43,765 results match your criteria intolerance

A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1-mediated oxidative stress.

EMBO J 2021 Apr 13:e106491. Epub 2021 Apr 13.

Nutritional Sciences and Toxicology Department, University of California Berkeley, Berkeley, CA, USA.

Exercise can alter the skeletal muscle DNA methylome, yet little is known about the role of the DNA methylation machinery in exercise capacity. Here, we show that DNMT3A expression in oxidative red muscle increases greatly following a bout of endurance exercise. Muscle-specific Dnmt3a knockout mice have reduced tolerance to endurance exercise, accompanied by reduction in oxidative capacity and mitochondrial respiration. Read More

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Fructose intolerance is not associated with malabsorption in patients with functional gastrointestinal disorders.

Neurogastroenterol Motil 2021 Apr 12:e14150. Epub 2021 Apr 12.

Department of Pharmacy, National University of Singapore, Singapore City, Singapore.

Background: Symptoms following fructose ingestion, or fructose intolerance, are common in patients with functional gastrointestinal disorders (FGID) and are generally attributed to intestinal malabsorption. The relationships between absorption, symptoms, and intestinal gas production following fructose ingestion were studied in patients with FGID.

Methods: Thirty FGID patients ingested a single dose of fructose 35 g or water in a randomized, double-blind, crossover study. Read More

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A generic emergency protocol for patients with inborn errors of metabolism causing fasting intolerance: a retrospective, single-center study and the generation of www.emergencyprotocol.net.

J Inherit Metab Dis 2021 Apr 12. Epub 2021 Apr 12.

Section of Metabolic Diseases, Beatrix Children's Hospital, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands.

Introduction: Patients with inborn errors of metabolism causing fasting intolerance can experience acute metabolic decompensations. Long-term data on outcomes using emergency letters are lacking.

Methods: This is a retrospective, observational, single-center study of the use of emergency letters based on a generic emergency protocol in patients with hepatic glycogen storage diseases (GSD) or fatty acid oxidation disorders (FAOD). Read More

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Evaluation of glucagon-like peptide-1 receptor expression in non-diabetic and diabetic atherosclerotic mice using PET tracer Ga-NODAGA-exendin-4.

Am J Physiol Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Turku PET Centre, University of Turku, Finland.

Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling attenuates development of atherosclerosis and vascular inflammation. However, the expression of GLP-1R in atherosclerotic arteries remains uncertain. We evaluated whether a positron emission tomography (PET) tracer Ga-NODAGA-exendin-4 enables detection and imaging of GLP-1R expression in the mouse atherosclerotic aorta. Read More

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An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes.

Am J Physiol Endocrinol Metab 2021 Apr 12. Epub 2021 Apr 12.

Internal Medicine, Yale University School of Medicine, United States.

Carter et al. report that exposure to static magnetic and electric fields (sBE), for as little as 3 days, reverses glucose intolerance and insulin resistance in diet-induced and genetic mouse models of type 2 diabetes (1). They hypothesize that sBE triggers a systemic redox response to modulate insulin sensitivity and that sBE could therefore be used as a noninvasive treatment for type 2 diabetes. Read More

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The Factors Influencing the Unmet Effects of Alpha Hydroxy Acid Peels on Acne Vulgaris: A Single Tertiary Center Experience.

Dermatol Ther 2021 Apr 11:e14956. Epub 2021 Apr 11.

Department of Plastic Surgery & Cosmetic Surgery, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China.

Acne vulgaris is a common condition. Alpha hydroxy acid (AHA) peels have been previously recommended as an option for patients with intolerance to first-line treatments especially when long-term use. The safety and efficacy of AHA peels for acne have been established, but the factors influencing the ultimate effects are unknown. Read More

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Intercept of minute ventilation versus carbon dioxide output relationship as an index of ventilatory inefficiency in chronic obstructive pulmonary disease.

