6,167 results match your criteria interventions cholesterol


The Effect of Daily Methylsulfonylmethane (MSM) Consumption on High-Density Lipoprotein Cholesterol in Healthy Overweight and Obese Adults: A Randomized Controlled Trial.

Nutrients 2021 Oct 15;13(10). Epub 2021 Oct 15.

Department of Nutrition and Exercise Physiology, Elson S. Floyd College of Medicine, Washington State University, Spokane, WA 99202, USA.

Interventions to decrease inflammation and improve metabolic function hold promise for the prevention of obesity-related diseases. Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates antioxidant and anti-inflammatory effects. Improvements in measures of metabolic health have been observed in mouse models of obesity and diabetes following MSM treatment. Read More

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October 2021

Aberrant Mechanical Efficiency during Exercise Relates to Metabolic Health and Exercise Intolerance in Adolescents with Obesity.

Int J Environ Res Public Health 2021 Oct 9;18(20). Epub 2021 Oct 9.

REVAL-Rehabilitation Research Center, Faculty of Rehabilitation Sciences, Hasselt University, 3590 Diepenbeek, Belgium.

Background: Mechanical efficiency (ME) might be an important parameter evaluating cardiometabolic health and the effectiveness of physical activity interventions in individuals with obesity. However, whether these cardiometabolic risk factors may relate to ME in adolescents with obesity is not known yet. Therefore, this study aims to compare the mechanical efficiency during maximal exercise testing between adolescents with obesity and lean adolescents, and to examine associations with exercise tolerance and metabolic health. Read More

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October 2021

Associations between SNPs in Intestinal Cholesterol Absorption and Endogenous Cholesterol Synthesis Genes with Cholesterol Metabolism.

Biomedicines 2021 Oct 14;9(10). Epub 2021 Oct 14.

Department of Nutrition and Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, 6200 MD Maastricht, The Netherlands.

Single nucleotide polymorphisms (SNPs) have been associated with cholesterol metabolism and may partly explain large inter-individual variability in intestinal cholesterol absorption and endogenous cholesterol synthesis rates. This cross-sectional study therefore examined whether SNPs in genes encoding for proteins involved in intestinal cholesterol absorption ( and ) and endogenous cholesterol synthesis (, , , , , and ) were associated with intestinal cholesterol absorption markers (total cholesterol (TC) standardized campesterol and sitosterol levels), an endogenous cholesterol synthesis marker (TC-standardized lathosterol levels), and serum low-density lipoprotein cholesterol (LDL-C) concentrations in a European cohort. (rs4245786) and the tag SNP (rs4245791) were significantly associated with serum campesterol and/or sitosterol levels. Read More

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October 2021

Trans-ethnic Mendelian-randomization study reveals causal relationships between cardiometabolic factors and chronic kidney disease.

Int J Epidemiol 2021 Oct 20. Epub 2021 Oct 20.

Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Background: This study was to systematically test whether previously reported risk factors for chronic kidney disease (CKD) are causally related to CKD in European and East Asian ancestries using Mendelian randomization.

Methods: A total of 45 risk factors with genetic data in European ancestry and 17 risk factors in East Asian participants were identified as exposures from PubMed. We defined the CKD by clinical diagnosis or by estimated glomerular filtration rate of <60 ml/min/1. Read More

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October 2021

Technology-based nutrition interventions using the Mediterranean diet: a systematic review.

Nutr Rev 2021 Oct 19. Epub 2021 Oct 19.

Nada Benajiba is with the Department of Health Basic Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. Elizabeth Dodge is with the College of Graduate & Professional Studies, University of New England, Portland, Maine, USA. Meghit Boumédiène Khaled is with the Faculty of Life and Natural Science, Department of Biology, Laboratory of Nutrition, Pathology, Biotechnology and Health, Djillali Liabes University of Sidi-Bel-Abbes, Sidi-Bel-Abbes, Algeria. Enmanuel A. Chavarria is with the Rollins School of Public Health, Department of Behavioral, Social, and Health Education Sciences, Emory University, Atlanta, Georgia, USA. Cara J. Sammartino is with the College of Health & Wellness, Department of Health Science, Johnson & Wales University, Providence, Rhode Island, USA. Basil H. Aboul-Enein is with the Faculty of Public Health and Policy, London School of Hygiene & Tropical Medicine, London, United Kingdom.

