148,872 results match your criteria interventions risk


Contemporary Clinical Use of Aspirin: Mechanisms of Action, Current Concepts, Unresolved Questions, and Future Perspectives.

Semin Thromb Hemost 2021 Jun 15. Epub 2021 Jun 15.

Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.

The ability of aspirin to inhibit platelet aggregation has positioned this agent within the most frequently used drugs worldwide. The aim of this article is to review the contemporary clinical use of aspirin and also to discuss unresolved issues not yet translated into clinical practice. Results from several clinical trials have led to strong guideline recommendations for aspirin use in the acute management and secondary prevention of cardiovascular disease. Read More

View Article and Full-Text PDF

Comparison of Outcomes After Robotic-Assisted or Conventional Total Hip Arthroplasty at a Minimum 2-Year Follow-up: A Systematic Review.

JBJS Rev 2021 06 16;9(6). Epub 2021 Jun 16.

Ascension Borgess Orthopedics, Kalamazoo, Michigan.

Background: This systematic review aimed to present an updated analysis of the evidence comparing outcomes between robotic-assisted total hip arthroplasty (robotic THA) and conventional manual total hip arthroplasty (manual THA).

Methods: A PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) systematic review was performed using the Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, PubMed, MEDLINE, and Embase. Controlled studies comparing primary robotic THA and manual THA utilizing patient-reported outcome measures (PROMs) at a minimum follow-up of 2 years were included. Read More

View Article and Full-Text PDF

An analysis of the relative and absolute incidence of somatic morbidity in patients with affective disorders-A nationwide cohort study.

J Affect Disord 2021 Jun 7;292:204-211. Epub 2021 Jun 7.

Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospitals, Nordre Fasanvej 57, 2000 Frederiksberg, Denmark; Section for Epidemiology, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, Copenhagen K 1014, Denmark.

Background: Patients with affective disorder seem to experience higher risks of several somatic diseases, but no studies have provided estimates of both absolute and relative risks for these diseases in the same population.

Methods: A prospective cohort of all patients age ≥18 years old with a hospital contact with affective disorder between 1997-2014 (n=246,282) and a random sample from the background population (n=167,562) was followed for hospitalizations with cardiovascular disease, diabetes, cancers, chronic obstructive pulmonary disease (COPD), asthma, inflammatory bowel disease, hip fracture, psoriasis, migraine, or dementia. Adjusted absolute and relative risk estimates were calculated using multivariable adjusted Aalen's additive and Cox proportional hazard regression models. Read More

View Article and Full-Text PDF

Early multidrug treatment of SARS-CoV-2 infection (COVID-19) and reduced mortality among nursing home (or outpatient/ambulatory) residents.

Med Hypotheses 2021 Jun 5;153:110622. Epub 2021 Jun 5.

Concerned Ontario Doctors, Toronto, ON, Canada. Electronic address:

The outbreak of COVID-19 from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread all over the world with tremendous morbidity and mortality in the elderly. In-hospital treatment addresses the multifaceted nature of the illness including initial viral replication, cytokine storm, and endothelial injury with thrombosis. We identified nine reports of early treatment outcomes in COVID-19 nursing home patients. Read More

View Article and Full-Text PDF

Nutritional Risk at intensive care unit admission and outcomes in survivors of critical illness.

Clin Nutr 2021 May 11;40(6):3868-3874. Epub 2021 May 11.

Critical Illness, Brain Dysfunction, and Survivorship (CIBS) Center, Nashville, TN, USA; Division of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State University College of Medicine, Columbus OH, USA; Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus, OH, USA. Electronic address:

Background And Aims: Risk factors for poor outcomes after critical illness are incompletely understood. While nutritional risk is associated with mortality in critically ill patients, its association with disability, cognitive, and health-related quality of life is unclear in survivors of critical illness. This study's objective was to determine whether greater nutritional risk at ICU admission is associated with greater disability, worse cognition, and worse HRQOL at 3 and 12-month follow-up. Read More

View Article and Full-Text PDF

Effects of Mediterranean Diet on plasma metabolites and their relationship with insulin resistance and gut microbiota composition in a crossover randomized clinical trial.

