3,528 results match your criteria invasive migratory

Association between the expression of core 3 synthase and survival outcomes of patients with cholangiocarcinoma.

Oncol Lett 2021 Nov 3;22(5):760. Epub 2021 Sep 3.

Graduate School of Comprehensive Human Sciences, Major in Medical Sciences, Clinical Sciences Program, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.

Cholangiocarcinoma (CCA) is a highly aggressive and metastatic type of malignant carcinoma that is associated with high mortality rates and is difficult to detect at early stages. Core 3 structure is a mucin-type -glycans synthesized by β1,3--acetylglucosaminyltransferase 6 (core 3 synthase), which plays an important role in the digestive system, in particular gastrointestinal goblet cells. It has been reported that core 3 synthase-expressing cells show lower migratory and invasive rates, and lower metastatic activity. Read More

View Article and Full-Text PDF
November 2021

Expression of oncogenic long noncoding RNA PSMG3-antisense 1 in lung squamous cell carcinoma.

Oncol Lett 2021 Nov 27;22(5):751. Epub 2021 Aug 27.

Department of Interventional Oncology, The Fourth People's Hospital of Shenyang, Shenyang, Liaoning 110031, P.R. China.

Lung squamous cell carcinoma (LUSC) is one of the most common subtypes of lung cancer that accounts for ~50% of all lung cancer cases. Long noncoding RNA (lncRNA) PSMG3-antisense (AS) 1 has been suggested to play an important role in various types of cancer. Therefore, the aim of the present study was to investigate the role of PSMG3-AS1 using clinical specimens and data from 130 patients with LUSC. Read More

View Article and Full-Text PDF
November 2021

The role of transforming growth factor β in upper gastrointestinal cancers: A systematic review.

Cancer Treat Rev 2021 Sep 2;100:102285. Epub 2021 Sep 2.

Department of Medical Oncology, Cancer Center Amsterdam, Amsterdam University Medical Centers, University of Amsterdam, De Boelelaan 1117-1118, 1081 HV Amsterdam, The Netherlands.

Esophageal and gastric malignancies are associated with poor prognosis, in part due to development of recurrences or metastases after curative treatment. The transforming growth factor β (TGF-β) pathway might play a role in the development of treatment resistance. In this systematic review, we provide an overview of preclinical studies investigating the role of TGF-β in esophageal and gastric malignancies. Read More

View Article and Full-Text PDF
September 2021

Polybrominated diphenyl ethers BDE-47 and BDE-99 modulate murine melanoma cell phenotype in vitro.

Environ Sci Pollut Res Int 2021 Sep 17. Epub 2021 Sep 17.

Departamento de Biologia Celular, Universidade Federal do Paraná, PO Box: 19031, CEP, Curitiba, PR, 81531-980, Brazil.

Cancer is one of the leading causes of mortality worldwide. Even with the advances of pharmaceutical industry and treatments, the mortality rate for various types of cancer remains high. In particular, phenotypic alterations of tumor cells concerning drug efflux, migratory and invasive capabilities may represent a hurdle for cancer treatment and contribute to poor prognosis. Read More

View Article and Full-Text PDF
September 2021

hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma.

Ann Transl Med 2021 Aug;9(15):1242

Department of Orthopaedics, General Hospital of Chinese People's Liberation Army, Beijing, China.

Background: Osteosarcoma (OS) is considered to be the most highly prevalent bone tumor. In the progression of different human cancers, the role of circular RNAs (circRNAs) has been extensively studied. Microarray analysis has indicated that hsa_circ_0000006 expression was lower in OS, but the mechanism of hsa_circ_0000006 in regulating the progression of OS remains elusive. Read More

View Article and Full-Text PDF

SRGN-Triggered Aggressive and Immunosuppressive Phenotype in a Subset of TTF-1-Negative Lung Adenocarcinomas.

J Natl Cancer Inst 2021 Sep 15. Epub 2021 Sep 15.

Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan.

Background: About 20% of lung adenocarcinoma (LUAD) is negative for the lineage-specific oncogene Thyroid transcription factor 1 (TTF-1) and exhibits worse clinical outcome with a low frequency of actionable genomic alterations. To identify molecular features associated with TTF-1-negative LUAD, we compared the transcriptomic and proteomic profiles of LUAD cell lines. SRGN, a chondroitin sulfate proteoglycan Serglycin, was identified as a markedly overexpressed gene in TTF-1-negative LUAD. Read More

View Article and Full-Text PDF
September 2021

Inhibition of BRD4 Suppresses the Growth of Esophageal Squamous Cell Carcinoma.

