8,551,690 results match your criteria interventional procedures

Opioid availability statistics from the International Narcotics Control Board do not reflect the medical use of opioids: comparison with sales data from Scandinavia.

Scand J Pain 2021 Jul 27. Epub 2021 Jul 27.

The NEPI Foundation and Unit of Health Care Analysis, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

Objectives: Opioid analgesics are essential in clinical practice, but their excessive use is associated with addiction risk. Increases in opioid prescription rates have fuelled an epidemic of opioid addiction in the USA, making statistics on medical opioid use a critical warning signal. A dramatic 150% increase in Swedish opioid access 2001-2013 was recently reported based on data from the International Narcotics Control Board (INCB; Berterame et al. Read More

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Second trimester prediction of gestational diabetes: maternal analytes as an additional screening tool.

J Perinat Med 2021 Jul 27. Epub 2021 Jul 27.

Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Hawaii, Honolulu, HI, USA.

Objectives: Early diagnosis of gestational diabetes can lead to greater optimization of glucose control. We evaluated associations between maternal serum analytes (alpha-fetoprotein [AFP], free beta-human chorionic gonadotropin [beta-hCG], inhibin, and estriol) and the development of gestational diabetes mellitus (GDM).

Methods: This retrospective cohort study identified single-ton pregnancies with available second trimester serum analytes between 2009 and 2017. Read More

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Students with dyslexia between school and university: Post-diploma choices and the reasons that determine them. An Italian study.

Dyslexia 2021 Jul 27. Epub 2021 Jul 27.

Research Methods and Diagnosis in Education Department, Doctoral Programme of Education Sciences, University of Granada, Campus Universitario de la Cartuja, Granada, Spain.

Although the number of students with dyslexia enrolled in Italian universities is constantly growing, their presence remains relatively limited. The aim of this study was therefore to investigate the choices made by students with dyslexia in relation to university studies, and the underlying reasons for their choices. This study also compares these choices for students with and without dyslexia. Read More

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Ultra-Low Energy Cycled Burst Spinal Cord Stimulation Yields Robust Outcomes in Pain, Function, and Affective Domains: A Subanalysis From Two Prospective, Multicenter, International Clinical Trials.

Neuromodulation 2021 Jul 27. Epub 2021 Jul 27.

University of Chicago Medical Center, Chicago, IL, USA.

Introduction: DeRidder's burst stimulation design has become a key spinal cord stimulation (SCS) waveform because it reduces the intensity of pain as well as its associated emotional distress. The brain pathways underlying these outcomes may also allow for the effects of stimulation to carry over after stimulation is turned off, making it amenable to intermittent application. Here, the utility of intermittently cycled burst was evaluated using data from two large real-world prospective studies (TRIUMPH, REALITY). Read More

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Cancer patient perspective in the arena of COVID-19 pandemic.

Psychooncology 2021 Jul 27. Epub 2021 Jul 27.

Clinical Oncology, Università Politecnica delle Marche, AOU Ospedali Riuniti di Ancona, Ancona, Italy.

Objective: The coronavirus disease 2019 (COVID-19) outbreak has been declared a global pandemic of unprecedented proportions. Italy is a country which has been heavily affected. Cancer patients are at a higher risk owing to their intrinsic fragility related to their underlying disease and oncologic treatment. Read More

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Potential for optimizing management of obesity in the secondary prevention of coronary heart disease.

Eur Heart J Qual Care Clin Outcomes 2021 Jul 27. Epub 2021 Jul 27.

Department of Medicine, Solna, Karolinska Institutet, FoU - Tema Hjärta och Kärl, S1:02, Karolinska Universitetssjukhuset/Solna, SE-171 76, Stockholm, Sweden.

Aims: Prevention guidelines have identified the management of obese patients as an important priority to reduce the burden of incident and recurrent cardiovascular disease. Still, studies have demonstrated that over 80% of patients with coronary heart disease (CHD) fail to achieve their weight target. Here, we describe advice received and actions reported by overweight CHD patients since being discharged from hospital and how weight changes relate to their risk profile. Read More

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Word synonym relationships for text analysis: A graph-based approach.