J Thorac Dis 2021 Mar;13(3):1553-1563

Department of Respiratory Medicine, Capital Medical University Affiliated Beijing Friendship Hospital, Beijing, China.

Background: Ventilatory inefficiency contributes to exercise intolerance in chronic obstructive pulmonary disease (COPD). The intercept of the minute ventilation (V) carbon dioxide output (V CO) plot is a key ventilatory inefficiency parameter. However, its relationships with lung hyperinflation (LH) and airflow limitation are not known. Read More

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Reversal of cardiopulmonary exercise intolerance in patients with post-thrombotic obstruction of the inferior vena cava.

Thromb Res 2021 Apr 8. Epub 2021 Apr 8.

Clinic for Angiology, University Hospital Zurich, Switzerland. Electronic address:

Background: It is unclear whether cardiopulmonary exercise intolerance in patients with chronic obstruction of the inferior vena cava (IVC) is reversible following endovascular IVC reconstruction.

Methods: In 17 patients (mean age 45 ± 15 years, 71% men) with post-thrombotic syndrome due to IVC obstruction and preserved left ventricular ejection fraction (mean 58 ± 3%), we performed cardiopulmonary exercise testing before and 3 months after IVC reconstruction (mean 4.1 ± 1. Read More

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Insulin receptor substrate 1 (IRS1), but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice.

J Biol Chem 2021 Apr 8:100646. Epub 2021 Apr 8.

Islet Cell and Regenerative Biology, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Harvard Stem Cell Institute, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

Dysregulated glucagon secretion deteriorates glycemic control in type 1 and type 2 diabetes. Although insulin is known to regulate glucagon secretion via its cognate receptor (insulin receptor, INSR) in pancreatic alpha cells, the role of downstream proteins and signaling pathways underlying insulin's activities are not fully defined. Using in vivo (knockout) and in vitro (knockdown) studies targeting insulin receptor substrate (IRS) proteins, we compared the relative roles of IRS1 and IRS2 in regulating alpha cell function. Read More

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Early enteral feeding versus traditional feeding in neonatal congenital gastrointestinal malformation undergoing intestinal anastomosis: A randomized multicenter controlled trial of an enhanced recovery after surgery (ERAS) component.

J Pediatr Surg 2021 Mar 18. Epub 2021 Mar 18.

Department of Neonatal Surgery, Guangzhou Women and Children's Medical Center, Guangzhou, China. Electronic address:

Purpose: the aim of this clinical trial was to evaluate the safety and efficacy of early enteral feeding (EEN) following intestinal anastomosis in neonates with congenital gastrointestinal malformation.

Methods: a multicenter, prospective, randomized controlled trial (registered under chictr.org. Read More

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Development of a behavioural measure of Intolerance of Uncertainty in preadolescent children: Adaptation of the beads task.

J Behav Ther Exp Psychiatry 2021 Mar 26;72:101654. Epub 2021 Mar 26.

Department of Psychology and Clinical Language Sciences, University of Reading, Reading, RG6 6AL, UK. Electronic address:

Background And Objectives: Intolerance of Uncertainty (IU) may be important for the development and maintenance of anxiety disorders but research with preadolescent children has relied entirely on questionnaire measures to assess IU. Here we aimed to develop a behavioural measure of IU that was appropriate for preadolescent children by adapting the beads task (Jacoby, Abramowitz, Buck, & Fabricant, 2014).

Methods: Participants were 51 typically developing children (26 female; 7-11 years). Read More

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Effects of high fat diets and supplemental tart cherry and fish oil on obesity and type 2 diabetes in male and female C57BL/6J and TALLYHO/Jng mice.

J Nutr Biochem 2021 Apr 7:108644. Epub 2021 Apr 7.

