16,687 results match your criteria investigated high-performance


Determination of six parabens in biological samples by magnetic solid-phase extraction with magnetic mesoporous carbon adsorbent and UHPLC-MS/MS.

J Chromatogr B Analyt Technol Biomed Life Sci 2021 Jul 3;1179:122817. Epub 2021 Jul 3.

School of Biology and Chemistry, Key Laboratory of Chemical Synthesis and Environmental Pollution Control-Remediation Technology of Guizhou Province, Xingyi Normal University for Nationalities, Xingyi 562400, PR China. Electronic address:

Although parabens are useful due to their antiseptic properties, their widespread use has caused concerns regarding their potential toxicological effects. In this study, a novel magnetic solid-phase extraction combined with ultra-high-performance liquid chromatography-tandem mass spectrometry (MSPE-UHPLC-MS/MS) was developed, based on ordered magnetic mesoporous carbon (MMC), for paraben analysis. The MMC was prepared by soft-template synthesis, with a unique pore structure and a highly specific surface response, indicating potential as an excellent adsorbent. Read More

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Dummy molecularly imprinted membranes based on an eco-friendly synthesis approach for recognition and extraction of enrofloxacin and ciprofloxacin in egg samples.

J Chromatogr A 2021 Jul 14;1653:462411. Epub 2021 Jul 14.

School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road Shenhe District, Shenyang, Liaoning, 110016, PR China. Electronic address:

In this work, novel dummy molecularly imprinted membranes (MIMs) were fabricated using the nylon-66 (NY-66) membranes as the subtracts based on an eco-friendly "sandwich" technology with less consumption of organic reagents at mild conditions for recognition and extraction of enrofloxacin (ENR) and ciprofloxacin (CIP) in egg samples. The prepared MIMs were characterized by SEM, ATR-FTIR and TGA, showing the successful construction of uniform and porous polymers on the surface of membranes. A series of adsorption affinity tests were investigated, indicating the prepared materials had specific recognition capacity and excellent stability as novel sorbents. Read More

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Design of High-Performance Pyridine/Quinoline Hydrazone Photoswitches.

J Org Chem 2021 Jul 29. Epub 2021 Jul 29.

Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovičova 6, 84215 Bratislava, Slovakia.

The design of P-type photoswitches with thermal stability of the metastable form of hundreds of years that would efficiently transform using excitation wavelengths above 350 nm remains a challenge in the field of photochromism. In this regard, we designed and synthesized an extended set of 13 pyridine/quinoline hydrazones and systematically investigated the structure-property relationships, defining their kinetic and photoswitching parameters. We show that the operational wavelengths of the pyridine hydrazone structural motif can be effectively shifted toward the visible region without simultaneous loss of their high thermal stability. Read More

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Sudden cardiac death after acute decompensation in heart failure patients: implications of discharge haemoglobin levels.

ESC Heart Fail 2021 Jul 29. Epub 2021 Jul 29.

Department of Cardiology, Sakakibara Heart Institute, Tokyo, Japan.

Aims: Heart failure (HF) patients have a high risk of mortality due to sudden cardiac death (SCD) and non-SCD, including pump failure death (PFD). Anaemia predicts more severe symptomatic burden and higher morbidity, as noted by markedly increased hospitalizations and readmission rates, and mortality, underscoring its importance in HF management. Herein, we aimed to determine whether haemoglobin (Hb) level at discharge affects the mode of death and influences SCD risk prediction. Read More

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Simultaneous enantio- and diastereo-selective high-performance liquid chromatography separation of paroxetine on an immobilized amylose-based chiral stationary phase under green reversed-phase conditions.

J Chromatogr A 2021 Jul 14;1653:462406. Epub 2021 Jul 14.