Hend Alrasheed

PLoS One 2021 27;16(7):e0255127. Epub 2021 Jul 27.

Department of Information Technology, College of Computer and Information Sciences, King Saud University, Riyadh, Saudi Arabia.

Keyword extraction refers to the process of detecting the most relevant terms and expressions in a given text in a timely manner. In the information explosion era, keyword extraction has attracted increasing attention. The importance of keyword extraction in text summarization, text comparisons, and document categorization has led to an emphasis on graph-based keyword extraction techniques because they can capture more structural information compared to other classic text analysis methods. Read More

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Feasibility and Effectiveness of a Quality Improvement Curriculum for Combined Medicine Subspecialty Fellows.

Am J Med Qual 2021 Jul 27. Epub 2021 Jul 27.

Division of Geriatrics and Palliative Medicine, University of Texas Medical Branch, Galveston, TX Division of General Internas and Palliative Medicinel Medicine, Department of Medicine, University of Texas Medical Branch, Galveston, TX.

Background: The Accreditation Council for Graduate Medical Education (ACGME) requires training in quality improvement (QI) yet many programs struggle to incorporate appropriate content. Small fellowship programs may find it particularly difficult, limited by a lack of well-trained faculty. We report on the feasibility and effectiveness of a consolidated curriculum for subspecialty fellowship programs. Read More

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Outcomes after Acute Peritoneal Dialysis for Critical Cardiorenal Syndrome Type 1.

Cardiorenal Med 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Medicine, Maharat Nakhon Ratchasima Hospital, Nakhonratchasima, Thailand.

Introduction: The aim of the study was to demonstrate the outcomes of peritoneal dialysis (PD) in critically ill cardiorenal syndrome type 1 (CRS1).

Methods: A cohort of 147 patients with CRS1 who received PD from 2011 to 2019 in a referral hospital in Thailand was analyzed. The primary outcome was 30-day in-hospital mortality. Read More

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Public Health and Nephrology: Contributions of Epidemiology to the Study, Understanding, Prevention and Treatment of Kidney Disease.

Contrib Nephrol 2021 Jul 27;199:1-14. Epub 2021 Jul 27.

School of Primary Care, Population Science and Medical Education, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

Kidney disease is frequently described as a public health problem. This chapter will unpack what we mean by "public health" and by "taking a public health approach." We will consider the global burden of kidney diseases and their determinants, with a focus on chronic kidney disease. Read More

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Epidemiology of Epilepsy in Low- and Middle-Income Countries: Experience of a Standardized Questionnaire over the Past Two Decades.

Neuroepidemiology 2021 Jul 27:1-12. Epub 2021 Jul 27.

INSERM, Univ. Limoges, CHU Limoges, IRD, U1094, Tropical Neuroepidemiology, Institute of Epidemiology and Tropical Neurology, GEIST, Limoges, France.

Introduction: Epilepsy affects >50 million people worldwide, with 80% of them living in low- and middle-income countries (LMICs). Studies with a standardized methodology are required to obtain comparable data on epilepsy and implement health policies in order to reduce the treatment gap and improve the diagnosis and management of epilepsy. In 2000, following the guidelines of the International League Against Epilepsy (ILAE), the "questionnaire for investigation of epilepsy in tropical countries" (IENT questionnaire) was developed to promote epidemiological surveys on epilepsy using a standard methodology. Read More

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Comparative Safety and Efficacy of Therapeutic Options in Resectable and Advanced/Metastatic Pancreatic Cancer: A Systematic Review and Indirect Comparison.

Oncol Res Treat 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Pharmacotherapy, College of Pharmacy, University of Utah, Salt Lake City, Utah, USA.

