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The impact of different gas mixtures on inflammatory responses in advanced recreational divers.

Diving Hyperb Med 2021 Jun;51(2):140-146

Department of Surgical and Medical Science and Translation Medicine, Sapienza University, Rome, Italy.

Introduction: Decompression sickness (DCS) is considered a 'bubble disease'. Intravascular bubbles activate inflammatory responses associated with endothelial dysfunction. Breathing gas has been proposed as a potential risk factor but this is inadequately studied. Read More

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Deconvolution-based partial volume correction of PET images with parallel level set regularization.

Phys Med Biol 2021 Jun 22. Epub 2021 Jun 22.

Radiology and Physics, The University of British Columbia, Vancouver, British Columbia, V6T 1Z4, CANADA.

The partial volume effect (PVE), caused by the limited spatial resolution of positron emission tomography (PET), degrades images both qualitatively and quantitatively. Anatomical information provided by magnetic resonance (MR) images has the potential to play an important role in partial volume correction (PVC) methods. Post-reconstruction MR-guided PVC methods typically use segmented MR tissue maps, and further, assume that PET activity distribution is uniform in each region, imposing considerable constraints through anatomical guidance. Read More

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Intra-operative enteroscopic polypectomy-An innovative hybrid approach using straight sticks.

Int J Surg Case Rep 2021 Jun 16;84:106102. Epub 2021 Jun 16.

Department of General Surgery, Grant Medical College & Sir JJ Group of Hospitals, Mumbai, India.

Background: Peutz-Jeghers Syndrome (PJS) is an uncommon intestinal polyposis disorder. Bowel obstructions are a recurring problem in PJS and as many as 50% of these patients require surgery. The current standard of care for these patients is to perform a flexible enteroscopic polypectomy. Read More

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A Nation-wide Review of Elective Surgery and COVID-Surge Capacity.

J Surg Res 2021 Jun 19;267:211-216. Epub 2021 Jun 19.

Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland; Surgery Service, Veterans Affairs Medical Centre, Baltimore, Maryland. Electronic address:

Background: The COVID-19 pandemic has resulted in over 225,000 excess deaths in the United States. A moratorium on elective surgery was placed early in the pandemic to reduce risk to patients and staff and preserve critical care resources. This report evaluates the impact of the elective surgical moratorium on case volumes and intensive care unit (ICU) bed utilization. Read More

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IBA-U-Net: Attentive BConvLSTM U-Net with Redesigned Inception for medical image segmentation.

Comput Biol Med 2021 Jun 12;135:104551. Epub 2021 Jun 12.

Department of Systems and Computer Engineering, Carleton University, Ottawa, ON, KIS 5B6, Canada.

Accurate segmentation of medical images plays an essential role in their analysis and has a wide range of research and application values in fields of practice such as medical research, disease diagnosis, disease analysis, and auxiliary surgery. In recent years, deep convolutional neural networks have been developed that show strong performance in medical image segmentation. However, because of the inherent challenges of medical images, such as irregularities of the dataset and the existence of outliers, segmentation approaches have not demonstrated sufficiently accurate and reliable results for clinical employment. Read More

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Salvianolic acid A attenuates steroid resistant nephrotic syndrome through suPAR/uPAR-αvβ3 signaling Inhibition.

J Ethnopharmacol 2021 Jun 19:114351. Epub 2021 Jun 19.

School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai, 264005, PR China. Electronic address:

Ethnopharmacological Relevance: Salvianolic acid A (SAA) is extracted from traditional Chinese medicine Salvia miltiorrhiza and is the main water-soluble and the biologically active ingredient. SAA possesses a variety of pharmacological activities and has an excellent protective effect on kidney disease, especially steroid resistant nephrotic syndrome (SRNS), and has advantages in improving the efficacy of glucocorticoids, but its mechanism needs to be further explored.

Purpose: The study was designed to explore the effect of suPAR and uPAR in SRNS patients and evaluate the potential effect of SAA in improving podocyte steroid resistance and explore its mechanism. Read More

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Clean Cut (adaptive, multimodal surgical infection prevention programme) for low-resource settings: a prospective quality improvement study.

Br J Surg 2021 Jun;108(6):727-734

Department of Surgery, Stanford University, Stanford, USA.

