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Evaluation of Barricade® to enhance survival entomopathogenic nematodes on cowhide.

J Invertebr Pathol 2021 Apr 18:107592. Epub 2021 Apr 18.

United States Dept. of Agriculture, Agricultural Research Service, Plains Area, Knipling-Bushland U.S. Livestock Insects Research laboratory, Cattle Fever Tick Research Laboratory, Edinburg, TX 78541, United States; United States Department of Agriculture, Agricultural Research Service, Plains Area; Knipling-Bushland U.S. Livestock Insects Research Laboratory, Cattle Fever Tick Research Laboratory; 22675 N. Moorefield Rd., Moore Airbase, Building 6419, Edinburg, Texas, USA 78541. Electronic address:

Entomopathogenic nematodes (EPNs), Steinernema riobrave and Heterorhabditis floridensis are under evaluation for eradication of the southern cattle fever tick, Rhipicephalus microplus infesting nilgai antelope, in South Texas. Cattle fever ticks are a significant threat to the U.S. Read More

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Encapsulation of lipid-based formulations in porous carriers for controlled drug delivery.

Curr Med Chem 2021 Apr 19. Epub 2021 Apr 19.

Institute of Research and Development, Duy Tan University, Danang 550000, Vietnam.

Lipid-based formulations have recently been investigated as a promising approach to enhance the bioavailability of drugs, especially poorly water-soluble drugs. The encapsulation of lipid-based formulations in porous materials can result in a transformation of liquids or semisolid forms to solid dosage forms. Moreover, the specific structure of porous carriers could offer an enhanced ability to load and control active pharmaceutical ingredients. Read More

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Radiological features of central giant cell granuloma: comparative study of 7 cases and literature review.

Dentomaxillofac Radiol 2021 Apr 21:20200429. Epub 2021 Apr 21.

Department Of Medical Imaging, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China.

Objective: To review and analyze the clinical and imaging features of central giant cell granuloma patients and to review the relevant literatures for the diagnosis and clinical manifestation of central giant cell granuloma.

Methods: Seven cases of central giant cell granuloma were retrospectively selected for the study, all of which were confirmed by pathology and had relevant imaging investigations. All seven cases had undergone CT scan, three cases had undergone MRI scan. Read More

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CDC20 and PTTG1 are Important Biomarkers and Potential Therapeutic Targets for Metastatic Prostate Cancer.

Adv Ther 2021 Apr 21. Epub 2021 Apr 21.

Department of Urology, The First Hospital of Qinhuangdao, No. 258 of Cultural North Road, Haigang District, Qinhuangdao, 066000, China.

Introduction: Metastatic prostate cancer (mPCa) is responsible for most prostate cancer (PCa) deaths worldwide. The present study aims to explore the molecular differences between mPCa and PCa.

Methods: The authors downloaded GSE6752, GSE6919, and GSE32269 from the Gene Expression Omnibus and employed integrated analysis to identify differentially expressed genes (DEGs) between mPCa and PCa. Read More

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Pharmaceutical Excipients Enhance Iron-Dependent Photo-Degradation in Pharmaceutical Buffers by near UV and Visible Light: Tyrosine Modification by Reactions of the Antioxidant Methionine in Citrate Buffer.

Pharm Res 2021 Apr 21. Epub 2021 Apr 21.

Department of Pharmaceutical Chemistry, University of Kansas, 2095 Constant Avenue, Lawrence, Kansas, 66047, USA.

Purpose: To evaluate the effect of excipients, including sugars and amino acids, on photo-degradation reactions in pharmaceutical buffers induced by near UV and visible light.

Methods: Solutions of citrate or acetate buffers, containing 1 or 50 μM Fe, the model peptides methionine enkephalin (MEn), leucine enkephalin (LEn) or proctolin peptide (ProP), in the presence of commonly used amino acids or sugars, were photo-irradiated with near UV or visible light. The oxidation products were analyzed by reverse-phase HPLC and HPLC-MS/MS. Read More

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extract promotes longevity and stress resistance of DAF-16 and SKN-1.

