261 results match your criteria investigating caffeine

Female Fertility and the Nutritional Approach: The Most Essential Aspects.

Adv Nutr 2021 Jun 17. Epub 2021 Jun 17.

Department of Gastroenterology, Dietetics and Internal Diseases, Poznan University of Medical Sciences, the Heliodor Swiecicki Hospital, Poznan, Poland.

Infertility is an increasing problem that affects couples attempting pregnancy. A growing body of evidence points to a link between diet and female fertility. In fact, data show that a diet high in trans fats, refined carbohydrates, and added sugars can negatively affect fertility. Read More

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The Effect of Dietary Supplements on Endurance Exercise Performance and Core Temperature in Hot Environments: A Meta-analysis and Meta-regression.

Sports Med 2021 Jun 15. Epub 2021 Jun 15.

A-STEM Centre, College of Engineering, Swansea University, Swansea, UK.

Background: The ergogenic effects of dietary supplements on endurance exercise performance are well-established; however, their efficacy in hot environmental conditions has not been systematically evaluated.

Objectives: (1) To meta-analyse studies investigating the effects of selected dietary supplements on endurance performance and core temperature responses in the heat. Supplements were included if they were deemed to: (a) have a strong evidence base for 'directly' improving thermoneutral endurance performance, based on current position statements, or (b) have a proposed mechanism of action that related to modifiable factors associated with thermal balance. Read More

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G2/M Checkpoint Abrogation With Selective Inhibitors Results in Increased Chromatid Breaks and Radiosensitization of 82-6 hTERT and RPE Human Cells.

Front Public Health 2021 28;9:675095. Epub 2021 May 28.

Institute of Medical Radiation Biology, Medical School, University of Duisburg-Essen, Essen, Germany.

While technological advances in radiation oncology have led to a more precise delivery of radiation dose and a decreased risk of side effects, there is still a need to better understand the mechanisms underlying DNA damage response (DDR) at the DNA and cytogenetic levels, and to overcome tumor resistance. To maintain genomic stability, cells have developed sophisticated signaling pathways enabling cell cycle arrest to facilitate DNA repair via the DDR-related kinases and their downstream targets, so that DNA damage or DNA replication stress induced by genotoxic therapies can be resolved. ATM, ATR, and Chk1 kinases are key mediators in DDR activation and crucial factors in treatment resistance. Read More

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Caffeine supplementation in the hospital: Potential role for the treatment of caffeine withdrawal.

Food Chem Toxicol 2021 Jul 28;153:112228. Epub 2021 Apr 28.

Cardiovascular Division, Department of Medicine, University of Miami Leonard M. Miller School of Medicine, Miami, FL, USA. Electronic address:

Caffeine use in the population is widespread. Caffeine withdrawal in the hospital setting is an underappreciated syndrome with symptoms including drowsiness, difficulty concentrating, mood disturbances, low motivation, flu-like symptoms, and headache. Withdrawal may occur upon abstinence from chronic daily exposure at doses as low as 100 mg/day and following only 3-7 days of consumption at higher doses. Read More

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Using Pressure-Driven Membrane Processes to Remove Emerging Pollutants from Aqueous Solutions.

Int J Environ Res Public Health 2021 04 12;18(8). Epub 2021 Apr 12.

Chemical Engineering Department, Campus de Espinardo, University of Murcia, 30100 Murcia, Spain.

Currently, there is great concern about global water pollution. Wastewater generally contains substances called emerging pollutants, and if the removal of these pollutants is not given sufficient attention, the pollutants can enter into the water cycle and reach the water supply for domestic use, causing adverse effects on the well-being of people. In order to avoid this menace, a multitude of techniques to reduce the high concentration levels of these substances dissolved in water are being researched and developed. Read More

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Use of therapeutic caffeine in acute care postoperative and critical care settings: a scoping review.

BMC Anesthesiol 2021 Mar 31;21(1):100. Epub 2021 Mar 31.

Department of Intensive Care Services, Royal Brisbane and Women's Hospital and Faculty of Health, Queensland University of Technology (QUT), Brisbane, Queensland, Australia.

Background: Caffeine is the most utilised psychoactive drug worldwide. However, caffeine withdrawal and the therapeutic use of caffeine in intensive care and in the perioperative period have not been well summarised. Our objective was to conduct a scoping review of caffeine withdrawal and use in the intensive care unit (ICU) and postoperative patients. Read More

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Modifiable lifestyle risk factors for dry eye disease.

