15,056 results match your criteria inventory insulin

Questionnaire-based Survey of Demographic and Clinical Characteristics, Health Behaviors, and Mental Health of Young Korean Adults with Early-onset Diabetes.

J Korean Med Sci 2021 Jul 5;36(26):e182. Epub 2021 Jul 5.

Department of Internal Medicine, School of Medicine, Kangwon National University, Chuncheon, Korea.

Background: The incidence of early-onset diabetes is increasing among young adults. However, there are limited data on the characteristics and management of young Korean adults with diabetes. This study assessed the clinical and demographic characteristics, health behaviors, and mental health among young Korean adults with diabetes mellitus. Read More

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Optical Glucose Sensor Using Pressure Sensitive Paint.

Jongwon Park

Sensors (Basel) 2021 Jun 30;21(13). Epub 2021 Jun 30.

Department of Biomedical Engineering, Kyungil University, Gyeongsan 38428, Korea.

A glucose sensor is used as an essential tool for diagnosing and treating diabetic patients and controlling processes during cell culture. Since the development of an electrochemical-based glucose sensor, an optical glucose sensor has been devised to overcome its shortcomings, but this also poses a problem because it requires a complicated manufacturing process. This study aimed to develop an optical glucose sensor film that could be fabricated with a simple process using commercial pressure sensitive paints. Read More

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Sustained Release of Insulin-Like Growth Factor-1 from L. Silk Fibroin Delivery for Diabetic Wound Therapy.

Int J Mol Sci 2021 Jun 10;22(12). Epub 2021 Jun 10.

Institute of Molecular Medicine, National Tsing Hua University, Hsinchu 300044, Taiwan.

The goals of this study are to develop a high purity patented silk fibroin (SF) film and test its suitability to be used as a slow-release delivery for insulin-like growth factor-1 (IGF-1). The release rate of the SF film delivering IGF-1 followed zero-order kinetics as determined via the Ritger and Peppas equation. The release rate constant was identified as 0. Read More

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Ultrasound Microbubbles Enhance the Efficacy of Insulin-Like Growth Factor-1 Therapy for the Treatment of Noise-Induced Hearing Loss.

Molecules 2021 Jun 13;26(12). Epub 2021 Jun 13.

Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei 11490, Taiwan.

The application of insulin-like growth factor 1 (IGF-1) to the round window membrane (RWM) is an emerging treatment for inner ear diseases. RWM permeability is the key factor for efficient IGF-1 delivery. Ultrasound microbubbles (USMBs) can increase drug permeation through the RWM. Read More

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Human amniotic mesenchymal stem cells-conditioned medium protects mice from high-fat diet-induced obesity.

Stem Cell Res Ther 2021 06 26;12(1):364. Epub 2021 Jun 26.

The National Engineering Research Center for Bioengineering Drugs and the Technologies, Institute of Translational Medicine, Nanchang University, No. 1299 Xuefu Road, Honggutan District, Nanchang, 330031, China.

Background: Obesity is a metabolic disorder syndrome characterized by excessive fat accumulation that is related to many diseases. Human amniotic mesenchymal stem cells (hAMSCs) have a great potential for cell-based therapy due to their characteristics such as pluripotency, low immunogenicity, no tumorigenicity, potent paracrine effects, and no ethical concern. Recently, we observed that both hAMSCs and their conditioned medium (hAMSCs-CM) efficiently repaired skin injury, inhibited hepatocellular carcinoma, and alleviated high-fat diet (HFD)-induced diabetes. Read More

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A Pilot Study of Youth With Type 1 Diabetes Initiating Use of a Hybrid Closed-Loop System While Receiving a Behavioral Economics Intervention.

Endocr Pract 2021 Jun 15;27(6):545-551. Epub 2020 Dec 15.

Department of Pediatrics, Yale University School of Medicine, One Long Wharf Drive, New Haven, Connecticut.

Objective: Many youth do not use the hybrid closed-loop system for type 1 diabetes effectively. This study evaluated the impact of financial incentives for diabetes-related tasks on use of the 670G hybrid closed-loop system and on glycemia.