Food Funct 2021 Apr 21. Epub 2021 Apr 21.

Department of Food Science, Cornell University, Ithaca, New York 14853, USA.

The effects of Rhodiola extract (RE) on longevity and stress resistance in Caenorhabditis elegans (C. elegans), and the underlying molecular mechanisms were explored in the present study. Results showed that the lifespan of C. Read More

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Web-Based Apps for Responding to Acute Infectious Disease Outbreaks in the Community: Systematic Review.

JMIR Public Health Surveill 2021 Apr 21;7(4):e24330. Epub 2021 Apr 21.

Sydney Local Health District, Camperdown Public Health Unit, Royal Prince Alfred Hospital Campus, Camperdown, Sydney, NSW, Australia.

Background: Web-based technology has dramatically improved our ability to detect communicable disease outbreaks, with the potential to reduce morbidity and mortality because of swift public health action. Apps accessible through the internet and on mobile devices create an opportunity to enhance our traditional indicator-based surveillance systems, which have high specificity but issues with timeliness.

Objective: The aim of this study is to describe the literature on web-based apps for indicator-based surveillance and response to acute communicable disease outbreaks in the community with regard to their design, implementation, and evaluation. Read More

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Chatbot-Based Assessment of Employees' Mental Health: Design Process and Pilot Implementation.

JMIR Form Res 2021 Apr 21;5(4):e21678. Epub 2021 Apr 21.

Vitalk, TNH Health, São Paulo, Brazil.

Background: Stress, burnout, and mental health problems such as depression and anxiety are common, and can significantly impact workplaces through absenteeism and reduced productivity. To address this issue, organizations must first understand the extent of the difficulties by mapping the mental health of their workforce. Online surveys are a cost-effective and scalable approach to achieve this but typically have low response rates, in part due to a lack of interactivity. Read More

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Exploring opportunities to enhance effectiveness of mobile health and nutrition strategy for providing health and nutrition services amongst pastoralists in Somali region, Ethiopia.

Afr J Prim Health Care Fam Med 2021 Apr 9;13(1):e1-e7. Epub 2021 Apr 9.

UNICEF Somali Region, UNICEF Ethiopia, Jijiga.

Background: The health system in Ethiopia's Somali Region is weak with limited number of health facilities with more than 60% of the population living more than 5 km to the nearest health facilities. The deployment of mobile health and nutrition teams has played critical role in providing essential health and nutrition services.

Aim: This study aimed to assess the effectiveness of the mobile health and nutrition strategy in providing health and nutrition services in the targeted woredas (districts). Read More

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Evaluating Nursing Home Resident and Staff Experiences With a Life Story Program.

J Appl Gerontol 2021 Apr 21:7334648211008682. Epub 2021 Apr 21.

Benjamin Rose Institute on Aging, Cleveland, OH, USA.

Life story programs hold promise for improving person-centered care and relationships between nursing home residents and staff. A pilot life story intervention study in 16 nursing homes provided residents with complimentary biographical life story books and summaries, and staff with action plans to enhance care planning. Trained volunteers and program staff collected life stories, and researchers interviewed 170 residents at three points in time. Read More

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Optimized Photoactivatable Lipid Nanoparticles Enable Red Light Triggered Drug Release.

Small 2021 Apr 20:e2008198. Epub 2021 Apr 20.

Department of Biochemistry and Molecular Biology, University of British Columbia, 2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.

Encapsulation of small molecule drugs in long-circulating lipid nanoparticles (LNPs) can reduce toxic side effects and enhance accumulation at tumor sites. A fundamental problem, however, is the slow release of encapsulated drugs from these liposomal systems at the disease site resulting in limited therapeutic benefit. Methods to trigger release at specific sites are highly warranted. Read More

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Association Between Added Sugars from Infant Formulas and Rapid Weight Gain in US Infants and Toddlers.