Context: Over the past 2 decades, overweight and obesity rates have increased exponentially, along with related comorbidities including type 2 diabetes, hypertension, cardiovascular disease, and some cancers. The Mediterranean Diet (MDiet) has been suggested as a potential way to mitigate the health burdens related to overweight and obesity.

Objective: For this review, the literature on MDiet-focused digital interventions was examined to determine efficacy, best practices, and potential limitations. Read More

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October 2021

Potential effects on cardiometabolic risk factors and body composition by short message service (SMS)-guided training after recent minor stroke or transient ischaemic attack: post hoc analyses of the STROKEWALK randomised controlled trial.

BMJ Open 2021 Oct 18;11(10):e054851. Epub 2021 Oct 18.

Department of Public Health and Caring Sciences, Clinical Nutrition and Metabolism, Uppsala Universitet Medicinska fakulteten, Uppsala, Sweden.

Objectives: To evaluate effects of mobile phone text-messaging exercise instructions on body composition, cardiometabolic risk markers and self-reported health at 3 months after stroke.

Design: Randomised controlled intervention study with per-protocol analyses.

Setting: University Hospital in Sweden. Read More

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October 2021

Assessment of Diabetes-Related Health Disparities among the Marshallese Living in the Republic of the Marshall Islands.

Hawaii J Health Soc Welf 2021 Oct;80(10):235-241

Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR (JS, HF).

There is a high prevalence of type 2 diabetes mellitus (T2DM) among the Marshallese in the Republic of the Marshall Islands (RMI). However, no prior literature has examined self-reported health indicators, self-management activities, barriers to care, diabetes knowledge, and family support for diabetes management. This study examined health indicators among participants with T2DM (n=41). Read More

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October 2021

Balancing the efficacy vs. the toxicity of promiscuous natural products: Paclitaxel-based acid-labile lipophilic prodrugs as promising chemotherapeutics.

Eur J Med Chem 2021 Oct 8;227:113891. Epub 2021 Oct 8.

National Center for Natural Products Research, University of Mississippi, University, MS, 38677, USA. Electronic address:

TumorSelect® is an anticancer technology that combines cytotoxics, nanotechnology, and knowledge of human physiology to develop innovative therapeutic interventions with minimal undesirable side effects commonly observed in conventional chemotherapy. Tumors have a voracious appetite for cholesterol which facilitates tumor growth and fuels their proliferation. We have transformed this need into a stealth delivery system to disguise and deliver anticancer drugs with the assistance of both the human body and the tumor cell. Read More

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October 2021

Duodenal-Jejunal Bypass Liner for the management of Type 2 Diabetes Mellitus and Obesity: A Multicenter Randomized Controlled Trial.

Ann Surg 2021 Jun 14. Epub 2021 Jun 14.

Department of Surgery and Cancer, Imperial College, London, UK Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK Division of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK PsychoNeuroEndocrinology Research Group, Neuropsychopharmacology Unit, Center for Psychiatry and Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of Brain Sciences, Imperial College London, UK Imperial College London, Department of Public Health, Imperial Clinical Trials Unit, London, UK Psychiatry and Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of Brain Sciences, Imperial College London, UK Diabetes Complications Research Center, University College Dublin, Ireland Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia Southampton Health Technology Assessment Center, University of Southampton, Southampton, UK Section of Nutritional research, Department of Metabolism, Digestion and Reproduction, Imperial College London, UK Department of Endocrinology, King's College Hospital NHS Trust, London, UK University Hospital Southampton NHS Foundation Trust, Biomedical Research Center, Southampton, UK Primary Care, Population Sciences and Medical Education, University of Southampton Medical School, Southampton, UK.

Objective: The aim of this study was to examine the clinical efficacy and safety of the duodenal-jejunal bypass liner (DJBL) while in situ for 12 months and for 12 months after explantation.