Cancer Invest 2021 Sep 14:1-16. Epub 2021 Sep 14.

Department of Tumor Biological Treatment, The Third Affiliated Hospital of Soochow University, Changzhou, China.

Background: Bromodomain-containing protein 4 (BRD4) binds acetylated lysine residues on histones to facilitate the epigenetic regulation of many genes, and it plays a key role in many cancer types. Despite many prior reports that have explored the importance of BRD4 in oncogenesis and the regulation of epigenetic memory, its role in esophageal squamous cell carcinoma (ESCC) progression is poorly understood. Here, we investigated expression in human ESCC tissues to understand how it regulates the biology of these tumor cells. Read More

View Article and Full-Text PDF
September 2021

miR-146a-5p-mediated suppression on trophoblast cell progression and epithelial-mesenchymal transition in preeclampsia.

Biol Res 2021 Sep 13;54(1):30. Epub 2021 Sep 13.

Department of Gynecology and Obstetrics, the First People's Hospital of Yichang, Yichang, 443000, Hubei, People's Republic of China.

Objective: This study aims to identify the effect of miR-146a-5p on trophoblast cell invasion as well as the mechanism in preeclampsia (PE).

Methods: Expression levels of miR-146a-5p and Wnt2 in preeclamptic and normal placentae were quantified. Trophoblast cells (HTR-8) were separately transfected with miR-146a-5p mimic, miR-146a-5p inhibitor, pcDNA3. Read More

View Article and Full-Text PDF
September 2021

Combination of curcumin with N-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/β-catenin signaling.

Phytomedicine 2021 Oct 14;91:153706. Epub 2021 Aug 14.

Department of Pharmacology, Shantou University Medical College, No. 22 Xinling Road, Shantou 515041, Guangdong, China. Electronic address:

Background: Hepatocellular carcinoma (HCC) is one of the most common cause of cancer-related death worldwide. Curcumin (C) has been extensively investigated in different types of malignancies, including hepatocellular carcinoma, but its physicochemical properties have significantly influenced its clinical use. Several approaches are being explored to enhance curcumin's therapeutic response, including its combination with various drugs. Read More

View Article and Full-Text PDF
October 2021

miR-519d downregulates LEP expression to inhibit preeclampsia development.

Open Med (Wars) 2021 25;16(1):1215-1227. Epub 2021 Aug 25.

Obstetrics and Gynecology Department, Ningbo Women & Children's Hospital, No. 339, Liuting Road, Ningbo 315000, Zhejiang Province, People's Republic of China.

The purpose of the current study was to characterize role of microRNA (miR)-519d in trophoblast cells and preeclampsia (PE) development and its potential underlying mechanism. Regulation of leptin (LEP) by miR-519d was verified using a dual-luciferase reporter gene assay. Loss- and gain-of-function assays were conducted to detect the roles of miR-519d and LEP in proliferation, migratory ability, and invasive capacity of HTR-8/SVneo cells by means of CCK-8 assay, scratch test, and Transwell invasion assay, respectively. Read More

View Article and Full-Text PDF

Spheroid-on-chip microfluidic technology for the evaluation of the impact of continuous flow on metastatic potential in cancer models .

Biomicrofluidics 2021 Jul 27;15(4):044103. Epub 2021 Aug 27.

Hypoxia and Tumour Microenvironment Lab, Department of Biomedical Sciences, University of Hull, Cottingham Road, Hull HU6 7RX, United Kingdom.

The majority of cancer deaths are linked to tumor spread, or metastasis, but 3D metastasis models relevant to the tumor microenvironment (including interstitial fluid flow) remain an area of unmet need. Microfluidics allows us to introduce controlled flow to an cancer model to better understand the relationship between flow and metastasis. Here, we report new hybrid spheroid-on-chip models for the impact of interstitial fluid flow on cancer spread. Read More

View Article and Full-Text PDF

Suppression of circ_0008932 inhibits tumor growth and metastasis in osteosarcoma by targeting miR-145-5p.

Exp Ther Med 2021 Oct 3;22(4):1106. Epub 2021 Aug 3.

Department of Radiation Oncology, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing 400030, P.R. China.