Background: Clean Cut is an adaptive, multimodal programme to identify improvement opportunities and safety changes in surgery by enhancing outcomes surveillance, closing gaps in surgical infection prevention standards, and strengthening underlying processes of care. Surgical-site infections (SSIs) are common in low-income countries, so this study assessed a simple intervention to improve perioperative infection prevention practices in one.

Methods: Clean Cut was implemented in five hospitals in Ethiopia from August 2016 to October 2018. Read More

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Health-related quality of life following total minimally invasive, hybrid minimally invasive or open oesophagectomy: a population-based cohort study.

Br J Surg 2021 Jun;108(6):702-708

Surgical Care Science, Department of Molecular Medicine and Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Background: Minimally invasive oesophagectomy has been shown to reduce the risk of pulmonary complications compared with open oesophagectomy, but the effects on health-related quality of life (HRQoL) and oesophageal cancer survivorship remain unclear. The aim of this study was to assess the longitudinal effects of minimally invasive compared with open oesophagectomy for cancer on HRQoL.

Methods: All patients who had surgery for oesophageal cancer in Sweden from January 2013 to April 2018 were identified. Read More

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Seroprevalence of Chlamydia trachomatis, herpes simplex 2, Epstein-Barr virus, hepatitis C and associated factors among a cohort of men ages 18-70 years from three countries.

PLoS One 2021 22;16(6):e0253005. Epub 2021 Jun 22.

Center for Infection Research in Cancer, Moffitt Cancer Center, Tampa, Florida, United States of America.

Objectives: To estimate the seroprevalence of Chlamydia trachomatis (CT), herpes simplex type-2 (HSV2), hepatitis C (HCV), Epstein-Barr virus (EBV) and nine human papilloma virus (HPV) types, and investigated factors associated with the seropositivity among men from three countries (Brazil, Mexico and U.S).

Methods: Archived serum specimens collected at enrollment for n = 600 men were tested for antibodies against CT, HSV2, HCV, EBV, and 9-valent HPV vaccine types (6/11/16/18/31/33/45/52/58) using multiplex serologic assays. Read More

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Reducing stroke burden through a targeted self-management intervention for reducing stroke risk factors in high-risk Ugandans: A protocol for a randomized controlled trial.

PLoS One 2021 22;16(6):e0251662. Epub 2021 Jun 22.

Neurological and Behavioral Outcomes Center, University Hospitals Cleveland Medical Center & Case Western Reserve University School of Medicine, Cleveland, OH, United States of America.

Introduction: Stroke burden is rapidly increasing globally. Modifiable risk factors offer an opportunity to intervene, and targeting hypertension is a key actionable target for stroke risk reduction in sub-Saharan Africa. This 3-site planned randomized controlled trial builds on promising preliminary data. Read More

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J Med Internet Res 2021 May 17. Epub 2021 May 17.


Background: The COVID-19 health crisis has posed an unprecedented challenge for governments worldwide to manage and communicate about the pandemic effectively, while maintaining public trust. Good leadership image in times of a health emergency is paramount to ensure public confidence towards government's ability to manage the crisis.

Objective: The aim of this study is to identify types of image repair strategies utilized by the Malaysian government in their communication about COVID-19 in the media. Read More

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Public Awareness and Utilization of 937-telephone health services Before and During the COVID-19 Pandemic: A longitudinal study.

J Med Internet Res 2021 Jun 2. Epub 2021 Jun 2.

Risk Management Unit, Directorate of Quality and Safety, King Fahah Hospital of The University, Imam Abdulrahman bin Faisal University, Dammam, SA.

Background: Telehealth plays a key role in supporting healthcare systems and influencing methods of healthcare delivery. Government laws and medical operating protocols have been largely modified to provide remote care in order to reduce social contact and ensure a safer patient environment. In the Kingdom of Saudi Arabia (KSA), the Ministry of Health (MOH) introduced several forms of telemedicine as alternatives to face-to face consultations in clinical settings. Read More

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Factors Affecting Fast Food Consumption among College Students in South Asia: A Systematic Review.

J Am Coll Nutr 2021 Jun 22:1-11. Epub 2021 Jun 22.

