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Swimming Exercise Ameliorates Hypertension-Induced Kidney Dysfunction via Alleviating Renal Interstitial Fibrosis and Apoptosis.

Kidney Blood Press Res 2021 Apr 13:1-10. Epub 2021 Apr 13.

School of Physical Education, Shaanxi Normal University, Xi'an, China.

Background: Hypertensive nephropathy is one of the major causes of ESRD. Exercise has been considered a nonpathological therapy for hypertension and its complications, yet mechanisms remain unclear. We sought to investigate whether periodic swimming could ameliorate hypertension-induced kidney dysfunction and its underlying mechanisms. Read More

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Grand canonical Monte Carlo simulations of methane adsorption in fullerene pillared graphene nanocomposites.

J Mol Graph Model 2021 Apr 1;106:107909. Epub 2021 Apr 1.

Hitit University, Faculty of Engineering, Department of Chemical Engineering, Cevre Yolu Avenue, 19030, Corum, Turkey. Electronic address:

The objective of this study is to investigate the methane adsorption performance of fullerene pillared graphene nanocomposites (FPGNs) with adjustable micro and meso porous morphology and high surface/weight ratios. Different types of fullerenes are considered as pillar units to adjust the porosity of FPGNs. The gravimetric, volumetric and deliverable methane storage capacities of FPGNs are examined using grand canonical Monte Carlo (GCMC) simulations. Read More

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Damages to biological macromolecules in gonadal subcellular fractions of scallop Chlamys farreri following benzo[a]pyrene exposure: Contribution to inhibiting gonadal development and reducing fertility.

Environ Pollut 2021 Apr 3;283:117084. Epub 2021 Apr 3.

The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, 266003, PR China.

Benzo[a]pyrene (B[a]P), a representative polycyclic aromatic hydrocarbon (PAH) compound in marine ecosystem, has great potential for chronic toxicity to marine animals. It is becoming increasingly apparent that reproductive system is the major target of B[a]P, but the adverse effects of B[a]P on subcellular fractions in bivalve gonads have not been elucidated. Scallops Chlamys farreri are used as the experimental species since they are sensitive to environmental pollutants. Read More

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Education M&M: Reviving Intraoperative Teaching and Learning.

J Surg Res 2021 Apr 10;264:462-468. Epub 2021 Apr 10.

Ohio State University Wexner Medical Center, Columbus, Ohio.

Background: Using the platform of morbidity and mortality conference, we developed and executed a combined faculty-resident intervention called "Education M&M" to discuss challenges faced by both parties in the operating room (OR), identify realistic solutions, and implement action plans. This study aimed to investigate the impact of this intervention on resident OR training.

Materials And Methods: Two resident case presentations were followed by audience discussion and recommendations regarding actionable solutions aimed at improving resident OR training from an expert faculty panel. Read More

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De Ritis Ratio as a Significant Prognostic Factor in Patients with Sepsis: A Retrospective Analysis.

J Surg Res 2021 Apr 10;264:375-385. Epub 2021 Apr 10.

Department of General Surgery, First Medical Center of Chinese PLA General Hospital, Beijing, People's Republic of China. Electronic address:

Purpose: This study was performed to investigate the relationship between the aspartate transaminase and/or alanine transaminase ratio (DRR) and long-term mortality of patients diagnosed with sepsis or septic shock.

Materials And Methods: We conducted a retrospective study among adult septic patients who were admitted to the surgical intensive care unit (ICU) of the Chinese People's Liberation Army (PLA) General Hospital from January 2014 to December 2018. Baseline characteristics were compared between survivors and non survivors. Read More

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Prevalence and molecular characterization of C. pecorum detected in Swiss fattening pigs.

Vet Microbiol 2021 Mar 31;256:109062. Epub 2021 Mar 31.

Institute of Veterinary Pathology, Vetsuisse-Faculty University Zurich, Zurich, 8057, Switzerland; Center for Clinical Studies, Vetsuisse-Faculty, University of Zurich, Zurich, 8057, Switzerland.

