2,378 results match your criteria invasive foci

The Usefulness of Spectral Mammography in Surgical Planning of Breast Cancer Treatment-Analysis of 999 Patients with Primary Operable Breast Cancer.

Curr Oncol 2021 Jul 12;28(4):2548-2559. Epub 2021 Jul 12.

Department of Oncology and Radiotherapy, Prof. Kornel Gibiński Independent Public Central Clinical Hospital, Medical University of Silesia, 40-514 Katowice, Poland.

Contrast-enhanced spectral mammography (CESM) is a promising, digital breast imaging method for planning surgeries. The study aimed at comparing digital mammography (MG) with CESM as predictive factors in visualizing multifocal-multicentric cancers (MFMCC) before determining the surgery extent. We analyzed 999 patients after breast cancer surgery to compare MG and CESM in terms of detecting MFMCC. Read More

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Panton-valentine leukocidin Staphylococcus aureus severe infection in an infant: a case report and a review of the literature.

Ital J Pediatr 2021 Jul 17;47(1):158. Epub 2021 Jul 17.

University of Milan, Milan, Italy.

Background: Panton-Valentine leukocidin (PVL) is one of the major virulence factor of Staphylococcus aureus (SA) that might be associated with invasive life-threating infections. A prompt diagnosis and adequate treatment are essential in achieving the best outcome and avoiding serious sequelae. We describe a case of severe invasive PVL-SA infection in an infant. Read More

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Adopting MR-guided stereotactic laser ablations for epileptic lesions: initial clinical experience and lessons learned.

Acta Neurochir (Wien) 2021 Jul 16. Epub 2021 Jul 16.

Functional Neurosurgery Unit, Department of Neurosurgery, Tel-Aviv Medical Center, Tel-Aviv, Israel.

Objective: MR-guided laser interstitial thermal therapy (MRgLITT) is a minimally invasive technique for ablating brain lesions under real-time MRI feedback and control of the ablation process. The Medtronic Visualase system was recently approved for use in Europe and Israel. We report our initial technical experience using the system in the first 16 cases in which the system was used to ablate focal epileptogenic lesions. Read More

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Intraductal Carcinoma of the Prostate: Extreme Nuclear Size Is Not a Diagnostic Parameter.

Am J Surg Pathol 2021 Jul 15. Epub 2021 Jul 15.

Aquesta Uropathology Department of Pathology, University of Queensland School of Medicine Wesley Hospital, Brisbane, QLD, Australia Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand Department of Oncology-Pathology, Karolinska Institute, Stockholm, Sweden.

High-grade prostatic adenocarcinoma involving duct/acinar structures is labeled intraductal carcinoma of the prostate (IDCP). As numerous studies have shown that IDCP is associated with high stage disease with a significant negative impact on cancer-specific survival, accurate diagnosis is crucial to ensure appropriate patient management. The definition of IDCP recommended by 2016 World Health Organization (WHO) classification suggests that cases of IDCP with micropapillary or loose cribriform architecture without comedonecrosis should have cells with ≥6× nuclear enlargement. Read More

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Cell-Free DNA Detection of Tumor Mutations in Heterogeneous, Localized Prostate Cancer Via Targeted, Multiregion Sequencing.

JCO Precis Oncol 2021 27;5. Epub 2021 Apr 27.

Department of Epidemiology and Biostatistics, University of California, San Francisco, CA.

Cell-free DNA (cfDNA) may allow for minimally invasive identification of biologically relevant genomic alterations and genetically distinct tumor subclones. Although existing biomarkers may detect localized prostate cancer, additional strategies interrogating genomic heterogeneity are necessary for identifying and monitoring aggressive disease. In this study, we aimed to evaluate whether circulating tumor DNA can detect genomic alterations present in multiple regions of localized prostate tumor tissue. Read More

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Simultaneous primary invasive breast carcinoma and ipsilateral cutaneous melanoma of the back: Surgical approach and considerations, a case report.

Int J Surg Case Rep 2021 Jul 29;84:106155. Epub 2021 Jun 29.

