mar 30.

Department of Engineering Materials and Biomaterials, Silesian University of Technology, 18A Konarskiego Street, 44-100 Gliwice, Poland.

This work presents the results of phase transformation kinetics during continuous cooling in newly developed high strength low-alloy steel (HSLA). Initial theoretical calculations for the determination of heat treatment parameters were conducted. To determine the structural constituents formed due to the austenite decomposition the dilatometry approach was used. Read More

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Antibiotic Treatment Decrease the Fitness of Honeybee () Larvae.

Insects 2021 Mar 30;12(4). Epub 2021 Mar 30.

College of Animal Science (Bee Science), Fujian Agriculture and Forestry University, Fuzhou 350002, China.

Symbiotic bacteria could increase the nutrient provision, regulate the physiological state, and promote immunity in their insect host. Honeybee larvae harbor plenty of bacteria in their gut, but their functions are not well studied. To determine their effect on honeybee larvae, the 1-day-old larvae were grafted on to 24-well plates from the comb and artificially reared in the lab. Read More

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Biochemical, Ameliorative and Cytotoxic Effects of Newly Synthesized Curcumin Microemulsions: Evidence from In Vitro and In Vivo Studies.

Nanomaterials (Basel) 2021 Mar 23;11(3). Epub 2021 Mar 23.

Department of Chemistry, University of Zabol, P.O. Box. 98613-35856, Zabol, PIran.

Curcumin is known to exhibit antioxidant and tissue-healing properties and has recently attracted the attention of the biomedical community for potential use in advanced therapies. This work reports the formulation and characterization of oil-in-water F127 microemulsions to enhance the bioavailability of curcumin Microemulsions showed a high encapsulation efficiency and prolonged release. To investigate the interactions of curcumin with one unit of the polymeric chain of surfactant F127, ethyl butyrate, and sodium octanoate, as well as the interaction between ethyl butyrate and one unit of the F127 polymer chain, the Density Functional Theory (DFT) calculations at the M06-2X level of theory, were performed in water solution. Read More

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Thermochemical Mechanism of the Epoxy-Glutamic Acid Reaction with Sn-3.0 Ag-0.5 Cu Solder Powder for Electrical Joining.

Polymers (Basel) 2021 Mar 20;13(6). Epub 2021 Mar 20.

ICT Creative Research Laboratory/Materials & Components Research Division/Emerging Materials Research Section at Electronics and Telecommunications Research Institute (ETRI), 218 Gajeong-ro, Yuseong-gu, Daejeon 34129, Korea.

An epoxy-based solder paste (ESP) is a promising alternative to conventional solder pastes to improve the reliability of fine-pitch electrical joining because the epoxy encapsulates the solder joint. However, development of an appropriate epoxy formulation and investigation of its reaction mechanism with solder powder is challenging. In this study, we demonstrate a newly designed ESP consisting of diglycidyl ether of bisphenol F (DGEBF) resin, Sn-3. Read More

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The First Record and Classification of Planktonic Radiolarian () and Phaeodarian () in the Eastern Indian Ocean.

Biology (Basel) 2021 Mar 8;10(3). Epub 2021 Mar 8.

National Ocean Service, NOAA, 331 Fort Johnson Road, Charleston, SC 29412, USA.

Siliceous planktonic species of the phyla Retaria and Cercozoa were investigated from the surface to a 200 m depth around the eastern Indian Ocean (80.00°-96.10° E, 10. Read More

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Autosomal Microsatellite Investigation Reveals Multiple Genetic Components of the Highlanders from Thailand.

Genes (Basel) 2021 Mar 8;12(3). Epub 2021 Mar 8.

Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.

The hill tribes of northern Thailand comprise nine officially recognized groups: the Austroasiatic-speaking (AA) Khmu, Htin and Lawa; the Hmong-Mien-speaking (HM) IuMien and Hmong; and the Sino-Tibetan-speaking (ST) Akha, Karen, Lahu and Lisu. Except the Lawa, the rest of the hill tribes migrated into their present habitats only very recently. The Thai hill tribes were of much interest to research groups focusing on study of cultural and genetic variation because of their unique languages and cultures. Read More

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Treatment of secondary central nervous system involvement in systemic aggressive B cell lymphoma using R-MIADD chemotherapy: a single-center study.

Chin Neurosurg J 2021 Apr 2;7(1):20. Epub 2021 Apr 2.

Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Secondary central nervous system lymphoma (SCNSL) is defined as lymphoma involvement within the central nervous system (CNS) that originated elsewhere, or a CNS relapse of systemic lymphoma. Prognosis of SCNSL is poor and the most appropriate treatment is still undetermined.

Methods: We conducted a retrospective study to assess the feasibility of an R-MIADD (rituximab, high-dose methotrexate, ifosfamide, cytarabine, liposomal formulation of doxorubicin, and dexamethasone) regimen for SCNSL patients. Read More

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Phylogeny of the Bacillus altitudinis Complex and Characterization of a Newly Isolated Strain with Antilisterial Activity.

J Food Prot 2021 Apr 1. Epub 2021 Apr 1.

The University of Tennessee Assistant Professor Food Science 2600 River Drive UNITED STATES Knoxville TN 37996.

Here, a Bacillus strain, UTK D1-0055, is described that was isolated from a laboratory environment. It was of interest as it demonstrated antilisterial activity. The genome was sequenced, which identified the strain as Bacillus altitudinis, and a high-quality complete annotated genome was produced. Read More

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Limited progression of subclinical Dupuytren's disease.

Bone Joint J 2021 Apr;103-B(4):704-710

Department of Plastic Surgery, University Medical Center Groningen, Groningen, the Netherlands.

Aims: With novel promising therapies potentially limiting progression of Dupuytren's disease (DD), better patient stratification is needed. We aimed to quantify DD development and progression after seven years in a population-based cohort, and to identify factors predictive of disease development or progression.

Methods: All surviving participants from our previous prevalence study were invited to participate in the current prospective cohort study. Read More

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