Chlamydia (C.) pecorum, an obligate intracellular bacterial species commonly found in ruminants, can also occur in pigs. However, its significance as a potential porcine pathogen, or commensal, is still unclear. Read More

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Spectroscopic Photoacoustic Imaging of Cartilage Damage.

Osteoarthritis Cartilage 2021 Apr 10. Epub 2021 Apr 10.

PULS/e, Dept. of Biomedical Engineering, Eindhoven University of Technology, the Netherlands; Cardiovascular Biomechanics, Dept. of Biomedical Engineering, Eindhoven University of Technology, the Netherlands. Electronic address:

Objective: Osteoarthritis (OA) is a chronic joint disease characterized by progressive degradation of cartilage. It affects more than 10% of the people aged over 60 years-old worldwide with a rising prevalence due to the increasingly aging population. OA is a major source of pain, disability, and socioeconomic cost. Read More

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Mettl14-mediated mA Modification Facilitates Liver Regeneration by Maintaining Endoplasmic Reticulum Homeostasis.

Cell Mol Gastroenterol Hepatol 2021 Apr 10. Epub 2021 Apr 10.

Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHC, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China.

Background & Aims: N-methyladenosine (mA), the most prevalent and dynamic posttranscriptional methylation modification of mammalian mRNA, is involved in various biological processes, but its role in liver regeneration has not been characterized.

Methods: We first conducted transcriptome-wide mA mRNA sequencing (mA-seq) and characterized the expression pattern of mA in regenerating mouse liver. Next, we generated hepatocyte-specific Mettl3- or Mettl14-deficient mice and investigated their role in liver regeneration. Read More

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SSEP amplitudes add information for prognostication in postanoxic coma.

Resuscitation 2021 Apr 10. Epub 2021 Apr 10.

Department of Intensive Care, Amsterdam UMC and University of Amsterdam, The Netherlands; Amsterdam Neuroscience, Amsterdam, the Netherlands.

Objective: To investigate whether somatosensory evoked potential (SSEP) amplitude adds information for prediction of poor outcome in postanoxic coma.

Methods: In this retrospective cohort study we included adult patients admitted after cardiac arrest between January 2010 and June 2018 who remained in coma and had SSEP recorded for prognostication. Outcome was dichotomized in poor (Cerebral Performance Category (CPC) 4-5) and good (CPC 1-3) at ICU discharge. Read More

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Low risk of SARS-CoV-2 in blood transfusion.

PLoS One 2021 13;16(4):e0249069. Epub 2021 Apr 13.

Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.

Background: The novel coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), continues to remain a global challenge. There is emerging evidence of SARS-CoV-2 virus found in the blood of patients from China and some developed countries. However, there is inadequate data reported in Ghana and other parts of Africa, where blood transfusion service heavily relies on voluntary and replacement blood donors. Read More

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Degradation of Polyamide Nanofiltration Membranes by Bromine: Changes of Physiochemical Properties and Filtration Performance.

Environ Sci Technol 2021 Apr 13. Epub 2021 Apr 13.

Department of Civil Engineering, University of Hong Kong, Pokfulam, Hong Kong.

The potential coexistence and interaction of bromine and polyamide membranes during membrane-based water treatment prompts us to investigate the effect of bromine on membrane performance. For fully aromatic polyamide membrane NF90 exposed under a mild bromination condition (10 mg/L), bromine incorporation resulted in more negatively charged (-13 vs -25 mV) and hydrophobic (55.2 vs 58. Read More

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The Association of Energy and Macronutrient Intake at Dinner Versus Breakfast With The Incidence of Type 2 Diabetes Mellitus in Cohort Study: The China Health and Nutrition Survey, 1997-2011.

J Diabetes 2021 Apr 13. Epub 2021 Apr 13.

National Key Discipline, Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, P. R. China.

Background: This study aims to investigate the association of energy and macronutrient intake at dinner versus breakfast with the incidence of type 2 diabetes mellitus (T2DM).