J Nutr 2021 Apr 20. Epub 2021 Apr 20.

Division of Behavioral Medicine, Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

Background: Formulas often contain high amounts of added sugars, though little research has studied their connection to obesity.

Objectives: This study assessed the contribution of added sugars from formulas during complementary feeding on total added sugar intakes, and the association between these sugars and upward weight-for-age percentile (WFA%) crossing (i.e. Read More

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A Randomized Multiple Micronutrient Powder Point-of-Use Fortification Trial Implemented in Indian Preschools Increases Expressive Language and Reduces Anemia and Iron Deficiency.

J Nutr 2021 Apr 20. Epub 2021 Apr 20.

Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Background: Anemia is a global public health problem that undermines childhood development. India provides government-sponsored integrated nutrition/child development preschools.

Objectives: This double-masked, cluster-randomized controlled trial examines whether point-of-use multiple micronutrient powder (MNP) compared with placebo fortification of preschool meals impacts child development and whether effects vary by preschool quality (primary outcome) and biomarkers of anemia and micronutrients (secondary outcomes). Read More

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Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants.

bioRxiv 2021 Apr 14. Epub 2021 Apr 14.

Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the dominant circulating strains that continue to fuel the COVID-19 pandemic despite intensive vaccination efforts throughout the world. We report here cryo-EM structures of the full-length spike (S) trimers of the B.1. Read More

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Prevalence and Risk Factors of Gestational Diabetes Mellitus among Women Attending Antenatal Care in Hadiya Zone Public Hospitals, Southern Nation Nationality People Region.

Biomed Res Int 2021 5;2021:5564668. Epub 2021 Apr 5.

Department of Health Service Management, College of Medicine and Health Sciences, Wachemo University, Hossana, Ethiopia.

Introduction: In low- and middle-income countries, gestational diabetes mellitus is increasing globally; it is also a double burden of illness for both mothers and children. While gestational diabetes mellitus is recognized in Ethiopia, according to recent diagnostic criteria, information regarding it remains scarce.

Objective: To assess the prevalence of gestational diabetes mellitus and associated factors among women attending antenatal care in Hadiya Zone public Hospitals, Southern Ethiopia. Read More

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Humanized Culture Medium for Clinical-Grade Generation of Erythroid Cells from Umbilical Cord Blood CD34 Cells.

Adv Pharm Bull 2021 Feb 29;11(2):335-342. Epub 2020 Feb 29.

Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.

Transfusion of red blood cells (RBCs) is a supportive and common treatment in surgical care, trauma, and anemia. However, in vivo production of RBC seems to be a suitable alternative for blood transfusions due to the limitation of blood resources, the possibility of disease transmission, immune reactions, and the presence of rare blood groups. Cell cultures require serum-free or culture media supplemented with highly expensive animal serum, which can transmit xenoviruses. Read More

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February 2021

Tailored Limonene-Based Nanosized Microemulsion: Formulation, Physicochemical Characterization and Skin Irritation Assessment.

Adv Pharm Bull 2021 Feb 9;11(2):274-285. Epub 2020 Aug 9.

Department of Pharmaceutical Technology, Faculty of Pharmacy, Beirut Arab University, Beirut, Lebanon.

Microemulsion (ME) achieved progressing consequences on both the research and industry levels due to their distinctive properties. ME based-limonene system is considered as a surrogate to the traditional microemulsion composed of conventional oils. Thus, a novel microemulsion based on D-limonene and Gelucire® 44/12 had been designed and evaluated with assessing the factors affecting its physicochemical characteristics and in vivo skin irritation. Read More

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February 2021

Assessment of Extra-Cortical Bone Bridge Interface in Cemented Mega Endoprosthesis for Limb Salvage Surgery.

Malays Orthop J 2021 Mar;15(1):93-99

Department of Orthopaedics, Universiti Sains Malaysia, Kubang Kerian, Malaysia.