Department of Food Technology and Nutrition Science, Noakhali Science and Technology University, Noakhali, Bangladesh.

Unhealthy dietary practices have increased among college students in South Asia. Higher intakes of energy-dense foods may increase health risks such as weight gain in college students. The purpose of the study was to gather evidence on fast food consumption patterns and factors that influenced fast food consumption among college students in South Asia. Read More

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Open-Label Phase II Prospective, Randomized, Controlled Study of Romyelocel-L Myeloid Progenitor Cells to Reduce Infection During Induction Chemotherapy for Acute Myeloid Leukemia.

J Clin Oncol 2021 Jun 22:JCO2001739. Epub 2021 Jun 22.

Cellerant Therapeutics, San Carlos, CA.

Purpose: Standard cytotoxic induction chemotherapy for acute myeloid leukemia (AML) results in prolonged neutropenia and risk of infection. Romyelocel-L is a universal, allogeneic myeloid progenitor cell product being studied to reduce infection during induction chemotherapy.

Patients And Methods: One hundred sixty-three patients with de novo AML (age ≥ 55 years) receiving induction chemotherapy were randomly assigned on day 0 (d0), of whom 120 were evaluable. Read More

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Modulation of Adenosine Receptors by Hops and Xanthohumol in Cell Cultures.

ACS Chem Neurosci 2021 Jun 22. Epub 2021 Jun 22.

Department of Inorganic, Organic and Biochemistry. Faculty of Chemical and Technological Sciences, School of Medicine of Ciudad Real, Regional Center of Biomedical Research (CRIB), Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain.

Adenosine receptors (ARs) have been involved in neurodegenerative diseases such as Alzheimer disease, where oxidative stress contributes to neurodegeneration and cell death. Therefore, there is increasing interest in developing antioxidative strategies to avoid or reduce neurodegeneration. We have previously described that different beer extracts modulate ARs and protect glioma and neuroblastoma cells from oxidative stress. Read More

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Purifying the Air over the Operating Field and Reducing the Possibility of Airborne Contamination with a New Mobile Laminar Airflow Device.

J Cataract Refract Surg 2021 Feb 9. Epub 2021 Feb 9.

Cincinnati Eye Institute, Cincinnati, Ohio, USA. Professor of Ophthalmology, University of Cincinnati, Cincinnati, Ohio, USA. Cincinnati Eye Institute, Cincinnati, Ohio, USA. D'Olhos Hospital Dia, S. J. Rio Preto, Brazil. Columbia University Harkness Eye Institute, New York, New York, USA. Hudson Eye Physicians and Surgeons, Jersey City, New Jersey, USA. Narvik Eye Institue, Narvik, Norway.

Purpose: To investigate the effectiveness of a mobile laminar airflow (LAF) device designed to reduce both airborne particles and lint fibers within the sterile field during cataract surgery.

Setting: Cincinnati Eye Institute, Cincinnati, Ohio, USA.

Design: Prospective case series. Read More

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February 2021

Limited evidence for a positive relationship between hybridization and diversification across seed plant families.

Evolution 2021 Jun 22. Epub 2021 Jun 22.

Department of Biology, University of New Mexico, Albuquerque, NM, 87131, United States.

Hybridization has experimental and observational ties to evolutionary processes and outcomes such as adaptation, speciation, and radiation. Although it has been hypothesized that hybridization and diversification are positively correlated, this idea remains largely untested empirically, and hybridization can also potentially reduce diversity. Here, we use a hybridization database on 170 seed plant families, life history information, and a time-calibrated phylogeny to test for phylogenetically-corrected associations between hybridization and diversification rates, while also taking into account life-history traits that may be correlated with both processes. Read More

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Assessing the mechanism of barriers towards green finance and public spending in small and medium enterprises from developed countries.

Environ Sci Pollut Res Int 2021 Jun 22. Epub 2021 Jun 22.

Jiangsu University, Zhenjiang, China.

Due to their different abilities to improve financial growth and improve social development, small and medium enterprises (SMEs) have been referred to as the economy's backbone. Small- and medium-sized enterprises are crucial for both high- and low-income nations' financial development. Customers grow more conscious of their purchase choices, preferences, and environmental consequences. Read More

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Non-antibiotic interventions for prevention of urinary tract infections in children: a systematic review and meta-analysis of randomized controlled trials.

