13,816 results match your criteria intima-media thickness

Influence of Moxonidine and Bisoprolol on Morphofunctional Condition of Arterial Wall and Telomerase Activity in Postmenopausal Women with Arterial Hypertension and Osteopenia. The Results from a Moscow Randomized Study.

Cardiovasc Drugs Ther 2021 Sep 15. Epub 2021 Sep 15.

Pirogov Russian National Research Medical University, Moscow, Russia.

Purpose: To compare the effect of 12 months of treatment with moxonidine or bisoprolol on telomerase activity (TA) and parameters characterizing the arterial wall state in postmenopausal women with arterial hypertension (AH) and osteopenia.

Methods: An open-label randomized study with 114 postmenopausal women with hypertension and osteopenia; pulse wave velocity (PWV), intima-media thickness (IMT), and TA were analyzed initially and after 12 months of therapy with moxonidine (n = 57) or bisoprolol (n = 57).

Results: Both medications effectively lowered blood pressure (BP) in both groups. Read More

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September 2021

Isolated diastolic hypertension and target organ damage: Findings from the STANISLAS cohort.

Clin Cardiol 2021 Sep 15. Epub 2021 Sep 15.

Université de Lorraine, Inserm, Centre d'Investigations Cliniques, - Plurithématique 14-33, and Inserm U1116, CHRU Nancy, F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France.

Background: Isolated diastolic hypertension (IDH) is defined as diastolic blood pressure (DBP) ≥80 mmHg and systolic blood pressure (SBP) <130 mmHg according to 2017 ACC/AHA guidelines. The effective cardiovascular risk linked to IDH is debated.

Hypothesis: IDH might contribute marginally to hypertension-related target organ damage (TOD) development. Read More

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September 2021

Glucose as a modifiable cause of atherosclerotic cardiovascular disease: Insights from type 1 diabetes and transplantation.

Peter A Senior

Atherosclerosis 2021 Sep 9;335:16-22. Epub 2021 Sep 9.

Division of Endocrinology and Metabolism. Director, Alberta Diabetes Institute. Charles A. Allard Chair in Diabetes Research. University of Alberta, 1.005 Li Ka Shing Centre for Health Research Innovation Edmonton, AB, T6G 2E1, Canada. Electronic address:

Diabetes is a major risk factor for cardiovascular (CV) disease. In contrast to the clear benefits from treatments which reduce blood pressure and lipids, clinical trials targeting blood glucose have not shown clear CV benefits. Interventions to intensify glycemic control early in the course of diabetes may have benefits in long term observational studies (DCCT-EDIC/UKPDS), but may not be helpful if introduced late in the course of type 2 diabetes (ACCORD, ADVANCE, VA-DT). Read More

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September 2021

Higher Trimethylamine--Oxide Plasma Levels with Increasing Age Are Mediated by Diet and Trimethylamine-Forming Bacteria.

mSystems 2021 Sep 14:e0094521. Epub 2021 Sep 14.

Microbial Interactions and Processes Research Group, Helmholtz Centre for Infection Researchgrid.7490.a, Braunschweig, Germany.

The gut microbiota-dependent metabolite trimethylamine--oxide (TMAO) is linked to an increased risk for cardiovascular diseases. Trimethylamine (TMA), which is subsequently oxidized to TMAO in the liver, is formed by intestinal bacteria via distinct biochemical routes from dietary precursors that are enriched in animal product-based foods. To get a full picture of the entire process of the diet > gut microbiota > TMAO axis, we quantified potential TMA-forming gut bacteria and plasma metabolites using gene-targeted assays and targeted metabolomics on a subsample ( = 425) of a German population-based cohort study. Read More

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September 2021

Functional versus morphological assessment of vascular age in patients with coronary heart disease.

Sci Rep 2021 Sep 13;11(1):18164. Epub 2021 Sep 13.

Comprehensive Heart Failure Center, University and University Hospital Würzburg, Würzburg, Germany.

Communicating cardiovascular risk based on individual vascular age (VA) is a well acknowledged concept in patient education and disease prevention. VA may be derived functionally, e.g. Read More

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September 2021

Vascular calcification progression in patients with end-stage chronic kidney disease.