National Centre for the Control and Evaluation of Medicines, Chemical Medicines Unit, Istituto Superiore di Sanità (ISS), Viale Regina Elena 299, 00161, Rome, Italy. Electronic address:

A simple and green high-performance liquid chromatography method for the separation of paroxetine from its enantiomeric and diastereomeric impurities has been developed. The simultaneous chromatographic resolution was carried out on the amylose-based Chiralpak IA-3 chiral stationary phase using the mixture ethanol-water-diethylamine 80:20:0.1 (v/v/v) as a mobile phase. Read More

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Intercalation of Thin-Film Gd-Doped Ceria Barrier Layers in Electrolyte-Supported Solid Oxide Cells: Physicochemical Aspects.

ACS Appl Mater Interfaces 2021 Jul 28. Epub 2021 Jul 28.

German Aerospace Centre (DLR), Institute of Engineering Thermodynamics, Pfaffenwaldring 38-40, Stuttgart 70569, Germany.

To minimize alteration of the LaSrCoFeO (LSCF)/GdCeO(CGO20)/YZrO(3YSZ) interface via strontium zirconate formation in solid oxide cells, electron beam physical vapor deposition was employed to manufacture dense, thin gadolinium-doped ceria (CGO) interlayers. CGO layers with thicknesses of 0.15, 0. Read More

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Structural characteristics and improved in vitro hepatoprotective activities of Maillard reaction products of decapeptide IVTNWDDMEK and ribose.

J Food Sci 2021 Jul 27. Epub 2021 Jul 27.

School of Food Science and Technology, Dalian Polytechnic University, Dalian, P.R. China.

Here, a novel decapeptide IVTNWDDMEK with Maillard reactivity derived from scallop Chlamys farreri mantle was identified. The structural characteristics and in vitro hepatoprotective effects of IVTNWDDMEK conjugated with ribose were further investigated. The changes in decapeptide structures were determined by ultraviolet-visible (UV-vis), Fourier transform infrared (FTIR), and atomic force microscopy (AFM), and the modification sites induced by Maillard reaction of IVTNWDDMEK and ribose were monitored by high performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS). Read More

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First-principles Investigations on a Two-dimensional SN/Black Phosphorene van der Waals Heterostructure: Mechanical, Carrier Transport and Thermoelectric Anisotropy.

J Phys Condens Matter 2021 Jul 27. Epub 2021 Jul 27.

Central South University, Central South University, Changsha, 410083, CHINA.

Isolated monolayer two-dimensional (2D) materials have attracted great attentions due to their unique optical, electrical, mechanical, thermoelectric properties and potential applications in nanoelectronic, optoelectronic and thermoelectric devices. However, it more and more difficult to find high performance and multifunctional monolayer 2D materials. The 2D van der Waals (vdW) heterostructure, which holds two different 2D materials together by vdW interactions, has opened up a new horizon in modulation of the energy band structure, the anisotropy of electrons and phonons, and the improvement of their thermoelectric properties for monolayer 2D materials. Read More

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Investigation of spectrophotometric simultaneous absorption of Salmeterol and Fluticasone in Seroflo spray by continuous wavelet transform and radial basis function neural network methods.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Jul 17;263:120192. Epub 2021 Jul 17.

Department of Chemistry, North Tehran Branch, Islamic Azad University, Tehran, Iran.

In this research, the simultaneous absorption of Salmeterol (SAL) and Fluticasone (FLU) in Seroflo spray was investigated using a spectrophotometric device via employing continuous wavelet transform (CWT) and radial basis function neural network (RBF-NN) methods. Root mean square error (RMSE) related to the RBF model was obtained 3.17 × 10 and 1. Read More

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Nanoparticles composed of the tea polysaccharide-complexed cationic vitamin B-conjugated glycogen derivative.

Food Funct 2021 Jul 27. Epub 2021 Jul 27.

School of Materials Science and Engineering, School of Chemistry, Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Guangdong Provincial Key Laboratory for High Performance Polymer-based Composites, Sun Yat-sen University, Guangzhou 510275, China.