Eur J Pediatr 2021 Jun 22. Epub 2021 Jun 22.

Division of Nephrology, Department of Pediatrics, ICMR Center for Advanced Research in Nephrology, All India Institute of Medical Sciences, New Delhi, India.

A considerable proportion of children experience a recurrence of urinary tract infection (UTI) following the first episode. While low-dose antibiotic prophylaxis has been the mainstay for the prevention of UTI, recent evidence raised concerns over their efficacy and safety. Hence, we aim to systematically synthesize evidence on the efficacy and safety of non-antibiotic prophylactic interventions for UTI. Read More

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[Decline in work and commuting injuries during the first lockdown in the SARS-CoV-2 pandemic : Comparison to the time period 2015-2019].

Unfallchirurg 2021 Jun 22. Epub 2021 Jun 22.

Klinik und Poliklinik für Unfallchirurgie, Klinikum rechts der Isar, Technische Universität München, Ismaninger Straße 22, 81675, München, Deutschland.

Background: Measures such as restrictions on personal contact and going out were taken to reduce SARS-CoV‑2 infection numbers, ultimately resulting in the first lockdown. This was intended to create capacity in the healthcare system to manage the pandemic.

Aim Of The Work: To analyze whether the number of work and commuting injuries decreased during the lockdown compared to the years 2015-2019. Read More

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Embeddings of genomic region sets capture rich biological associations in lower dimensions.

Bioinformatics 2021 Jun 22. Epub 2021 Jun 22.

Center for Public Health Genomics, University of Virginia.

Motivation: Genomic region sets summarize functional genomics data and define locations of interest in the genome such as regulatory regions or transcription factor binding sites. The number of publicly available region sets has increased dramatically, leading to challenges in data analysis.

Results: We propose a new method to represent genomic region sets as vectors, or embeddings, using an adapted word2vec approach. Read More

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Tree species mixing can increase stand productivity, density, and growth efficiency and attenuate the tradeoff between density and growth throughout the whole rotation.

Ann Bot 2021 Jun 22. Epub 2021 Jun 22.

Chair for Forest Growth and Yield Science, TUM School of Life Sciences, Weihenstephan, Technical University of Munich, Hans-Carl-von-Carlowitz-Platz 2, 85354 Freising, Germany.

Background And Aims: Many recent studies emphasize that mixed species is a promising silvicultural option for sustainable ecosystem management under uncertain and risky future environmental conditions. However, compared with monocultures, knowledge of mixed stands is still rather fragmentary. This comprehensive study analysed the most common Central European tree species combinations to determine the extent to which mono-layered species mixing (i) can increase stand productivity and stem diameter growth, (ii) increase stand density or growth efficiency, and (iii) reduce competition and attenuate the relationship between stand density and stem diameter growth compared with mono-specific stands. Read More

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Eliminating Hospital-Acquired Pressure Injuries Caused by Graduated Compression Stockings.

Am J Nurs 2021 Jul;121(7):60-65

Tessy Siby and Alice Shajimon are clinical nurse leaders in surgical oncology, and Uniqua Smith is associate director of nursing programs, all at the University of Texas MD Anderson Cancer Center, Houston. The authors acknowledge Colleen Villamin, MSN, RN, OCN, CNL, CPHQ, for her assistance in formatting the project data for this manuscript. Contact author: Tessy Siby, The authors have disclosed no potential conflicts of interest, financial or otherwise.

Purpose: The purpose of this evidence-based practice project was to reduce the incidence of pressure injuries (PIs) from the use of graduated compression stockings in patients on a gastrointestinal (GI) sarcoma surgery unit. Before this project, the standard of care for preventing deep vein thrombosis (DVT) included the use of graduated compression stockings, anticoagulation therapy, and intermittent pneumatic compression devices. We sought to examine the impact on PI and DVT risk of using only anticoagulation therapy and intermittent pneumatic compression devices. Read More

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Intermittent Auscultation Reduces Risk of Emergency Cesarean Delivery.