Int Angiol 2021 Sep 13. Epub 2021 Sep 13.

Department of Vascular Surgery, Valladolid University Hospital, Valladolid, Spain.

Background: Intima media thickness (IMT), vascular calcifications and ankle-brachial pressure index (ABPI) were shown to be independent predictors of mortality in end-stage renal disease (ESRD) patients.

Methods: Between January 2018 and March 2019, a physician-initiated, nonrandomized, prospective study was conducted. Carotid IMT, vascular calcifications analysis values and measurements of the ABPI, were made at baseline and after 1-year of follow-up. Read More

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September 2021

High-Level Serum Fibroblast Growth Factor 21 Concentration Is Closely Associated With an Increased Risk of Cardiovascular Diseases: A Systematic Review and Meta-Analysis.

Front Cardiovasc Med 2021 26;8:705273. Epub 2021 Aug 26.

Department of Geriatrics, Institute of Gerontology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The association between fibroblast growth factor 21 (FGF21) and cardiovascular disease (CVD) risk remains unclear. We conducted this systematic review and meta-analysis to evaluate the association between FGF21 and CVDs, and relevant vascular parameters. PubMed and Web of Science databases were systematically searched to identify relevant studies published before March 2021. Read More

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Prevalence and Extent of Subclinical Atherosclerosis and Associated Cardiovascular Risk Factors in Adult Patients With Psoriatic Arthritis: A Systematic Review.

Cureus 2021 Aug 3;13(8):e16853. Epub 2021 Aug 3.

Internal Medicine, California Institute of Behavioral Neurosciences & Psychology, Fairfield, USA.

Psoriatic arthritis (PsA) is a chronic T cell-mediated inflammatory condition affecting a considerable proportion of psoriasis (PSO) patients and a small segment of the general population. Recent studies have shown that patients with PsA are prone to premature atherosclerosis and are at an increased risk of cardiovascular disease (CVD) events, but the extent and prevalence of this are unknown. Our objective was to evaluate the prevalence and extent of subclinical atherosclerosis by measuring the intima-media thickness (IMT) of arteries in adult patients with PsA, as well as identify cardiovascular (CV) risk factors associated with PsA. Read More

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Cardiac changes in infants of diabetic mothers.

World J Diabetes 2021 Aug;12(8):1233-1247

Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta 35127, Egypt.

Diabetes mellitus (DM) is a systemic chronic metabolic disorder characterized by increased insulin resistance and/or β- cell defects. It affects all ages from the foetal life, neonates, childhood to late adulthood. Gestational diabetes is a critical risk factor for congenital heart diseases (CHDs). Read More

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The Relationship Between Carotid Intima Media Thickness, Inflammation and GLA Rich Protein Levels in Chronic Kidney Disease.

Int J Gen Med 2021 1;14:5119-5126. Epub 2021 Sep 1.

Department of Nephrology, Ataturk University Faculty of Medicine, Erzurum, Turkey.

Aim: Vascular calcification is a common complication in CKD. Studies conducted in patients with end-stage renal disease (ESRD) showed that calcification in vascular structures is an important component of the atherosclerosis process. GLA rich protein (GRP) has been suggested as a potential marker for vascular calcification. Read More

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September 2021

Carotid Intima-media Thickness in Patients with Non-alcoholic Fatty Liver Disease Attending a Tertiary Care Center: A Descriptive Cross-sectional Study.

JNMA J Nepal Med Assoc 2021 May 25;59(237):454-459. Epub 2021 May 25.

Bhaskar-Tejshree Memorial Foundation, Kathmandu, Nepal.

Introduction: Non-alcoholic fatty liver disease is fatty infiltration of the liver in the absence of other causes of steatosis. It is strongly associated with central adiposity, high body mass index, insulin resistance states, hypertension, hyperlipidemia which are features of metabolic syndrome. The objective of study is to find out the carotid intima-media thickness of non alcoholic fatty liver disease patients attending a tertiary care center. Read More

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Predictors of Concomitant Coronary Artery Disease and Major Cardiovascular Events in Patients with Acute Ischemic Stroke.