Tea polysaccharides exhibit multiple important bioactivities, but very few of them can be absorbed through the small intestine. To enhance the absorption efficacy of tea polysaccharides, a cationic vitamin B12-conjugated glycogen derivative bearing the diethylenetriamine residues (VB12-DETA-Gly) was synthesized and characterized using FTIR, 1H NMR, and UV-vis spectroscopy. An acidic tea polysaccharide (TPSA) was isolated from green tea. Read More

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Snake venom proteomics and antivenomics of two Sundaic lance-headed pit vipers: Trimeresurus wiroti (Malaysia) and Trimeresurus puniceus (Indonesia).

Comp Biochem Physiol Part D Genomics Proteomics 2021 Jul 5;40:100875. Epub 2021 Jul 5.

Venom Research & Toxicology Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. Electronic address:

Envenomation by two medically important Sundaic pit vipers, Trimeresurus wiroti (Malaysia) and Trimeresurus puniceus (Indonesia), causes hemotoxic syndrome with a potentially fatal outcome. Research on the compositions and antigenicity of these pit viper venoms is however lacking, limiting our understanding of the pathophysiology and treatment of envenomation. This study investigated the venom proteomes of both species through a protein decomplexation strategy, applying C reverse-phase high-performance liquid chromatography followed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), and protein identification through nano-electrospray ionization liquid chromatography-tandem mass spectrometry (nano-ESI-LCMS/MS) of trypsin-digested peptides. Read More

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Sex and brain region specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice.

J Neurochem 2021 Jul 26. Epub 2021 Jul 26.

Institute of Integrative Neuroanatomy, Charité University Medicine Berlin and Max-Planck-Institute for Biophysical Chemistry Göttingen, Germany.

The regulation of the serotonin transporter (SERT) by guanine nucleotide-binding protein alpha (Gα) q was investigated using Gαq knockout mice. In the absence of Gαq, SERT mediated uptake of 5-hydroxytryptamine (5HT) was enhanced in midbrain and frontal cortex synaptosomes, but only in female mice. The mechanisms underlying this sexual dimorphism were investigated using quantitative Western blot analysis revealing brain region specific differences. Read More

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Mechanistic Investigation of Electrostatic Field-Enhanced Water Evaporation.

Adv Sci (Weinh) 2021 Jul 26:e2100875. Epub 2021 Jul 26.

School of Mechanical and Aerospace Engineering, Nanyang Technological University, Singapore, 639798, Singapore.

Investigations on external electrostatic field (EEF)-enhanced liquid water evaporation have been reported decades ago, which suggest that molecular alignment and polarization tuned by EEF accelerating the phase change process could be responsible for EEF-enhanced water evaporation. However, a detailed study revealing the role of EEF in altering the intermolecular and intramolecular water structure is lacking. Herein, an EEF is proved to tune water state by accelerating the thermal movement of water molecules, lowering the molecular escaping energy, and loosening the hydrogen bond structure. Read More

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Manipulation of Gut Microbiota Using Acacia Gum Polysaccharide.

ACS Omega 2021 Jul 2;6(28):17782-17797. Epub 2021 Jul 2.

Faculty of Agricultural Science and Forestry, Universiti Putra Malaysia Kampus Bintulu Sarawak, Bintulu, Sarawak 97008, Malaysia.

Acacia gum (AG) is a branched-polysaccharide gummy exudate that consists of arabinose and galactose. The traditional practice in African-Middle Eastern countries uses this gum as medicine. Traditional use of AG is to treat stomach disease, which can be a potential functional food. Read More

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Direct Observation of Confinement Effects of Semiconducting Polymers in Polymer Blend Electronic Systems.

Adv Sci (Weinh) 2021 Jul 14;8(14):2100332. Epub 2021 May 14.

Heeger Center for Advanced Materials Gwangju Institute of Science and Technology Gwangju 61005 Republic of Korea.