Department of Surgical Oncology, Rutgers Cancer Institute of New Jersey, 195 Little Albany St, New Brunswick 08901, NJ, USA. Electronic address:

Introduction And Importance: A patient presented with ipsilateral, synchronous primary malignancies of left upper back melanoma and left breast invasive ductal carcinoma. This complex presentation was managed with a multidisciplinary approach.

Case Presentation: A 61-year-old female presented with multiple cutaneous lesions, revealed to be several foci of melanoma in situ as well as a T4b melanoma of the left upper back. Read More

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Periodontal and dental health in inflammatory bowel diseases: a systematic review.

Expert Rev Gastroenterol Hepatol 2021 Jul 19:1-15. Epub 2021 Jul 19.

Department of Gastroenterology, Amiens University Hospital, Picardie University, Amiens, France.

: An increased risk of dental caries and periodontal diseases has been reported for inflammatory bowel disease (IBD) patients and are challenging conditions to manage.: The authors searched international databases to find all studies assessing dental/periodontal outcomes in patients with IBD and other immune-mediated inflammatory disease (IMID), as well as the association between IMID medications and dental/periodontal status.: IBD are associated with a higher risk of both periodontitis and caries. Read More

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Pseudotumoral Endometriotic Nodule.

J Minim Invasive Gynecol 2021 Jul 2. Epub 2021 Jul 2.

Department of Obstetrics and Gynecology (Drs. Engels and Karampelas). Electronic address:

Study Objective: To demonstrate a rare case of a pediculated endometriotic nodule that was initially diagnosed as a solid adnexal mass.

Design: We present a stepwise narrated demonstration of our laparoscopic technique.

Setting: We present a case report of a patient aged 44 years, gravida 2 para 2, who was diagnosed with a solid (adnexal) mass during a gynecologic examination. Read More

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First case of an invasive Bacteroides dorei infection detected in a patient with a mycotic aortic aneurysm-raising a rebellion of major indigenous bacteria in humans: a case report and review.

BMC Infect Dis 2021 Jun 30;21(1):625. Epub 2021 Jun 30.

Department of Cardiovascular Surgery, Tohoku Medical and Pharmaceutical University, 1-12-1 Fukumuro, Miyagino Ward, Sendai, Miyagi, 983-8512, Japan.

Background: Bacteroides dorei is an anaerobic gram-negative bacterium first described in 2006. Because of the high similarity in mass spectra between B. dorei and Bacteroides vulgatus, discriminating between these species is arduous in clinical practice. Read More

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Laparoscopic Radical Hysterectomy Results in Higher Recurrence Rate Versus Open Abdominal Surgery for Stage IB1 Cervical Cancer Patients With Tumor Size Less Than 2 Centimeter: A Retrospective Propensity Score-Matched Study.

Front Oncol 2021 10;11:683231. Epub 2021 Jun 10.

Department of Gynecology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China.

Objective: To compare the oncologic outcomes between laparoscopic and open radical hysterectomy in patients with stage IB1 cervical cancer lesion less than 2 cm.

Methods: Patients diagnosed FIGO (2009) stage IB1 (tumor diameter <2 cm) and underwent radical hysterectomy in our hospital between March 2008 and November 2018 were studied. A propensity-matched comparison (1:2) was conducted to minimize selection biases. Read More

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[MR-guided laser interstitial thermal therapy in the treatment of brain tumours and epilepsy].

Ugeskr Laeger 2021 06;183(25)

MR-guided laser interstitial thermal therapy (LITT) is a minimally invasive neurosurgical procedure, which in the last decade has gained significant momentum of the treatment of intracranial tumours and epileptic foci. In brief, LITT utilises the heat from a stereotactically placed laser catheter to selectively ablate a lesion or a structure under real-time MRI guidance, which is summarised and discussed in this review. The first LITT system gained FDA approval in 2007 and was CE-marked in 2018. Read More

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Cytoproliferative activity in colorectal poorly differentiated clusters: Biological significance in tumor setting.

Ann Diagn Pathol 2021 Aug 16;53:151772. Epub 2021 Jun 16.

Department of Medical and Surgical Sciences for Children & Adults, Division of Pathology, University-Hospital of Modena and Reggio Emilia, Modena, Italy.

