582,577 results match your criteria introduction children's

Experiences of stigma among individuals in recovery from opioid use disorder in a rural setting: A qualitative analysis.

J Subst Abuse Treat 2021 May 21;130:108488. Epub 2021 May 21.

Maine Maternal Opioid Misuse Initiative (MaineMOM), MaineHealth Director of Perinatal IMAT, 22 Bramhall Street, Portland, ME 04102, United States.

Introduction: Stigma is a barrier to accessing treatment and support services for individuals with substance use disorder. Stigma is negatively associated with completion of treatment for substance use disorder and management of recovery.

Objective: To learn from individuals in recovery from opioid use disorder in a largely rural area about how their personal experiences of stigma affected their ability to enter into treatment and stay in recovery. Read More

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Bridge clinic buprenorphine program decreases emergency department visits.

J Subst Abuse Treat 2021 Apr 17;130:108410. Epub 2021 Apr 17.

Department of Emergency Medicine, Upstate Medical University, Syracuse, NY, USA.

Introduction: Opioid withdrawal due to opioid use disorder (OUD) is an increasing health emergency and complaint in emergency departments (EDs) across the United States. As a response to the increased need for OUD treatment, a low threshold buprenorphine program, or Bridge Clinic, was established within our hospital system. Patients are primarily connected to the Bridge Clinic through the ED, and are able to complete their consultation appointment reliably within 1-3 days of referral. Read More

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Studying caregiver-infant co-regulation in dynamic, diverse cultural contexts: A call to action.

Infant Behav Dev 2021 Jun 9;64:101586. Epub 2021 Jun 9.

University of California, Davis, United States.

Caregivers and infants co-regulate their physiology, emotions, and behavior in a way that is dynamically responsive to each other and the contexts in which they live. This paper is an introduction and call to action for researchers interested in understanding how to study caregiver-infant interactions in the home and diverse cultural contexts, including marginalized communities. We argue that research will be more valid, culturally relevant, and tapped-in to the daily lives of caregivers and infants if there is partnership and collaboration with the caregivers in the design of the questions, data collection and analysis, and distribution of the findings. Read More

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Retinal thickness and microvascular pathway in Idiopathic Rapid eye movement sleep behaviour disorder and Parkinson's disease.

Parkinsonism Relat Disord 2021 Jun 6;88:40-45. Epub 2021 Jun 6.

Department of Medical, Surgical Sciences and Advanced Technologies GF Ingrassia, Section of Neurosciences, University of Catania, Catania, CT, Italy. Electronic address:

Introduction: Retinal impairment has previously been described in Parkinson's Disease (PD), also in early stage of disease. Idiopathic Rapid-eye-movement sleep Behavior Disorder (iRBD) is considered the strongest marker in the diagnosis of "Prodromal PD". Thus, we evaluated the thickness of retinal layers and the microvascular retinal pattern in a group of iRBD patients compared to PD and healthy subjects (HCs). Read More

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Speciation, controlling steps and pathways of silver release from the sludge generated from coagulation of wastewater spiked with silver nanoparticles.

Chemosphere 2021 Jun 4;282:131093. Epub 2021 Jun 4.

Shandong Key Laboratory of Water Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Shandong University, Jinan, 250100, PR China.

Sludge generated in wastewater treatment facilities is an integral part for the introduction of silver nanoparticles (AgNPs) to the terrestrial environment, which would cause some adverse ecosystem responses. The understanding of silver release process from the sludge is important to evaluate their risks. In this study, the amount and speciation of the released silver were investigated by taking the sludge generated by wastewater coagulation with AgNPs added (denoted as sludge) an example, and kinetic analysis and density functional theory (DFT) calculations were first used to explore the controlling steps and pathways about the silver release. Read More

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PLAC1 affects cell to cell communication by interacting with the desmosome complex.

Placenta 2021 Jun 6;110:39-45. Epub 2021 Jun 6.

Laboratory of Genetics and Genomics, National Institute on Aging, Baltimore, MD, 21224, USA. Electronic address:

Introduction: X-linked PLAC1 is highly expressed in placenta during embryogenesis, and when ablated in mice, causes aberrant placental cell layer organization. It is also highly expressed in many types of cancer cell-lines. Although it has been shown that it promotes AKT phosphorylation in cancer cells, the exact mechanism by which it influences placental layer differentiation is unclear. Read More

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A retrospective evaluation of the indications, complications, and outcomes associated with epicardial pacemakers in 20 cats from a single institution.