Department of Biomedical Sciences, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV 25755, USA. Electronic address:

Obesogenic and diabetogenic high fat (HF) diets can influence genetic factors in disease development with sexual dimorphic responses. We investigated potential protective effects of tart cherry (TC), fish oil (FO) and TC+FO supplementation in TALLYHO/Jng (TH) and C57BL/6J (B6) mice fed HF diets. Male and female TH and B6 mice were weaned onto five different diets; low fat (LF), HF, and HF supplemented with TC, FO, or TC+FO and maintained. Read More

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Gluten-degrading bacteria: availability and applications.

Appl Microbiol Biotechnol 2021 Apr 10. Epub 2021 Apr 10.

Institute of Technology, University of Tartu, Tartu, Estonia.

Gluten is a mixture of storage proteins in wheat and occurs in smaller amounts in other cereal grains. It provides favorable structure to bakery products but unfortunately causes disease conditions with increasing prevalence. In the human gastrointestinal tract, gluten is cleaved into proline and gluten rich peptides that are not degraded further. Read More

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Efficacy and safety of pembrolizumab in patients with advanced mesothelioma in the open-label, single-arm, phase 2 KEYNOTE-158 study.

Lancet Respir Med 2021 Apr 6. Epub 2021 Apr 6.

University of Chicago, Chicago, IL, USA.

Background: Malignant pleural mesothelioma (MPM) has few treatment options. Pembrolizumab showed preliminary clinical benefit in programmed death ligand 1 (PD-L1)-positive MPM. We evaluated the efficacy and safety of pembrolizumab monotherapy in patients with previously treated MPM irrespective of PD-L1 status in the KEYNOTE-158 study. Read More

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Buprenorphine may be effective for treatment of paramyotonia congenita.

Muscle Nerve 2021 Apr 9. Epub 2021 Apr 9.

IRCCS Mondino Foundation, Pavia, Italy.

Introduction/aims: Paramyotonia congenita (PMC) is a skeletal muscle sodium channelopathy characterized by paradoxical myotonia, cold sensitivity, exercise/cold induced paralysis. Treatment with sodium channel-blocking anti-arrhythmics may expose the patients to a risk of arrhythmia or may be poorly tolerated or ineffective. We explored the effectiveness of non-anti-arrhythmic sodium channel blockers in two patients with PMC. Read More

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Clinical Outcomes and Complications of Primary Fingertip Reconstruction Using a Reverse Homodigital Island Flap: A Systematic Review.

Hand (N Y) 2021 Apr 9:15589447211003179. Epub 2021 Apr 9.

Royal North Shore Hospital, St Leonards, NSW, Australia.

Background: Reverse homodigital island flaps (RHIFs) are increasingly used to reconstruct traumatic fingertip injuries, but there is limited evidence on the efficacy of this technique. We performed a systematic review of the literature to establish the safety and functional outcomes of RHIF for traumatic fingertip injuries.

Methods: Electronic searches were performed using 3 databases (PubMed, Ovid Medline, Cochrane CENTRAL) from their date of inception to April 2020. Read More

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An Unusual Case of Multiple Food Allergies Comorbid with Multiple Chemical Sensitivity: A Case Report.

J Asthma Allergy 2021 31;14:317-323. Epub 2021 Mar 31.

Neuroscience Research Group "NeURos", Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá, Colombia.

Purpose: To report the case of a patient with multiple food allergies comorbid with multiple chemical sensitivity (MCS) who was misdiagnosed on various occasions, resulting in a negative impact on the patient's personal and social life.

Case Report: We present the case of a 43-year-old Colombian women with multiple food allergies concomitant with MCS. Symptoms started with a mild reaction to insecticides, car exhaust smoke, and perfumes and gradually evolved into a severe reaction to her environment. Read More

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Non-responsive celiac disease in children on a gluten free diet.

World J Gastroenterol 2021 Apr;27(13):1311-1320

Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA 02115, United States.

Background: Non-responsive celiac disease (NRCD) is defined as the persistence of symptoms in individuals with celiac disease (CeD) despite being on a gluten-free diet (GFD). There is scant literature about NRCD in the pediatric population.