Clin Nutr 2021 Apr 27;40(6):3798-3806. Epub 2021 Apr 27.

Department of Biochemistry and Biotechnology, Faculty of Medicine and Health Sciences, University Rovira i Virgili (URV), Reus, Spain; Institute of Health Pere Virgili, IISPV, University Hospital Sant Joan, Reus, Spain; Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background & Aims: The Mediterranean Diet (MedDiet) may decrease the cardiometabolic risk through modulation of metabolic pathways. Furthermore, the interplay between MedDiet, metabolites and microbial metabolism may improve our understanding on the metabolic effects of this diet. We aimed to evaluate the effect of the MedDiet compared to nuts supplementation on circulating metabolites and their relationship with cardiometabolic health. Read More

View Article and Full-Text PDF

Development and external validation of a risk calculator to predict internalising symptoms among Ugandan youths affected by HIV.

Psychiatry Res 2021 May 28;302:114028. Epub 2021 May 28.

International Center for Child Health and Development, Masaka, Uganda.

The aim of the study was to develop and externally validate a model to predict individualized risk of internalizing symptoms among AIDS-affected youths in low-resource settings in sub-Saharan Africa. Longitudinal data from 558 Ugandan adolescents orphaned by AIDS was used to develop our predictive model. Least Absolute Shrinkage and Selection Operator logistic regression was used to select the best subset of predictors using 10-fold cross-validation. Read More

View Article and Full-Text PDF

Patterns of Narcotic Utilization in Women Undergoing Hysterectomy for Benign Indications.

J Gynecol Obstet Hum Reprod 2021 Jun 12:102181. Epub 2021 Jun 12.

Department of Obstetrics and Gynecology, Division of Minimally Invasive Gynecologic Surgery, University of North Carolina School of Medicine, Chapel Hill, NC.

Objective: To determine whether perioperative narcotic utilization at the time of hysterectomy has decreased since 2012.

Study Design: Retrospective cohort study.

Setting: Academic university hospital. Read More

View Article and Full-Text PDF

Comparison of treatment modalities in post-irradiation carotid blowout syndrome: a multi-center retrospective review.

World Neurosurg 2021 Jun 12. Epub 2021 Jun 12.

Department of Neurosurgery, Tuen Mun Hospital, Hong Kong.

Background: Carotid blowout syndrome is not uncommon in our locality, where head and neck cancers, especially nasopharyngeal carcinoma, are prevalent. Traditionally it carries high morbidity and mortality rate. Treatment paradigm has evolved from open surgeries to endovascular interventions, with each treatment modality carries its merits and drawbacks. Read More

View Article and Full-Text PDF

Leveraging insights from behavioral economics to improve mobility for adults with stroke: Design and rationale of the BE Mobile clinical trial.

Contemp Clin Trials 2021 Jun 12;107:106483. Epub 2021 Jun 12.

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

Physical inactivity post-stroke can negatively impact long-term health outcomes and contribute to cardiovascular deconditioning, muscle loss, and increased risk for recurrent stroke. The limited number of interventions designed to improve daily physical activity post-stroke have lacked precision in step goals, are resource intensive, and difficult to scale. The purpose of the Leveraging Insights from Behavioral Economics to Improve Mobility for Adults with Stroke (BE Mobile) trial is to examine the preliminary effectiveness of a novel gamification with social incentives intervention for improving physical activity post-stroke. Read More

View Article and Full-Text PDF

Development and Validation of a Nomogram to Predict Frailty Progression in Nonfrail Chinese Community-Living Older Adults.

J Am Med Dir Assoc 2021 Jun 12. Epub 2021 Jun 12.

Department of General Practice, Zhongshan Hospital of Fudan University, Shanghai, China.

Objective: Frailty state progression is common among older adults, so it is necessary to identify predictors to implement individualized interventions. We aimed to develop and validate a nomogram to predict frailty progression in community-living older adults.

Design: Prospective cohort study. Read More

View Article and Full-Text PDF

Interventions to prevent preterm delivery in twin-twin transfusion with short cervix.