Objectives: FOLFIRINOX, gemcitabine/nab-paclitaxel (gem-nab/P), and gemcitabine-capecitabine (gem-cap) demonstrated superiority over gemcitabine monotherapy for pancreatic cancer (PC). It is still unclear which chemotherapy regimen is the most optimal. This study aimed to conduct a systematic review (SR) and indirect comparison to compare safety and efficacy of FOLFIRINOX versus gem-nab/P and gem-cap in PC. Read More

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The Risk Factors and Clinical Outcomes Associated with Acute Kidney Injury in Patients with COVID-19: Data from a Large Cohort in Iran.

Kidney Blood Press Res 2021 Jul 27:1-9. Epub 2021 Jul 27.

Department of Nephrology Diseases, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Kidney involvement, ranging from mild hematuria and proteinuria to acute kidney injury (AKI) in patients with coronavirus disease-2019 (COVID-19), is a recent finding with various incidence rates reported among hospitalized patients with COVID-19. Given the various AKI rates and their associated risk factors, lack of AKI recovery in the majority of patients hospitalized with COVID-19, and limited data regarding AKI in patients with COVID-19 in Iran, we aim to investigate the potential risk factors for AKI development and its incidence in patients hospitalized with COVID-19.

Methods: In this retrospective cohort study, we enrolled adult patients referred to the Sina Hospital, Iran, from February 20 to May 14, 2020, with either a positive PCR test or a highly susceptible chest computed tomography features consistent with COVID-19 diagnosis. Read More

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Efficacy of Chininum Sulphuricum 30C against Malaria: An in vitro and in vivo Study.

Complement Med Res 2021 Jul 27:1-10. Epub 2021 Jul 27.

Parasitology Laboratory, Department of Zoology, Panjab University, Chandigarh, India.

Background: New effective, economical and safe antimalarial drugs are urgently needed due to the development of multi-drug-resistant strains of the parasite. Homeopathy uses ultra-diluted doses of various substances to stimulate autoregulatory and self-healing processes to cure various ailments. The aim of the study was to evaluate the in vitro and in vivo antimalarial efficacy of a homeopathic drug, Chininum sulphuricum 30C. Read More

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Sarcopenia Is Associated with Mortality in Adults: A Systematic Review and Meta-Analysis.

Gerontology 2021 Jul 27:1-16. Epub 2021 Jul 27.

Department of Medicine and Aged Care, @AgeMelbourne, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Background: Sarcopenia can predispose individuals to falls, fractures, hospitalization, and mortality. The prevalence of sarcopenia depends on the population studied and the definition used for the diagnosis.

Objective: This systematic review and meta-analysis aimed to investigate the association between sarcopenia and mortality and if it is dependent on the population and sarcopenia definition. Read More

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Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging for the Analysis of Microvascular Permeability in Peritumor Brain Edema of Fibrous Meningiomas.

Eur Neurol 2021 Jul 27;84(5):361-367. Epub 2021 Jul 27.

Department of Radiology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.

Introduction: This study aims to analyze the permeability of intra- and peri-meningiomas regions and compare the microvascular permeability between peritumoral brain edema (PTBE) and non-PTBE using DCE-MRI.

Methods: This was a retrospective of patients with meningioma who underwent surgery. The patients were grouped as PTBE and non-PTBE. Read More

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Evolution of Evidence-Based Medicine in Stroke.

Graeme J Hankey

Cerebrovasc Dis 2021 Jul 27:1-12. Epub 2021 Jul 27.

Medical School, Faculty of Health and Medical Sciences, The University of Western Australia, Perth, Washington, Australia.

The introduction and evolution of evidence-based stroke medicine has realized major advances in our knowledge about stroke, methods of medical research, and patient outcomes that continue to complement traditional individual patient care. It is humbling to recall the state of knowledge and scientific endeavour of our forebears who were unaware of what we know now and yet pursued the highest standards for evaluating and delivering effective stroke care. The science of stroke medicine has evolved from pathophysiological theory to empirical testing. Read More

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Nephrologist Interventions to Avoid Kidney Replacement Therapy in Acute Kidney Injury.