Osteosarcoma (OS) is a common type of primary malignant tumor. Although the pathogenesis of OS has been extensively studied, the underlying molecular mechanisms have remained to be fully elucidated. Accumulating evidence has revealed that dysregulation of various circular RNAs (circRNAs) is associated with tumorigenesis and recent studies have indicated that circRNA circ_0008932 is aberrantly expressed in tumors. Read More

View Article and Full-Text PDF
October 2021

Anti-tumor effects of vitamin D in glioblastoma: mechanism and therapeutic implications.

Lab Invest 2021 Sep 9. Epub 2021 Sep 9.

Department of Surgery, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, Hong Kong.

Glioma is the most prevalent primary brain tumor in adults among which glioblastoma is the most malignant and lethal subtype. Its common resistance to conventional chemotherapeutics calls for the development of alternative or concomitant treatment. Taking advantage of its endocrine function as a neurosteroid, vitamin D has become a target of interest to be used in conjunction with different chemotherapies. Read More

View Article and Full-Text PDF
September 2021

Downregulation of miR-519d-3p is Associated with Poor Outcomes and Facilitates Tumor Progression in Papillary Thyroid Cancer by Regulating FOXQ1.

Horm Metab Res 2021 Sep 8;53(9):625-632. Epub 2021 Sep 8.

Department of General Surgery, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.

MicroRNA-519d-3p (miR-519d-3p) has emerged as a tumor suppressor in several human cancers. But whether miR-519d-3p is involved in papillary thyroid cancer (PTC) remains elusive. In this study, we investigated the potential relevance of miR-miR-519d-3p in PTC. Read More

View Article and Full-Text PDF
September 2021

A highly invasive malaria parasite has expanded its range to non-migratory birds in North America.

Biol Lett 2021 09 8;17(9):20210271. Epub 2021 Sep 8.

Department of Ecology and Evolutionary Biology, University of Colorado, Boulder, CO 80309, USA.

Parasite range expansions are a direct consequence of globalization and are an increasing threat to biodiversity. Here, we report a recent range expansion of the SGS1 strain of a highly invasive parasite, , to two non-migratory passerines in North America is considered one of the world's most invasive parasites and causes the disease avian malaria: this is the first reported case of SGS1 in wild non-migratory birds on the continent. Using a long-term database where researchers report avian malaria parasite infections, we summarized our current understanding of the geographical range of SGS1 and its known hosts. Read More

View Article and Full-Text PDF
September 2021

Taxifolin suppresses the malignant progression of gastric cancer by regulating the AhR/CYP1A1 signaling pathway.

Int J Mol Med 2021 Nov 7;48(5). Epub 2021 Sep 7.

Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

The development of novel approaches for the treatment of gastric cancer is of utmost importance. Taxifolin (Tax) has been reported to possess biological activities against a number of types of cancer. The objective of the present study was to examine the effects of Tax on gastric cancer and to explore its potential mechanisms of action. Read More

View Article and Full-Text PDF
November 2021

Epigenetic Inactivation of Acetyl-CoA Acetyltransferase 1 Promotes the Proliferation and Metastasis in Nasopharyngeal Carcinoma by Blocking Ketogenesis.

Front Oncol 2021 16;11:667673. Epub 2021 Aug 16.

Life Science Institute, Guangxi Medical University, Nanning, China.

The dysregulation of epigenetic modification and energy metabolism cooperatively contribute to the tumorigenesis of nasopharyngeal carcinoma (NPC). However, the detailed mechanisms underlying their joint contribution to NPC development and progression remain unclear. Here, we investigate the role of Acy1 Coenzyme A Acyltransferases1 (ACAT1), a key enzyme in the metabolic pathway of ketone bodies, in the proliferation and metastasis of NPC and to elucidate the underlying molecular mechanisms. Read More

View Article and Full-Text PDF

Quantitative proteomic analysis of the effects of dietary deprivation of methionine and cystine on A549 xenograft and A549 xenograft-bearing mouse.

Proteomics 2021 Sep 5:e2100007. Epub 2021 Sep 5.

Shanghai Key Laboratory of Molecular Imaging. Shanghai University of Medicine & Health Sciences, Shanghai, 201318, China.

