402,773 results match your criteria interventional pain


Opioid availability statistics from the International Narcotics Control Board do not reflect the medical use of opioids: comparison with sales data from Scandinavia.

Scand J Pain 2021 Jul 27. Epub 2021 Jul 27.

The NEPI Foundation and Unit of Health Care Analysis, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden.

Objectives: Opioid analgesics are essential in clinical practice, but their excessive use is associated with addiction risk. Increases in opioid prescription rates have fuelled an epidemic of opioid addiction in the USA, making statistics on medical opioid use a critical warning signal. A dramatic 150% increase in Swedish opioid access 2001-2013 was recently reported based on data from the International Narcotics Control Board (INCB; Berterame et al. Read More

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Ultra-Low Energy Cycled Burst Spinal Cord Stimulation Yields Robust Outcomes in Pain, Function, and Affective Domains: A Subanalysis From Two Prospective, Multicenter, International Clinical Trials.

Neuromodulation 2021 Jul 27. Epub 2021 Jul 27.

University of Chicago Medical Center, Chicago, IL, USA.

Introduction: DeRidder's burst stimulation design has become a key spinal cord stimulation (SCS) waveform because it reduces the intensity of pain as well as its associated emotional distress. The brain pathways underlying these outcomes may also allow for the effects of stimulation to carry over after stimulation is turned off, making it amenable to intermittent application. Here, the utility of intermittently cycled burst was evaluated using data from two large real-world prospective studies (TRIUMPH, REALITY). Read More

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Comorbidity in Stroke-Survivors: Prevalence and Associations with Functional Outcomes and Health.

J Stroke Cerebrovasc Dis 2021 Jul 24;30(10):106000. Epub 2021 Jul 24.

University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.

Objectives: The purpose of this study was to evaluate the prevalence and impact of stroke-related comorbidity in a community-based sample of stroke survivors. We sought to find out which types of comorbidity that were most important with respect to the patients' functional outcomes and general health.

Materials And Methods: All stroke survivors (n = 330) living in a medium-sized Swedish municipality were included. Read More

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Flexion contracture can be relieved by concurrent notchplasty in medial open wedge high tibial osteotomy.

Orthop Traumatol Surg Res 2021 Jul 24:103020. Epub 2021 Jul 24.

Department of Orthopedic Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Background: Given that medial open wedge high tibial osteotomy (OWHTO) not only delays the progression of osteoarthritis but also alleviates the resulting pain, surgical outcomes would be improved if limited ROM can also be managed. In this regard, the effect of concurrent notchplasty on flexion contracture has not been evaluated.

Hypothesis: (1) Concurrent notchplasty in OWHTO would relieve flexion contracture regardless of the severity of osteoarthritis and this effect would be maintained over time, and (2) concurrent notchplasty would not cause any added complications compared to the same procedure without notchplasty. Read More

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Prospective associations of chronic and intrusive pain with sarcopenia and physical disability amongst older Australian men: The Concord Health and Ageing in Men Project.

Exp Gerontol 2021 Jul 24:111501. Epub 2021 Jul 24.

School of Public Health, University of Sydney, New South Wales, Sydney, Australia; The ARC Centre of Excellence in Population Ageing Research, University of Sydney, New South Wales, Sydney, Australia.

Background: Associations of chronic and intrusive pain with sarcopenia and disability in older men are unclear.

Methods: 1452 community-dwelling men aged ≥70 years self-reported chronic pain (pain every day for ≥3 months) and intrusive pain (pain interfering with normal activities in the last 4 weeks) at baseline and five years later, and were classified as having no, prevalent (baseline only), incident (follow-up only) or persistent (both baseline and follow-up) pain. Appendicular lean mass (ALM), hand grip strength and gait speed were assessed. Read More

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Greater efficacy of a combination of conservative therapies for thumb base OA in individuals with lower radial subluxation - a pre-planned subgroup analysis of the COMBO trial.

Osteoarthritis Cartilage 2021 Jul 24. Epub 2021 Jul 24.

Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia.

Objective: To investigate heterogeneous effects of a combination of conservative therapies compared with an education comparator for thumb base (TB) osteoarthritis (OA) according to clinically relevant characteristics.