Methods: 11,153 adults, including 811 with T2DM, completed a questionnaire about energy and macronutrient intake in the China Health and Nutrition Survey (1997-2011). The differences (Δ) in energy and macronutrient intake between dinner and breakfast (Δ = dinner - breakfast) were categorized into quintiles. Read More

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Mesenchymal stem cells enhance the impact of KIR receptor-ligand mismatching on acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation in patients with acute myeloid leukemia but not in those with acute lymphocytic leukemia.

Hematol Oncol 2021 Apr 13. Epub 2021 Apr 13.

Department of Hematology, Fujian Medical University Union Hospital, Fuzhou, Fujian, China.

Killer cell immunoglobulin-like receptor (KIR) receptor-ligand mismatch has been shown to be protective for acute and chronic graft-versus-host disease (aGVHD, cGVHD) following allogeneic hematopoietic stem cell transplantation (allo-HSCT) for acute leukemia. Mesenchymal stem cells (MSC) have been considered as one of the most promising prophylaxis for severe GVHD. However, there are no prospective or retrospective studies determining whether they can work synergistically on GVHD. Read More

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The emergence of a complex pore-canal system in the dermal skeleton of Tremataspis (Osteostraci).

J Morphol 2021 Apr 13. Epub 2021 Apr 13.

Department of Organismal Biology, Uppsala University, Uppsala, Sweden.

Thyestiids are a group of osteostracans (sister-group to jawed vertebrates) ranging in time from the early Silurian to Middle Devonian. Tremataspis is unique among thyestiids in having a continuous mesodentine and enameloid cover on its dermal elements, and an embedded pore-canal system divided into lower and upper parts by a perforated septum. The origin of this upper mesh canal system and its potential homology to similar canal systems of other osteostracans has remained a matter of debate. Read More

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LncRNA LOC729178 acts as a sponge of miR-144-3p to mitigate cigarette smoke extract-induced inflammatory injury via regulating PHLPP2 in 16HBE cells.

J Mol Histol 2021 Apr 13. Epub 2021 Apr 13.

First People's Hospital of Jining City Affiliated to Jining Medical College, Jining City, Shandong Province, China.

Chronic obstructive pulmonary disease (COPD) is an inflammatory respiratory disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of COPD. In the present study, we set to investigate the role and mechanism of LOC729178 on cigarette smoke extract (CSE)-induced inflammatory damage in 16HBE cells. Read More

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Chronic kidney disease as a potential risk factor for retinal vascular disease: A 13-year nationwide population-based cohort study in Taiwan.

Medicine (Baltimore) 2021 Apr;100(15):e25224

Department of Ophthalmology, Eye Center, China Medical University Hospital.

Abstract: We investigate whether patients with chronic kidney disease (CKD) are at increased risk of retinal vascular disease (RVD). Data was collected from the Taiwan National Health Insurance system and included patients newly diagnosed with CKD between 2000 and 2012. The endpoint of interest was a diagnosis of RVD. Read More

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Adverse Events in Healthcare Workers after the First Dose of ChAdOx1 nCoV-19 or BNT162b2 mRNA COVID-19 Vaccination: a Single Center Experience.

J Korean Med Sci 2021 Apr 12;36(14):e107. Epub 2021 Apr 12.

Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

Coronavirus disease 2019 vaccinations for healthcare workers (HCWs) have begun in South Korea. To investigate adverse events (AEs) of the first dose of each vaccine, any symptom was collected daily for seven days after vaccination in a tertiary hospital. We found that 1,301 of 1,403 ChAdOx1 nCoV-19 recipients and 38 of 80 BNT162b2 recipients reported AEs respectively (90. Read More

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Transport of emerging contaminants: a column experimental study in granitic, gneissic, and quaternary alluvial soils from Porto Alegre, Southern Brazil.

Environ Monit Assess 2021 Apr 12;193(5):262. Epub 2021 Apr 12.

Universidade Estadual de Campinas Instituto de Química Laboratório de Química Ambiental, Campinas, Brazil.