Summary Background Data: This is the largest randomized controlled trial (RCT) of the DJBL, a medical device used for the treatment of people with type 2 diabetes mellitus (T2DM) and obesity. Endoscopic interventions have been developed as potential alternatives to those not eligible or fearful of the risks of metabolic surgery. Read More

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Population awareness of cardiovascular disease risk factors and health care seeking behavior in the UAE.

Am J Prev Cardiol 2021 Dec 25;8:100255. Epub 2021 Sep 25.

Health Informatics and Smart Health Department, Health Regulation Sector, Dubai Health Authority, Dubai, United Arab Emirates.

Objectives: We aimed to determine the awareness, knowledge, and attitude of people residing in Dubai, United Arab Emirates, regarding cardiovascular disease (CVD) risk factors. Our aim was to further identify prospects to increase awareness of modifiable CVD risk factors and influence behavior.

Methods: This observational study was conducted in Dubai: a global city in the United Arab Emirates. Read More

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December 2021

Serum Fetuin-B Levels Are Elevated in Women with Metabolic Syndrome and Associated with Increased Oxidative Stress.

Oxid Med Cell Longev 2021 4;2021:6657658. Epub 2021 Oct 4.

Key Laboratory of Diagnostic Medicine (Ministry of Education) and Department of Clinical Biochemistry, College of Laboratory Medicine, Chongqing Medical University, 400016 Chongqing, China.

Previous studies on serum fetuin-B (fetuin-like protein IRL685) have investigated its association with T2DM; however, the reason for the variation in serum fetuin-B and its regulatory factors in metabolic disease remain unclear. Here, we evaluated serum fetuin-B levels in women with newly diagnosed MetS and performed multiple interventions to investigate the role of fetuin-B in the pathogenesis of MetS. Serum fetuin-B levels were assessed using ELISA. Read More

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October 2021

Application of Machine Learning Techniques to Identify Data Reliability and Factors Affecting Outcome After Stroke Using Electronic Administrative Records.

Front Neurol 2021 27;12:670379. Epub 2021 Sep 27.

Neurosciences Department, University Hospital Geelong, Geelong, VIC, Australia.

To use available electronic administrative records to identify data reliability, predict discharge destination, and identify risk factors associated with specific outcomes following hospital admission with stroke, compared to stroke specific clinical factors, using machine learning techniques. The study included 2,531 patients having at least one admission with a confirmed diagnosis of stroke, collected from a regional hospital in Australia within 2009-2013. Using machine learning (penalized regression with Lasso) techniques, patients having their index admission between June 2009 and July 2012 were used to derive predictive models, and patients having their index admission between July 2012 and June 2013 were used for validation. Read More

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September 2021

HDL and reverse cholesterol transport in humans and animals: Lessons from pre-clinical models and clinical studies.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Oct 9;1867(1):159065. Epub 2021 Oct 9.

Division of Translational Medicine & Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3600 Spruce Street, Philadelphia, PA 19104, USA.

The ability to accept cholesterol from cells and to promote reverse cholesterol transport (RCT) represents the best characterized antiatherogenic function of HDL. Studies carried out in animal models have unraveled the multiple mechanisms by which these lipoproteins drive cholesterol efflux from macrophages and cholesterol uptake to the liver. Moreover, the influence of HDL composition and the role of lipid transporters have been clarified by using suitable transgenic models or through experimental design employing pharmacological or nutritional interventions. Read More

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October 2021

Effectiveness of system-based intervention in reducing incidence of type 2 diabetes and to improve the postnatal metabolic profiles in women with gestational diabetes mellitus: a randomized controlled study.

Gynecol Endocrinol 2021 Oct 12:1-8. Epub 2021 Oct 12.

Klinik Kesihatan Teluk Panglima Garang, Ministry of Health Malaysia, Teluk Panglima Garang, Malaysia.

Aim: The objective of this study was to determine the effectiveness of system-based intervention in reducing the incidence of diabetes and to improve the postnatal metabolic profiles among women with gestational diabetes mellitus (GDM).