Methods: Pre-planned subgroup analysis of the COMBO trial (n=204) which compared a combination of education on self-management and ergonomic principles, a prefabricated neoprene splint, hand exercises, and diclofenac sodium gel, with education alone for radiographic and symptomatic TB OA. Primary outcomes were change in pain (visual analogue scale [VAS], 0-100 mm) and hand function (Functional Index for Hand Osteoarthritis questionnaire, 0-30) from baseline to week-6. Read More

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The Role of Chiropractic Care in Providing Health Promotion and Clinical Preventive Services for Adult Patients with Musculoskeletal Pain: A Clinical Practice Guideline.

J Altern Complement Med 2021 Jul 26. Epub 2021 Jul 26.

University of Western States, Portland, Oregon, USA.

To develop evidence-based recommendations on best practices for delivery of clinical preventive services by chiropractors and to offer practical resources to empower provider applications in practice. Clinical practice guideline based on evidence-based recommendations of a panel of practitioners and experts on clinical preventive services. Synthesizing the results of a literature search for relevant clinical practice guidelines and systematic reviews, a multidisciplinary steering committee with training and experience in health promotion, clinical prevention, and/or evidence-based chiropractic practice drafted a set of recommendations. Read More

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The COVID-19 Vaccine and Interventional Procedures: exploring the relationship between steroid administration and subsequent vaccine efficacy.

Pain Pract 2021 Jul 27. Epub 2021 Jul 27.

University of Colorado Medical Center, Department of Anesthesiology, Denver, CO, USA.

Objective: Collate available evidence and provide guidance on whether to delay steroid injections after receiving a vaccine, and whether to delay vaccination if a recent steroid injection has been administered, leaving formal recommendations to various national societies.

Methods: A literature search was performed to identify information pertinent to steroid administration and the subsequent downstream effects on vaccine efficacy. The search was initiated on December 20, 2020 and the terms used were (steroid OR cortisone OR dexamethasone) AND (vaccine). Read More

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CAPABLE program improves disability in multiple randomized trials.

J Am Geriatr Soc 2021 Jul 27. Epub 2021 Jul 27.

Johns Hopkins School of Nursing, Baltimore, Maryland, USA.

Background: Programs to reduce disability are crucial to the quality of life for older adults with disabilities. Reducing disability is also important to avert unnecessary and costly hospitalizations, relocation, or nursing home placements. Few programs reduce disability and few have been replicated and scaled beyond initial research settings. Read More

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Epigenetics and postsurgical pain: A scoping review.

Pain Med 2021 Jul 27. Epub 2021 Jul 27.

Medical Research Unit in Reproductive Medicine, Unidad Médica de Alta Especialidad, Hospital de Gineco Obstetricia No. 4, "Luis Castelazo Ayala", Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Objective: Multiple factors are involved in the physiology and variability of postsurgical pain, a great part of which can be explained by genetic and environmental factors and their interaction. Epigenetics refers to the mechanism by which the environment alters the stability and expression of genes. We conducted a scoping review to examine the available evidence in both animal models and clinical studies on epigenetic mechanisms involved in regulation of postsurgical and chronic postsurgical pain. Read More

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The 5-year course of neck pain among natural disaster survivors: The association of prior neck pain with new episodes of neck pain.

Pain Med 2021 Jul 27. Epub 2021 Jul 27.

Division of Epidemiology, Department of Health Informatics and Public Health, Tohoku University Graduate School of Public Health, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

Objective: Neck pain is a common health problem among both the general population and natural disaster survivors. However, the long-term course of neck pain has rarely been reported. The aim of this study was to elucidate the 5-year course of neck pain among survivors of the Great East Japan Earthquake (GEJE) by assessing the association of neck pain 2 and 4 years after the disaster with that at 7 years. Read More

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Frequency-Specific Alterations in Brain Function in Patients with Primary Dysmenorrhea.

Pain Med 2021 Jul 26. Epub 2021 Jul 26.

Acupuncture and Brain Science Research Center, A, cupuncture and Tuina School, Chengdu University of Traditional Chinese Medicine, Chengdu, China.

Objective: Recent neuroimaging studies have found that brain function is abnormal in primary dysmenorrhea (PDM). The present study aimed to explore frequency-specific brain alterations and their occurrence in the PDM.

Methods: Forty-seven patients with PDM and 36 matched healthy controls were enrolled in the study and underwent resting-state functional magnetic resonance imaging. Read More

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High sedation needs of critically ill COVID-19 ARDS patients-A monocentric observational study.