Aim: To determine the incidence, clinical characteristics and underlying causes of NRCD in children. Read More

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Novel TNNT1 mutation and mild nemaline myopathy phenotype in an Italian patient.

Neuromuscul Disord 2021 Mar 6. Epub 2021 Mar 6.

UOC Neurofisiopatologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo Agostino Gemelli 8, Rome 00168, Italy; Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, Roma, Italy.

Mutations in the TNNT1 gene cause an infantile, lethal form of myopathy named "Amish" Nemaline Myopathy. Adult patients are very rarely described. We report a 49-year-old patient who presented a slowly progressive phenotype characterized by myalgia, exercise intolerance and dyspnea since infancy. Read More

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[Vocal cord dysfunction in athletes: Interest of rehabilitation to effort].

Rev Mal Respir 2021 Apr 5. Epub 2021 Apr 5.

CIC-CRB 1404, unité de physiologie respiratoire et sportive, centre hospitalier universitaire de Rouen, 1, rue de Germont, 76000 Rouen, France.

Introduction: Vocal Cord Dysfunction (VCD) is a syndrome characterized by paradoxical adduction of the vocal folds during breathing. Its non-specific clinical manifestations frequently lead to misdiagnosis and delay in its treatment. The treatment of VCD is not pharmacological but rehabilitative and remains poorly appreciated. Read More

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One-year real life data of our patients with moderate-severe Crohn's disease who underwent ustekinumab therapy.

Scott Med J 2021 Apr 9:369330211008587. Epub 2021 Apr 9.

Professor of Gastroenterology, Department of Gastroenterology, Ankara City Hospital, Ankara, Turkey.

Aim: The aim of this study was to present one-year real-life data of our patients with CD who showed unresponsiveness and/or intolerance to biological agents and then received ustekinumab treatment through an early access program.

Materials And Methods: The retrospective study reviewed the 52-week clinical data of 10 patients with moderate or severe CD who underwent ustekinumab therapy.

Results: The 10 patients comprised 7 (70%) men and 3 (30%) women with a mean age of 38 ± 11. Read More

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Duplex Ultrasound as a reliable alternative to CT angiography for treatment planning of Peripheral Artery Disease.

Int Angiol 2021 Apr 9. Epub 2021 Apr 9.

Vascular Surgery Department, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Background: The aim of this work is to compare the diagnostic accuracy of Duplex ultrasound (DUS) and CT angiography (CTA) in the study of arterial vessels, in patients with chronic peripheral arterial disease (PAD) of the lower limbs to undergo endovascular revascularization with the use of intraprocedural digital angiography (DSA).

Methods: 94 patients with obstructive pathology of the arterial axes of the lower limbs were enrolled in the study. In all patients, endovascular revascularization treatment was considered the most suitable therapeutic choice. Read More

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[Effects of supernatants on inflammatory responses of human periodontal ligament cells under pressure].

Zhonghua Kou Qiang Yi Xue Za Zhi 2021 Apr;56(4):335-341

Department of Operative Dentistry and Endodontics, Yantai Stomatological Hospital Affiliated to Binzhou Medical College, Yantai 264008, China.

To study the effect of various concentrations of (Ef) supernatants on human periodontal ligament cell (hPDLC) and the inflammatory response of hPDLC under static pressure. The method of methyl thiazolyl tetrazolium (MTT) was used to detect the effect of various concentrations of Ef supernatants on the proliferation of hPDLCs and the flow cytometry was used to detect the expression of Toll-like receptor 2 (TLR-2) on the surface of hPDLC after 24-hour-stimulation of Ef supernatant. Furthermore, the hPDLCs were divided into non inducing group without Ef supernatant and inducing group with 5% Ef supernatant, and hPDLCs in each group were loaded with 0, 49 and 196 Pa static pressures respectively. Read More

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Relationships between frustration intolerance beliefs, cognitive emotion regulation strategies and burnout among geriatric nurses and care assistants.