Methods: At auto mode initiation and for 16 weeks thereafter, participants received a flat rate for wearing and calibrating the sensor ($1/day), administering at least 3 mealtime insulin boluses per day ($1/day), and uploading ($5/week). Read More

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American Association of Clinical Endocrinology Clinical Practice Guideline: The Use of Advanced Technology in the Management of Persons With Diabetes Mellitus.

Endocr Pract 2021 06;27(6):505-537

Unger Primary Care Concierge Medical Group, Rancho Cucamonga, California.

Objective: To provide evidence-based recommendations regarding the use of advanced technology in the management of persons with diabetes mellitus to clinicians, diabetes-care teams, health care professionals, and other stakeholders.

Methods: The American Association of Clinical Endocrinology (AACE) conducted literature searches for relevant articles published from 2012 to 2021. A task force of medical experts developed evidence-based guideline recommendations based on a review of clinical evidence, expertise, and informal consensus, according to established AACE protocol for guideline development. Read More

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[Technologies and type 1 diabetes: what measures and effects in adolescents?]

Soins Pediatr Pueric 2021 May-Jun;42(320):12-15. Epub 2021 Mar 26.

Hôpital Clocheville, Centre hospitalier régional universitaire de Tours, 49 boulevard Béranger, 37000 Tours, France. Electronic address:

The management of type 1 diabetes in paediatrics has evolved considerably over the last 20 years, mainly through the use of new technologies. The challenge of managing this disease is to achieve good glycaemic control in order to prevent complications while maintaining a good quality of life. What are the current and future means of achieving this? Read More

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Effectiveness of Logotherapy on Death Anxiety, Hope, Depression, and Proper use of Glucose Control Drugs in Diabetic Patients with Depression.

Int J Prev Med 2021 19;12. Epub 2021 Jan 19.

Department of Psychology, School of Medical Sciences, Islamic Azad University, Sari, Iran.

Background: Logotherapy encourages the individual to find meaning in life, which is recognized as the driving force of every individual in their lifetime. Diabetes, caused by the impairment in metabolism of glucose, fat, and protein, is associated with lack of secretion or dysfunction of insulin. This study aims to investigate the effectiveness of logotherapy on death anxiety, hope, depression, and proper use of glucose control medication in diabetic patients with depression. Read More

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January 2021

LSTMs and Deep Residual Networks for Carbohydrate and Bolus Recommendations in Type 1 Diabetes Management.

Sensors (Basel) 2021 May 10;21(9). Epub 2021 May 10.

School of Electrical Engineering and Computer Science, Ohio University, Athens, OH 45701, USA.

To avoid serious diabetic complications, people with type 1 diabetes must keep their blood glucose levels (BGLs) as close to normal as possible. Insulin dosages and carbohydrate consumption are important considerations in managing BGLs. Since the 1960s, models have been developed to forecast blood glucose levels based on the history of BGLs, insulin dosages, carbohydrate intake, and other physiological and lifestyle factors. Read More

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A pathway phenotype linking metabolic, immune, oxidative, and opioid pathways with comorbid depression, atherosclerosis, and unstable angina.

CNS Spectr 2021 May 27:1-15. Epub 2021 May 27.

Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Background: There is strong comorbidity between atherosclerosis (ATS) and depression which is attributed to increased atherogenicity, insulin resistance (IR), and immune and oxidative stress.

Aim Of The Study: To examine the role of the above pathways and mu-opioid receptor (MOR), β-endorphin levels, zinc, copper, vitamin D3, calcium, and magnesium in depression due to ATS/unstable angina (UA).

Methods: Biomarkers were assayed in 58 controls and 120 ATS patients divided into those with moderate and severe depression according to the Beck Depression Inventory-II (BDI-II) scores >19 and >29, respectively. Read More

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The accuracy and precision of insulin administration using human and veterinary pen-injectors and syringes for administration of insulin.

J Vet Intern Med 2021 May 15;35(3):1255-1264. Epub 2021 May 15.

Department of Veterinary Medical Sciences, University of Bologna, Ozzano dell'Emilia, Italy.