J Vet Cardiol 2021 May 13;36:89-98. Epub 2021 May 13.

Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Dr. Madison, WI 53706, USA.

Introduction: The objective of this retrospective study was to describe the indications, complications, and long-term outcomes in a group of cats that received an epicardial pacing (EP) system.

Animals: Twenty client-owned cats.

Materials And Methods: Medical records were reviewed for signalment, presenting complaint, primary electrocardiogram (ECG) diagnosis, presence of structural heart disease, presence of congestive heart failure (CHF), presence of major or minor complications, and survival time. Read More

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Anticoagulant-induced hemorrhagic cholecystitis with hemobilia after deceased donor kidney transplant and literature review.

Int J Surg Case Rep 2021 May 26;84:106027. Epub 2021 May 26.

Augusta University, Department of Surgery, United States of America. Electronic address:

Introduction And Importance: Hemobilia and hemorrhagic cholecystitis are uncommon causes of right upper quadrant abdominal pain. The development of intra-gallbladder and biliary bleeding has been primarily associated with abdominal trauma, malignancy, liver transplant, and iatrogenic injury to the biliary tree and vasculature. Spontaneous anticoagulant induced hemorrhagic cholecystitis and hemobilia are incredibly rare events and have only been documented by a handful of case reports. Read More

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Hirschsprung disease with Edward syndrome: A rare association: A case report.

Int J Surg Case Rep 2021 Jun 9;84:106084. Epub 2021 Jun 9.

Department of GI and General Surgery, Tribhuvan University Teaching Hospital, Institute of Medicine, Kathmandu, Nepal. Electronic address:

Introduction And Importance: Edward's syndrome (ES) occurs as a result of trisomy of chromosome 18 and is associated with multisystem congenital anomalies. The association of ES with various gastrointestinal malformations but Hirschsprung disease (HD) is well documented.

Case Presentation: A female infant on her 5th day of life presented with episodes of bilious vomiting along with abdominal distension and no passage of stool. Read More

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A rare case of large left internal maxillary artery pseudoaneurysm secondary to mandibular fracture: A case report and review of the literature.

Int J Surg Case Rep 2021 Jun 9;84:106072. Epub 2021 Jun 9.

Department of Surgery, Division of Trauma and Surgical Critical Care, Kendall Regional Medical Center, Miami, FL, USA; University of South Florida, Tampa, FL, USA.

Introduction And Importance: Pseudoaneurysms secondary to traumatic vessel wall disruption are a rare but potentially fatal complication after traumatic injury. The majority of the cases are found incidentally.

Case Presentation: An 80-year-old woman was brought into our Level 1 Trauma Center after sustaining a ground-level fall with significant facial swelling. Read More

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Subacute duodenal obstruction caused by Common Celiaco-Mesenteric Trunk anomaly-A case report.

Int J Surg Case Rep 2021 May 26;83:106043. Epub 2021 May 26.

Department of General Surgery, Grant Government Medical College and Sir J&J Group of Hospitals, Mumbai, India.

Introduction And Importance: The origin of the mesenteric vasculature is highly variable. One such variation is the common celiaco-mesenteric trunk (CMT). To our knowledge, this is the first reported case of subacute duodenal obstruction caused by common CMT. Read More

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Impending cauda equina syndrome due to Kummell disease; A case report and literature review.

Int J Surg Case Rep 2021 May 26;83:106041. Epub 2021 May 26.

The School of Medicine, University of Central Lancashire, Preston, Lancashire, United Kingdom. Electronic address:

Introduction: Kummell disease (KD) is a rare cause of vertebral fracture due to osteonecrosis. The natural history of the disease is characterized by a previous minor trauma, a subclinical window period, and then a symptomatic period presenting with disabling pain, kyphosis, or neurologic deficit.

Importance: As an important but rare cause of non-discogenic cauda equina syndrome. Read More

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Emergency endoscopic surgery for pituitary apoplexy presenting as cerebral infarction in a limited resources condition: A case report.