Ultrasound Obstet Gynecol 2021 Jun 15. Epub 2021 Jun 15.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology and Reproductive Sciences, UTHealth The University of Texas McGovern Medical School and the Fetal Center at Children's Memorial Hermann Hospital, Houston, TX.

Objective: Pre-operative short cervical length (CL) remains a major risk factor for preterm birth after laser surgery for twin-twin transfusion syndrome (TTTS). Interventions to prolong pregnancy remain elusive. The objective of this study is to compare secondary preventive methods used in the setting of short CL at the time of laser surgery by five North American Fetal Treatment Network (NAFTNet) centers. Read More

View Article and Full-Text PDF

Current clinical concepts: hamstring strain injury rehabilitation.

J Athl Train 2021 Jun 15. Epub 2021 Jun 15.

University of Wisconsin-Madison, Madison, WI, USA.

Hamstring strain injuries are common among athletes and often require rehabilitation to prepare for timely return to sport performance, while also minimizing re-injury risk. Return to sport is typically achieved within weeks of the injury, but subsequent athlete performance may be impaired and re-injury rates are high. Improving these outcomes requires rehabilitation practitioners (e. Read More

View Article and Full-Text PDF

Disability, pain, and wound-specific concerns self-reported by adults at risk of limb loss: A cross-sectional study using the World Health Organization Disability Assessment Schedule 2.0.

PLoS One 2021 15;16(6):e0253288. Epub 2021 Jun 15.

Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Introduction: There has been limited study of patient-reported outcomes (PROs) in patients at risk of limb loss. Our primary objective was to estimate the prevalence of disability in this patient population using the World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2. Read More

View Article and Full-Text PDF

Cement augmentation for trochanteric femur fractures: A meta-analysis of randomized clinical trials and observational studies.

PLoS One 2021 15;16(6):e0251894. Epub 2021 Jun 15.

Department of Orthopaedic and Trauma Surgery, Lucerne Cantonal Hospital, Lucerne, Switzerland.

Introduction: To date, it is unclear what the clinical benefit of cement augmentation in fixation for trochanteric fractures is. The aim of this meta-analysis is to compare cement augmentation to no augmentation in fixation of trochanteric femur fractures in the elderly patients (>65 years) following low energy trauma.

Methods: PubMed/Medline/Embase/CENTRAL/CINAHL were searched for both randomized clinical trials (RCT) and observational studies comparing both treatments. Read More

View Article and Full-Text PDF

Describing the Mental Health State of Nurses in British Columbia: A Province-Wide Survey Study.

Healthc Policy 2021 May;16(4):31-45

Case and Contact Management, Pandemic Response, Island Health; Former Consultant, Former Executive Councillor of Occupational Health and Safety, British Columbia Nurses' Union, Burnaby, BC.

A cross-sectional province-wide survey study of 3,978 British Columbia (BC) nurses was conducted to explore the mental health state of the nursing workforce in BC. About one third of nurses reported depression and anxiety; about half reported symptoms of post-traumatic stress disorder and at least one third reported high levels of one or more dimensions of burnout. Mental health problems were about 1. Read More

View Article and Full-Text PDF

Obesogenic Behaviors of Rural Children on School and Nonschool Days.

Child Obes 2021 Jun 15. Epub 2021 Jun 15.

School of Social Work, College of Health Professions and Sciences, University of Central Florida, Orlando, FL, USA.

Children living in rural areas are at increased risk of overweight and obesity compared with their urban-dwelling counterparts. The purpose of this study was to provide preliminary evidence of rural children's obesogenic behaviors ( activity, sedentary behaviors, sleep, and diet) during school days, nonschool weekdays, and weekend days. A repeated measures 14-day observational study was conducted early March 2020. Read More

View Article and Full-Text PDF

Treatment for grade 4 peripheral intravenous infiltration with type 3 skin tears: A case report and literature review.

Int Wound J 2021 Jun 15. Epub 2021 Jun 15.

Ottawa Hospital Research Institute Clinical Epidemiology Program, Ottawa, Ontario, Canada.