Background: Poorly differentiated clusters (PDCs) have gained a significant prognostic role in colorectal carcinomas (CRCs) being associated to high risk of lymph node metastasis, shorter survival time and poor prognosis. The knowledge in PDC biology is not completely clear.

Materials And Methods: We assessed Ki-67 LI in 45 CRCs showing ≥10 PDCs. Read More

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Invasive Group B Streptococcus Disease With Recurrence and in Multiples: Towards a Better Understanding of GBS Late-Onset Sepsis.

Front Immunol 2021 2;12:617925. Epub 2021 Jun 2.

Department of Neonatology, Vest Children's Hospital Datteln, University Witten-Herdecke, Witten-Herdecke, Germany.

Group B Streptococcus (GBS) is a common intestinal colonizer during the neonatal period, but also may cause late-onset sepsis or meningitis in up to 0.5% of otherwise healthy colonized infants after day 3 of life. Transmission routes and risk factors of this late-onset form of invasive GBS disease (iGBS) are not fully understood. Read More

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Gossypiboma - Successful retrieval through laparoscopy: A case report.

Int J Surg Case Rep 2021 Jul 10;84:106109. Epub 2021 Jun 10.

Department of General & Minimally Invasive Surgery, Atal Bihari Vajpayee Institute of Medical Sciences & Dr Ram Manohar Lohia Hospital, New Delhi, India.

Introduction: Numerous complications can occur after a surgery, but gossypiboma is undoubtedly the most unwanted and undesirable complication of a procedure for any surgeon with legal implications. Once suspected, the minimally invasive surgical approach should be considered for its management.

Presentation Of Case: An adult PLE female presented to the surgery OPD with a painless abdominal mass which progressively increased in size in the past 4 months. Read More

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Clinical information and management status of de novo stage IV breast cancer patients: a Chinese multicenter investigation (CSBrS-002).

Chin Med J (Engl) 2021 Jun 7;134(13):1569-1575. Epub 2021 Jun 7.

Department of Breast Surgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.

Background: Although de novo stage IV breast cancer is so far incurable, it has entered an era of individualized treatment and chronic disease management. Based on systemic treatment, whether the surgical resection of primary or metastatic foci of de novo stage IV breast cancer can bring survival benefits is currently controversial. We aimed to explore the clinicopathological factors and current status of the management of de novo stage IV breast cancer in China to provide a reference for clinical decisions. Read More

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Comparative Characterization of Lymphoid Infiltration in Different Molecular-Biological Subtypes of Invasive Breast Cancer.

Bull Exp Biol Med 2021 May 28;171(1):62-67. Epub 2021 May 28.

Research Institute of Human Morphology, Moscow, Russia.

The morphometric study examined the cell profile of lymphoid structures and leukocytic infiltrates in mammary glands of women with different molecular-biological subtypes of invasive breast cancer (BC). A high degree of lymphoid infiltration with the formation of lymphoid nodules was typical of luminal B (LumB) subtype of BC characterized by high tumor proliferation index (Ki-67≥30%) and in triple negative BC with Ki-67 ranging 33-35%. In these BC subtypes, extensive necrotic foci and pronounced stromal fibrosis of the mammary glands were observed. Read More

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Pagetoid involvement of bronchioles by metastatic breast carcinoma.

Pathologica 2021 Apr;113(2):121-125

Department of Pathology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ.

We report a case of a 36-year-old female with endobronchiolar spread of breast carcinoma in the lung. The patient had recently been diagnosed with invasive ductal breast carcinoma and imaging of the lungs revealed bilateral lung nodules. She then underwent a wedge resection of a lung nodule. Read More

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Overview of the molecular mechanisms of migration and invasion in glioblastoma multiforme.

J Chin Med Assoc 2021 07;84(7):669-677

Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.

Glioblastoma (GBM) is one of the most devastating cancers, with an approximate median survival of only 16 months. Although some new insights into the fantastic heterogeneity of this kind of brain tumor have been revealed in recent studies, all subclasses of GBM still demonstrate highly aggressive invasion properties to the surrounding parenchyma. This behavior has become the main obstruction to current curative therapies as invasive GBM cells migrate away from these foci after surgical therapies. Read More

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Prospective surveillance for invasive Staphylococcus aureus and group A Streptococcus infections in a setting with high community burden of scabies and impetigo.