PLoS One 2021 27;16(7):e0253778. Epub 2021 Jul 27.

Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, University Hospital Frankfurt, Goethe-University Frankfurt, Hessen, Germany.

Background: Therapy of severely affected coronavirus patient, requiring intubation and sedation is still challenging. Recently, difficulties in sedating these patients have been discussed. This study aims to describe sedation practices in patients with 2019 coronavirus disease (COVID-19)-induced acute respiratory distress syndrome (ARDS). Read More

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Volar Plate Fixation Versus Cast Immobilization in Acceptably Reduced Intra-Articular Distal Radial Fractures: A Randomized Controlled Trial.

J Bone Joint Surg Am 2021 Jul 27. Epub 2021 Jul 27.

Department of Trauma and Hand Surgery, Maasstad Hospital, Rotterdam, the Netherlands.

Background: The evidence for the treatment of acceptably reduced intra-articular distal radial fractures remains inconclusive. We therefore compared the functional outcomes of cast immobilization (nonoperative) and volar plate fixation (operative) for patients with these fractures.

Methods: This multicenter randomized controlled trial enrolled patients between 18 and 75 years old with an acceptably reduced intra-articular distal radial fracture. Read More

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Immediate Effects of a Continuous Peripheral Nerve Block on Postamputation Phantom and Residual Limb Pain: Secondary Outcomes From a Multicenter Randomized Controlled Clinical Trial.

Anesth Analg 2021 Jul 27. Epub 2021 Jul 27.

Departments of General Anesthesia and Outcomes Research, Cleveland Clinic, Cleveland, Ohio.

Background: We recently reported that a 6-day continuous peripheral nerve block reduced established postamputation phantom pain 3 weeks after treatment ended. However, the immediate effects of perineural infusion (secondary outcomes) have yet to be reported.

Methods: Participants from 5 enrolling academic centers with an upper or lower limb amputation and established phantom pain received a single-injection ropivacaine peripheral nerve block(s) and perineural catheter insertion(s). Read More

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Opioid-sparing analgesic effects of peripheral nerve blocks in percutaneous nephrolithotomy: a systematic review.

J Endourol 2021 Jul 27. Epub 2021 Jul 27.

Johns Hopkins University, Brady Urological Institute, Baltimore, Maryland, United States;

Introduction: Multimodal analgesia regimens incorporating peripheral nerve blocks (PNB) have demonstrated reduced postoperative pain, opioid use, and recovery time in various disease states. However, this remains a subject of limited investigation in the percutaneous nephrolithotomy (PCNL) domain. In the face of an ongoing opioid epidemic and collective push to enhance prescribing stewardship, we sought to examine the potential opioid-sparing effect of PNB in PCNL. Read More

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Models of Inflammation: Carrageenan- or Complete Freund's Adjuvant (CFA)-Induced Edema and Hypersensitivity in the Rat.

Curr Protoc 2021 Jul;1(7):e202

Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana.

Animal models of inflammation are used to assess the production of inflammatory mediators at sites of inflammation, the processing of pain sensation at CNS sites, the anti-inflammatory properties of agents such as nonsteroidal anti-inflammatory drugs (NSAIDs), and the efficacy of putative analgesic compounds in reversing cutaneous hypersensitivity. Detailed in this article are methods to elicit and measure carrageenan- and complete Freund's adjuvant (CFA)-induced cutaneous inflammation. Due to possible differences between the dorsal root sensory system and the trigeminal sensory system, injections into either the footpad or vibrissal pad are described. Read More

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Headache Attributed to Vaccination Against COVID-19 (Coronavirus SARS-CoV-2) with the ChAdOx1 nCoV-19 (AZD1222) Vaccine: A Multicenter Observational Cohort Study.

Pain Ther 2021 Jul 27. Epub 2021 Jul 27.

Kiel Migraine and Headache Centre, Kiel, Germany.

Introduction: The most frequently reported neurological adverse event of ChAdOx1 nCoV-19 (AZD1222) vaccine is headache in 57.5%. Several cases of cerebral venous thrombosis (CVT) have developed after vaccination. Read More

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MSC-Derived Extracellular Vesicles in Preclinical Animal Models of Bone Injury: A Systematic Review and Meta-Analysis.

