883,512 results match your criteria investigated human


Preconditioning of mesenchymal stem cells with ghrelin exerts superior cardioprotection in aged heart through boosting mitochondrial function and autophagy flux.

Eur J Pharmacol 2021 May 2:174142. Epub 2021 May 2.

Department of Cardiology, Shandong Provincial Hospital, Huaiyin District, Jinan, Shandong Province, 250021, China. Electronic address:

Application of mesenchymal stem cells (MSCs) is considered as a promising cell-based therapy to induce cardioprotection against ischemia-reperfusion (IR) injury. Preconditioning of MSCs is the key strategy to improve MSCs functions in vitro and their efficacy in vivo, especially in elderly subjects in whom cardioprotection is lost. This study investigated the effects of preconditioning of human umbilical cord-derived MSCs with ghrelin and their combination with nicotinamide-mononucleotide (NMN) on cardioprotection, and the role of autophagy flux and mitochondrial function in aged hearts subjected to IR injury. Read More

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Sleep disturbance and memory dysfunction in early multiple sclerosis.

Ann Clin Transl Neurol 2021 May 5. Epub 2021 May 5.

Icahn School of Medicine at Mount Sinai, Division of Pulmonary, Critical Care and Sleep Medicine, New York, New York, USA.

Objective: Sleep-dependent memory processing occurs in animals including humans, and disturbed sleep negatively affects memory. Sleep disturbance and memory dysfunction are common in multiple sclerosis (MS), but little is known about the contributions of sleep disturbance to memory in MS. We investigated whether subjective sleep disturbance is linked to worse memory in early MS independently of potential confounders. Read More

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Temporal lobe epilepsy alters neural responses to human and avatar facial expressions in the face perception network.

Brain Behav 2021 May 5:e02140. Epub 2021 May 5.

Swiss Epilepsy Center, Zurich, Switzerland.

Background And Objective: Although avatars are now widely used in advertisement, entertainment, and business today, no study has investigated whether brain lesions in neurological patients interfere with brain activation in response to dynamic avatar facial expressions. The aim of our event-related fMRI study was to compare brain activation differences in people with epilepsy and controls during the processing of fearful and neutral dynamic expressions displayed by human or avatar faces.

Methods: Using functional magnetic resonance imaging (fMRI), we examined brain responses to dynamic facial expressions of trained actors and their avatar look-alikes in 16 people with temporal lobe epilepsy (TLE) and 26 controls. Read More

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Can pupillometry distinguish accurate from inaccurate familiarity?

Psychophysiology 2021 May 5:e13825. Epub 2021 May 5.

School of Biological Sciences, Division of Neuroscience & Experimental Psychology, University of Manchester, Manchester, UK.

Pupillometry, the measurement of pupil diameter, has become increasingly popular as a tool to investigate human memory. It has long been accepted that the pupil is able to distinguish familiar from completely novel items, a phenomenon known as "pupil old/new effect". Surprisingly, most pupillometric studies on the pupil old/new effect tend to disregard the possibility that the pupillary response to familiarity memory may not be entirely exclusive. Read More

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Human-associated scarcity of hosts for tsetse flies (Diptera: Glossinidae) is related to an increase in prevalence of trypanosome infection in flies in north-eastern Zambia.

Trop Anim Health Prod 2021 May 5;53(2):305. Epub 2021 May 5.

School of Life Sciences, University of KwaZulu-Natal, Durban, South Africa.

Occurrence of nutritional stress (due to depletion of fat reserves) in tsetse flies, associated with inadequate levels of access to blood meals, enhances susceptibility of the flies to trypanosome infection. Thus, in a tsetse-infested area, a spatial gradient of reducing tsetse habitat quality is potentially a gradient of increasing prospects for occurrence of stress in tsetse flies. This study investigated prevalence of trypanosome infection in Glossina morsitans morsitans and G. Read More

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Activation-induced deaminase is critical for the establishment of DNA methylation patterns prior to the germinal center reaction.

Nucleic Acids Res 2021 May 5. Epub 2021 May 5.

Epigenetics and Immune Disease Group, Josep Carreras Research Institute (IJC), 08916 Badalona, Barcelona, Spain.