Int J Infect Dis 2021 May 19;108:333-339. Epub 2021 May 19.

Tropical Diseases Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia; Melbourne Children's Global Health, Melbourne Children's Campus, The Royal Children's Hospital, Parkville, Victoria, Australia.

Background: Invasive Staphylococcus aureus (iSA) and group A Streptococcus (iGAS) impose significant health burdens globally. Both bacteria commonly cause skin and soft tissue infections (SSTIs), which can result in invasive disease. Understanding of the incidence of iSA and iGAS remains limited in settings with a high SSTI burden. Read More

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Clinical factors influencing the pregnancy outcome after laparoscopic treatment in endometriosis-associated infertility patients: a retrospective study.

Am J Transl Res 2021 15;13(4):2399-2409. Epub 2021 Apr 15.

Department of Reproductive Medicine Center of The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang, PR China.

Introduction: Endometriosis is an illness caused by the presence of foci of endometrial implants outside the uterine cavity. Laparoscopy (minimally invasive surgical method) is considered as the definitive treatment for Endometriosis.

Method: Clinical data from January 2014 till December 2018, between the ages of 20 and 40 years were collected. Read More

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Metastasis-suppressor NME1 controls the invasive switch of breast cancer by regulating MT1-MMP surface clearance.

Oncogene 2021 Jun 19;40(23):4019-4032. Epub 2021 May 19.

INSERM UMR_S 938, Saint-Antoine Research Center, CRSA, University Sorbonne, Paris, France.

Membrane Type 1 Matrix Metalloprotease (MT1-MMP) contributes to the invasive progression of breast cancers by degrading extracellular matrix tissues. Nucleoside diphosphate kinase, NME1/NM23-H1, has been identified as a metastasis suppressor; however, its contribution to local invasion in breast cancer is not known. Here, we report that NME1 is up-regulated in ductal carcinoma in situ (DCIS) as compared to normal breast epithelial tissues. Read More

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Hypothyroidism induces oxidative stress and DNA damage in breast.

Endocr Relat Cancer 2021 Jun 20;28(7):505-519. Epub 2021 Jun 20.

Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.

Breast cancer and thyroid dysfunctions have been associated for decades. Although many studies suggest a biological correlation, the mechanisms linking these two pathologies have not been elucidated. Reactive oxygen species (ROS) can oxidize lipids, proteins, and DNA molecules and may promote tumor initiation. Read More

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Localization of Epileptic Foci Based on Simultaneous EEG-fMRI Data.

Front Neurol 2021 27;12:645594. Epub 2021 Apr 27.

Control and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, College of Engineering, University of Tehran, Tehran, Iran.

Combining functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) enables a non-invasive investigation of the human brain function and evaluation of the correlation of these two important modalities of brain activity. This paper explores recent reports on using advanced simultaneous EEG-fMRI methods proposed to map the regions and networks involved in focal epileptic seizure generation. One of the applications of EEG and fMRI combination as a valuable clinical approach is the pre-surgical evaluation of patients with epilepsy to map and localize the precise brain regions associated with epileptiform activity. Read More

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Ultra-High-Frequency Ultrasound in the Evaluation of Paediatric Pilomatricoma Based on the Histopathologic Classification.

Front Med (Lausanne) 2021 26;8:673861. Epub 2021 Apr 26.

Institute of Biomedical Engineering, Chinese Academy of Medical Sciences, Tianjin, China.

Pilomatricoma (PM) is one of the most common benign tumours in children. However, the inaccuracy of preoperative diagnosis and evaluation is high. Non-invasive examinations, including dermoscopy and ultrasound are helpful for diagnosing and evaluating PM. Read More

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Clinical Relevance of Mesenchymal- and Stem-Associated Phenotypes in Circulating Tumor Cells Isolated from Lung Cancer Patients.

Cancers (Basel) 2021 Apr 29;13(9). Epub 2021 Apr 29.