Stem Cell Rev Rep 2021 Jul 27. Epub 2021 Jul 27.

Stem Cells, Canadian Blood Services, Ottawa, ON, Canada.

Background And Objective: Mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) are a promising treatment for bone injuries, although studies remain preclinical. A systematic review and meta-analysis can assess the efficacy of MSC-EVs and identify treatment aspects associated with enhanced bone repair.

Methods: English language, preclinical, controlled, in vivo studies identified in our systematic search (up to May 8, 2020) examining the use of MSC-EVs in bone healing were included. Read More

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Prophylactic Administration of Diphenhydramine/Acetaminophen and Ondansetron Reduced Postoperative Nausea and Vomiting and Pain Following Laparoscopic Sleeve Gastrectomy: a Randomized Controlled Trial.

Obes Surg 2021 Jul 27. Epub 2021 Jul 27.

Department of Anesthesiology, Sina Hospital, Tehran University of Medical Sciences, Imam Khomeini St, Tehran, 11367-46911, Iran.

Purpose: Postoperative nausea and vomiting (PONV) and pain following bariatric surgery are problematic and affect the outcome of patients. Intraoperative multimodal antiemetic prophylaxis is essential to improve postoperative outcomes. This study investigated the effect of adding diphenhydramine to acetaminophen and ondansetron in reducing postoperative nausea and vomiting and pain following laparoscopic sleeve gastrectomy (LSG). Read More

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The Dutch Multidisciplinary Occupational Health Guideline to Enhance Work Participation Among Low Back Pain and Lumbosacral Radicular Syndrome Patients.

J Occup Rehabil 2021 Jul 27. Epub 2021 Jul 27.

Department of Public and Occupational Health, Amsterdam UMC, Amsterdam, The Netherlands.

Purpose Based on current scientific evidence and best practice, the first Dutch multidisciplinary practice guideline for occupational health professionals was developed to stimulate prevention and enhance work participation in patients with low back pain (LBP) and lumbosacral radicular syndrome (LRS). Methods A multidisciplinary working group with health care professionals, a patient representative and researchers developed the recommendations after systematic review of evidence about (1) Risk factors, (2) Prevention, (3) Prognostic factors and (4) Interventions. Certainty of the evidence was rated with GRADE and the Evidence to Decision (EtD) framework was used to formulate recommendations. Read More

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Percutaneous cryoablation of chondroblastoma and osteoblastoma in pediatric patients.

Insights Imaging 2021 Jul 27;12(1):106. Epub 2021 Jul 27.

Department of Interventional Radiology, Hospital Clínic Barcelona, Barcelona, Spain.

Background: To review the safety and efficacy of percutaneous cryoablation for the treatment of chondroblastoma and osteoblastoma in the pediatric and adolescent population.

Materials And Methods: A retrospective review from 2016 to 2020 was performed to evaluate clinical and imaging response to percutaneous cryoablation in 11 symptomatic patients with diagnosis of chondroblastoma and osteoblastoma treated from two pediatric hospitals with at least 12-month follow-up. Technical success (correct needle placement and potential full coverage of the tumor with the planned ablation zone) and clinical success (relief of the symptoms) were evaluated. Read More

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Expected impact of lockdown measures due to COVID-19 on disabling conditions: a modelling study of chronic low back pain.

Eur Spine J 2021 Jul 27. Epub 2021 Jul 27.

IRCCS Istituto Ortopedico Galeazzi, Via Galeazzi 4, 20161, Milan, Italy.

Purpose: The COVID-19 pandemic and the containment measures such as social distancing, mobility restrictions and quarantine have significantly impacted the delivery of healthcare services, with possible negative effects on low back pain patients. In this study, we used an innovative agent-based model to quantify the effects of COVID-19 on the prevalence and severity of low back pain in the general population.

Methods: Epidemiological data were used to simulate the low back pain evolution in a population of 300,000 agents. Read More

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Grice subtalar arthrodesis of bilateral adult flatfoot in a professional dancer: a case report.

Acta Biomed 2021 Jul 26;92(S3):e2021003. Epub 2021 Jul 26.

Orthopaedics and Traumatology Clinic, Department of Medicine and Surgery, University of Parma, Parma, Italy.

