Blood Coagul Fibrinolysis 2021 Apr 23. Epub 2021 Apr 23.
Kawsar Human Genetics Research Center, Tehran Dr Davarnia Genetic Counseling and Diagnosis Center, Imam Reza Hospital, Ardabil Department of Medical Genetics and Molecular Biology, Faculty of Medicine, Iran University of Medical Sciences (IUMS) Department of Medical Genetics, Ali-Asghar Children's Hospital Department of Molecular Medicine, Biotechnology Research Center, Pasteur Institute of Iran, Tehran, Iran.
Congenital afibrinogenemia is a rare autosomal recessive disorder that is caused by defects in the fibrinogen. Fibrinogen is a hexameric glycoprotein made of two pairs of three homologous polypeptide chains including Aα, Bβ, and γ that are encoded by three genes named FGA, FGB, and FGG. We aim to study four Iranian families who were referred to our lab for molecular diagnosis of afibrinogenemia. Read More