Cont Lens Anterior Eye 2021 Jan 21:101409. Epub 2021 Jan 21.

Department of Ophthalmology, New Zealand National Eye Centre, The University of Auckland, New Zealand; Ophthalmic Research Group, School of Life and Health Sciences, Aston University, Birmingham, United Kingdom. Electronic address:

Purpose: To examine the association between modifiable lifestyle factors and dry eye disease.

Methods: Three hundred and twenty-two community residents (186 females, 136 males; mean ± SD age, 41 ± 22 years) with no major systemic or ophthalmic conditions (other than dry eye disease) were recruited in a cross-sectional study. A lifestyle factor questionnaire was administered, and dry eye symptomology, ocular surface characteristics, and tear film quality were evaluated for each participant within a single clinical session, in accordance with the global consensus recommendations of the TFOS DEWS II reports. Read More

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January 2021

Dietary natural methylxanthines and colorectal cancer: a systematic review and meta-analysis.

Food Funct 2020 Dec 18;11(12):10290-10305. Epub 2020 Nov 18.

Student Research Committee, Faculty of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran.

Some evidence suggests that caffeine, theophylline, and theobromine, as natural methylxanthines (MTXs), possess anti-cancer effects. We systematically reviewed the animal and human studies investigating the effect of (or association between) dietary natural MTXs on (and) colorectal cancer (CRC) and performed a meta-analysis of epidemiological studies. Relevant studies were identified by searching MEDLINE, Embase, Scopus, and Web of Knowledge through September 2020. Read More

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December 2020

The Influence of Recreational Substance Use in TMS Research.

Brain Sci 2020 Oct 18;10(10). Epub 2020 Oct 18.

Department of Kinesiology, McMaster University, Hamilton, ON L8S 4L8, Canada.

(1) Background: Transcranial magnetic stimulation (TMS) approaches are widely used to study cortical and corticospinal function. However, responses to TMS are subject to significant intra-and inter-individual variability. Acute and chronic exposure to recreational substances alters the excitability of the sensorimotor system and may contribute to the variability in TMS outcome measures. Read More

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October 2020

Investigating the Relationships between Basic Tastes Sensitivities, Fattiness Sensitivity, and Food Liking in 11-Year-Old Children.

Foods 2020 Sep 18;9(9). Epub 2020 Sep 18.

Nofima, Norwegian Institute of Food, Fisheries and Aquaculture Research, 1433 Ås, Norway.

This study investigates the relationships between basic tastes and fattiness sensitivity and food liking in 11-year-old children. The basic taste sensitivity of 106 children was measured using different methods, namely detection (DT) and recognition (RT) thresholds, and taste responsiveness. Caffeine and quinine (bitter), sucrose (sweet), citric acid (sour), sodium chloride (salty), and monosodium glutamate (umami) were investigated for DT and RT at five concentrations in water solutions. Read More

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September 2020

Ryanodine Receptor Type 2: A Molecular Target for Dichlorodiphenyltrichloroethane- and Dichlorodiphenyldichloroethylene-Mediated Cardiotoxicity.

Toxicol Sci 2020 11;178(1):159-172

Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California 95616-5270.

Dichlorodiphenyltrichloroethane (DDT) and its metabolite dichlorodiphenyl-dichloroethylene (DDE) are ubiquitously found in the environment and linked to cardiovascular diseases-with a majority of the work focused on hypertension. Studies investigating whether DDx can interact with molecular targets on cardiac tissue to directly affect cardiac function are lacking. Therefore, we investigated whether o,p'-DDT, p,p'-DDT, o,p'-DDE, or p,p'-DDE (DDx, collectively) can directly alter the function of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) by assessing their effect(s) on hiPSC-CMs Ca2+ dynamics. Read More

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November 2020

Up in the Air: Evidence of Dehydration Risk and Long-Haul Flight on Athletic Performance.

Nutrients 2020 Aug 25;12(9). Epub 2020 Aug 25.

Faculty of Sport, University of Ljubljana, Gortanova 22, 1000 Ljubljana, Slovenia.