Activation-induced deaminase (AID) initiates antibody diversification in germinal center B cells by deaminating cytosines, leading to somatic hypermutation and class-switch recombination. Loss-of-function mutations in AID lead to hyper-IgM syndrome type 2 (HIGM2), a rare human primary antibody deficiency. AID-mediated deamination has been proposed as leading to active demethylation of 5-methycytosines in the DNA, although evidence both supports and casts doubt on such a role. Read More

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Effects of Genetic Polymorphisms on the Sulfation of Doxorubicin by Human SULT1C4 Allozymes.

J Biochem 2021 May 5. Epub 2021 May 5.

Department of Pharmacology, College of Pharmacy and Pharmaceutical Sciences, University of Toledo Health Science Campus, Toledo, OH 43614 USA.

Doxorubicin is a chemotherapeutic drug widely utilized in cancer treatment. An enzyme critical to doxorubicin metabolism is the cytosolic sulfotransferase (SULT) SULT1C4. This study investigated the functional impact of SULT1C4 single nucleotide polymorphisms (SNPs) on the sulfation of doxorubicin by SULT1C4 allozymes. Read More

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"I don't need any treatment" - barriers to mental health treatment in the general population of a megacity.

Braz J Psychiatry 2021 Apr 30. Epub 2021 Apr 30.

Núcleo de Epidemiologia Psiquiátrica (LIM-23), Departamento de Psiquiatria, Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.

Objective: Most countries fail to treat individuals with psychopathologies. Investigating treatment barriers and reasons for dropout are key elements to overcoming this scenario.

Methods: A representative sample of 2,942 urban-dwelling adults was interviewed face-to-face within a cross-sectional, stratified, multistage probability survey of the general population. Read More

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Krϋppel-like factor 15 suppresses renal glomerular mesangial cell proliferation via enhancing P53 SUMO1 conjugation.

J Cell Mol Med 2021 May 4. Epub 2021 May 4.

Department of Nephrology, First Medical Center of Chinese PLA General Hospital, Nephrology Institute of the Chinese People's Liberation Army, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, Beijing Key Laboratory of Kidney Diseases, Chinese PLA Institute of Nephrology, Chinese PLA General Hospital, Beijing, China.

Mesangial cell (MC) proliferation is a key pathological feature in a number of common human renal diseases, including mesangial proliferative nephritis and diabetic nephropathies. Knowledge of MC responses to pathological stimuli is crucial to the understanding of these disease processes. We previously determined that Krϋppel-like factor 15 (KLF15), a kidney-enriched zinc-finger transcription factor, was required for inhibition of MC proliferation. Read More

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Interaction study of astilbin, isoastilbin and neoastilbin toward CYP2D6 by multi-spectroscopy and molecular docking.

Luminescence 2021 May 4. Epub 2021 May 4.

The College of Chemistry, Changchun Normal University, Changchun, China.

Astilbin, isoastilbin and neoastilbin are the three flavonoid isomers prevalent in Rhizoma Smilax glabra (S. glabra). The interactions between human cytochrome P450 2D6 (CYP2D6) and the three isomers were investigated by multiple spectroscopic coupled with molecular docking. Read More

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Recent developments in antimicrobial and antifouling coatings to reduce or prevent contamination and cross-contamination of food contact surfaces by bacteria.

Compr Rev Food Sci Food Saf 2021 May 5. Epub 2021 May 5.

Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas, USA.

Illness as the result of ingesting bacterially contaminated foodstuffs represents a significant annual loss of human quality of life and economic impact globally. Significant research investment has recently been made in developing new materials that can be used to construct food contacting tools and surfaces that might minimize the risk of cross-contamination of bacteria from one food item to another. This is done to mitigate the spread of bacterial contamination and resultant foodborne illness. Read More

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Temporal binding is enhanced in social contexts.

Psychon Bull Rev 2021 May 4. Epub 2021 May 4.

Research Center Juelich, Institute of Neuroscience and Medicine, Cognitive Neuroscience (INM3), Juelich, Germany.

Temporal binding (TB) refers to an underestimation of time intervals between two events, most commonly for actions and their effects. This temporal contraction is measurable for both perceived changes in social stimuli such as faces, as well as for interactions with a partner. We investigated TB in two separate experiments to uncover the individual influences of (i) participants' belief in an interaction with a human partner (as compared to a computer), and (ii) a face-like stimulus versus an abstract stimulus mediating the interaction. Read More

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Targeted radioimmunotherapy with the iodine-131-labeled caerin 1.1 peptide for human anaplastic thyroid cancer in nude mice.