Geriatr Nurs 2021 Apr 5;42(3):700-707. Epub 2021 Apr 5.

Department of Psychology, University of Angers, Angers, France.

The purpose of this study was to address cognitive emotional factors (frustration intolerance beliefs, cognitive emotion regulation strategies) related to burnout among professionals caring for older persons. A sample of 202 nurses and care assistants for older people completed online questionnaires about their cognitive emotion regulation strategies, frustration intolerance beliefs, and burnout. Use of maladaptive strategies, especially self-blame and catastrophizing, predicted greater emotional exhaustion and depersonalization. Read More

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Lactose Intolerance and Its Dietary Management: An Update.

J Am Coll Nutr 2021 Apr 8:1-11. Epub 2021 Apr 8.

Department of Food Technology and Nutrition, Lovely Professional University, Phagwara, India.

Milk is the most common food consumed worldwide and is also a major ingredient in the preparation of various dairy products. However, despite the high production and consumption of milk and milk-based products, there is a large percent of the world's population that suffer from allergies to milk solids and lactose intolerance. Lactose intolerance specifically means the inability of the body to breakdown the sugar to its simplest form for assimilation and it is due to the inefficiency or lack of the enzyme in the human body. Read More

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Gain-of-function Lrp5 Mutation Improves Bone Mass and Strength and Delays Hyperglycemia in a Mouse Model of Insulin-Deficient Diabetes.

J Bone Miner Res 2021 Apr 8. Epub 2021 Apr 8.

Department of Medicine, Division of Bone and Mineral Diseases, Musculoskeletal Research Center.

High fracture rate and high circulating levels of the Wnt inhibitor, sclerostin have been reported in diabetic patients. We studied the effects of Wnt signaling activation on bone health in a mouse model of insulin-deficient diabetes. We introduced the sclerostin-resistant Lrp5 mutation, associated with high bone mass, in mice carrying the Ins2 mutation (Akita), which results in loss of beta cells, insulin deficiency and diabetes in males. Read More

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Greater intolerance to uncertainty predicts poorer quality of life in adults with cyclic vomiting syndrome.

Neurogastroenterol Motil 2021 Apr 8:e14159. Epub 2021 Apr 8.

Department of Medicine, Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA.

Background: Cyclic vomiting syndrome (CVS) is an idiopathic disorder of gut-brain interaction characterized by recurrent bouts of nausea and vomiting. Although CVS negatively impacts quality of life (QOL), the determinants of impaired QOL among adult CVS sufferers are not fully understood. The unpredictability of CVS attacks may generate anticipatory anxiety and worsen quality of life in a substantial proportion of patients with CVS. Read More

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Dietary Selenium Requirement for the Prevention of Glucose Intolerance and Insulin Resistance in Middle-Aged Mice.

J Nutr 2021 Apr 8. Epub 2021 Apr 8.

Department of Food Science, Nutrition, and Health Promotion, Mississippi State University, Mississippi State, MS, USA.

Background: Although dietary selenium (Se) deficiency or excess induces type 2 diabetes-like symptoms in mice, suboptimal body Se status usually causes no symptoms but may promote age-related decline in overall health.

Objectives: We sought to determine the dietary Se requirement for protection against type 2 diabetes-like symptoms in mice.

Methods: Thirty mature (aged 4 mo) male C57BL/6J mice were fed a Se-deficient torula yeast AIN-93M diet supplemented with Na2SeO4 in graded concentrations totaling 0. Read More

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Does faecal calprotectin increase may be linked to lactose intolerance in patients with irritable bowel syndrome?

Minerva Gastroenterol (Torino) 2021 Apr 8. Epub 2021 Apr 8.

Gastroenterology Unit, North Hospital, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France.

Background: Irritable bowel syndrome (IBS) is a multifactorial condition without any specific investigation. Faecal calprotectin (FC) may be elevated in IBS without any explanation. In addition, some patients with IBS have symptoms related to lactose intolerance. Read More

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