The microclimate of an airline cabin consists of dry, recirculated, and cool air, which is maintained at lower pressure than that found at sea level. Being exposed to this distinctive, encapsulated environment for prolonged durations, together with the short-term chair-rest immobilization that occurs during long-haul flights, can trigger distinct and detrimental reactions to the human body. There is evidence that long-haul flights promote fluid shifts to the lower extremity and induce changes in blood viscosity which may accelerate dehydration, possibly compromising an athlete's potential for success upon arrival at their destination. Read More

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Environment-wide association study on childhood obesity in the U.S.

Environ Res 2020 12 22;191:110109. Epub 2020 Aug 22.

Department of Biostatistics and Epidemiology, University of North Texas Health Science Center, Fort Worth, TX, USA.

Background: Childhood obesity is a national public health issue with increasing prevalence. It has been linked to diet, lack of physical activity, and genetic susceptibility, with more recent evidence that it could also result from environmental factors. Studies linking it to environmental factors are limited, unsystematic, incomprehensive, and inconclusive. Read More

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December 2020

Prevention of Oxygen-Induced Inflammatory Lung Injury by Caffeine in Neonatal Rats.

Oxid Med Cell Longev 2020 7;2020:3840124. Epub 2020 Aug 7.

Department of Neonatology, Charité-Universitätsmedizin Berlin, Berlin, Germany.

Background: Preterm birth implies an array of respiratory diseases including apnea of prematurity and bronchopulmonary dysplasia (BPD). Caffeine has been introduced to treat apneas but also appears to reduce rates of BPD. Oxygen is essential when treating preterm infants with respiratory problems but high oxygen exposure aggravates BPD. Read More

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Pretreatment and posttreatment in the biolistic transformation of tea plant () somatic embryos.

Plant Biotechnol (Tokyo) 2020 Jun;37(2):195-203

Department of Integrated System Engineering, Advanced Course, National Institute of Technology (KOSEN), Numazu College, 3600 Ooka, Numazu, Shizuoka 410-8501, Japan.

The tea plant () contains various metabolic substances, including catechins and caffeine, for which genetic transformation techniques are essential for investigating the associated metabolic pathways. In this study, we sought to optimize the conditions and culture process for particle bombardment-mediated transformation of tea plant somatic embryos. We describe somatic embryo pretreatment for effective transient transformation in biolistic bombardment and the posttreatment conditions of somatic embryos for accelerating differentiation after bombardment. Read More

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A pilot study investigating the impact of a caffeine-nap on alertness during a simulated night shift.

Chronobiol Int 2020 Sep-Oct;37(9-10):1469-1473. Epub 2020 Aug 20.

Sleep and Chronobiology Laboratory, University of South Australia, Adelaide, Australia.

Consuming coffee immediately prior to a nap, known as a caffeine-nap, has been shown to improve alertness during the day, but it is unknown whether a caffeine-nap is effective at reducing sleep inertia during the night. A simulated shiftwork cross-over laboratory study was conducted whereby participants (N = 6, 4 F, 21-36y) consumed 200 mg of caffeine, or decaffeinated coffee (placebo), immediately prior to a 30 min nap opportunity at 03:30 h. Compared to placebo, the caffeine-nap resulted in improved vigilant attention and subjective fatigue in the 45 min post-nap opportunity. Read More

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Data on advanced glycation end-products concentrations and haemodynamic parameters following caffeine and nicotine consumption in nursing students.

Data Brief 2020 Oct 23;32:106063. Epub 2020 Jul 23.

Midwifery Department, University of West Attica, Athens, Greece.

This work presents data from a non-invasive interventional trial investigating the early effects of caffeine and nicotine on both the concentrations of advanced glycation end-products (AGEs) and haemodynamic parameters in 178 healthy nursing students aged between 18 and 40. These students were allocated into four groups (A, B, C and D) and the concentrations of AGEs as well as haemodynamic parameters were measured non-invasively using the AgeReader and the Finometer devices, respectively. The haemodynamic parameters that were measured included systolic blood pressure, diastolic blood pressure, mean arterial pressure, heart rate, inter-beat interval, stroke volume, cardiac output, ventricular ejection time, total peripheral resistance, ascending aorta impedance and total arterial compliance. Read More

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October 2020

The Effect of Coffee on Pharmacokinetic Properties of Drugs : A Review.

Biomed Res Int 2020 24;2020:7909703. Epub 2020 Jul 24.

Department of Pharmaceutics, School of Pharmacy, College of Health Sciences, Mekelle University, Ethiopia.