Neurol India 2021 Jul-Aug;69(4):916-922

Department of Cardiology, Marmara University School of Medicine, Istanbul, Turkey.

Background: Coronary artery disease (CAD) and ischemic stroke share the same risk factors.

Objective: The aim of the study was to explore the prevalence and predictors of concomitant CAD in acute ischemic stroke patients.

Methods: One hundred and five patients (64. Read More

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September 2021

Household air pollution and blood pressure, vascular damage and sub-clinical indicators of cardiovascular disease in older Chinese adults.

Am J Hypertens 2021 Sep 10. Epub 2021 Sep 10.

Institute for Health and Social Policy, and Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, Quebec, Canada.

Background: Limited data suggest that household air pollution from cooking and heating with solid fuel (i.e., coal and biomass) stoves may contribute to the development of hypertension and vascular damage. Read More

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September 2021

Vascular effects following intensification of glycemic control in poorly controlled patients with long-standing type 2 diabetes mellitus.

Hormones (Athens) 2021 Sep 9. Epub 2021 Sep 9.

Department of Endocrinology, University of Ioannina, 45110, Ioannina, Greece.

Purpose: The aim of the present study was to investigate the effect of intensive antidiabetic therapy on vascular indices in type 2 diabetes mellitus (T2DM) patients.

Methods: Poorly controlled T2DM patients (n = 62, mean age 64 years, T2DM duration 14 years, HbA1c ≥ 7.5%) were studied at baseline and following intensive treatment to achieve optimal glycemic control. Read More

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September 2021

Pleiotropic effects between cardiovascular disease risk factors and measures of cognitive and physical function in long-lived adults.

Sci Rep 2021 Sep 9;11(1):17980. Epub 2021 Sep 9.

Department of Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA.

Cardiovacular disease (CVD) is the leading cause of death among older adults and is often accompanied by functional decline. It is unclear what is driving this co-occurrence, but it may be behavioral, environmental and/or genetic. We used a family-based study to estimate the phenotypic and shared genetic correlation between CVD risk factors and physical and cognitive functional measures. Read More

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September 2021

Education and household income and carotid intima-media thickness in Japan: baseline data from the Aidai Cohort Study in Yawatahama, Uchiko, Seiyo, and Ainan.

Environ Health Prev Med 2021 Sep 9;26(1):88. Epub 2021 Sep 9.

Department of Community Medicine, Ehime University Graduate School of Medicine, Toon, Japan.

Background: Epidemiological evidence for the relationship between education and income and carotid intima-media thickness (CIMT) has been limited and inconsistent. The present cross-sectional study investigated this issue using baseline data from the Aidai Cohort Study.

Methods: Study subjects were 2012 Japanese men and women aged 34-88 years. Read More

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September 2021

Beneficial Effect of Successful Simultaneous Pancreas-Kidney Transplantation on Plasma Profile of Metalloproteinases in Type 1 Diabetes Mellitus Patients.

J Clin Med 2021 Aug 25;10(17). Epub 2021 Aug 25.

Department of Nephrology, Transplantation and Internal Medicine, Medical University of Silesia, 40-027 Katowice, Poland.

It is not fully elucidated whether the restoring of normal glucose metabolism after successful simultaneous pancreas-kidney transplantation (SPK) improves vascular wall morphology and function in type 1 diabetic (T1D) patients. Therefore, we compared arterial stiffness, assessed by pulse wave velocity (PWV), carotid intima-media thickness (IMT), and biomarkers of arterial wall calcification in T1D patients after SPK or kidney transplantation alone (KTA). In 39 SPK and 39 KTA adult patients of similar age, PWV, IMT, circulating matrix metalloproteinases (MMPs) and calcification biomarkers were assessed at median 83 months post transplantation. Read More

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Carotid intima-media thickness in patients with psoriasis with and without metabolic syndrome.

Arch Cardiol Mex 2021 Sep 9. Epub 2021 Sep 9.

Endocrinology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.

Introduction: Patients with psoriasis have an increased prevalence of cardiovascular risk factors as well as cardiovascular disease.