Int J Surg Case Rep 2021 May 26;83:106015. Epub 2021 May 26.

Department of Surgery, Hanoi Medical University, Hanoi, Viet Nam; Department of Neurosurgery I, Viet Duc University Hospital, Hanoi, Viet Nam. Electronic address:

Introduction And Importance: Pituitary apoplexy is defined as a sudden onset of neurologic deficit due to infarction or hemorrhage of the pituitary tumor. We report a case of emergency endoscopic surgery for pituitary apoplexy presenting as cerebral infarction due to ICA compression in a limited resources condition.

Case Presentation: A 38-year-old female presented with acute onset of severe headache, decreased level of consciousness, decreased visual acuity bilaterally, aphasia, and right hemiparesis. Read More

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Multifocal pancreatic PPoma in the setting of MEN1: Case report and review of literature.

Int J Surg Case Rep 2021 May 23;83:106008. Epub 2021 May 23.

Department of Surgery, Division of Surgical Oncology, University of California San Francisco, San Francisco, CA, USA. Electronic address:

Introduction And Importance: Functioning pancreatic neuroendocrine tumors (pNETs) that express pancreatic polypeptide-PPomas-do not yet have a pathognomonic clinical syndrome associated with them due to their overall rarity and diverse symptoms. Moreover, in patients with MEN1, the often multifocal nature of pNETs presents a unique clinical issue.

Case Presentation: We report a case of a 22-year-old man with a known MEN1 gene mutation who was suffering from severe diarrhea (7-8 bowel movements per day) and was found to have only elevated PP levels on biochemical work-up. Read More

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Effect of thiamine supplementation in critically ill patients: A systematic review and meta-analysis.

J Crit Care 2021 Jun 4;65:104-115. Epub 2021 Jun 4.

Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, VCU School of Medicine, Richmond, VA, USA. Electronic address:

Introduction: Several studies have previously shown the benefit of thiamine supplementation in critically ill patients. In order to fully appraise the available data, we performed a meta-analysis of 18 published studies.

Methods: A thorough systematic search was conducted. Read More

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Point-of-care testing for sexually transmitted infections in low-resource settings.

Clin Microbiol Infect 2021 Jun 9. Epub 2021 Jun 9.

UNDP-UNFPA-UNICEF-WHO-World Bank Special Programme of Research, Development and Research Training in Human Reproduction (HRP), Department of Sexual and Reproductive Health and Research, World Health Organization, 20 Avenue Appia, 1211 Geneva, Switzerland.

Background: Both the global incidence and prevalence of sexually transmitted infections continue to increase, affecting hundreds of millions of individuals, particularly in low-to middle-income countries. While a definitive diagnosis is desirable to inform STI treatment, syndromic management is the most widely used strategy in resource-limited settings. With the development of point-of-care (POC) tests, it is important to discuss how laboratories will need to adapt to new training and supervisory roles in support of testing which will largely be performed by peripheral clinical staff. Read More

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Lignin-containing polyurethane elastomers with enhanced mechanical properties via hydrogen bond interactions.

Int J Biol Macromol 2021 Jun 9;184:1-8. Epub 2021 Jun 9.

College of Material Science and Engineering, Northeast Forestry University, Harbin 150040, PR China; Key Laboratory of Bio-based Materials Science & Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, PR China. Electronic address:

In this work, lignin-containing polyester polyol (LPES) was successfully synthesized by vacuum melting method with lignin instead of polyol, and then reacted with isocyanate and chain extender to obtain lignin-based polyurethane elastomer (LPUE). The effects of lignin as reactive raw material, chain extender, and filler on the structure, thermostability, mechanical performance, and self-healing properties of elastomers were systematically studied, respectively. The comprehensive mechanical properties of the obtained materials were significantly enhanced after the introduction of lignin, especially the maximum tensile strength increased to 26. Read More

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Termination of Pregnancy Services in Irish General Practice from January 2019 to June 2019.

Contraception 2021 Jun 9. Epub 2021 Jun 9.

Broadlane Family Practice, 72 Great William O'Brien St, Blackpool, Cork, T23 EDX9.