Background: Many diabetic dogs and cats require small doses of insulin that must be administered accurately.

Objectives: To compare the accuracy and precision of insulin syringes and pen-injectors.

Animals: None. Read More

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Diabetes: Device Therapy.

FP Essent 2021 May;504:28-33

University of Central Florida College of Medicine, 6850 Lake Nona Blvd, Orlando, FL 32827.

Insulin pumps, continuous glucose monitors (CGMs), and hybrid closed-loop insulin pumps with CGMs are available for the management of type 1 diabetes in patients of all ages and type 2 diabetes in patients treated with multiple daily injections of insulin. These devices have numerous benefits for patients, including improved diabetes control, fewer hypoglycemia and diabetic ketoacidosis events, and improved quality of life. Currently, there are seven insulin pumps on the US market, five CGMs, and four closed-loop systems. Read More

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Diabetes: Type 1 Diabetes.

FP Essent 2021 May;504:11-15

University of Texas at Austin Dell Medical School Department of Population Health, 1601 Trinity St. Bldg. B Stop Z0500, Austin, TX 78712.

Type 1 diabetes is defined as a state of hyperglycemia due to insulin deficiency caused by autoimmune pancreatic beta-cell destruction. The risk among individuals in the general population has been estimated at 0.5%. Read More

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Saffron improves life and sleep quality, glycaemic status, lipid profile and liver function in diabetic patients: A double-blind, placebo-controlled, randomised clinical trial.

Int J Clin Pract 2021 Aug 26;75(8):e14334. Epub 2021 May 26.

Nutrition Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Type 2 diabetes (T2D) is a metabolic disorder that is related to hyperglycaemia, hyperlipidaemia and liver dysfunction and has detrimental effects on a patient's mental health. Hence, the current study investigated the effects of saffron supplementation on dietary intake, anthropometric measures, mood, sleep quality and metabolic biomarkers in overweight/obese patients with T2D.

Methods: In a double-blind, randomised controlled trial, 70 overweight/obese patients with T2D were randomly allocated to two groups and received 100 mg/day saffron or placebo for 8 weeks. Read More

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Position statement: The need for EU legislation to require disclosure and labelling of the composition of medical devices.

J Eur Acad Dermatol Venereol 2021 Jul 6;35(7):1444-1448. Epub 2021 May 6.

Contact Allergy Unit, Department of Dermatology, University Hospital KU Leuven, Leuven, Belgium.

Background: In recent years, skin reactions secondary to the use of medical devices (MD), such as allergic contact dermatitis have increasingly been observed (e.g. to continuous blood sugar monitoring systems, insulin pumps, wound dressings, medical gloves, etc. Read More

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Cellular Response to Individual Components of the Platelet Concentrate.

Int J Mol Sci 2021 Apr 26;22(9). Epub 2021 Apr 26.

Department of Tissue Engineering, Institute of Experimental Medicine, The Czech Academy of Sciences, Videnska 1083, 142 20 Prague, Czech Republic.

Platelet concentrates and especially their further product platelet lysate, are widely used as a replacement for cell culturing. Platelets contain a broad spectrum of growth factors and bioactive molecules that affect cellular fate. However, the cellular response to individual components of the human platelet concentrate is still unclear. Read More

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In Situ LSPR Sensing of Secreted Insulin in Organ-on-Chip.

Biosensors (Basel) 2021 Apr 28;11(5). Epub 2021 Apr 28.

Biosensors for Bioengineering Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology (BIST), Baldiri I Reixac, 10-12, 08028 Barcelona, Spain.

Organ-on-a-chip (OOC) devices offer new approaches for metabolic disease modeling and drug discovery by providing biologically relevant models of tissues and organs in vitro with a high degree of control over experimental variables for high-content screening applications. Yet, to fully exploit the potential of these platforms, there is a need to interface them with integrated non-labeled sensing modules, capable of monitoring, in situ, their biochemical response to external stimuli, such as stress or drugs. In order to meet this need, we aim here to develop an integrated technology based on coupling a localized surface plasmon resonance (LSPR) sensing module to an OOC device to monitor the insulin in situ secretion in pancreatic islets, a key physiological event that is usually perturbed in metabolic diseases such as type 2 diabetes (T2D). Read More

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Activation of Insulin Signaling by Botanical Products.