Methionine (Met) and cystine (CySS) are key sulfur donors in cell metabolism and are important nutrients for sustaining tumor growth; however, the molecular effects associated with their deprivation remain to be characterized. Here, we devised a xenograft mouse model to assess the impact of their deprivation on A549 xenografts and the xenograft-bearing animal. Results show that Met and CySS deprivation inhibits A549 growth in vitro, not in vivo. Read More

View Article and Full-Text PDF
September 2021

Antineoplastic activity of products derived from cellulose-containing materials: levoglucosenone and structurally-related derivatives as new alternatives for breast cancer treatment.

Invest New Drugs 2021 Sep 3. Epub 2021 Sep 3.

Área Investigación, Instituto de Oncología Ángel H. Roffo, Universidad de Buenos Aires, Av. San Martín 5481, C1417DTB, Buenos Aires, Argentina.

Breast cancer is the leading cause of cancer death among women worldwide. For this reason, the development of new therapies is still essential. In this work we have analyzed the antitumor potential of levoglucosenone, a chiral building block derived from the pyrolysis of cellulose-containing materials such as soybean hulls, and three structurally related analogues. Read More

View Article and Full-Text PDF
September 2021

Eugenol modulates genomic methylation and inactivates breast cancer-associated fibroblasts through E2F1-dependent downregulation of DNMT1/DNMT3A.

Mol Carcinog 2021 Sep 2. Epub 2021 Sep 2.

Department of Molecular Oncology, King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.

Active cancer-associated fibroblasts (CAFs) are major components of the tumor microenvironment, which promote carcinogenesis and modulate response to therapy. Therefore, targeting these cells or reducing their paracrine pro-carcinogenic effects could be of great therapeutic value. To this end, we sought to investigate the effect of eugenol, a natural phenolic molecule, on active breast CAFs. Read More

View Article and Full-Text PDF
September 2021

Loss of miR-1469 expression mediates melanoma cell migration and invasion.

PLoS One 2021 1;16(9):e0256629. Epub 2021 Sep 1.

The Arthur G. James Cancer Hospital and Solove Research Institute, The Ohio State University, Columbus, Ohio, United States of America.

Tumor ulceration is considered one of the most prognostically significant findings in primary cutaneous melanoma, associated with decreased disease-free and overall survival. However, the unique features associated with ulcerated melanoma that contribute to a poor prognosis in affected patients remain poorly defined. microRNAs are small, non-coding RNAs that function to inhibit expression of specific gene targets, therefore altering the functions of cells in which they are expressed. Read More

View Article and Full-Text PDF
September 2021

Alantolactone exhibits antiproliferative and apoptosis-promoting properties in colon cancer model via activation of the MAPK-JNK/c-Jun signaling pathway.

Mol Cell Biochem 2021 Aug 30. Epub 2021 Aug 30.

The MOE key Laboratory of Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, and the SATCM key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai, 201203, China.

Colorectal cancer (CRC) is one of the most common human malignancies in the digestive tract with high mortality. Alantolactone (ATL), as a plant-derived sesquiterpene lactone, has shown a variety of pharmacological activities, such as antibacterial, anti-inflammatory, anti-virus and so on. However, the exact molecular mechanism of ATL in colorectal cancer remains largely unknown. Read More

View Article and Full-Text PDF

FHOD1 is upregulated in gastric cancer and promotes the proliferation and invasion of gastric cancer cells.

Oncol Lett 2021 Oct 5;22(4):712. Epub 2021 Aug 5.

Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China.

Gastric cancer (GC) is one of the main causes of cancer-associated morbidity and mortality worldwide. The present study aimed to investigate the role of the gene encoding formin homology 2 domain containing 1 (FHOD1) protein in GC development. Data from The Cancer Genome Atlas were firstly analyzed, and immunohistochemistry was conducted on GC tissues. Read More

View Article and Full-Text PDF
October 2021

Potential function of oxymatrine as a novel suppressor of epithelial-to-mesenchymal transition in lung tumor cells.

Life Sci 2021 Aug 26;284:119893. Epub 2021 Aug 26.

Department of Science in Korean Medicine, Kyung Hee University, 24 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea. Electronic address:

Aims: Tumor cells metastasis as well as proliferation are important factors that can substantially determines the prognosis of cancer. In particular, epithelial-mesenchymal transition (EMT) is key phenomena which can cause tumor cell transition into other organs by promoting the disruption of the cell-cell junctions. Because oxymatrine (OMT) have been reported to attenuate the tumor growth, we investigated whether OMT can down-regulate EMT process in tumor cells. Read More

View Article and Full-Text PDF

MicroRNA-27b-3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP-13.