Objective: To determine if patients with psoriasis and metabolic syndrome (MS) have a higher frequency of subclinical atherosclerosis compared with those with psoriasis without MS.

Materials And Methods: A cross-sectional study was conducted in patients with psoriasis; MS was defined according to ATP III criteria. Read More

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September 2021

Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study.

World J Gastroenterol 2021 Aug;27(30):5112-5125

Department of Medicine of the UAB, Hospital Universitari Vall d'Hebron, Barcelona 08035, Spain.

Background: There is an increased risk of atherosclerosis in patients with chronic hepatitis C or human immunodeficiency virus, but there is scarce data on hepatitis B virus infection. The hypothesis of this study is that hepatitis B virus infection increases the risk of carotid plaques and subclinical atherosclerosis in naïve hepatitis B e antigen (HBeAg) negative subjects.

Aim: To assess the rate of carotid plaques and subclinical atherosclerosis in naïve HBeAg negative subjects in comparison with a cohort of healthy controls. Read More

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Arterial Hypertension and Serum Uric Acid in Elderly- SEPHAR III Study.

Arq Bras Cardiol 2021 08;117(2):378-384

University of Medicine and Pharmacy Victor Babes Timisoara - Department of Internal Medicine, Timisoara - Romênia.

Background: Hyperuricemia is a frequent finding in patients with arterial hypertension, and there is increasing evidence that this entity is also a risk factor for cardiovascular disease.

Objective: In the context of an aging population, this study aims to evaluate serum uric acid levels and arterial hypertension prevalence and control in a subgroup of Romanian adults (>65 years), concerning the influence of age on these parameters.

Method: The study sample consists of 1,920 adults included in SEPHAR III survey, of whom 447 were elderly patients (>65 years of age). Read More

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Effect of age stratification on the association between carotid intima-media thickness and cognitive impairment in Chinese hypertensive patients: new insight from the secondary analysis of the China Stroke Primary Prevention Trial (CSPPT).

Hypertens Res 2021 Sep 7. Epub 2021 Sep 7.

Department of Cardiovascular, Nanchang University Second Affiliated Hospital, Nanchang, China.

The current study aimed to explore the association between carotid intima-media thickness (CIMT) and cognitive function assessed by the Mini-Mental State Examination (MMSE) and to examine possible effect modifiers in hypertensive patients. A total of 14,322 hypertensive participants (mean age 64.2 ± 7. Read More

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September 2021

Prevalence of hypertension mediated organ damage in subjects with high-normal blood pressure without known hypertension as well as cardiovascular and kidney disease.

J Hum Hypertens 2021 Sep 7. Epub 2021 Sep 7.

Cardiology IV, "A.De Gasperis" Department, ASTT GOM Niguarda Ca' Granda, Milan, Italy.

Purpose of our study was to assess the prevalence of hypertension mediated organ damage (HMOD) in healthy subjects with high-normal Blood Pressure (BP) comparing them with subjects with BP values that are considered normal (<130/85 mmHg) or indicative of hypertension (≥140/90 mmHg). Seven hundred fifty-five otherwise healthy subjects were included. HMOD was evaluated as pulse wave velocity (PWV), left ventricular mass index (LVMI), and carotid intima-media thickness (IMT) and plaque. Read More

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September 2021

Reciprocal regulation of endothelial-mesenchymal transition by MAPK7 and EZH2 in intimal hyperplasia and coronary artery disease.

Sci Rep 2021 Sep 7;11(1):17764. Epub 2021 Sep 7.

Laboratory for Cardiovascular Regenerative Medicine, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Hanzeplein 1 (EA11), 9713GZ, Groningen, The Netherlands.

Endothelial-mesenchymal transition (EndMT) is a form of endothelial dysfunction wherein endothelial cells acquire a mesenchymal phenotype and lose endothelial functions, which contributes to the pathogenesis of intimal hyperplasia and atherosclerosis. The mitogen activated protein kinase 7 (MAPK7) inhibits EndMT and decreases the expression of the histone methyltransferase Enhancer-of-Zeste homologue 2 (EZH2), thereby maintaining endothelial quiescence. EZH2 is the catalytic subunit of the Polycomb Repressive Complex 2 that methylates lysine 27 on histone 3 (H3K27me3). Read More

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September 2021

ethanol extract improves vascular dysfunction by suppressing inflammation in postmenopausal rats fed a high-fat diet.