Background And Aim: Adult acquired flatfoot deformity (AAFD) is a common pathology and an important cause of pain and disability. This deformity causes a progressive flattening of the foot arch which has traditionally been associated with posterior tibialis tendon (PTT) dysfunction. Operative treatment is indicated after the failure of conservative management aiming to achieve proper alignment of the hindfoot and to maintain as much flexibility as possible. Read More

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Long-term results after modified Burton-Pellegrini's technique in 24 cases affected by advanced rhizarthrosis.

Acta Biomed 2021 Jul 26;92(S3):e2021005. Epub 2021 Jul 26.

Orthopaedic Clinic, Department of Medicine and Surgery, University Hospital of Parma, Parma (Italy).

Background And Aim: Rhizarthrosis common in elderly and represents 10% of all artrhitic manifestations. Trapeziectomy with ligament reconstruction and tendon interposition remains the gold standard for stages II to IV according to Eaton and Littler. This retrospective study aimed to evaluate the results of 24 patients affected by advanced rhizarthrosis who underwent to modified Burton-Pellegrini's trapeziectomy with ligamentoplasty using the entire flexor carpi radialis tendon. Read More

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Open fracture-dislocation of the knee associated with nonunion of the medial femoral condyle and chronic tendon patellar rupture.

Acta Biomed 2021 Jul 26;92(S3):e2021013. Epub 2021 Jul 26.

Università Degli Studi di Parma.

Background And Aim Of Work: The incidence of coronal fractures of the femoral condyle, Hoffa fractures, ranges from 8.7% to 13% of all fractures of the distal femur and are often observed in polytraumas. Hoffa fractures may be misdiagnosed and consequently not properly treated. Read More

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Bucket-handle meniscal tears in children under the age of 10: a literature review.

Acta Biomed 2021 Jul 26;92(S3):e2021020. Epub 2021 Jul 26.

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Background And Aim Of The Work: Traumatic meniscal tears are raising in skeletally immature patients due to increasing participation in sport activities. Nonetheless, meniscal tears remain a rare injury in children, with a lack of evidence regarding treatment and outcome. The aim of the study is to review the literature on BHMT in children aged under 10 years. Read More

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Physical activity domains are differently related with quality of life in breast cancer survivors: a cross-sectional study.

Menopause 2021 Jul 26. Epub 2021 Jul 26.

Department of Physiotherapy, School of Technology and Sciences, São Paulo State University (Unesp), Presidente Prudente, SP, Brazil Department of Physical Education, School of Technology and Sciences, São Paulo State University (Unesp), Presidente Prudente, SP, Brazil Department of Medicine, Universidade do Oeste Paulista, Presidente Prudente, SP, Brazil.

Objectives: Treatments for breast cancer (BC) can lead to physical and mental impairments which may affect quality of life (QoL). Physical activity (PA) is highly recommended for this population due to its protective effect against BC relapse and its ability to reduce the health impact of treatment. However, it is not clear whether the different domains of PA are associated with better QoL of BC survivors. Read More

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Effects of calcium electroporation, electrochemotherapy, and irreversible electroporation on quality of life and progression-free survival in patients with pancreatic cancer: IREC clinical study.

Adv Clin Exp Med 2021 Jul 27. Epub 2021 Jul 27.

Department of Molecular and Cellular Biology, Wroclaw Medical University, Poland.

Background: According to the National Cancer Registry, 3486 people (1744 men and 1742 women) were diagnosed with pancreatic adenocarcinoma in Poland in 2018, resulting in 4908 deaths (2396 men and 2512 women). The only chance of successful treatment is through surgical resection, which is possible in only 20-30% of patients (stage I, II and some stage III cases).The remaining 70-80% of patients are those with stage III and IV disease, for whom resection is not possible. Read More

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Clinical Benefit of Ripretinib Dose Escalation After Disease Progression in Advanced Gastrointestinal Stromal Tumor: An Analysis of the INVICTUS Study.

Oncologist 2021 Jul 27. Epub 2021 Jul 27.

Centre Léon Bérard & Université Claude Bernard, Lyon, France.

Background: Ripretinib 150 mg once daily (QD) is indicated for advanced gastrointestinal stromal tumor (GIST) as ≥fourth-line therapy. In INVICTUS, ripretinib intra-patient dose escalation (IPDE) to 150 mg twice daily (BID) was allowed after progressive disease (PD) on 150 mg QD by blinded independent central review using modified RECIST 1.1. Read More

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