Objective: To describe how a general-practitioner-delivered community medical abortion service is provided in Ireland, including a description of the unique model of care delivered within the framework of new legislation. To investigate the characteristics and contraceptive choices of women attending in the first six months of the service.

Study Design: Twenty-seven general practitioners conducted a retrospective chart review. Read More

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Successful perioperative management of a primary pulmonary arterial angiosarcoma - Case report.

Braz J Anesthesiol 2021 Jun 9. Epub 2021 Jun 9.

Hospital Universitari Son Espases, Cardiovascular Surgery, Quiron Clinica Rotger and Head of Service, Lead Consultant Cardiac Surgeon, Palma de Mallorca, Spain.

Introduction: Primary pleomorphic pulmonary angiosarcomas are extremely rare tumors which could be easily mistaken for pulmonary emboli.

Background And Findings: We describe the successful perioperative management of a patient with a pulmonary arterial mass which turned out to be a primary pulmonary angiosarcoma. The severe pulmonary hypertension was a particular challenge compounded with the site and adhesions of the tumor, and pulmonary hemorrhage. Read More

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Ultrasound-guided erector spinae plane block for open inguinal hernia repair: a randomized controlled trial.

Braz J Anesthesiol 2021 Jun 9. Epub 2021 Jun 9.

SIANEST/Hospital Florianópolis, Unidade de Anestesiologia, Florianópolis, SC, Brazil; Universidade do Sul de Santa Catarina (UNISUL), Florianópolis, SC, Brazil; TSA, Sociedade Brasileira de Anestesiologia, Brazil.

Introduction And Objectives: Inguinal hernia repair is associated with significant postoperative pain. We assessed the analgesia efficacy of unilateral Erector Spinae Plane block (ESP) performed under ultrasound guidance in patients submitted to open unilateral inguinal hernia repair, comparing ESP to spinal anesthesia administered with or without opioid.

Method: Forty-five patients with ages ranging from 27 to 83 years were randomly allocated into three groups: control group receiving spinal anesthesia (n = 14), ESP group receiving ESP block combined with spinal anesthesia (n = 16), and spinal morphine group receiving spinal anesthesia with morphine 1 mcg. Read More

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Syringe irrigation in minimally-shaped root canals using three endodontic needles: a Computational Fluid Dynamics study.

J Endod 2021 Jun 9. Epub 2021 Jun 9.

Department of Endodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.

Introduction: The aim of this study was to compare the irrigant flow in curved root canals prepared to various apical sizes by constant-taper or variable-taper instruments during syringe irrigation with three endodontic needles at two different flow rates.

Methods: Two matched curved mesial root canals of human mandibular molars were imaged by micro-computed tomography after preparation to apical size 20, 25, and 30/.06 taper either by constant-taper or variable-taper instruments. Read More

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The effect of root canal preparation size and taper of middle mesial canals on fracture resistance of the mandibular molar teeth: An in vitro study.

J Endod 2021 Jun 9. Epub 2021 Jun 9.

(Associate Professor) Department of Endodontology, Faculty of Dentistry, Ege University, Izmir, Turkey. Electronic address:

Introduction: The aim of the present study was to investigate the influence of root canal preparation size and taper of middle mesial (MM) canals on fracture resistance of mandibular molars.

Methods: Fifty-five mandibular molar teeth having MM canal were selected based on the cone-beam computed tomography analysis. Following the decoronation and distal root separation procedure, the lengths of the mesial roots were standardized to 13 mm. Read More

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A comparison of SARS-CoV-2 nucleocapsid and spike antibody detection using three commercially available automated immunoassays.

Clin Biochem 2021 Jun 9. Epub 2021 Jun 9.

Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Health System, Lebanon, NH, United States; he Geisel School of Medicine at Dartmouth, Hanover, NH, United States.

Introduction: Commercially available serological assays for SARS-CoV-2 detect antibodies to either the nucleocapsid or spike protein. Here we compare the performance of the Beckman-Coulter SARS-CoV-2 spike IgG assay to that of the Abbott SARS-CoV-2 nucleocapsid IgG and Roche Anti-SARS-CoV-2 nucleocapsid total antibody assays. In addition, we document the trend in nucleocapsid and spike antibodies in sequential samples collected from convalescent plasma donors. Read More

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Using an economic evaluation approach to support specialist nursing services for people with Parkinson's in a regional community.