Ann Nucl Med 2021 May 4. Epub 2021 May 4.

Department of Nuclear Medicine, The First Affiliated Hospital/Clinical Medical School, Guangdong Pharmaceutical University, Guangzhou, 510080, Guangdong, China.

Objective: The combination of two or more drugs with different mechanisms is a promising strategy for cancer treatment, and radioimmunotherapy (RIT) is a trending antitumor strategy. Radiotherapy (RT) can promote and activate antitumor immune effects, and immunotherapy can strengthen the effects of selective internal radiotherapy (SIRT); the RIT combination is synergistic and can overcome the adverse side effects of monotherapy. In this study, we developed a radioimmunoconjugate (RIC)-the iodine-131 (I)-labeled caerin 1. Read More

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Bioaccumulation and human health risk assessment of heavy metals in food crops irrigated with freshwater and treated wastewater: a case study in Southern Cairo, Egypt.

Environ Sci Pollut Res Int 2021 May 5. Epub 2021 May 5.

Deanship of Scientific Research, Umm Al-Qura University, Al Mukarramah, Makkah, Saudi Arabia.

Food safety has often attracted attention worldwide. Few studies have investigated the heavy metal (HM) pollution and health risk assessment of crops and vegetables. The current work was conducted to evaluate the human risk assessment of HM (Cu, Cd, Cr, Pb, and Zn) in radish, lettuce, tomato, onion, turnip, squash, okra, sunflower, Jews mallow, and garden rocket cultivated in treated wastewater (TWW)-irrigated sites as compared with those cultivated in freshwater (FW)-irrigated sites. Read More

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Visual Detection and Decoding Skills of Aerial Photography by Adults with Autism Spectrum Disorder (ASD).

J Autism Dev Disord 2021 May 4. Epub 2021 May 4.

School of Optometry and Vision Science, Faculty of Life Science, Bar-Ilan University, Ramat Gan, Israel.

Despite challenges in social communication skills people with ASD often display strengths in visual processing. Aerial photography analysis is an occupation reliant on strong visual processing skills that matches this unique profile. We investigated basic-vision and "real-life" visual tasks in 20 cognitively-able young adults with ASD and 20 typically-developed (TD) "gamers". Read More

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Sources of Antibiotic Resistant Bacteria (ARB) and Antibiotic Resistance Genes (ARGs) in the Soil: A Review of the Spreading Mechanism and Human Health Risks.

Rev Environ Contam Toxicol 2021 May 5. Epub 2021 May 5.

Key Laboratory of Pollution Processes and Environmental Criteria at Ministry of Education, Tianjin Key Laboratory of Environmental Remediation and Pollution Control, College of Environmental Science and Engineering, Nankai University, Tianjin, People's Republic of China.

Soil is an essential part of our ecosystem and plays a crucial role as a nutrient source, provides habitat for plants and other organisms. Overuse of antibiotics has accelerated the development and dissemination of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs). ARB and ARGs are recognized as emerging environmental contaminants causing soil pollution and serious risks to public health. Read More

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Data on G-quadruplex topology, and binding ability of G-quadruplex forming sequences found in the promoter region of biomarker proteins and those relations to the presence of nuclear localization signal in the proteins.

Data Brief 2021 Jun 1;36:107028. Epub 2021 Apr 1.

Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Naka-cho, Koganei, Tokyo 184-8588, Japan.

Aptamer is a nucleic acid ligand which specifically binds to its target molecule. Previously, we have designed an identification method of aptamer called "G-quadruplex (G4) promoter-derived aptamer selection (G4PAS)" [1]. In G4PAS procedure, putative G4 forming sequences (PQS) were explored in a promoter region of a target protein in human gene through computational analysis, and evaluated binding ability towards the gene product encoded in the downstream of the promoter. Read More

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Apoptotic endocrinal toxic effects of perchlorate in human placental cells.

Toxicol Rep 2021 17;8:863-870. Epub 2021 Apr 17.

Forensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Cairo University, Egypt.

Background: Perchlorate is a strong oxidizing agent and has many adverse health effects. This study investigated the potential oxidative, apoptotic, and endocrinal toxic effects of perchlorate in human placenta-derived mesenchymal stem cells (HP-MSCs).