Introduction: Mega endoprosthesis replacement for resection of primary malignant bone tumour requires immediate and long-term stability, particularly in the young and active patient. Extracortical bone bridge interface (EBBI) is a technique whereby autograft is wrapped around the interface junction of bone and porous-coated implant to induce and enhance bone formation for biological incorporation. This procedure increases the mean torsional stiffness and the mean maximum torque, which eventually improves the implant's long-term survival. Read More

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[Efficacy of two barrier membranes and deproteinized bovine bone mineral on bone regeneration in extraction sockets: A microcomputed tomographic study in dogs].

Beijing Da Xue Xue Bao Yi Xue Ban 2021 Mar;53(2):364-370

Department of Prosthodontics, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To evaluate the effect of two barrier membranes [multilaminated small intestinal submucosa (mSIS) and bioresorable collagen membrane (Bio-Gide)] combined with deproteinized bovine bone mineral Bio-Oss on guided bone regeneration through a canine extraction sockets model.

Methods: The distal roots of 18 premolars of the Beagle' s bilateral maxillary and mandibular were removed, and 18 extraction sockets were obtained. They were randomly divided into 3 groups, and the following procedures were performed on the sockets: (1) filled with Bio-Oss and covered by mSIS (mSIS group), (2) filled with Bio-Oss and covered by Bio-Gide (BG group), (3) natural healing (blank control group). Read More

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The effect of traditional Chinese medicine treatment for post-viral olfactory dysfunction: A protocol for systematic review and meta-analysis.

Medicine (Baltimore) 2021 Apr;100(16):e25536

Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Dongcheng District, Beijing.

Background: Post-viral olfactory dysfunction (PVOD) have been reported in infections caused by several respiratory viruses, especially in COVID-19 which influence severely the quality of life of affected subjects. Few study has been published on the treatment of PVOD. Traditional Chinese medicine (TCM) is an effective method for PVOD which effects and safety have been confirmed. Read More

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Measuring perceived adequacy of staffing to incorporate nurses' judgement into hospital capacity management: a scoping review.

BMJ Open 2021 Apr 20;11(4):e045245. Epub 2021 Apr 20.

Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, The Netherlands.

Background: Matching demand and supply in nursing work continues to generate debate. Current approaches focus on objective measures, such as nurses per occupied bed or patient classification. However, staff numbers do not tell the whole staffing story. Read More

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I text for I COUGH: A clinical pilot study to evaluate the impact of text messaging upon postoperative ambulation in the hospital.

Am J Surg 2021 Apr 17. Epub 2021 Apr 17.

Boston University, School of Medicine & Boston Medical Center, 1 Boston Medical Center Pl, Boston, Massachusetts, 02118, USA.

Background: The "I COUGH" protocol is associated with improved postoperative pulmonary outcomes, and ambulation is an essential component. I COUGH is an acronym for Incentive spirometry, Coughing, Oral care, Understanding (patient and staff education), Getting-out-of-bed, and Head-of-bed elevation. This trial sought to enhance one component, specifically ambulation after operations. Read More

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Urine proteomics for profiling of mouse toxoplasmosis using liquid chromatography tandem mass spectrometry analysis.

Parasit Vectors 2021 Apr 20;14(1):211. Epub 2021 Apr 20.

Key Laboratory of Fujian-Taiwan Animal Pathogen Biology, College of Animal Sciences (College of Bee Science), Fujian Agriculture and Forestry University, Fuzhou, 350002, Fujian, China.

Background: Toxoplasma gondii is an obligate intracellular parasite that causes toxoplasmosis. Urine is an easily obtained clinical sample that has been widely applied for diagnostic purposes. However, changes in the urinary proteome during T. Read More

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Development and validation of a web-based patient decision aid for immunotherapy for patients with metastatic melanoma: study protocol for a multicenter randomized trial.

Trials 2021 Apr 20;22(1):294. Epub 2021 Apr 20.