Karen Rosenberg

Am J Nurs 2021 Jul;121(7):59

According to this study: Compared with other fetal surveillance methods, intermittent auscultation seems to reduce the risk of emergency cesarean delivery without increasing that of adverse neonatal and maternal outcomes.Newer methods of fetal surveillance didn't improve neonatal outcomes or reduce the risk of unnecessary maternal interventions. Read More

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Association of co-pay elimination with medication adherence and total cost.

Am J Manag Care 2021 Jun;27(6):249-254

Blue Cross and Blue Shield of Louisiana, 5525 Reitz Ave, Baton Rouge, LA 70809. Email:

Objectives: To determine whether elimination of co-pays for prescription drugs affects medication adherence and total health care spending.

Study Design: Retrospective comparative study.

Methods: We conducted a difference-in-differences comparison in the year before and after expansion of a Zero Dollar Co-pay (ZDC) prescription drug benefit in commercially insured Louisiana residents. Read More

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COVID-19 and clinic workflow optimization using lean six sigma.

Am J Manag Care 2021 Jun;27(6):225-226

Mayo Clinic, 200 First St SW, Rochester, MN 55905. Email:

Objectives: The COVID-19 pandemic has fundamentally changed the workflow of clinics. We applied Lean Six Sigma processes to optimize clinic workflow to reduce patient wait times and improve the patient experience.

Study Design: Prospective cohort study. Read More

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Jump performance during a season in elite volleyball players.

J Sports Med Phys Fitness 2021 Jun 22. Epub 2021 Jun 22.

Orthopedic Department, San Gerardo Hospital, University of Milano-Bicocca, Monza, Italy.

Background: The purpose of this study was to measure and compare jump load and dynamic performance in elite volleyball athletes under varied conditions over an entire season of practices and games. Jump load and dynamic performance were compared among (i) best jump height, (ii) mean jump height, as well as according to (iii) the number of jumps per game or practice session and (iv) the proportion of jumps higher than 50 cm relative to the total number of jumps in a practice or game.

Methods: Every jump performed by each of 12 players, in all practices and regular games (813 player-sessions in total), was measured by a particle accelerometer in accordance with a validated protocol (Vert®). Read More

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The impact of COVID-19 outbreak on the Transfusion Medicine Unit of a Northern Italy Hospital and Cancer Centre.

Vox Sang 2021 Jun 22. Epub 2021 Jun 22.

Transfusion Medicine Unit, AUSL-IRCCS di Reggio Emilia, Reggio Emilia, Italy.

Background And Objectives: The first wave of coronavirus disease-2019 (COVID-19) dramatically affected the Transfusion Medicine Unit of the Azienda Unità Sanitari Locale - Istituto di Ricovero e Cura a Carattere Scientifico (AUSL-IRCCS) di Reggio Emilia, which faced a total rearrangement of the procedures for donors and patients. This study aims to assess the major implications of COVID-19 on our department, focusing on the blood transfusion chain and therapies, in order to support transfusion specialists in seeking efficient ways to face similar future emergencies.

Materials And Methods: This retrospective study compares our Transfusion Medicine Unit data collected between February and May 2020 with the same period in 2017-2019. Read More

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Resident Involvement in Posterior Lumbar Interbody Fusion is Associated With Increased Readmissions and Operative Time, But No Increased Short-term Risks.

Clin Spine Surg 2021 Jul;34(6):E364-E369

Department of Orthopedic Surgery, Cleveland Clinic, Cleveland, OH.

Study Design: A retrospective cohort study.

Objective: The aim was to compare rates of adverse events and additional posterior lumbar interbody fusion (PLIF) cases assisted by residents versus cases performed solely by an orthopedic attending.

Summary Of Background Data: PLIF is a widely accepted surgical technique for the management of a variety of spinal conditions requiring spinal stabilization and fusion. Read More

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Wiad Lek 2021 ;74(4):934-939


Objective: The aim: To obtain the first national estimates of the current prevalence rate of SSI after CSEC and antimicrobial resistance of causing pathogens in Ukraine.

Patients And Methods: Materials and methods: We performed a retrospective multhicentre cogort study based surveillance data was conducted from May 2017 to December 2019. The study population consisted of all women who had a cesarean section in 11 regional women hospitals of Ukraine. Read More

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January 2021