Materials And Methods: For women in the intervention arm ( = 130), they received one session of individualized health education at 36 gestational weeks, a booklet of diabetes prevention, five-session of postpartum booster educational program which were conducted including 1 session of dietary and exercise counseling by dietician and physiotherapist at 6 weeks postpartum. For women in the control group ( = 168), standard treatment whereby they had received group therapy on diet and physical activity modification by dietician and staff nurses during the antenatal period. Read More

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October 2021

Tawazon- An Intensive Lifestyle Diabetes Prevention Program: The Saudi Arabian Pilot.

J Multidiscip Healthc 2021 1;14:2767-2775. Epub 2021 Oct 1.

Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.

Background: Lifestyle modification interventions help prevent or postpone Type 2 Diabetes and its complications with diet modification and increasing physical activity. This is translational research of Tawazon-DPP in which we evaluate the efficacy of the intensive lifestyle modification program.

Methods: Tawazon was piloted in 2 phases over 6 and 9 months at a Tertiary Hospital. Read More

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October 2021

Mechanisms of induction of tumors by cholesterol and potential therapeutic prospects.

Biomed Pharmacother 2021 Oct 6;144:112277. Epub 2021 Oct 6.

Department of Oncology, Huzhou Central Hospital, Affiliated Central Hospital Huzhou University, No.1558, Sanhuan North Road, Wuxing District, Huzhou, Zhejiang 313000, China. Electronic address:

Increasing evidence suggested that cholesterol is an important integrant of cell membranes, that plays a key role in tumor progression, immune dysregulation, and pathological changes in epigenetic mechanisms. Based on these theories, there is a growing interest on targeting cholesterol in the treatment of cancer. Here, we comprehensively reviewed the major function of cholesterol on oncogenicity, the therapeutic targets of cholesterol and its metabolites in cancer, and provide detailed insight into the essential roles of cholesterol in mediating immune and epigenetic mechanisms of the tumor microenvironment. Read More

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October 2021

Genetics and regulation of HDL metabolism.

Biochim Biophys Acta Mol Cell Biol Lipids 2021 Oct 6;1867(1):159060. Epub 2021 Oct 6.

Institute of Biosciences and Applications, National Center for Scientific Research "Demokritos", Agia Paraskevi, Athens, Greece.

The inverse association between plasma HDL cholesterol (HDL-C) levels and risk for cardiovascular disease (CVD) has been demonstrated by numerous epidemiological studies. However, efforts to reduce CVD risk by pharmaceutically manipulating HDL-C levels failed and refused the HDL hypothesis. HDL-C levels in the general population are highly heterogeneous and are determined by a combination of genetic and environmental factors. Read More

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October 2021

Hypomorphic ASGR1 modulates lipid homeostasis via INSIG1-mediated SREBP signaling suppression.

JCI Insight 2021 Oct 8;6(19). Epub 2021 Oct 8.

Center for Health Research, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

A population genetic study identified that the asialoglycoprotein receptor 1 (ASGR1) mutation carriers had substantially lower non-HDL-cholesterol (non-HDL-c) levels and reduced risks of cardiovascular diseases. However, the mechanism behind this phenomenon remained unclear. Here, we established Asgr1-knockout mice that represented a plasma lipid profile with significantly lower non-HDL-c and triglyceride (TG) caused by decreased secretion and increased uptake of VLDL/LDL. Read More

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October 2021

Feasibility of a high-PRotein Mediterranean-style diet and resistance Exercise in cardiac Rehabilitation patients with sarcopenic obesity (PRiMER): Study protocol for a randomised control trial.

Clin Nutr ESPEN 2021 10 15;45:492-498. Epub 2021 Aug 15.