Oncol Lett 2021 Oct 10;22(4):729. Epub 2021 Aug 10.

Medical Cosmetology Department, University of Chinese Academy of Sciences, Shenzhen Hospital, Shenzhen, Guangdong 518000, P.R. China.

Cutaneous squamous cell carcinoma is a common malignant tumor. The aim of the present study was to examine the biological function of microRNA (miR)-27b-3p in cutaneous squamous cell carcinoma (CSCC) and its underlying mechanism. The relative expression levels of miR-27b-3p were determined in A-431, Colo-16 and NHEK/SVTERT3-5 cell lines. Read More

View Article and Full-Text PDF
October 2021

GATA6-AS1 inhibits ovarian cancer cell proliferation and migratory and invasive abilities by sponging miR-19a-5p and upregulating TET2.

Oncol Lett 2021 Oct 9;22(4):718. Epub 2021 Aug 9.

Department of Obstetrics, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China.

GATA6 antisense RNA 1 (GATA6-AS1) has been reported to be involved in the progression of several types of cancer. In the present study, the role of GATA6-AS1 in ovarian cancer (OC) was explored. Reverse transcription quantitative PCR was used to detect the expression of GATA6-AS1, microRNA (miR)-19a-5p and tet methylcytosine dioxygenase 2 (TET2) in OC and adjacent normal tissues. Read More

View Article and Full-Text PDF
October 2021

OIP5-AS1 contributes to the development in endometrial carcinoma cells by targeting miR-152-3p to up-regulate SLC7A5.

Cancer Cell Int 2021 Aug 21;21(1):440. Epub 2021 Aug 21.

Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong Univercity of Science and Technology, No. 2177 Liberation Avenue, Wuhan, 430022, China.

Background: Endometrial carcinoma (EC) is one common gynecological tumor, threatening physical and psychological health of females. Huge amount of essays indicated that long non-coding RNAs (lncRNAs) were widely reported to serve as a crucial regulator in the biological movements among multiple carcinomas, including EC.

Methods: RT-qPCR was implemented to detect the expression of target genes. Read More

View Article and Full-Text PDF

LncRNA MANCR positively affects the malignant progression of lung adenocarcinoma.

BMC Pulm Med 2021 Aug 21;21(1):272. Epub 2021 Aug 21.

Department of Medical Oncology, The Seventh Medical Center of PLA General Hospital, 5 Nanmencang, Dongcheng District, Beijing, 100700, China.

Background: LncRNA MANCR (mitosis-related lncRNA, LINC00704) is deemed as a pivotal regulator in various cancers, yet the biological function it performs in lung adenocarcinoma (LUAD) was rarely reported. We made an in-depth study to clarify its effect during the progression of this cancer.

Methods: Expression data and clinical information were first accessed from TCGA LUAD dataset ( https://portal. Read More

View Article and Full-Text PDF

Prognostic Value of miR-1826 in Prostate Cancer and Its Regulatory Effect on Tumor Progression.

Onco Targets Ther 2021 13;14:4467-4475. Epub 2021 Aug 13.

Department of Urology, Affiliated Hospital of Weifang Medical University, Weifang, 261031, Shandong, People's Republic of China.

Purpose: miRNAs can act as oncogenes or tumor suppressors and participate in the development and progression of tumors, thus affecting the prognosis and survival of cancer patients. In this paper, we mainly studied the role of miR-1826 in prostate cancer.

Patients And Methods: The expression of miR-1826 was studied by quantitative real-time PCR (qRT-PCR). Read More

View Article and Full-Text PDF

Prioritizing native migratory fish passage restoration while limiting the spread of invasive species: A case study in the Upper Mississippi River.

Sci Total Environ 2021 Oct 8;791:148317. Epub 2021 Jun 8.

Department of Fisheries and Wildlife, Michigan State University, USA.

Despite increasing efforts globally to remove dams and construct fish passage structures, broad-scale analyses balancing tradeoffs between cost and habitat gains from these mitigations infrequently consider invasive species. We present an optimization-based approach for prioritizing dam mitigations to restore habitat connectivity for native fish species, while limiting invasive species spread. Our methodology is tested with a case study involving 240 dams in the Upper Mississippi River, USA. Read More

View Article and Full-Text PDF
October 2021