Background: Coffee has been the most commercialized food product and most widely consumed stimulant beverage in the world. It is a major source of caffeine which is the most bioactive component of coffee. Although both the United States Department of Agriculture and European Food Safety Authority consider daily intake of coffee which contains 400 mg of caffeine as safe for health, it causes different clinically significant pharmacokinetic interactions with many drugs. Read More

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The Ambiguous Role of Caffeine in Migraine Headache: From Trigger to Treatment.

Nutrients 2020 Jul 28;12(8). Epub 2020 Jul 28.

Department of Sensory Organs Examination, Faculty of Health Sciences, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland.

Migraine is a chronic disorder, and caffeine has been linked with migraine for many years, on the one hand as a trigger, and on the other hand as a cure. As most of the population, including migraineurs, consume a considerable amount of caffeine daily, a question arises as to whether it influences their headaches. Indeed, drinking coffee before a migraine attack may not be a real headache trigger, but a consequence of premonitory symptoms, including yawning, diminished energy levels, and sleepiness that may herald a headache. Read More

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Mechanism underlying the vasodilation induced by diosmetin in porcine coronary artery.

Eur J Pharmacol 2020 Oct 27;884:173400. Epub 2020 Jul 27.

School of Life Sciences, University of Nottingham Medical School, Queen's Medical Centre, Nottingham, NG7 2UH, England, UK. Electronic address:

Diosmetin is a flavonoid present naturally in citrus fruit. Plants containing diosmetin have been reported to have anti-hypertensive and vasorelaxant effects. Therefore, experiments were carried out to study the effects of diosmetin in segments of the porcine coronary artery (PCA). Read More

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October 2020

Caffeine as a tool for investigating the integration of Cdc25 phosphorylation, activity and ubiquitin-dependent degradation in .

Cell Div 2020 29;15:10. Epub 2020 Jun 29.

Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, Gothenburg, SE- 405 30 Sweden.

The evolutionarily conserved Cdc25 phosphatase is an essential protein that removes inhibitory phosphorylation moieties on the mitotic regulator Cdc2. Together with the Wee1 kinase, a negative regulator of Cdc2 activity, Cdc25 is thus a central regulator of cell cycle progression in . The expression and activity of Cdc25 is dependent on the activity of the Target of Rapamycin Complex 1 (TORC1). Read More

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Characteristics of pharmaceutically active compounds in surface water in Beijing, China: Occurrence, spatial distribution and biennial variation from 2013 to 2017.

Environ Pollut 2020 Sep 8;264:114753. Epub 2020 May 8.

State Key Joint Laboratory of Environmental Simulation and Pollution Control, Beijing Key Laboratory of Emerging Organic Contaminants Control, School of Environment, Tsinghua University, Beijing, 100084, China; Research Institute for Environmental Innovation (Suzhou), Tsinghua, Suzhou, 215163, China.

Pharmaceutically active compounds (PhACs) are widely found in the environment due to vast human consumption. Lots of work has been devoted to investigating the occurrence and seasonal variations globally. To fully understand characteristics and cross-year variation of PhACs in Beijing, 35 PhACs were analyzed in 46 sites across Beijing from both urban and suburban areas. Read More

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September 2020

Association of maternal caffeine intake during pregnancy with low birth weight, childhood overweight, and obesity: a meta-analysis of cohort studies.

Feng Jin Chong Qiao

Int J Obes (Lond) 2021 Feb 9;45(2):279-287. Epub 2020 Jun 9.

Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, China.

Background: Epidemiological studies reported inconsistent results on the associations between maternal caffeine intake during pregnancy and risk of low birth weight (LBW) and childhood overweight and obesity in their offspring.

Methods: We conducted a meta-analysis of cohort studies to quantitatively assess these associations. Pertinent studies were identified by searching PubMed and Embase through June 2019. Read More

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February 2021

Effects of coffee consumption on arterial stiffness and endothelial function: a systematic review and meta-analysis of randomized clinical trials.

Crit Rev Food Sci Nutr 2021 15;61(6):1013-1026. Epub 2020 Apr 15.

Department of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Background: Endothelial function (EF) and arterial stiffness (AS) are predictors of cardiovascular disease. As previous research concerning the effect of coffee intake on EF and AS was controversial, we conducted a systematic review and meta-analysis to synthesize research.

