Ann Surg 2021 Jun 14. Epub 2021 Jun 14.
Department of Surgery and Cancer, Imperial College, London, UK Department of Metabolism, Digestion and Reproduction, Imperial College, London, UK Division of Surgery, University Hospital Southampton NHS Foundation Trust, Southampton, UK PsychoNeuroEndocrinology Research Group, Neuropsychopharmacology Unit, Center for Psychiatry and Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of Brain Sciences, Imperial College London, UK Imperial College London, Department of Public Health, Imperial Clinical Trials Unit, London, UK Psychiatry and Computational, Cognitive and Clinical Neuroimaging Laboratory, Department of Brain Sciences, Imperial College London, UK Diabetes Complications Research Center, University College Dublin, Ireland Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia Southampton Health Technology Assessment Center, University of Southampton, Southampton, UK Section of Nutritional research, Department of Metabolism, Digestion and Reproduction, Imperial College London, UK Department of Endocrinology, King's College Hospital NHS Trust, London, UK University Hospital Southampton NHS Foundation Trust, Biomedical Research Center, Southampton, UK Primary Care, Population Sciences and Medical Education, University of Southampton Medical School, Southampton, UK.
Objective: The aim of this study was to examine the clinical efficacy and safety of the duodenal-jejunal bypass liner (DJBL) while in situ for 12 months and for 12 months after explantation.
Summary Background Data: This is the largest randomized controlled trial (RCT) of the DJBL, a medical device used for the treatment of people with type 2 diabetes mellitus (T2DM) and obesity. Endoscopic interventions have been developed as potential alternatives to those not eligible or fearful of the risks of metabolic surgery. Read More