Emerging contaminants is a topic that has been in evidence, especially in the last decades. These compounds are pesticides, pharmaceuticals, and personal care products that are present in several locations, mainly in large urban centers. The aim of this work was to investigate the fate of seven compounds (atrazine, simazine, ametrine, tebuthiuron, 2,4-D, fipronil, and diclofenac) using leaching column experiments to evaluate accumulation and transfer in 5 different types of urban soils from Porto Alegre, Southern Brazil. Read More

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Multiscale modeling of glioma pseudopalisades: contributions from the tumor microenvironment.

J Math Biol 2021 Apr 12;82(6):49. Epub 2021 Apr 12.

TU Kaiserslautern, Felix-Klein-Zentrum für Mathematik, Paul-Ehrlich-Street 31, 67663, Kaiserslautern, Germany.

Gliomas are primary brain tumors with a high invasive potential and infiltrative spread. Among them, glioblastoma multiforme (GBM) exhibits microvascular hyperplasia and pronounced necrosis triggered by hypoxia. Histological samples showing garland-like hypercellular structures (so-called pseudopalisades) centered around the occlusion site of a capillary are typical for GBM and hint on poor prognosis of patient survival. Read More

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Long non‑coding RNA LINC00460 serves as a potential biomarker and oncogene via regulation of the miR‑320b/PBX3 axis in acute myeloid leukemia.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Emergency, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325035, P.R. China.

Long non‑coding RNA 00460 (LINC00460) has been reported to be involved in the tumorigenesis of various cancer types. However, the function of LINC00460 in acute myeloid leukemia (AML) remains elusive. Therefore, the present study aimed to investigate the role of LINC00460 in AML. Read More

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LncRNA NR024118 is downregulated in sepsis and inhibits LPS‑induced apoptosis of cardiomyocytes.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

ICU Department, Guangxi Zhuang Autonomous National Hospital, Nanning, Guangxi Zhuang Autonomous Region 530001, P.R. China.

It has been reported that lncRNA‑NR024118 can suppress lipopolysaccharide (LPS)‑induced inflammatory responses, which promote sepsis. The present study aimed to investigate the involvement of NR024118 in sepsis. Research subjects included 82 patients with sepsis without myocardial dysfunction (MD), 35 patients with sepsis with MD and 82 healthy controls. Read More

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Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways.

Mol Med Rep 2021 Jun 13;23(6). Epub 2021 Apr 13.

Department of Radiotherapy, Qingdao Jiaozhou City Central Hospital, Jiaozhou, Qingdao 266300, P.R. China.

Hepatocellular carcinoma (HCC) is a commonly diagnosed malignancy worldwide with poor prognosis and high metastasis and recurrence rates. Although apatinib has been demonstrated to have potential antitumor activity in multiple solid tumors, the underlying mechanism of apatinib in HCC treatment remains to be elucidated. In the present study, apatinib were used to treat HCC cells transfected with or without VEGFR2 overexpression vectors. Read More

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Containing the COVID-19 pandemic with drones - Feasibility of a drone enabled back-up transport system.

Transp Policy (Oxf) 2021 Jun 3;106:141-152. Epub 2021 Apr 3.

Department of Operations, Energy, and Environmental Management, Universitaet Klagenfurt, Universitätsstraße 65 - 67, 9020, Klagenfurt, Austria.

The COVID-19 pandemic has profoundly altered common social and economic patterns as governments all over the world have been forced to take drastic measures to counter the spread of the disease. Among them, quarantine, the closure of borders, and social distancing are the ones that have affected transportation systems most severely. With the clear need to avoid all unnecessary direct human contact, an increased interest in contactless transportation and delivery modes emerged. Read More

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Association of genetic variants in TPMT, ITPA, and NUDT15 with azathioprine-induced myelosuppression in southwest china patients with autoimmune hepatitis.

Sci Rep 2021 Apr 12;11(1):7984. Epub 2021 Apr 12.

Department of Laboratory Medicine/Research Center of Clinical Laboratory Medicine, West China Hospital of Sichuan University, No.37, Guoxue Xiang, Wuhou District, Chengdu, 610041, China.