The advent of special types of polymeric semiconductors, known as "polymer blends," presents new opportunities for the development of next-generation electronics based on these semiconductors' versatile functionalities in device applications. Although these polymer blends contain semiconducting polymers (SPs) mixed with a considerably high content of insulating polymers, few of these blends unexpectedly yield much higher charge carrier mobilities than those of pure SPs. However, the origin of such an enhancement has remained unclear owing to a lack of cases exhibiting definite improvements in charge carrier mobility, and the limited knowledge concerning the underlying mechanism thereof. Read More

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Re-Engineering the Human Resource Strategies Amid and Post-Pandemic Crisis: Probing into the Moderated Mediation Model of the High-Performance Work Practices and Employee's Outcomes.

Front Psychol 2021 9;12:710266. Epub 2021 Jul 9.

School of Management, Jiangsu University, Zhenjiang, China.

By incorporating the conservation of resource theory, this study examines how high-performance work practices (HPWPs) affect the employee's in-role performance (EIRP) and employee's task performance (ETP) during the coronavirus disease 2019 (COVID-19) pandemic. Furthermore, this study investigates how organization-based self-esteem (OBSE) and positive psychological capital (PPC) affect the relationship between HPWPs and outcomes of employees such as EIRP and ETP. A quantitative technique based on the survey method was used to gather the primary data of the investigation. Read More

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Ionic liquid as an effective green media for the synthesis of (5Z, 8Z)-7H-pyrido[2,3-d]azepine derivatives and recycable Fe3O4/TiO2/multi-wall cabon nanotubes magnetic nanocomposites as high performance organometallic nanocatalyst.

Mol Divers 2021 Jul 24. Epub 2021 Jul 24.

Department of Chemistry, Azadshahr Branch, Islamic Azad University, Azadshahr, Iran.

In this research we investigated the preparation of new (5Z, 8Z)-7H-pyrido[2,3-d]azepine derivatives in high yields via multicomponent reaction of isatins, alkyl bromides, activated acetylenic compounds and ammonium acetate using ionic liquid 1-octhyl-3-methyl imidazolium bromide ([OMIM]Br) as a stabilizer and soft template at room temperature in the presence of FeO/TiO/Carbon nanotubes magnetic nanocomposites as a reusable and effective nanocatalyst that are synthesized using ionic liquid [OMIM]Br as a stabilizer, soft template, green media and moderate base. Because of having a NH group in the synthesized pyridine derivatives, we investigate antioxidant property of some synthesized compounds by diphenyl-picrylhydrazine (DPPH) radical trapping and power of ferric reduction experiment. Short time of reaction, high yields of product, easy separation of catalyst and products are some advantages of this procedure. Read More

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Arsenate reducing bacteria isolated from the marine sponge Theonella swinhoei: Bioremediation potential.

Ecotoxicol Environ Saf 2021 Jul 22;222:112522. Epub 2021 Jul 22.

School of Zoology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel.

Arsenic (As) contamination of freshwater resources constitutes a major environmental issue affecting over 200 million people worldwide. Although the use of microorganisms for the bioremediation of As has been well studied, only very few candidates have been identified to date. Here, we investigated bacteria associated with the Red Sea sponge Theonella swinhoei and their potential to reduce As in a low-salinity liquid medium. Read More

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Individuals with and without military-related PTSD differ in subjective sleepiness and alertness but not objective sleepiness.

J Psychiatr Res 2021 Jul 14;141:301-308. Epub 2021 Jul 14.

University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Posttraumatic stress disorder-related sleep disturbances may increase daytime sleepiness and compromise performance in individuals with posttraumatic stress disorder. We investigated nighttime sleep predictors of sleepiness in Veterans with and without posttraumatic stress disorder. Thirty-seven post-9/11 Veterans with posttraumatic stress disorder and 47 without posttraumatic stress disorder (Control) completed a 48-h lab stay. Read More

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Comparative metabolomics analysis of different sesame (Sesamum indicum L.) tissues reveals a tissue-specific accumulation of metabolites.