Department of General Internal Medicine and Psychosomatics, Center for Psychosocial Medicine, Heidelberg University Hospital, Thibautstraße 4, 69115, Heidelberg, Germany.

Background: Patients with metastatic melanoma and their physicians are confronted with a complex decision regarding first-line therapy. Risks and benefits vary considerably between various treatment options. With this in mind, we aim to develop and evaluate a patient decision aid (PtDA) to inform patients about the risks and benefits of treatment options, namely, immunotherapy as monotherapy, immunotherapy as combination therapy, and treatment with BRAF/MEK inhibitors. Read More

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Costing electronic private sector malaria surveillance in the Greater Mekong Subregion.

Malar J 2021 Apr 20;20(1):192. Epub 2021 Apr 20.

Independent Consultant, New York, NY, USA.

Background: Private sector malaria programmes contribute to government-led malaria elimination strategies in Cambodia, Lao PDR, and Myanmar by increasing access to quality malaria services and surveillance data. However, reporting from private sector providers remains suboptimal in many settings. To support surveillance strengthening for elimination, a key programme strategy is to introduce electronic surveillance tools and systems to integrate private sector data with national systems, and enhance the use of data for decision-making. Read More

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Oral cancer knowledge and screening behavior among smokers and non-smokers in rural communities.

BMC Cancer 2021 Apr 20;21(1):430. Epub 2021 Apr 20.

Department of Health Outcomes and Biomedical Informatics, College of Medicine, University of Florida, PO Box 100177, 2004 Mowry Road, Suite 2251, Gainesville, FL, 32610-0177, USA.

Background: Research suggests having an oral and pharyngeal cancer (OPC) examination for early diagnosis can increase survival rate. However, the OPC screening rate is low in certain populations. To improve OPC screening rate, this study identified factors that are associated with having an OPC examination. Read More

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Crucial Music Components Needed for Speech Perception Enhancement of Pediatric Cochlear Implant Users: A Systematic Review and Meta-Analysis.

Audiol Neurootol 2021 Apr 20:1-25. Epub 2021 Apr 20.

Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.

Background: Although many clinicians have attempted music training for the hearing-impaired children, no specific effects have yet been reported for individual music components. This paper seeks to discover specific music components that help in improving speech perception of children with cochlear implants (CI) and to identify the effective training periods and methods needed for each component.

Method: While assessing 5 electronic databases, that is, ScienceDirect, Scopus, PubMed, CINAHL, and Web of Science, 1,638 articles were found initially. Read More

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Pediatric Emergency Medical Care in Yerevan, Armenia: A Knowledge and Attitudes Survey of Out-of-hospital Emergency Nurses.

Int Emerg Nurs 2021 Apr 17;56:100998. Epub 2021 Apr 17.

Virginia Commonwealth University School of Medicine, Department of Emergency Medicine Richmond, VA. Electronic address:

Background: Emergency Medical Services (EMS) system in Armenia follows the Franco-German model in which physician - nurse dyads staff ambulances. This study aims to evaluate the knowledge and attitudes of EMS nurses regarding pediatric rapid assessment and resuscitation.

Methods: This is a cross-sectional, anonymous, self-administered survey study of a convenience sample of 200 out-of-hospital emergency nurses in June and July 2015. Read More

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A "Co-CREATES" framework to foster a positive learning environment for nursing students' professional development in Rwanda.

Nurse Educ Pract 2021 Apr 7;53:103053. Epub 2021 Apr 7.

Western University, Arthur Labatt Family School of Nursing, Faculty of Health Sciences, Western University, London, ON N6A 5B9, Canada. Electronic address:

Aim: The future of the nursing profession in Rwanda in large part depends on the students who join the workforce and the education they have received. Preparing students with the necessary knowledge, values and judgement requires practice settings to be learner-centered. This study aimed at exploring strategies that might improve the current practice-based learning environment. Read More

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