This study aimed to investigate the influence of TPMT*3C, ITPA, NUDT15, and 6-thioguanine nucleotides (6-TGN) on azathioprine (AZA)-induced myelosuppression in Southwest China patients with autoimmune hepatitis (AIH). A total of 113 Chinese patients with AIH receiving AZA maintenance treatment were evaluated. The relevant clinical data of the patients were collected from the hospital information system. Read More

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He-Ne laser accelerates seed germination by modulating growth hormones and reprogramming metabolism in brinjal.

Sci Rep 2021 Apr 12;11(1):7948. Epub 2021 Apr 12.

Department of Plant Sciences, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.

A plant's ability to maximize seed germination, growth, and photosynthetic productivity depends on its aptitude to sense, evaluate, and respond to the quality, quantity, and direction of the light. Among diverse colors of light possessing different wavelengths and red light shown to have a high impact on the photosynthetic and growth responses of the plants. The use of artificial light sources where the quality, intensity, and duration of exposure can be controlled would be an efficient method to increase the efficiency of the crop plants. Read More

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Lerf-Klinowski-type models of graphene oxide and reduced graphene oxide are robust in analyzing non-covalent functionalization with porphyrins.

Sci Rep 2021 Apr 12;11(1):7977. Epub 2021 Apr 12.

Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224, Warsaw, Poland.

Graphene-based nanohybrids are good candidates for various applications. However, graphene exhibits some unwanted features such as low solubility in an aqueous solution or tendency to aggregate, limiting its potential applications. On the contrary, its derivatives, such as graphene oxide (GO) and reduced graphene oxide (RGO), have excellent properties and can be easily produced in large quantities. Read More

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Intake of food rich in saturated fat in relation to subclinical atherosclerosis and potential modulating effects from single genetic variants.

Sci Rep 2021 Apr 12;11(1):7866. Epub 2021 Apr 12.

Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Nobels väg 13, Box 210, 17177, Stockholm, Sweden.

The relationship between intake of saturated fats and subclinical atherosclerosis, as well as the possible influence of genetic variants, is poorly understood and investigated. We aimed to investigate this relationship, with a hypothesis that it would be positive, and to explore whether genetics may modulate it, using data from a European cohort including 3,407 participants aged 54-79 at high risk of cardiovascular disease. Subclinical atherosclerosis was assessed by carotid intima-media thickness (C-IMT), measured at baseline and after 30 months. Read More

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Intrahepatic Cholestasis of Pregnancy Is Associated with Reduced Nitric Oxide Synthase (iNOS) in Plasma and Placentas: A Pilot Study.

Med Sci Monit 2021 Apr 13;27:e930176. Epub 2021 Apr 13.

Department of Obstetrics and Gynecology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, Jiangsu, China (mainland).

BACKGROUND Intrahepatic cholestasis of pregnancy (ICP) is a condition specific to pregnancy, leading to increased fetal morbidity and mortality. Nitric oxide synthase (iNOS) may be a factor regulating the vasodilation of blood vessels, which are relevant to ischemic-hypoxic conditions. We aimed to explore the potential relationship between iNOS and ICP. Read More

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High rate of second ACL injury following ACL reconstruction in male professional footballers: an updated longitudinal analysis from 118 players in the UEFA Elite Club Injury Study.

Br J Sports Med 2021 Apr 12. Epub 2021 Apr 12.

Football Research Group, Linköping University, Linköping, Sweden.

Background: Studies on subsequent anterior cruciate ligament (ACL) ruptures and career length in male professional football players after ACL reconstruction (ACLR) are scarce.

Aim: To investigate the second ACL injury rate, potential predictors of second ACL injury and the career length after ACLR.

Study Design: Prospective cohort study. Read More

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Pain Medication Disposal Rates After Pediatric Surgery.

Hosp Pediatr 2021 Apr 12. Epub 2021 Apr 12.

Departments of Orthopedics and.

Objectives: To investigate prescription opiate usage, disposal rates, and methods of disposal after pediatric surgery.

Methods: This was a retrospective chart review of patients <18 years of age who underwent a surgical procedure at our institution and were given a postoperative opiate prescription between April 2017 and June 2018. A follow-up phone survey was conducted between 60 and 90 days postoperatively to ask about prescription opiate usage and disposal. Read More

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