Grade 4 peripheral intravenous infiltration with skin tears has seldom been reported. On 4 August 2020, a 35-year-old female patient was admitted to the emergency department of our hospital because of postprandial abdominal pain for 2 hours. She was diagnosed with a severe acute pancreatitis with type II diabetes mellitus. Read More

View Article and Full-Text PDF

Social isolation and psychosis: an investigation of social interactions and paranoia in daily life.

Eur Arch Psychiatry Clin Neurosci 2021 Jun 15. Epub 2021 Jun 15.

Department of Psychosis Studies, King's College London, Institute of Psychiatry, Psychology and Neuroscience, De Crespigny Park, London, SE5 8AF, UK.

Social isolation has been suggested to foster paranoia. Here we investigate whether social company (i.e. Read More

View Article and Full-Text PDF

Excess mortality after hip fracture: fracture or pre-fall comorbidity?

Osteoporos Int 2021 Jun 15. Epub 2021 Jun 15.

Division of Policy, Research and Evaluation, Ministry of Health, Singapore, Singapore.

Comorbidity and hip fracture independently increased mortality risk for 9 years in both sexes, with a significant additive interaction in the first year among women and through 6 years among men.

Introduction: Hip fracture is associated with a persistently elevated mortality risk, but it is unknown whether the elevated risk is due to the fracture or to pre-fracture comorbidity.

Methods: In a population-based study in Singapore with 9 years of follow-up, patients age > 50 with first hip fracture from 2008 to 2017 were pair-matched to a cohort without hip fracture by age, sex, ethnicity, and pre-fracture Charlson Comorbidity Index (CCI). Read More

View Article and Full-Text PDF

Patterns and prevalence of daily tobacco smoking in Australia by industry and occupation: 2007-2016.

Nicotine Tob Res 2021 Jun 15. Epub 2021 Jun 15.

National Centre for Education and Training on Addiction, Flinders University.

Introduction: Australian workers' daily tobacco smoking over time was examined by industry, and occupation, to identify factors associated with high/low prevalence.

Methods: Secondary analyses of 2007, 2010, 2013 and 2016 National Drug Strategy Household Surveys were undertaken (pooled n=49,395). Frequency analyses informed subsequent modelling of select industries and occupations. Read More

View Article and Full-Text PDF

Acute Treatments for Episodic Migraine in Adults: A Systematic Review and Meta-analysis.

JAMA 2021 Jun;325(23):2357-2369

Mayo Clinic Evidence-based Practice Center, Rochester, Minnesota.

Importance: Migraine is common and can be associated with significant morbidity, and several treatment options exist for acute therapy.

Objective: To evaluate the benefits and harms associated with acute treatments for episodic migraine in adults.

Data Sources: Multiple databases from database inception to February 24, 2021. Read More

View Article and Full-Text PDF

Efficacy of continuous positive airway pressure in neonates with respiratory distress syndrome: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Jun;100(24):e26406

Department of Pediatrics, The First People's Hospital of Jiangxia District.

Background: Respiratory distress syndrome (RDS) is a condition caused by a deficiency in pulmonary surfactant. Many interventions, including pulmonary surfactant, non-invasive respiratory support, and other supportive treatments have been used to prevent RDS. However, recent studies have focused on the continuous positive airway pressure as a significant potential agent for preventing RDS. Read More

View Article and Full-Text PDF

The use of cisplatin in patients after kidney transplantation with chronic renal insufficiency: Is the benefit higher than potential risks in therapy of non-seminomatous germ cell tumors?

Medicine (Baltimore) 2021 Jun;100(24):e26381

Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute.

Rationale: The use of cisplatin in patients with chronic kidney disease (CKD) is risky and depends on a number of factors. The optimal procedure in stage I of a non seminomatous germ cell tumor without proven lymphangioinvasion after orchiectomy is controversial and is the subject of a number of discussions due to the lack of randomized studies assessing individual treatment options. The adjuvant method of choice is surveillance or application of cisplatin-based chemotherapy with the risk of treatment related nephrotoxicity. Read More

View Article and Full-Text PDF

Joint effects of children's emotional problems and parental depressive symptoms on the occurrence of internet gaming disorder among children and adolescents: A longitudinal study.

J Behav Addict 2021 Jun 15. Epub 2021 Jun 15.