Methods: HP-MSCs were treated with two doses of perchlorate (5 and 15 μg/L) for three days. Read More

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Genetically determined elevated C-reactive protein associated with primary colorectal cancer risk: Mendelian randomization with lifestyle interactions.

Am J Cancer Res 2021 15;11(4):1733-1753. Epub 2021 Apr 15.

Department of Epidemiology, Fielding School of Public Health, University of California Los Angeles, CA 90095, USA.

Systemic inflammation-related etiologic pathways via inflammatory cytokines in the development of colorectal cancer (CRC) have not been convincingly determined and may be confounded by lifestyle factors or reverse causality. We investigated the genetically predicted C-reactive protein (CRP) phenotype in the potential causal pathway of primary CRC risk in postmenopausal women in a Mendelian randomization (MR) framework. We employed individual-level data of the Women's Health Initiative Database for Genotypes and Phenotypes Study, which consists of 5 genome-wide association (GWA) studies, including 10,142 women, 737 of whom developed primary CRC. Read More

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CAN017, a novel anti-HER3 antibody, exerted great potency in mouse avatars of esophageal squamous cell carcinoma with NRG1 as a biomarker.

Am J Cancer Res 2021 15;11(4):1697-1708. Epub 2021 Apr 15.

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen 518116, China.

CAN017 (AV-203), a novel anti-HER3 antibody, exerts very promising anti-tumor activities in several human tumor models. The aim of this study was to further investigated the efficacy and possible responsive biomarkers of CAN017 in esophageal squamous cell carcinoma (ESCC) with Chinese characteristics. Two separate cohorts of ESCC patient-derived xenograft (PDX) models including 24 (cohort 1 as training models, from Crown Bioscience Inc. Read More

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New insight into the role of ANXA1 in melanoma progression: involvement of stromal expression in dissemination.

Am J Cancer Res 2021 15;11(4):1600-1615. Epub 2021 Apr 15.

Université Clermont Auvergne, INSERM, Imagerie Moléculaire et Stratégies Théranostiques UMR1240, 58 Rue Montalembert, Clermont-Ferrand Cedex 63005, France.

ANXA1, first described in the context of inflammation, appears to be deregulated in many cancers and increased in melanomas compared with melanocytes. To date, few studies have investigated the role of ANXA1 in melanoma progression. Furthermore, this protein is expressed by various cell types, including immune and endothelial cells. Read More

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EZH2 is involved in psoriasis progression by impairing miR-125a-5p inhibition of SFMBT1 and leading to inhibition of the TGFβ/SMAD pathway.

Ther Adv Chronic Dis 2021 15;12:2040622320987348. Epub 2021 Apr 15.

Department of Dermatology, The Second Hospital of Jilin University, No. 218, Ziqiang Road, Changchun, Jilin Province 130041, P.R. China.

Aims: In this study, we aimed to decipher the impact of enhancer of zeste homolog 2 (EZH2) in psoriasis as well as the underlying mechanism.

Methods: A mouse model of psoriasis was developed by means of imiquimod induction, with the expression of EZH2, microRNA-125a-5p (miR-125a-5p), and SFMBT1 determined. The role of EZH2, miR-125a-5p, and SFMBT1 in malignant phenotypes of HaCaT cells and the development of psoriasis was subsequently investigated through gain- and loss-of-function experiments. Read More

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Factors Associated With Lower Limb Injuries in Recreational Runners: A Cross-Sectional Survey Including Mental Aspects and Sleep Quality.

J Sports Sci Med 2021 Jun 5;20(2):204-215. Epub 2021 Mar 5.

University of Groningen, University Medical Center Groningen, Center for Human Movement Science, The Netherlands.

Knowledge about prevalence and etiology of running-related injuries (RRIs) is important to design effective RRI prevention programs. Mental aspects and sleep quality seem to be important potential risk factors, yet their association with RRIs needs to be elucidated. The aims of this study are to investigate the epidemiology of RRIs in recreational runners and the association of mental aspects, sleep, and other potential factors with RRIs. Read More

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Exposure to airborne bacteria depends upon vertical stratification and vegetation complexity.

Sci Rep 2021 May 4;11(1):9516. Epub 2021 May 4.

College of Science and Engineering, Flinders University, Bedford Park, SA, 5042, Australia.