Methods: We performed a systematic search in PubMed, Scopus and Web of Science to find clinical trials investigating the effect of coffee intake on EF or AS up to March 2020. Read More

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Investigating the genetic and causal relationship between initiation or use of alcohol, caffeine, cannabis and nicotine.

Drug Alcohol Depend 2020 05 20;210:107966. Epub 2020 Mar 20.

Translational Neurogenomics, QIMR Berghofer Medical Research Institute, 300 Herston Road, Brisbane, QLD 4006, Australia. Electronic address:

Background: Caffeine, alcohol, nicotine and cannabis are commonly used psychoactive substances. While the use of these substances has been previously shown to be genetically correlated, causality between these substance use traits remains unclear. We aimed to revisit the genetic relationships among different measures of SU using genome-wide association study (GWAS) summary statistics from the UK Biobank, International Cannabis Consortium, and GWAS & Sequencing Consortium of Alcohol and Nicotine use. Read More

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A Randomised, Placebo-Controlled, Crossover Study Investigating the Optimal Timing of a Caffeine-Containing Supplement for Exercise Performance.

Sports Med Open 2020 Mar 30;6(1):17. Epub 2020 Mar 30.

University of Exeter, St Luke's Campus, Heavitree Road, Exeter, EX1 2 LU, UK.

Background: Pre-exercise supplements containing low doses of caffeine improve endurance exercise performance, but the most efficacious time for consumption before intense endurance exercise remains unclear, as does the contribution of caffeine metabolism.

Methods: This study assessed the timing of a commercially available supplement containing 200 mg of caffeine, 1600 mg of β-alanine and 1000 mg of quercetin [Beachbody Performance Energize, Beachbody LLC, USA] on exercise performance, perception of effort and plasma caffeine metabolites. Thirteen cyclists (V̇O 64. Read More

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Current Evidence on Cell Death in Preterm Brain Injury in Human and Preclinical Models.

Front Cell Dev Biol 2020 18;8:27. Epub 2020 Feb 18.

Department of Fundamental Neurosciences, University of Lausanne, Lausanne, Switzerland.

Despite tremendous advances in neonatal intensive care over the past 20 years, prematurity carries a high burden of neurological morbidity lasting lifelong. The term encephalopathy of prematurity (EoP) coined by Volpe in 2009 encompasses all aspects of the now known effects of prematurity on the immature brain, including altered and disturbed development as well as specific lesional hallmarks. Understanding the way cells are damaged is crucial to design brain protective strategies, and in this purpose, preclinical models largely contribute to improve the comprehension of the cell death mechanisms. Read More

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February 2020

Diet and sleep health: a scoping review of intervention studies in adults.

J Hum Nutr Diet 2020 06 27;33(3):308-329. Epub 2020 Jan 27.

Physical Activity and Nutrition, Priority Research Centre, Newcastle, NSW, Australia.

Background: Recent research has demonstrated an association between dietary intake and sleep health that can influence chronic disease risk factors. A scoping review of research studies investigating dietary intake and sleep was undertaken to determine the extent and scope of research in laboratory-based, free-living and mixed settings. Additionally, this review determines how well subpopulations and geographical locations are represented and the methodologies used to assess outcome measures. Read More

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Mass Spectrom Rev 2020 09 12;39(5-6):553-573. Epub 2020 Jan 12.

Nano-Inspired Biomedicine Lab, Fondazione Istituto di Ricerca Pediatrica Città della Speranza, I35127, Padova, Italy.

In the study of natural products new strategies which favor a holistic approach, integrating the traditional reductionist methods usually employed, have been proposed. In this frame, the studies carried out by us in the last decade show that fingerprints, mainly obtained by electrospray ionization mass spectrometry (ESI-MS), lead to the characterization of natural extracts from different botanical species but also of phytotherapeutic products constituted by mixtures of extracts from different plants. Laser desorption ionization and matrix-assisted laser desorption ionization techniques were also employed and by the use of different matrices some complementary results were achieved. Read More

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September 2020

Candidate mechanisms of caffeine improving memory dysfunction.

A Alhowail

Pharmazie 2019 12;74(12):705-710

Caffeine is the most common psycho-stimulant that is broadly known to cause peripheral effects. Caffeine is well known as an adenosine receptor antagonist. Adenosine receptors are present in all areas of the brain, which makes caffeine's effects very prevalent. Read More

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December 2019