Kidney Blood Press Res 2021 Jul 27:1-10. Epub 2021 Jul 27.

Nephrology Service, Civil Hospital of Guadalajara Fray Antonio Alcalde, Guadalajara, Mexico.

Background: Based on the pathophysiology of acute kidney injury (AKI), it is plausible that certain early interventions by the nephrologist could influence its trajectory. In this study, we investigated the impact of 5 early nephrology interventions on starting kidney replacement therapy (KRT), AKI progression, and death.

Methods: In a prospective cohort at the Hospital Civil of Guadalajara, we followed up for 10 days AKI patients in whom a nephrology consultation was requested. Read More

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The Association between Glomerular Diameter and Secondary Focal Segmental Glomerulosclerosis in Chronic Kidney Disease.

Kidney Blood Press Res 2021 Jul 27:1-8. Epub 2021 Jul 27.

Department of Cardiovascular Medicine, Nephrology and Neurology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

Introduction: When nephron loss occurs, the glomerular filtration rate (GFR) is suggested to be maintained by glomerular hypertrophy, but excessive hypertrophy can rather lead to the formation of focal segmental glomerulosclerosis (FSGS), thereby causing progressive kidney damage. However, it is not clear how much glomerular hypertrophy leads to the formation of FSGS. We examined the association between glomerular diameter and FSGS lesions in chronic kidney disease (CKD) patients. Read More

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Recent progress on emergent two-dimensional magnets and heterostructures.

Nanotechnology 2021 Jul 27. Epub 2021 Jul 27.

Chinese Academy of Sciences - National Center for Nanoscience and Technology, Beijing, P. R. China, Beijing, CHINA.

Intrinsic 2D magnetic materials own strong long-range magnetism while their characteristics of the ultrathin thickness and smooth surface provide an ideal platform for manipulating the magnetic properties at 2D limit. This makes them to be potential candidates in various spintronic applications compared to their corresponding bulk counterparts. The discovery of magnetic ordering in 2D CrI3 and Gr2Ge2Te6 (CGT) nanostructures stimulated tremendous research interest in both experimental and theoretical studies on various intrinsic magnets at 2D limit. Read More

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An experimental method to correct low-frequency concentric artifacts in photon counting CT.

Phys Med Biol 2021 Jul 27. Epub 2021 Jul 27.

Department of Medical Physics and Department of Radiology, University of Wisconsin-Madison, 1111 Highland Ave. Rm 1005, Madison, Wisconsin, 53705, UNITED STATES.

Large-area photon counting detectors (PCDs) are usually built by tiling multiple semiconductor panels that often have slightly different spectral responses to input x-rays. As a result of this spectral inconsistency, experimental PCD-CT images of large, human-sized objects may show high-frequency ring artifacts and low-frequency band artifacts. Due to the much larger width of the bands compared with the rings, the concentric artifact problem in PCD-CT images of human-sized objects cannot be adequately addressed by conventional CT ring correction methods. Read More

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Stereotactic technology for 3D bioprinting: From the perspective of robot mechanism.

Biofabrication 2021 Jul 27. Epub 2021 Jul 27.

School of Biological Science and Medical Engineering, Beihang University, 37# XueYuan, Haidian District, Beijing, P.R.China, Beijing, 100083, CHINA.

Three-dimensional (3D) bioprinting has been widely applied in the field of biomedical engineering because of its rapidly individualized fabrication and precisely geometric designability. The emerging demand for bioprinted tissues/organs with bio-inspired anisotropic property is stimulating new bioprinting strategies. Stereotactic bioprinting is regarded as a preferable strategy for this purpose, which can perform bioprinting at the target position from any desired orientation in 3D space. Read More

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Maternal near-miss attributable to haemorrhagic stroke in patients with hypertensive disorders of pregnancy in Japan: A national cohort study.