6Department of Biostatistics, Clinical Research Coordinating Center, The Catholic University of Korea, Seoul, Korea.

Background And Aims: Parental depressive symptoms may aggravate the effects of children's emotional problems on risks for Internet gaming disorder (IGD). Here we examined the joint effects of children's emotional problems and parents' depressive symptoms on the incidence of IGD.

Methods: A large prospective, population-based cohort tested potential interactions between children's emotional problems, parents' depressive symptoms, and incidence of high risk of IGD (HRIGD). Read More

View Article and Full-Text PDF

Effect of Mobile Phone Text Message Reminders on the Completion and Timely Receipt of Routine Childhood Vaccinations: Superiority Randomized Controlled Trial in Northwest Ethiopia.

JMIR Mhealth Uhealth 2021 Jun 15;9(6):e27603. Epub 2021 Jun 15.

Department of Health Informatics, Institute of Public Health, University of Gondar, Gondar, Ethiopia.

Background: Nonattendance at vaccination appointments is a big challenge for health workers as it is difficult to track routine vaccination schedules. In Ethiopia, 3 out of 10 children have incomplete vaccination and the timely receipt of the recommended vaccines is low. Thus, innovative strategies are required to reach the last mile where mobile technology can be effectively utilized to achieve better compliance. Read More

View Article and Full-Text PDF

Antibody Levels to Plasmodium falciparum Erythrocyte Membrane Protein 1-DBLγ11 and DBLδ-1 Predict Reduction in Parasite Density.

mSystems 2021 Jun 15:e0034721. Epub 2021 Jun 15.

Molecular and Pathogenesis Biomarkers Section, Laboratory of Malaria Immunology and Vaccinology (LMIV), National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIH), Bethesda, Maryland, USA.

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a variant surface antigen family expressed on infected red blood cells that plays a role in immune evasion and mediates adhesion to vascular endothelium. PfEMP1s are potential targets of protective antibodies as suggested by previous seroepidemiology studies. Here, we used previously reported proteomic analyses of PfEMP1s of clinical parasite isolates collected from Malian children to identify targets of immunity. Read More

View Article and Full-Text PDF

Genetic architecture of 11 organ traits derived from abdominal MRI using deep learning.

Elife 2021 Jun 15;10. Epub 2021 Jun 15.

Calico Life Sciences LLC, South San Francisco, United States.

Cardiometabolic diseases are an increasing global health burden. While socioeconomic, environmental, behavioural, and genetic risk factors have been identified, a better understanding of the underlying mechanisms is required to develop more effective interventions. Magnetic resonance imaging (MRI) has been used to assess organ health, but biobank-scale studies are still in their infancy. Read More

View Article and Full-Text PDF

Circadian characteristics of the rest-activity rhythm, executive function, and glucose fluctuations in young adults with type 1 diabetes.

Chronobiol Int 2021 Jun 15:1-11. Epub 2021 Jun 15.

Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, Ohio, USA.

Circadian alignment is an important element in individual health, and one behavioral marker, rest-activity rhythm, could influence self-management in young adults with type 1 diabetes (T1D). Little is known about the rest-activity rhythms, executive function, and glycemia among young adults with type 1 diabetes (T1D). The purpose of this study was to evaluate parametric and nonparametric circadian characteristics of the rest-activity rhythm and the associations between these variables, sleep-wake behavior, executive function, and glycemia among young adults with T1D. Read More

View Article and Full-Text PDF

Endovascular surgery is not protective against new persistent opioid use development compared to open vascular surgery.

Vascular 2021 Jun 15:17085381211024514. Epub 2021 Jun 15.

Section of Vascular Surgery, Department of Surgery, 1259University of Michigan, Ann Arbor, MI, USA.

Objective: Endovascular techniques continue to be increasingly utilized to treat vascular disease, but the effect of these minimally invasive techniques on opioid use following surgery is not known.

Methods: Using Medicare data, we identified opioid-naive patients undergoing vascular procedures between 2009 and 2017. We selected patients ≥65 years old with continuous enrollment 12 months before and 6 months after surgery and had no additional operations. Read More

View Article and Full-Text PDF