Research Institute of Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK; Institute for Health Research, Liverpool John Moores University, Liverpool, UK. Electronic address:

Background: Cardiac rehabilitation (CR) is an essential component of long-term recovery following a cardiac event. Typical CR may not be optimal for patients presenting with sarcopenic obesity (SO) who present with reduced muscle mass and elevated adipose tissue, and may indicate greater cardiovascular disease (CVD) risk. Resistance exercise and high-protein diets are known to increase muscle mass, while Mediterranean-style diets have been shown to reduce CVD risk. Read More

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October 2021

Forecast of ameliorating effect of dietary flavonol consumption in white tea with or without aerobic training on type 2 diabetes (T2D) in females.

Clin Nutr ESPEN 2021 10 2;45:134-140. Epub 2021 Sep 2.

Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

Background And Aims: Diabetes Mellitus (D.M.) is a chronic metabolic disease characterized by hyperglycemia due to insufficient or inefficient insulin secretory response that has become a widespread epidemic primarily due to the increasing prevalence and incidence of type 2 diabetes. Read More

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October 2021

Strategies for screening for familial hypercholesterolaemia in primary care and other community settings.

Cochrane Database Syst Rev 2021 Oct 7;10:CD012985. Epub 2021 Oct 7.

Centre for Evidence Based Healthcare, Division of Epidemiology and Public Health, Clinical Sciences Building Phase 2, University of Nottingham, Nottingham, UK.

Background: Familial hypercholesterolaemia is a common inherited condition that is associated with premature cardiovascular disease. The increased cardiovascular morbidity and mortality, resulting from high levels of cholesterol since birth, can be prevented by starting lipid-lowering therapy. However, the majority of patients in the UK and worldwide remain undiagnosed. Read More

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October 2021

Personalized diet study of dietary advanced glycation end products (AGEs) and fatty acid desaturase 2 (FADS) genotypes in obesity.

Sci Rep 2021 Oct 5;11(1):19725. Epub 2021 Oct 5.

Department of Biochemistry and Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Attar-Neishabouri Ave, Golgasht St, 5165665931, Tabriz, Iran.

Obesity prevalence have tripled in the past decades. It is logical to consider new approaches to halt its prevalence. In this concept, considering the effect of interaction between fatty acid desaturase 2 (FADS) gene variants and dietary advanced glycation end products (AGEs) on obesity-related characteristics seems to be challenging. Read More

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October 2021

Effect of Financial Incentives for Process, Outcomes, or Both on Cholesterol Level Change: A Randomized Clinical Trial.

JAMA Netw Open 2021 Oct 1;4(10):e2121908. Epub 2021 Oct 1.

Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.

Importance: Financial incentives may improve health behaviors. It is unknown whether incentives are more effective if they target a key process (eg, medication adherence), an outcome (eg, low-density lipoprotein cholesterol [LDL-C] levels), or both.

Objective: To determine whether financial incentives awarded daily for process (adherence to statins), awarded quarterly for outcomes (personalized LDL-C level targets), or awarded for process plus outcomes induce reductions in LDL-C levels compared with control. Read More

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October 2021

Association of Statin Therapy Initiation With Diabetes Progression: A Retrospective Matched-Cohort Study.

JAMA Intern Med 2021 Oct 4. Epub 2021 Oct 4.

Department of Population and Data Sciences, University of Texas Southwestern Medical Center, Dallas.

Importance: Statin therapy has been associated with increased insulin resistance; however, its clinical implications for diabetes control among patients with diabetes is unknown.

Objective: To assess diabetes progression after initiation of statin use in patients with diabetes.

Design, Setting, And Participants: This was a retrospective matched-cohort study using new-user and active-comparator designs to assess associations between statin initiation and diabetes progression in a national cohort of patients covered by the US Department of Veterans Affairs from fiscal years 2003-2015. Read More

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October 2021

Effectiveness of a lifestyle weight-loss intervention targeting inactive former elite athletes: the Champ4Life randomised controlled trial.

Br J Sports Med 2021 Oct 1. Epub 2021 Oct 1.

Exercise and Health Laboratory, CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Cruz Quebrada, Portugal.