Exposure to biodiverse aerobiomes supports human health, but it is unclear which ecological factors influence exposure. Few studies have investigated near-surface green space aerobiome dynamics, and no studies have reported aerobiome vertical stratification in different urban green spaces. We used columnar sampling and next generation sequencing of the bacterial 16S rRNA gene, combined with geospatial and network analyses to investigate urban green space aerobiome spatio-compositional dynamics. Read More

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Cohort-based analysis of paternal opioid use in relation to offspring's BMI and plasma lipid profile.

Sci Rep 2021 May 4;11(1):9462. Epub 2021 May 4.

Non-Communicable Diseases Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

A growing body of evidence suggests that opioid use may affect consumer's offspring by second-hand passive smoke exposure, as well as by transgenerational impacts mediated by genetic and epigenetic alterations of paternal gametes. In human studies, these effects are limited to investigating the neural, behavioral and cognitive characteristics of offspring. Only animal studies have investigated the metabolic parameters influenced by passive opium smoke exposure. Read More

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Empirical relationships between algorithmic SDA-M-based memory assessments and human errors in manual assembly tasks.

Sci Rep 2021 May 4;11(1):9473. Epub 2021 May 4.

Center for Cognitive Interaction Technology (CITEC), Neurocognition and Action Group, Bielefeld University, 33615, Bielefeld, Germany.

The majority of manufacturing tasks are still performed by human workers, and this will probably continue to be the case in many industry 4.0 settings that aim at highly customized products and small lot sizes. Technical systems could assist on-the-job training and execution of these manual assembly processes, using augmented reality and other means, by properly treating and supporting workers' cognitive resources. Read More

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A MicroRNA Gene Panel Predicts the Vaginal Microbiota Composition.

mSystems 2021 May 4;6(3). Epub 2021 May 4.

Department of Microbiology, Tumor and Cell Biology, Centre for Translational Microbiome Research (CTMR), Karolinska Institutet, Stockholm, Sweden

The vaginal microbiota plays an essential role in vaginal health. The vaginas of many reproductive-age women are dominated by one of the species. However, the vaginas of a large number of women are characterized by the colonization of several other anaerobes. Read More

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A Phase I study of alpelisib in combination with trastuzumab and LJM716 in patients with -mutated HER2-positive metastatic breast cancer.

Clin Cancer Res 2021 May 4. Epub 2021 May 4.

Medicine, Memorial Sloan-Kettering Cancer Center/Weill Cornell Medical College

Purpose: Activating mutations in PIK3CA promote resistance to HER2-targeted therapy in breast cancer, however inhibition of PI3K alone leads to escape via feedback upregulation of HER3. Combined inhibition of HER2, HER3 and PI3K overcomes this mechanism preclinically.

Experimental Design: This phase I study investigated the maximum tolerated dose (MTD) of alpelisib given in combination with trastuzumab and LJM716 (a HER3-targeted antibody) in patients with PIK3CA-mutant HER2-positive metastatic breast cancer (MBC) using the continual reassessment method. Read More

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Functional neuroimaging in hearing research and audiology.

Authors:
Stefan Uppenkamp

Z Med Phys 2021 May 1. Epub 2021 May 1.

Medizinische Physik, Fakultät VI Medizin und Gesundheitswissenschaften Carl von Ossietzky Universität, 26111 Oldenburg, Germany. Electronic address:

The various methods of medical imaging are essential for many diagnostic issues in clinical routine, e.g., for the diagnostics and localisation of tumorous diseases, or for the clarification of other lesions in the central nervous system. Read More

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Investigating the effects of two novel 4-MMPB analogs as potent lipoxygenase inhibitors for prostate cancer treatment.

J Biol Res (Thessalon) 2021 May 4;28(1):10. Epub 2021 May 4.

Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran.

Background: Lipoxygenases are one of the critical signaling mediators which can be targeted for human prostate cancer (PC) therapy. In this study, 4-methyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine (4-MMPB) and its two analogs, 4-propyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine (4-PMPB) and 4-ethyl-2-(4-methylpiperazinyl)pyrimido[4,5-b]benzothiazine (4-EMPB), were proposed to have anti-tumor properties in prostate cancer.

Methods: After synthesizing the compounds, cytotoxic effects of 4-MMPB and its two analogs against PC-3 cancerous and HDF normal cells were investigated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay and then mechanism of cell death was assessed by flow cytometry. Read More

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