Int J Mol Sci 2021 Apr 18;22(8). Epub 2021 Apr 18.

Department of Molecular Cell Biology, Rehovot and Faculty of Life Sciences, Weizmann Institute of Science, Bar-Ilan University, Ramat-Gan 5290002, Israel.

Type 2 diabetes (T2D) is a worldwide health problem, ranked as one of the leading causes for severe morbidity and premature mortality in modern society. Management of blood glucose is of major importance in order to limit the severe outcomes of the disease. However, despite the impressive success in the development of new antidiabetic drugs, almost no progress has been achieved with regard to the development of novel insulin-sensitizing agents. Read More

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Clinical and radiographic variables related to implants with simultaneous grafts among type 2 diabetic patients treated with different hypoglycemic medications: a retrospective study.

BMC Oral Health 2021 04 27;21(1):214. Epub 2021 Apr 27.

State key Laboratory of military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi Engineering Research Center for Dental Materials and Advanced Manufacture, Department of Oral Implants, School of Stomatology, The Fourth Military Medical University, Xi'an, 710032, Shaanxi, China.

Background: The influence of different hypoglycemic agents on peri-implant variables among type 2 diabetes mellitus patients is still unclear. Therefore, the aim of this study was to assess the radiographic marginal bone loss and clinical parameters around implants in patients using different hypoglycemic agents.

Methods: In this retrospective cohort study, the dental implant records of type 2 diabetes mellitus patients who met the inclusion criteria were collected. Read More

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Application of Nano-Insulin Pump in Children with Diabetic Ketoacidosis.

J Nanosci Nanotechnol 2021 10;21(10):5051-5056

Department of Pediatrics, The First Affiliated Hospital of Jiamusi University, Jiamusi 154000, Heilongjiang, PR China.

Type 1 diabetes is an insulin-dependent type of diabetes that is most common among children. Due to absolute deficiency of insulin in patients, diabetic ketoacidosis (DKA) can easily ensue. Insulin pump can simulate the physiological secretion of islet, but increases the risk of pain and infection in children due to its traumatic effect. Read More

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October 2021

Fast-acting insulin aspart (Fiasp®) improves glycemic outcomes when used with MiniMed 670G hybrid closed-loop system in simulated trials compared to NovoLog®.

Comput Methods Programs Biomed 2021 Jun 8;205:106087. Epub 2021 Apr 8.

Medtronic Diabetes, United States.

Introduction: Medtronic has developed a virtual patient simulator for modeling and predicting insulin therapy outcomes for people with type 1 diabetes (T1D). An enhanced simulator was created to estimate outcomes when using the MiniMed 670G system with standard NovoLog® (EU: NovoRapid, US: NovoLog) versus Fiasp ® by using clinical data.

Methods: Sixty-seven participants' PK profiles were generated per type of insulin (Total of 134 PK profiles). Read More

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Islet-on-a-chip: Biomimetic micropillar-based microfluidic system for three-dimensional pancreatic islet cell culture.

Biosens Bioelectron 2021 Jul 2;183:113215. Epub 2021 Apr 2.

Medical Biotechnology, Faculty of Chemistry, Warsaw University of Technology, Poland. Electronic address:

Type 2 diabetes is currently one of the most common metabolic diseases, affecting all ages worldwide. As the incidence of type 2 diabetes increases, a growing number of studies focus on islets of Langerhans. A three-dimensional research model that maps islet morphology and maintains hormonal balance in vivo is still needed. Read More

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Real-world outcomes with different technology modalities in type 1 diabetes.

Nutr Metab Cardiovasc Dis 2021 06 3;31(6):1845-1850. Epub 2021 Mar 3.

Endocrinology and Nutrition Department. Badajoz University Hospital, Badajoz, Spain.