Objectives: Many athletes struggle in managing the end of their career, often gaining weight and adopting unhealthy lifestyles. Lifestyle programmes targeting former athletes who have gained substantial fat mass (FM) postsports career are lacking. We studied the effects of the Champ4Life programme on body composition and other health-related outcomes in former elite athletes with overweight or obesity. Read More

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October 2021

OTUB1 Alleviates Nonalcoholic Steatosis through Inhibition of the TRAF6-ASK1 Signaling Pathways.

Hepatology 2021 Sep 30. Epub 2021 Sep 30.

Cardiovascular Hospital, the First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, 450052, China.

Background & Aims: Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of the metabolic syndrome, which includes insulin resistance (IR), obesity and hyperlipidemia. Nonalcoholic steatohepatitis (NASH) is a progressive stage of NAFLD with severe hepatic steatosis, hepatocyte death, inflammation and fibrosis. Currently, no pharmacological interventions specifically tailored for NASH are approved. Read More

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September 2021

Improving the Dietary Intake of Healthcare Workers Through Workplace Dietary Interventions: A Systematic Review and Meta-Analysis.

Adv Nutr 2021 Sep 30. Epub 2021 Sep 30.

Department of Nutrition and Dietetics, King's College London, 150 Stamford Street, London, SE1 9NH, United Kingdom.

The workplace has been identified as a potential location for dietary intervention delivery due to the amount of time spent and the meals eaten in this setting. It is recommended that interventions are tailored to specific occupational groups, and to date, there is limited synthesis of the evidence relating to healthcare workers. This review characterises and evaluates the effectiveness of dietary interventions in healthcare workers to aid the design and implementation of interventions. Read More

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September 2021

Investigation of the Interplay between Circulating Lipids and IGF-I and Relevance to Breast Cancer Risk: An Observational and Mendelian Randomization Study.

Cancer Epidemiol Biomarkers Prev 2021 Sep 28. Epub 2021 Sep 28.

Medical Research Council (MRC) Integrative Epidemiology Unit, Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom.

Background: Circulating lipids and insulin-like growth factor 1 (IGF-I) have been reliably associated with breast cancer. Observational studies suggest an interplay between lipids and IGF-I, however, whether these relationships are causal and if pathways from these phenotypes to breast cancer overlap is unclear.

Methods: Mendelian randomization (MR) was conducted to estimate the relationship between lipids or IGF-I and breast cancer risk using genetic summary statistics for lipids (low-density lipoprotein cholesterol, LDL-C; high-density lipoprotein cholesterol, HDL-C; triglycerides, TGs), IGF-I and breast cancer from GLGC/UKBB ( = 239,119), CHARGE/UKBB ( = 252,547), and Breast Cancer Association Consortium ( = 247,173), respectively. Read More

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September 2021

A lifestyle intervention with an energy-restricted Mediterranean diet and physical activity enhances HDL function: a substudy of the PREDIMED-Plus randomized controlled trial.

Am J Clin Nutr 2021 Sep 28. Epub 2021 Sep 28.

Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Medical Research Institute, Barcelona, Spain.

Background: Consumption of a Mediterranean diet, adequate levels of physical activity, and energy-restricted lifestyle interventions have been individually associated with improvements in HDL functions. Evidence of intensive interventions with calorie restriction and physical activity is, however, scarce.

Objectives: To determine whether an intensive lifestyle intervention with an energy-restricted Mediterranean diet plus physical activity enhanced HDL function compared to a non-hypocaloric Mediterranean eating pattern without physical activity. Read More

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September 2021

Dietary Lipids and Dyslipidemia in Chronic Kidney Disease.

Nutrients 2021 Sep 9;13(9). Epub 2021 Sep 9.

Department of Biochemistry, Faculty of Medicine, Medical University of Gdansk, 80-210 Gdansk, Poland.

The progression of chronic kidney disease (CKD) leads to altered lipid metabolism. CKD patients exhibit high blood triglyceride (TG) levels, reduced concentrations and functionality of high-density lipoproteins (HDL), and elevated levels of atherogenic small, dense, low-density lipoproteins (sdLDL). Disorders of lipid metabolism and other metabolic disturbances place CKD patients at high risk for cardiovascular disease (CVD). Read More

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September 2021