J Adv Nurs 2021 Jun 12. Epub 2021 Jun 12.

Charles Sturt University, School of Nursing, Midwifery and Indigenous Health, Orange, New South Wales, Australia.

Aim: This study aims to provide economic evidence of the cost-effectiveness of employing specialist Parkinson's nurses in a regional community in Australia.

Study Design: This retrospective study utilized hospital service usage data to compare outcomes for people with Parkinson's disease before and after the employment of a specialist Parkinson's nurse in a regional community.

Methods: A representative sample was drawn from the target population of people with a diagnosis of Parkinson's admitted to a regional hospital over a 4-year period (2013-2014 and 2016-2017). Read More

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A hungry Histiocyte, altered immunity and myriad of problems: Diagnostic challenges for Pediatric HLH.

Int J Lab Hematol 2021 Jun 12. Epub 2021 Jun 12.

Division of Pediatric Hematology/Oncology, Department of Pediatrics, VMMC and Safdarjung Hospital, New Delhi, India.

Introduction: Hemophagocytic lymphohistiocytosis (HLH) is an immune deregulation disorder with varied clinical presentation which clinically overlaps with widespread tropical infections.

Methods: We conducted a retrospective chart review of children diagnosed with HLH at our center from February-2017 to October-2020.

Results: Out of the nine diagnosed patients, genetic predisposition was present in three children; two had identified infectious triggers. Read More

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No need for secondary Pneumocystis jirovecii pneumonia prophylaxis in adult people living with HIV from Europe on ART with suppressed viraemia and a CD4 cell count greater than 100 cells/µL.

J Int AIDS Soc 2021 Jun;24(6):e25726

Department of Infectious Diseases, Bern University Hospital, Inselspital, University of Bern, Bern, Switzerland.

Introduction: Since the beginning of the HIV epidemic in resource-rich countries, Pneumocystis jirovecii pneumonia (PjP) is one of the most frequent opportunistic AIDS-defining infections. The Collaboration of Observational HIV Epidemiological Research Europe (COHERE) has shown that primary Pneumocystis jirovecii Pneumonia (PjP) prophylaxis can be safely withdrawn in patients with CD4 counts of 100 to 200 cells/µL if plasma HIV-RNA is suppressed on combination antiretroviral therapy. Whether this holds true for secondary prophylaxis is not known, and this has proved difficult to determine due to the much lower population at risk. Read More

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Phase 1 pharmacokinetics and safety study of extended duration dapivirine vaginal rings in the United States.

J Int AIDS Soc 2021 Jun;24(6):e25747

Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Introduction: Vaginal rings are a promising approach to provide a woman-centred, long-acting HIV prevention strategy. Prior trials of a 25 mg dapivirine (DPV) ring have shown a favourable safety profile and approximately 30% risk reduction of HIV-1 infection. Extended duration rings replaced every three months may encourage user adherence, improve health service efficiency and reduce cost overall. Read More

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Prognostic impacts of peripheral blood erythroblasts after single-unit cord blood transplantation.

Int J Lab Hematol 2021 Jun 12. Epub 2021 Jun 12.

Department of Hematology/Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.

Introduction: The appearance of erythroblasts (EBLs) in peripheral blood occurs in a variety of serious conditions and has been associated with mortality in critically ill patients. However, the incidence, risk factor, and outcomes of EBLs after cord blood transplantation (CBT) remain unclear.

Methods: We have investigated the impact of EBLs on transplant outcomes on 225 adult patients who underwent single-unit CBT at our single institute. Read More

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Nasogastric Tube Insertion in intubated patients with the guide of Wire rope: A Prospective Randomized Controlled Study.

Int J Clin Pract 2021 Jun 12:e14508. Epub 2021 Jun 12.

Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Nasogastric tube (NGT) insertion is sometimes required in intubated patients. NGTs are prone to kink and coil during blind insertion. We hypothesized that Wire rope guide-assisted NGT insertion with chin lift can significantly improve the first-attempt success rate over the conventional technique during its insertion in intubated patients. Read More

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