Pregnancy Hypertens 2021 Jul 23;25:240-243. Epub 2021 Jul 23.

Department of Gynaecology and Obstetrics, Kyoto University, Kyoto, Japan. Electronic address:

Objectives: To investigate the epidemiologic and clinical characteristics of maternal near-misses attributable to haemorrhagic stroke (HS) occurring in patients with hypertensive disorders of pregnancy (HDP), with a focus on severe neurological morbidity.

Methods: A national retrospective cohort study was conducted using the national database of health insurance claims for the period 2010 to 2017. The subjects were all insured women with a diagnosis of both HDP and HS. Read More

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Health behavior adherence and emotional adjustment during the COVID-19 pandemic in a US nationally representative sample: The roles of prosocial motivation and gratitude.

Soc Sci Med 2021 Jul 20;284:114243. Epub 2021 Jul 20.

Department of Psychology, Arizona State University, Tempe, AZ, 85287, USA.

Rationale: Substantial health behavior change (e.g., social distancing, mask-wearing) is needed to slow COVID-19. Read More

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Long noncoding RNA LINC-PINT retards the abnormal growth of airway smooth muscle cells via regulating the microRNA-26a-5p/PTEN axis in asthma.

Int Immunopharmacol 2021 Jul 24;99:107997. Epub 2021 Jul 24.

Department of Respiratory Medicine, Shanghai Children's Hospital, Shanghai Jiao Tong University, Shanghai City 200040, China. Electronic address:

Background: Asthma is a chronic respiratory disease worldwide. This study aimed to explore the functions of the long noncoding RNA LINC-PINT (LINC-PINT) in asthma and to determine its underlying molecular mechanisms.

Methods: Rat asthma model was established with ovalbumin sensitization and challenge. Read More

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Simultaneous transduction of dendritic cells with A20 and BTLA genes stimulates the development of stable and efficient tolerogenic dendritic cells and induces regulatory T cells.

Int Immunopharmacol 2021 Jul 24;99:107966. Epub 2021 Jul 24.

Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. Electronic address:

Background: This study investigated the potential of simultaneous overexpression of A20 and B- and T-lymphocyte attenuator (BTLA) genes in dendritic cells (DCs) to develop a tolerogenic phenotype in DCs and investigate their capabilities for induction of immunosuppression.

Methods: Plasmid vectors were designed harboring A20, BTLA, and A20 + BTLA genes and were transfected to HEK 293T cells to produce lentiviruses. DCs were transduced by the gene carrying viruses and evaluated for the surface expression of MHCII, CD40, and CD86 molecules by flow-cytometry. Read More

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Longitudinal associations with alcohol consumption during the first COVID-19 lockdown: Associations with mood, drinking motives, context of drinking, and mental health.

Drug Alcohol Depend 2021 Jul 21;226:108913. Epub 2021 Jul 21.

Department of Psychology, Institute of Population Health, University of Liverpool, United Kingdom; Liverpool Centre for Alcohol Research, United Kingdom.

Background: Coronavirus (COVID-19) resulted in lockdown measures in the UK, which has impacted alcohol use. Alcohol is often used as a coping mechanism and there are public health concerns regarding excessive consumption due to the pandemic. We aimed to longitudinally assess drinking behaviors, and associated factors, during the first UK government-mandated lockdown. Read More

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Stepped care for the treatment of depression: a systematic review and meta-analysis.

J Affect Disord 2021 Jul 18;294:391-409. Epub 2021 Jul 18.

Health Services Research on Chronic Patients Network (REDISSEC). Tenerife, Spain; Evaluation Unit (SESCS), Canary Islands Health Service (SCS), Tenerife, Spain.

Background: The Stepped Care Model (SCM) proposes a sequential approach in the treatment of depression, applying interventions of increasing intensity according to the level of severity of the individual.

Methods: A systematic review was carried out until January 2020 in eight electronic databases. We included randomized (RCT) and non-randomized controlled trials comparing the SCM to usual non-sequential care. Read More

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