Pharm Biol 2021 Dec;59(1):1203-1215

Department of Biochemistry, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia.

Context: (Lour.) Merr. (Asteraceae) has been reported to have various pharmacological activities including anti-inflammatory effects. Read More

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December 2021

The impact of age and 24-h blood pressure on arterial health in acute ischemic stroke patients: The Norwegian stroke in the young study.

J Clin Hypertens (Greenwich) 2021 Sep 7. Epub 2021 Sep 7.

Department of Clinical Sciences, Lund University, Skane University Hospital, Malmö, Sweden.

The impact of age and 24-h ambulatory blood pressure (ABPM) on arterial stiffness and carotid intima-media thickness (cIMT) in ischemic stroke patients younger than 60 years of age is poorly explored. A total of 385 acute ischemic stroke patients (aged 49.6±9. Read More

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September 2021

Magnesium intake and vascular structure and function: the Hoorn Study.

Eur J Nutr 2021 Sep 7. Epub 2021 Sep 7.

Department of Epidemiology and Biostatistics, Amsterdam Public Health Institute, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands.

Purpose: Circulating and dietary magnesium have been shown to be inversely associated with the prevalence of cardiovascular disease (CVD) and mortality in both high and low-risk populations. We aimed to examine the association between dietary magnesium intake and several measures of vascular structure and function in a prospective cohort.

Methods: We included 789 participants who participated in the vascular screening sub-cohort of the Hoorn Study, a population-based, prospective cohort study. Read More

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September 2021

Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases.

Front Aging Neurosci 2021 20;13:712385. Epub 2021 Aug 20.

Department of Diabetes, Metabolism, and Endocrinology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan.

White matter abnormalities may reflect cerebral microvessel disease. Diffusion tensor imaging (DTI) can help detect early changes in white matter integrity in each tract. However, studies investigating the relationship between subclinical atherosclerosis markers and white matter alterations in DTI findings are limited. Read More

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Predictors of Carotid Intima-Media Thickness Progression in Adolescents-The EVA-Tyrol Study.

J Am Heart Assoc 2021 Sep 6:e020233. Epub 2021 Sep 6.

Department of Neurology Medical University of Innsbruck Innsbruck Austria.

Background Cardiovascular disease depends on the duration and time course of risk factor exposure. Previous reports on risk factors of progression of carotid intima-media thickness (cIMT) in the young were mostly restricted to high-risk populations or susceptible to certain types of bias. We aimed to unravel a risk factor signature for early vessel pathology based on repeated ultrasound assessments of the carotid arteries in the general population. Read More

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September 2021

Age at Menopause in Relationship to Lipid Changes and Subclinical Carotid Disease Across 20 Years: Study of Women's Health Across the Nation.

J Am Heart Assoc 2021 Sep 6:e021362. Epub 2021 Sep 6.

Department of Epidemiology University of Pittsburgh PA.

Background Younger age at final menstrual period (FMP) is associated with increased risk for cardiovascular disease events. This paper evaluated whether older age at FMP is associated with more favorable patterns of lipid changes during the menopause transition and whether these changes are associated with less subclinical carotid disease in the postmenopausal years. Methods and Results Lipids and lipoproteins were measured repeatedly among 1554 premenopausal women who had a natural menopause during follow-up years (median=18. Read More

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September 2021

Associations of urinary sodium excretion with central hemodynamics and changes in vascular structure and function at high altitude.

J Clin Hypertens (Greenwich) 2021 Sep 3. Epub 2021 Sep 3.

Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China.

Research reports on associations of urinary sodium excretion with central hemodynamic parameters and vascular changes are quite limited in general or non-hypertensive population. The purpose of the current study was to explore such associations in Chinese general Tibetans living at high altitude. This cross-sectional study was conducted in Luhuo County, Ganzi Tibetan Autonomous Prefecture with average elevation of 3800 meters from December 2018 to January 2019. Read More

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September 2021