Division of Genetics, Cell and Developmental Biology, Department of Biology, University of Patras, 26504 Patras, Greece.

Lung cancer is the leading cause of cancer-related mortality globally. Among the types of lung cancer, non-small-cell lung cancer (NSCLC) is more common, while small-cell lung cancer (SCLC) is less frequent yet more aggressive. Circulating tumor cells (CTCs), albeit rare, have been portrayed as essential players in the progression of lung cancer. Read More

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Breast MRI for Evaluation of Response to Neoadjuvant Therapy.

Radiographics 2021 May-Jun;41(3):665-679

From the Department of Radiology (B.R., A.A.L., L.H., H.K.T., S.L.H., Y.G., L.M.), Bernard and Irene Schwartz Center for Biomedical Imaging, Department of Radiology (L.M.), and Center for Advanced Imaging Innovation and Research (CAI2R) (L.M.), New York University Grossman School of Medicine, 160 E 34th St, New York, NY 10016; and Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Mass (L.D.).

Neoadjuvant therapy is increasingly being used to treat early-stage triple-negative and human epidermal growth factor 2-overexpressing breast cancers, as well as locally advanced and inflammatory breast cancers. The rationales for neoadjuvant therapy are to shrink tumor size and potentially decrease the extent of surgery, to serve as an in vivo test of response to therapy, and to reveal prognostic information for the patient. MRI is the most accurate modality to demonstrate response to therapy and to help ensure accurate presurgical planning. Read More

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The Cancer Cell Dissemination Machinery as an Immunosuppressive Niche: A New Obstacle Towards the Era of Cancer Immunotherapy.

Front Immunol 2021 13;12:654877. Epub 2021 Apr 13.

Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, New York City, NY, United States.

Although cancer immunotherapy has resulted in unpreceded survival benefits to subsets of oncology patients, accumulating evidence from preclinical animal models suggests that the immunosuppressive tumor microenvironment remains a detrimental factor limiting benefit for many patient subgroups. Recent efforts on lymphocyte-mediated immunotherapies are primarily focused on eliminating cancer foci at primary and metastatic sites, but few studies have investigated the impact of these therapies on the highly complex process of cancer cell dissemination. The metastatic cascade involves the directional streaming of invasive/migratory tumor cells toward specialized blood vessel intravasation gateways, called TMEM doorways, to the peripheral circulation. Read More

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Multi-magnification-based machine learning as an ancillary tool for the pathologic assessment of shaved margins for breast carcinoma lumpectomy specimens.

Mod Pathol 2021 Aug 26;34(8):1487-1494. Epub 2021 Apr 26.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

The surgical margin status of breast lumpectomy specimens for invasive carcinoma and ductal carcinoma in situ (DCIS) guides clinical decisions, as positive margins are associated with higher rates of local recurrence. The "cavity shave" method of margin assessment has the benefits of allowing the surgeon to orient shaved margins intraoperatively and the pathologist to assess one inked margin per specimen. We studied whether a deep convolutional neural network, a deep multi-magnification network (DMMN), could accurately segment carcinoma from benign tissue in whole slide images (WSIs) of shave margin slides, and therefore serve as a potential screening tool to improve the efficiency of microscopic evaluation of these specimens. Read More

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Type of Architecture, Presence of Punctate Necrosis, and Extent of Involvement in Atypical Ductal Hyperplasia Can Predict the Diagnosis of Breast Carcinoma on Excision: A Clinicopathologic Study of 143 Cases.

Int J Surg Pathol 2021 Apr 21:10668969211010954. Epub 2021 Apr 21.

22209Women & Infants Hospital of Rhode Island, Providence, RI, USA.

The literature shows a wide range in the frequencies of finding breast carcinoma in the excised specimens following a biopsy diagnosis of atypical ductal hyperplasia (ADH), likely due to a poor diagnostic reproducibility among different pathologists as well as an inherent heterogeneity in ADH. We evaluated whether histologic subtyping of ADH would help predict the risk of breast carcinoma. Our study consisted of 143 cases of ADH diagnosed by core needle biopsy and followed by excision. Read More

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