Background And Aims: Several treatment modalities are available for type 1 diabetes (T1D), including continuous glucose monitoring (CGM) and flash glucose monitoring (FGM) with MDI, sensor-augmented pumps with predictive low-glucose suspend function (SAP-PLGS) and hybrid closed-loop systems (HCL). The aim of the study was to evaluate the real-world benefits obtained with these treatment modalities.

Methods And Results: A cross-sectional study was performed, selecting 4 groups of T1D subjects, regarding their treatment modalities, paired by age, sex and diabetes duration. Read More

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The effect of insulin pump combined with ulinastatin on the levels of PCT, TG, PTX-3, and CX3CL1 in patients with diabetic ketoacidosis and pancreatitis.

Medicine (Baltimore) 2021 Apr;100(14):e25141

Department of Rheumatology and Immunology, Tangshan Worker Hospital, Tangshan, China.

Abstract: The aim of this research is to observe the effect of insulin pump combined with Ulinastatin on the levels of procalcitonin (PCT), triglycerides (TG), pentraxin-3(PTX-3), and C-X3-C motif chemokine ligand 1 (CX3CL1) in patients with diabetic ketoacidosis and pancreatitis.A total of 72 patients with diabetic ketoacidosis and pancreatitis who were admitted to our hospital from February 2016 to February 2020 were selected as the research subjects. They were divided into study groups (36 cases, given insulin pump combined Ulinastatin treatment) and control group (36 cases, given insulin pump treatment). Read More

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Fertility-Sparing Treatment for Atypical Endometrial Hyperplasia and Endometrial Cancer: A Cochrane Systematic Review Protocol.

Adv Ther 2021 05 8;38(5):2717-2731. Epub 2021 Apr 8.

Gynecology Department, Hospital El Pilar, Barcelona, Spain.

Introduction: Endometrial cancer is the fifth most common cancer in women and atypical endometrial hyperplasia is a precancerous lesion. Obesity is an important risk factor for endometrioid endometrial adenocarcinoma and endometrial hyperplasia. Progesterone is recommended as first-line treatment in endometrial cancer or atypical endometrial hyperplasia in women who wish to preserve fertility, but optimal treatment schedules have not been defined. Read More

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[Type 1 diabetes: an update].

Internist (Berl) 2021 Jun 7;62(6):627-637. Epub 2021 Apr 7.

Klinik für Diabetes und Stoffwechselerkrankungen, Klinikum Karlsburg, Karlsburg, Deutschland.

The incidence of type 1 diabetes (T1D) has been rising steadily over the last 30 years, especially among children and adolescents, with the result that the number of cases in this age group doubles every 20 years. The development of T1D goes through three stages, which can vary in duration from individual to individual. Late diagnosis or incorrect interpretation of the symptoms leads to the life-threatening diabetic ketoacidosis, from which every third child in Germany suffers at the manifestation of T1D. Read More

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An immune regulatory 3D-printed alginate-pectin construct for immunoisolation of insulin producing β-cells.

Mater Sci Eng C Mater Biol Appl 2021 Apr 5;123:112009. Epub 2021 Mar 5.

Department of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, EA 11, 9713 GZ Groningen, the Netherlands.

Different bioinks have been used to produce cell-laden alginate-based hydrogel constructs for cell replacement therapy but some of these approaches suffer from issues with print quality, long-term mechanical instability, and bioincompatibility. In this study, new alginate-based bioinks were developed to produce cell-laden grid-shaped hydrogel constructs with stable integrity and immunomodulating capacity. Integrity and printability were improved by including the co-block-polymer Pluronic F127 in alginate solutions. Read More

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, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet-A Pilot Study on Pediatric T1DM in Qatar.

Nutrients 2021 Mar 4;13(3). Epub 2021 Mar 4.

Research Department, Sidra Medicine, Doha P.O. Box 26999, Qatar.

In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome's relation to the continuous subcutaneous insulin infusion (CSII) therapy, dietary habits, and the HbA1c level in the pediatric T1DM subjects in Qatar. We recruited 28 T1DM subjects with an average age of 10. Read More

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