BMC Plant Biol 2021 Jul 24;21(1):352. Epub 2021 Jul 24.

Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Key Laboratory of Biology and Genetic Improvement of Oil Crops of the Ministry of Agriculture, Wuhan, 430062, China.

Background: Sesame (Sesamum indicum L.) leaves, flowers, especially seeds are used in traditional medicine to prevent or cure various diseases. Its seed's market is expanding. Read More

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Novel polysaccharide extracted from Sipunculus nudus inhibits HepG2 tumour growth in vivo by enhancing immune function and inducing tumour cell apoptosis.

J Cell Mol Med 2021 Jul 24. Epub 2021 Jul 24.

Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, Zhuhai Key Laboratory of Marine Bioresources and Environment, School of Marine Sciences, Sun Yat-Sen University, Guangzhou, China.

A novel polysaccharide was extracted from Sipunculus nudus (SNP). The molecular weight (MW) of SNP was determined to be 9223 Da by high-performance gel permeation chromatography analyses, and the structure of the SNP repeat units was determined to be →3,4-β-D-GlcpNAC (1→ and →4) -α-D-Glcp (1→ in the ratio of 15:1; →2) -α -D-Galp - (1→ as a side chain; and β-D-Galp-(1→ and α- D-Glcp - (1→ as end groups by GC-MS analysis and NMR assays. The effect of SNP on hepatoma HepG2-bearing mice was analysed to verify its potential in the clinical treatment of liver cancer. Read More

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Application of artificial neural networks and multiple linear regression on local bond stress equation of UHPC and reinforcing steel bars.

Sci Rep 2021 Jul 23;11(1):15061. Epub 2021 Jul 23.

Sichuan University, Chengdu, China.

We investigated the use of an Artificial Neural Network (ANN) to predict the Local Bond Stress (LBS) between Ultra-High-Performance Concrete (UHPC) and steel bars, in order to evaluate the accuracy of our LBS equation, proposed by Multiple Linear Regression (MLR). The experimental and numerical LBS results of specimens, based on RILEM standards and using pullout tests, were assessed by the ANN algorithm using the TensorFlow platform. For each specimen, steel bar diameters ([Formula: see text] of 12, 14, 16, 18, and 20, concrete compressive strength ([Formula: see text]), bond lengths ([Formula: see text]), and concrete covers ([Formula: see text]) of [Formula: see text], [Formula: see text], [Formula: see text] and [Formula: see text] were used as input parameters for our ANN. Read More

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Exploring the Functional Properties of Sodium Phytate Doped Polyaniline Nanofibers Modified FTO Electrodes for High-Performance Binder Free Symmetric Supercapacitors.

Polymers (Basel) 2021 Jul 15;13(14). Epub 2021 Jul 15.

National Centre of Excellence in Physical Chemistry 1, University of Peshawar, Peshawar 25120, Pakistan.

The performance of high-rate supercapacitors requires fine morphological and electrical properties of the electrode. Polyaniline (PANI), as one of the most promising materials for energy storage, shows different behaviour on different substrates. The present study reports on the surface modification of fluorine doped tin oxide (FTO) with the sodium phytate doped PANI without any binder and its utilization as a novel current collector in symmetric supercapacitor devices. Read More

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Fire Retardancy, Water Absorption, and Viscoelasticity of Borated Wood-Polycarbonate Biocomposites.

Polymers (Basel) 2021 Jul 7;13(14). Epub 2021 Jul 7.

Key Laboratory of Bio-Based Materials Science and Technology (Ministry of Education), Northeast Forestry University, Harbin 150040, China.

Demand for high-performance biocomposites is increasing due to their ease of processing, low environmental impact, and in-service performance. This study investigated the effect of boric acid modification of wood flour on polycarbonate (PC) wood composites' thermal stability, fire retardancy, water absorption, and creep behavior. The composites' fire retardancy increased with increasing wood flour content, and their char residue increased by 102. Read More

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Selective Anisotropy of Mechanical Properties in Inconel718 Alloy.

Materials (Basel) 2021 Jul 11;14(14). Epub 2021 Jul 11.

College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China.

Mechanical anisotropy behaviors are investigated in slightly rolled Inconel718 alloy with string-like δ phase and carbides produced during various solid-solution and aging treatments. A weak anisotropy in the strengths and rupture properties at 650 °C is visible, whereas ductility, i.e. Read More

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Chemopreventive Effect of (Jack) ssp. on Initial Stage Hepatocarcinogenesis in Rats.

Molecules 2021 Jul 12;26(14). Epub 2021 Jul 12.

Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

ssp. (Kurz) Gogelein (CP) is an indigenous plant found mainly in southeast Asia. Several in vitro studies have confirmed its activity against hepatocellular carcinoma; however, in vivo studies of the effect of CP on liver cancer are needed. Read More

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Quantification of Flavonoids, Phenols and Antioxidant Potential from Dropped Blanco Fruits Influenced by Drying Techniques.

Molecules 2021 Jul 8;26(14). Epub 2021 Jul 8.

ICAR-Central Citrus Research Institute, Nagpur 440 033, Maharashtra, India.

Physiologically dropped immature Blanco fruits are regarded as waste and discarded in the citrus orchard but are a good source of bioactive compounds including flavonoids, antioxidants and total phenols. A study was undertaken to identify and quantify these bioactive compounds and to investigate the influence of different drying techniques, namely freeze drying and hot air oven drying, on flavonoids namely flavanone glycosides, antioxidant potential and total phenol content in immature dropped fruits of Blanco. Flavonoids were quantified in high-performance liquid chromatography (HPLC). Read More

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Stability of Dexmedetomidine in Polyvinyl Chloride Bags Containing 0.9% Sodium Chloride Intended for Subcutaneous Infusions.

Int J Pharm Compd 2021 Jul-Aug;25(4):330-335

Department of Pharmacy, The Ottawa Hospital, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Dexmedetomidine is a sedative medication with co-analgesic effects that has been used primarily in critical care and anesthesia as a continuous intravenous infusion. Its utility in the treatment of refractory agitated delirium is being investigated in other settings including palliative care, but continuous intravenous infusions are not always feasible during end-of-life care. Subcutaneous infusions are more commonly used in this setting, but smaller volumes and higher concentrations are typically required. Read More

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The Study of Ginger-Derived Extracellular Vesicles as a Natural Nanoscale Drug Carrier and Their Intestinal Absorption in Rats.

AAPS PharmSciTech 2021 Jul 23;22(6):206. Epub 2021 Jul 23.

Marine College, Shandong University, No. 180 Wenhua West Road, Weihai, 264209, Shandong, China.

Extracellular vesicles have been widely used in drug delivery systems and clinical studies as a new natural nanoscale drug carrier. Most of these studies focused on the extracellular vesicles from animals, but few involved in the extracellular vesicles from edible plants. This study was the first to explore the potential and value of ginger-derived extracellular vesicles (GDEVs) as drug carrier by using the content ratio method and to further study their intestinal absorption in rats. Read More

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[Research and verification of quality evaluation method of Epimedii Folium based on quantitative analysis of multi-components by single marker].

Zhongguo Zhong Yao Za Zhi 2021 Jun;46(11):2843-2851

the Fifth Medical Center,General Hospital of the People's Liberation Army Beijing 100039,China.

The quality control of Epimedii Folium, composed of diverse constituents, is single at present. In view of this, an eva-luation method of 13 chemical constituents based on quantitative analysis of multi-components by single marker(QAMS) was established to further explore the composition differences of raw products and alcohol extracts in different batches and the influence of alcohol extraction on the composition, so as to provide a reference for improving the quality evaluation and control of Epimedii Folium. The fingerprints of different batches of Epimedii Folium were constructed by ultra-high performance liquid chromatography(UPLC) to evaluate the inter-batch consistency. Read More

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